Lectin-like oxidized low density lipoprotein receptor 1(LOX-1) levels and endothelial dysfunction in patients with primary essential hyperhidrosis

Year 2013, Volume: 40 Issue: 4, 529 - 532, 01.12.2013

Emine Nur Rifaioğlu Gamze Erfan Seval Doğruk Kaçar Savaş Güzel Seref Alpsoy Mustafa Kulaç Şemsettin Karaca Bilge Bülbül Şen Özlem Ekiz Nihat Sen

https://doi.org/10.5798/diclemedj.0921.2013.04.0327

Abstract

Objective: Primary essential hyperhidrosis (PEH) is a disorder characterized by excessive sweating of palms, soles and axilla. Although its etiology was not fully understand, increased activity of the autonomic nervous system may play a role in the pathogenesis of PEH. In the study we aimed to investigate flow mediated dilatation and lectin like oxide LDL receptor 1 (LOX-1) levels as an indicator of endothelial dysfunction in patient with PEH. Methods: Thirty-three PEH patients diagnosed with starch-iodine test and age- and sex-matched 19 healthy controls were included in the study. Flow-mediated dilatation was performed by ultrasonographical measurement of brachial artery. Serum LOX-1 levels were analyzed with Enzyme-Linked Immuno-Sorbent Assay (ELISA) kit. Results: Brachial artery FMD diameters and post-nitrate dilatation diameters were not different between patients and the controls. There was no difference between patient and control groups when compared for LOX-1 levels. Conclusion: Larger studies are needed to understand, indeed, whether excessive hyperhidrosis in PEH is only a peripheral excessive response to normal sympathetic activity or a systemic sympathetic hyperactivity with cardiovascular effects, which is disguised by compensatory mechanisms, such as nitric oxide (NO).

Keywords

endothelial dysfunction, flow mediated dilatation, lectin like oxidized low density lipoprotein receptor 1, primary essential hyperhidrosis

Primer esansiyel hiperhidroz hastalarında lektin benzeri okside düşük dansiteli lipoprotein reseptör 1(LOX-1) düzeyleri ve endotel disfonksiyonu

Abstract

Amaç: Primer esansiyel hiperhidroz avuç içi ayak tabanı ve aksiler bölgenin aşırı terlemesi ile karakterize bir hastalıktır. Etyolojisi henüz açıklığa kavuşmamış olmakla beraber otonom sinir sisteminin artmış aktivitesinin rolü tartışılmaktadır. Biz bu çalışmada primer esansiyel hiperhidroz hastalarında akım aracılı dilatasyon ve lektin benzeri okside düşük dansiteli lipoprotein reseptör 1 düzeylerini inceleyerek endotelyal disfonfonksiyonun varlığını araştırmayı amaçladık. Yöntemler: Tanısı nişasta iyot testi ile konmuş otuzüç primer esansiyel hiperhidroz hastası ile 19 yaş ve cinsiyet uyumlu kontrol bu çalışmaya dahil edildi. Akım aracılı dilatasyon ultrasonografik olarak brakiyel arterden ölçüldü. Serum LOX-1 seviyeleri Enzim-Bağlı İmmun Sorbent Testi (ELISA) ile ölçüldü. Bulgular: Brakiyel arter akım aracılı dilatasyon çapları ve post nitrat dilatasyon çapları hasta ve kontrol grubu için istatistiksel olarak farklı değildi. LOX-1 değerleri açısından karşılaştırıldığında da hasta ve kontrol grubu arasında istatistiksel olarak fark yoktu. Sonuç: Primer esansiyel hiperhidrozda aşırı terleme erkin bezlerin normal sempatik aktiviteye verdiği aşırı bir periferik yanıt mı yoksa kardiyovasküler etkileri nitrik oksit ile maskelenmiş sistemik sempatik bir hiperaktivite mi olduğunu anlamak için daha geniş çalışmalara ihtiyaç vardır.

Keywords

Endotel disfonksiyon, akım aracılı dilatasyon, lektin benzeri okside düşük dansiteli lipoprotein reseptör 1, primer esansiyel hiperhidroz

References

• Vorkamp T, Foo FJ, Khan S, et al. Hyperhidrosis: Evolving concepts and a comprehensive review. Surgeon 2010;8:287- 292.
• Kaufmann H, Saadia D, Polin C, et al. Primary hyperhidrosis -evidence for autosomal dominant inheritance. Clin Auton Res 2003;13:96-98.
• Kelm M. Flow-mediated dilatation in human circulation: di- agnostic and therapeutic aspects. Am J Physiol Heart Circ Physiol 2002;282:1-5.
• Naidu OA, Rajasekhar D, Latheef SA. Assessment of en- dothelial function by brachial artery flow mediated dila- tation in microvascular disease. Cardiovasc Ultrasound 2011;9:40-44.
• Ma FX, Zhou B, Chen Z, et al. Oxidized low-density lipo- protein impairs endothelial progenitor cells by regulation of endothelialnitric oxide synthase. J Lipid Res 2006;47:1227- 1237.
• Sawamura T, Kakino A, Fujita Y. LOX-1: a multiligand re- ceptor at the crossroads of response to danger signals. Curr Opin Lipidol 2012 ;23:439-445.
• De Marinis M, Colaizzo E, Petrelli RA, et al. Alterations in cardiovascular autonomic function tests in idiopathic hy- perhidrosis. Auton Neurosci 2012;167:34-8.
• Senard JM, Simonetta-Moreau M, Tran MA. Blood pressure and heart rate variability in patients with essential hyperhi- drosis. Clin Auton Res 2003;13:281-285.
• Kaya D, Karaca S, Barutcu I, et al. Heart rate variability in patients with essential hyperhidrosis: dynamic influence of sympathetic and parasympathetic maneuvers. Ann Nonin- vasive Electrocardiol 2005;10:1-6.
• Saglam M, Esen AM, Barutcu I, et al. Impaired left ven- tricular filling in patients with essential hyperhidrosis: an echo-Doppler study. Tohoku J Exp Med 2006;208:283-290.
• Li Y, Duan Z, Gao D, et al. The new role of LOX-1 in hyper- tension induced neuronal apoptosis. Biochem Biophys Res Commun 2012;425:735-740.
• Lepori M, Sartori C, Duplain H, et al. Sympathectomy poten- tiates the vasoconstrictor response to nitric oxide synthase inhibition in humans. Cardiovasc Res 1999;43:739-743.
• Karaca S, Kulac M, Uz E, et al. Is nitric oxide involved in the pathophysiology of essential hyperhidrosis? Int J Der- matol 2007;46:1027-1030.
• Ma FX, Zhou B, Chen Z, et al. Oxidized low-density li- poprotein impairs endothelial progenitor cells by regu- lation of endothelial nitric oxide synthase. J Lipid Res 2006;47:1227-1237.