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The relationship between subclinic atherosclerosis and red cell distribution width in patients with metabolic syndrome

Year 2013, Volume: 40 Issue: 4, 579 - 584, 01.12.2013

Ali Rıza Gülcan Mustafa Serkan Karakaş Barış Akdemir Mustafa Uçar Refik Emre Altekin Hüseyin Yılmaz

https://doi.org/10.5798/diclemedj.0921.2013.04.0336

Abstract

Objectıve: We have investigated the possible association between red cell distribution width (RDW) and subclinic atherosclerosis which can assessed by carotid intima-media thickness (CIMT) measurement in patients with metabolic syndrome (MetS). Methods: 74 patients with MetS were enrolled to the study. Patients were divided into 2 groups according to carotid intima-media thickness (CIMT) measurement: 35 patients with CIMT≥1.0 mm were at group 1 and 39 patients with CIMT

Keywords

red cell distribution width metabolic syndrome complete blood count

References

  • Reaven G. Insulin resistance, compensatory hyperinsu- linemia and coronary heart disease: Syndrome X revisited. In Jefferson LS, Cherrington AD, eds. Handbook of Physi- ology, Section 7, The Endocrine System, Vol II, The Pan- creas and Regulation of Metabolism. New York: Oxford University Press, 2001, pp 1169–1197.
  • Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a sys- tematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007;49:403-414.
  • Despres JP, Lamarche B, Mauriege P. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996;334:952–957.
  • Perkins SL. Examination of blood and bone marrow. In: Greer JP, Foerster J, Lukens JN, et al. eds. Wintrobe’s Clin- ical Hematology. 11th ed. Salt Lake City, UT: Lippincott Williams & Wilkins; 2003:5-25.
  • Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol 2010;105:312-317.
  • van Kimmenade RR, Mohammed AA, Uthamalingam S, et al. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail 2010;12:129-136.
  • Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40-47.
  • Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163- 168.
  • Ye Z, Smith C, Kullo IJ. Usefulness of red cell distribution width to predict mortality in patients with peripheral artery disease. Am J Cardiol 2011;107:1241-1245.
  • Zorlu A, Bektasoglu G, Guven FM, et al. Usefulness of ad- mission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol 2012; 109:128-134.
  • Patel KV, Ferrucci L, Ershler WB, et al. Red blood cell dis- tribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009;169:515-523.
  • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-1023.
  • Lippi G, Targher G, Montagnana M, et al. Relation between red blood cell distribution width and inflammatory bio- markers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-632.
  • Mallika V, Goswarni B, Rajappa M. Atherosclerosis pathophsiology and role of novel risk factors: a clinicobio- chemical perspective.Angiology 2007:58;513-522.
  • Sinha AK, Eigenbrodt M, Mehta JL.Does carotid intima media thickness indicate coronary atherosclerosis? Curr Opin Cardiol 2002:17;526-530.
  • Mukherjee D, Yadav JS. Carotid artery intima-medial thick- ness: indicator of atherosclerotic burden and response to risk factor modification. Am Heart J 2002;144: 753-759.
  • International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Avaliable at: http://www.idf.org/webdata/docs/IDF_Metasyndrome_ def .pdf Accessed October 4, 2005.
  • Özgen AG. Metabolik sendrom ve dislipidemi. Türkiye Kli- nikleri J Int Med Sci 2006;2:43-54.
  • Golden SH, Folsom AR, Coresh J, et al. Risk Factor Group- ings Related to Insulin Resistance and Their Synergistic Effects on Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities Study. Diabetes 2002;51:3069-3076.
  • Hassinen M, Komulainen P, Lakka TA, et al. Metabolic Syn- drome and the Progression of Carotid Intima-Media Thick- ness in Elderly Women. Arch Intern Med 2006;166:444- 449.
  • Kuller L, Borhani N, Furberg C, et al. Prevalence of sub- clinical atherosclerosis and cardiovascular disease and as- sociation with risk factors in the Cardiovascular Health Study. Am J Epidemiol 1994;139:1164-1179.
  • Lament D. Risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51: Lifecourse study. BJM 2000;320:273-278.
  • Androulakis AE, Andrikopoulos GK, Richter DJ, et al. The role of carotid atherosclerosis in the distinction between ischaemic and non-ischaemic cardiomyopathy. Eur Heart J 2000;21:919-926.
  • Bots ML, Baldassarre D, Simon A, et al. Carotid intima-me- dia thickness and coronary atherosclerosis: weak or strong relations? European Heart Journal 2007;28:398-406.
  • Chambless LE, Heiss G, Folsom AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study. 1987-1993. Am J Epidemiol 1997;146:483-494.
  • Zalawadiya SK, Veeranna V, Niraj A, et al. Red cell distri- bution width and risk of coronary heart disease events. Am J Cardiol 2010;106:988–993.
  • Fukuta H, Ohte N, Mukai S, et al. Elevated plasma levels of B-type natriuretic peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J 2009;50:301-312.
  • Libby P, Ridker PM, Maseri A. Inflammation and athero- sclerosis. Circulation 2002;105:1135–1143.
  • Allen LA, Felker GM, Mehra MR, et al. Validation and po- tential mechanisms of red cell distribution width as a prog- nostic marker in heart failure. J Card Fail 2010;16:230–238.
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103–108.
  • Cavusoglu E, Chopra V, Gupta A, et al. Relation between red blood cell distribution width (RDW) and all-cause mor- tality at two years in an unselected population referred for coronary angiography. Int J Cardiol 2010;141:141–146.
  • Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 2006;47:19-31.
  • Semba RD, Patel KV, Ferrucci L, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clin Nutr 2010;29:600-604.
  • Kishi T, Hirooka Y. Sympathoexcitation associated with renin-angiotensin system in metabolic syndrome. Interna- tional Journal of Hypertension Epub 2013 Feb 13.
  • Akin F, Köse N, Ayça B, et al. Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction. Angiology 2013;64:592-596.
  • Sánchez-Chaparro MA, Calvo-Bonacho E, González-Quin- tela A. Ibermutuamur Cardiovascular RIsk Assessment Study Group. Higher red blood cell distribution width is associated with the metabolic syndrome: results of the Iber- mutuamur Cardiovascular RIsk assessment study. Diabetes Care 2010;33:40.
  • Vayá A, Carmona P, Badia N, et al. Association between high red blood cell distribution width and metabolic syn- drome. Influence of abdominal obesity. Clin Hemorheol Microcirc 2011;47:75-77.

Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi

Year 2013, Volume: 40 Issue: 4, 579 - 584, 01.12.2013

Ali Rıza Gülcan Mustafa Serkan Karakaş Barış Akdemir Mustafa Uçar Refik Emre Altekin Hüseyin Yılmaz

https://doi.org/10.5798/diclemedj.0921.2013.04.0336

Abstract

Amaç: Çalışmamızda Metabolik sendrom (MetS)\'lu hastalarda karotis intima-media kalınlığı (KİMK) ölçümü ile değerlendirilen subklinik ateroskleroz ile eritrosit dağılım genişliği (EDG) arasında ilişki olup olmadığını araştırdık Yöntemler: Çalışmaya MetS\'lu 74 hasta alındı. Hastalar KİMK ölçümüne göre, KİMK≥1,0 mm olan 35 hasta grup 1, KİMK

Keywords

eritrosit dağılım genişliği metabolik sendrom total kan sayımı

References

  • Reaven G. Insulin resistance, compensatory hyperinsu- linemia and coronary heart disease: Syndrome X revisited. In Jefferson LS, Cherrington AD, eds. Handbook of Physi- ology, Section 7, The Endocrine System, Vol II, The Pan- creas and Regulation of Metabolism. New York: Oxford University Press, 2001, pp 1169–1197.
  • Gami AS, Witt BJ, Howard DE, et al. Metabolic syndrome and risk of incident cardiovascular events and death: a sys- tematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007;49:403-414.
  • Despres JP, Lamarche B, Mauriege P. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996;334:952–957.
  • Perkins SL. Examination of blood and bone marrow. In: Greer JP, Foerster J, Lukens JN, et al. eds. Wintrobe’s Clin- ical Hematology. 11th ed. Salt Lake City, UT: Lippincott Williams & Wilkins; 2003:5-25.
  • Dabbah S, Hammerman H, Markiewicz W, Aronson D. Relation between red cell distribution width and clinical outcomes after acute myocardial infarction. Am J Cardiol 2010;105:312-317.
  • van Kimmenade RR, Mohammed AA, Uthamalingam S, et al. Red blood cell distribution width and 1-year mortality in acute heart failure. Eur J Heart Fail 2010;12:129-136.
  • Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50:40-47.
  • Tonelli M, Sacks F, Arnold M, et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 2008;117:163- 168.
  • Ye Z, Smith C, Kullo IJ. Usefulness of red cell distribution width to predict mortality in patients with peripheral artery disease. Am J Cardiol 2011;107:1241-1245.
  • Zorlu A, Bektasoglu G, Guven FM, et al. Usefulness of ad- mission red cell distribution width as a predictor of early mortality in patients with acute pulmonary embolism. Am J Cardiol 2012; 109:128-134.
  • Patel KV, Ferrucci L, Ershler WB, et al. Red blood cell dis- tribution width and the risk of death in middle-aged and older adults. Arch Intern Med 2009;169:515-523.
  • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-1023.
  • Lippi G, Targher G, Montagnana M, et al. Relation between red blood cell distribution width and inflammatory bio- markers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009;133:628-632.
  • Mallika V, Goswarni B, Rajappa M. Atherosclerosis pathophsiology and role of novel risk factors: a clinicobio- chemical perspective.Angiology 2007:58;513-522.
  • Sinha AK, Eigenbrodt M, Mehta JL.Does carotid intima media thickness indicate coronary atherosclerosis? Curr Opin Cardiol 2002:17;526-530.
  • Mukherjee D, Yadav JS. Carotid artery intima-medial thick- ness: indicator of atherosclerotic burden and response to risk factor modification. Am Heart J 2002;144: 753-759.
  • International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. Avaliable at: http://www.idf.org/webdata/docs/IDF_Metasyndrome_ def .pdf Accessed October 4, 2005.
  • Özgen AG. Metabolik sendrom ve dislipidemi. Türkiye Kli- nikleri J Int Med Sci 2006;2:43-54.
  • Golden SH, Folsom AR, Coresh J, et al. Risk Factor Group- ings Related to Insulin Resistance and Their Synergistic Effects on Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities Study. Diabetes 2002;51:3069-3076.
  • Hassinen M, Komulainen P, Lakka TA, et al. Metabolic Syn- drome and the Progression of Carotid Intima-Media Thick- ness in Elderly Women. Arch Intern Med 2006;166:444- 449.
  • Kuller L, Borhani N, Furberg C, et al. Prevalence of sub- clinical atherosclerosis and cardiovascular disease and as- sociation with risk factors in the Cardiovascular Health Study. Am J Epidemiol 1994;139:1164-1179.
  • Lament D. Risk of cardiovascular disease measured by carotid intima-media thickness at age 49-51: Lifecourse study. BJM 2000;320:273-278.
  • Androulakis AE, Andrikopoulos GK, Richter DJ, et al. The role of carotid atherosclerosis in the distinction between ischaemic and non-ischaemic cardiomyopathy. Eur Heart J 2000;21:919-926.
  • Bots ML, Baldassarre D, Simon A, et al. Carotid intima-me- dia thickness and coronary atherosclerosis: weak or strong relations? European Heart Journal 2007;28:398-406.
  • Chambless LE, Heiss G, Folsom AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study. 1987-1993. Am J Epidemiol 1997;146:483-494.
  • Zalawadiya SK, Veeranna V, Niraj A, et al. Red cell distri- bution width and risk of coronary heart disease events. Am J Cardiol 2010;106:988–993.
  • Fukuta H, Ohte N, Mukai S, et al. Elevated plasma levels of B-type natriuretic peptide but not C-reactive protein are associated with higher red cell distribution width in patients with coronary artery disease. Int Heart J 2009;50:301-312.
  • Libby P, Ridker PM, Maseri A. Inflammation and athero- sclerosis. Circulation 2002;105:1135–1143.
  • Allen LA, Felker GM, Mehra MR, et al. Validation and po- tential mechanisms of red cell distribution width as a prog- nostic marker in heart failure. J Card Fail 2010;16:230–238.
  • Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. J Neurol Sci 2009;277:103–108.
  • Cavusoglu E, Chopra V, Gupta A, et al. Relation between red blood cell distribution width (RDW) and all-cause mor- tality at two years in an unselected population referred for coronary angiography. Int J Cardiol 2010;141:141–146.
  • Tsimikas S, Willerson JT, Ridker PM. C-reactive protein and other emerging blood biomarkers to optimize risk stratification of vulnerable patients. J Am Coll Cardiol 2006;47:19-31.
  • Semba RD, Patel KV, Ferrucci L, et al. Serum antioxidants and inflammation predict red cell distribution width in older women: the Women’s Health and Aging Study I. Clin Nutr 2010;29:600-604.
  • Kishi T, Hirooka Y. Sympathoexcitation associated with renin-angiotensin system in metabolic syndrome. Interna- tional Journal of Hypertension Epub 2013 Feb 13.
  • Akin F, Köse N, Ayça B, et al. Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction. Angiology 2013;64:592-596.
  • Sánchez-Chaparro MA, Calvo-Bonacho E, González-Quin- tela A. Ibermutuamur Cardiovascular RIsk Assessment Study Group. Higher red blood cell distribution width is associated with the metabolic syndrome: results of the Iber- mutuamur Cardiovascular RIsk assessment study. Diabetes Care 2010;33:40.
  • Vayá A, Carmona P, Badia N, et al. Association between high red blood cell distribution width and metabolic syn- drome. Influence of abdominal obesity. Clin Hemorheol Microcirc 2011;47:75-77.
There are 37 citations in total.

Details

Primary Language Turkish
Journal Section Research Articles
Authors

Ali Rıza Gülcan This is me

Mustafa Serkan Karakaş This is me

Barış Akdemir This is me

Mustafa Uçar This is me

Refik Emre Altekin This is me

Hüseyin Yılmaz This is me

Publication Date December 1, 2013
Submission Date March 2, 2015
Published in Issue Year 2013 Volume: 40 Issue: 4

Cite

APA Gülcan, A. R., Karakaş, M. S., Akdemir, B., Uçar, M., et al. (2013). Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi. Dicle Tıp Dergisi, 40(4), 579-584. https://doi.org/10.5798/diclemedj.0921.2013.04.0336
AMA Gülcan AR, Karakaş MS, Akdemir B, Uçar M, Altekin RE, Yılmaz H. Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi. diclemedj. December 2013;40(4):579-584. doi:10.5798/diclemedj.0921.2013.04.0336
Chicago Gülcan, Ali Rıza, Mustafa Serkan Karakaş, Barış Akdemir, Mustafa Uçar, Refik Emre Altekin, and Hüseyin Yılmaz. “Metabolik Sendromlu Hastalarda Eritrosit dağılım genişliğinin Subklinik Ateroskleroz Ile ilişkisi”. Dicle Tıp Dergisi 40, no. 4 (December 2013): 579-84. https://doi.org/10.5798/diclemedj.0921.2013.04.0336.
EndNote Gülcan AR, Karakaş MS, Akdemir B, Uçar M, Altekin RE, Yılmaz H (December 1, 2013) Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi. Dicle Tıp Dergisi 40 4 579–584.
IEEE A. R. Gülcan, M. S. Karakaş, B. Akdemir, M. Uçar, R. E. Altekin, and H. Yılmaz, “Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi”, diclemedj, vol. 40, no. 4, pp. 579–584, 2013, doi: 10.5798/diclemedj.0921.2013.04.0336.
ISNAD Gülcan, Ali Rıza et al. “Metabolik Sendromlu Hastalarda Eritrosit dağılım genişliğinin Subklinik Ateroskleroz Ile ilişkisi”. Dicle Tıp Dergisi 40/4 (December 2013), 579-584. https://doi.org/10.5798/diclemedj.0921.2013.04.0336.
JAMA Gülcan AR, Karakaş MS, Akdemir B, Uçar M, Altekin RE, Yılmaz H. Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi. diclemedj. 2013;40:579–584.
MLA Gülcan, Ali Rıza et al. “Metabolik Sendromlu Hastalarda Eritrosit dağılım genişliğinin Subklinik Ateroskleroz Ile ilişkisi”. Dicle Tıp Dergisi, vol. 40, no. 4, 2013, pp. 579-84, doi:10.5798/diclemedj.0921.2013.04.0336.
Vancouver Gülcan AR, Karakaş MS, Akdemir B, Uçar M, Altekin RE, Yılmaz H. Metabolik sendromlu hastalarda eritrosit dağılım genişliğinin subklinik ateroskleroz ile ilişkisi. diclemedj. 2013;40(4):579-84.