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Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus

Year 2012, Volume: 39 Issue: 1, - , 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0085

Abstract

Objectives: Lichen planus is an immunologic disease mediated by lymphocytes in which T lymphocytes target at basal cells. It is believed that TNF-α that is released from T lymphocytes and keratinocytes plays a key role in the starting and progression of lichen planus by inducing apoptosis. MHC Class-I antigens on basal keratinocytes and interleukin-2 (IL-2) and IFN-gamma (γ) that are produced from CD4+ T cells stimulate the apoptosis of keratinocytes in lichen planus. The aim of this study was to measured the IL-2 and TNF-α levels in peripheral blood from patients with Lichen planus. Materials and methods: A total of 26 lichen planus patients (18 females, 8 males) that applied to the dermatology policlinics in Dicle University Hosspital between 2004 and 2006 and a healthy control group were included in the study. Serum IL-2 and TNF-α levels were measured by using Immulate 1000 solid phase and two-site chemiluminescent immunometric assay method. The results of patients and control group were compared. Results: Level of IL-2 (1172.615 ± 774.967) and TNF-α (13.361 ± 5.638) were higher in lichen planus to compared controls. IL-2 and TNF-α levels in the patient group were found to be significantly high statistically compared to health control group, respectively p=0.004 and p

Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus

Year 2012, Volume: 39 Issue: 1, - , 01.03.2012
https://doi.org/10.5798/diclemedj.0921.2012.01.0085

Abstract

Amaç: Liken planus T lenfositlerin bazal hücreleri hedef aldığı lenfosit aracılı immünolojik bir hastalıktır. T lenfositlerinden ve keratinositlerden salınan TNF-α\'nın apoptozisi indükleyerek liken planusun başlangıç ve progresyonunda anahtar rolü oynadığı düşünülmektedir. Bazal keratinositlerin üzerindeki MHC Class-I antijenler ve CD4+ T hücrelerinden üretilen IL-2 ve IFN-gamma (γ) liken planusta keratinositlerin apoptozisini tetiklemektedir. Bizim çalışmamızın amacı liken planuslu hastaların periferik kanlarındaki İL-2 ve TNF-α seviyelerini saptamaktır. Gereç ve yöntem: Dicle Üniversitesi Tıp Fakültesi Dermatoloji polikliniğine 2004-2006 yılları arasında başvuran 26 liken planuslu hasta (18 kadın, 8 erkek) ve sağlıklı kontrol grubu çalışmaya alındı. Serum IL-2 ve TNF-α seviyeleri Immulate 1000 solid faz ve two-site chemiluminescent immunometric assay yöntemi kullanılarak ölçüldü. Hasta ve kontrol grubunun sonuçları istatistiksel olarak karşılaştırıldı. Bulgular: IL-2 (1172,615 ± 774,967) ve TNF-α (13.361 ± 5,638) seviyeleri liken planuslu hastalarda kontrollere göre daha yüksek saptandı. Hasta grubunda IL-2 ve TNF-α seviyeleri, sağlıklı kontrollere göre istatistiksel olarak anlamlı derecede yüksek bulundu (sırasıyla p=0.004 ve p

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Details

Primary Language Turkish
Journal Section Research Articles
Authors

Derya Uçmak This is me

Gökçen Balcı This is me

Mehmet Harman This is me

Publication Date March 1, 2012
Submission Date March 2, 2015
Published in Issue Year 2012 Volume: 39 Issue: 1

Cite

APA Uçmak, D., Balcı, G., & Harman, M. (2012). Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus. Dicle Tıp Dergisi, 39(1). https://doi.org/10.5798/diclemedj.0921.2012.01.0085
AMA Uçmak D, Balcı G, Harman M. Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus. diclemedj. March 2012;39(1). doi:10.5798/diclemedj.0921.2012.01.0085
Chicago Uçmak, Derya, Gökçen Balcı, and Mehmet Harman. “Evaluation of Interleukin-2 and Tumor Necrosis Factor-α Levels in Patients With Lichen Planus”. Dicle Tıp Dergisi 39, no. 1 (March 2012). https://doi.org/10.5798/diclemedj.0921.2012.01.0085.
EndNote Uçmak D, Balcı G, Harman M (March 1, 2012) Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus. Dicle Tıp Dergisi 39 1
IEEE D. Uçmak, G. Balcı, and M. Harman, “Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus”, diclemedj, vol. 39, no. 1, 2012, doi: 10.5798/diclemedj.0921.2012.01.0085.
ISNAD Uçmak, Derya et al. “Evaluation of Interleukin-2 and Tumor Necrosis Factor-α Levels in Patients With Lichen Planus”. Dicle Tıp Dergisi 39/1 (March 2012). https://doi.org/10.5798/diclemedj.0921.2012.01.0085.
JAMA Uçmak D, Balcı G, Harman M. Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus. diclemedj. 2012;39. doi:10.5798/diclemedj.0921.2012.01.0085.
MLA Uçmak, Derya et al. “Evaluation of Interleukin-2 and Tumor Necrosis Factor-α Levels in Patients With Lichen Planus”. Dicle Tıp Dergisi, vol. 39, no. 1, 2012, doi:10.5798/diclemedj.0921.2012.01.0085.
Vancouver Uçmak D, Balcı G, Harman M. Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus. diclemedj. 2012;39(1).