The relationship between prognostic parameters and tumor associated tissue eosinophilia in supraglottic laryngeal tumors
Abstract
Objective: Tumor-associated tissue eosinophilia (TATE) has been noted in human cancers, sometimes with dif­ferent results regarding their association with clinical out­come. In this study, the association between TATE and prognostic parameters of supraglottic laryngeal cancer was analyzed. Materials and methods: Sixty-two patients with diagno­sis of supraglottic laryngeal squamous cell carcinoma and who treated surgically in our center were evaluated. The cases were divided into 3 categories according to the av­erage number of eosinophils per high-power field (400x): 0 (negative), 1-5 (grade 1+), more than 5 (grade 2+). Results: We found 24 TATE-negative (38.7%) and 38 TATE-positive (61.3%) cases. There was not any statisti­cally significant correlation between TATE and tumor dif­ferentiation, vascular invasion, perineural invasion, lymph node metastasis, patients\' ages, T stages (p>0.05). As expected, vascular invasion correlated with lymph node metastasis (p=0.001). Conclusion: The results of this study showed that TATE has no correlation with prognostic parameters such as histologic differentiation, vascular invasion, perineural invasion, lymph node metastasis, patients\' ages and T stages in supraglottic laryngeal squamous cell carcino­ma. The data suggest that stromal eosinophilic infiltration is not useful for determining biological aggressiveness in supraglottic laryngeal cancer.
References
- Kirchner J A, Crater D. Pathology of the Larynx In: Mills SE, Carter D, Greeson JK, Stoler MH, Oberman HA, eds. Sten- berg’s Diagnostic Surgical Pathology. 4th edn. Philadelphia: Lippincott Williams and Wilkins; 2004; 1007-31.
- Myers EN, Alvi A. Management of carcinoma of the su- praglottic larynx: evolution, current concepts, and future trends. Laryngoscope 1996;106:559-67.
- Lotfi R, Lee JJ, Lotze MT. Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs) role in the inflammatory response within tumors. J Immu- nother 2007;30:16-28.
- Carusa R A, Ieni A, Fedele F, et al. Degranulation patterns of eosinophils in advanced gastric carcinoma: an electron microscopic study. Ultrastruct Pathol 2005;29:29-36.
- Dorta RG, Landman G, Kowalski LP, Lauris JR, Latorre MR, Oliveira DT. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. His- topathology 2002;41:152-7.
- Spiegel GW, Ashraf M, Brooks JJ. Eosinophils as a marker for invasion in cervical squamous neoplastic lesions. Int J Gynecol Pathol 21:117-24.
- Amini RM, Aaltonen K, Nevanlinna H, et al. Mast cells and eosinophils in invasive breast carcinoma. BMC Cancer 2007;7:165.
- Tutar E, Karataş E, Kibar Y, Bağlam T, Durucu C. Larinks karsinomlarında stromal eozinofilik reaksiyonun prognos- tik parametreler ile ilişkisi. KBB-Forum 2006;5:142-4.
- Ercan I, Çakır B, Başak T, Özdemir T, Sayın İ, Turgut S. Prognostic significance of stromal eosinophilic infiltra- tion in cancer of the larynx. Otolaryngol. Head Neck Surg 2005;132:869-73.
- Cann CI, Fried MP, Rothman KJ. Epidemiology of squa- mous cell cancer of the head and neck. Otolaryngol Clin North Am 1985;18: 367-88.
- Ali S, Kaur J, Patel KD. Intercellular cell adhesion mol- ecule-1, vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are ex- pressed by human breast carcinoma cells and support eosin- ophil adhesion and activation. Am J Pathol 2000;157:313- 21.
- Fujii M, Yamashita T, Ishiguro R, Tashiro M, Kameyama K. Significance of epidermal growth factor receptor and tumor associated tissue eosinophilia in the prognosis of patients with nasopharyngeal carcinoma. Auris Nasus Larynx 2002; 29:175-81.
- Katori H, Nozawa A, Tsukuda M. Histopathological param- eters of recurrence and malignant transformation in sinona- sal inverted papilloma. Acta Otolaryngol 2006;126:214-8.
- Tadbir AA, Ashraf MJ, Sardari Y. Prognotic significance of stromal eosinophilic infiltration in oral squamous cell car- cinoma. J Craniofac Surg 2009;20:287-9.
- Sessions DG, Lenox J, Spector GJ. Supraglottic laryn- geal cancer: analysis of treatment results. Laryngoscope 2005;115:1402-10.
- Rodrigo JP, Dominguez F, Alvarez C, Manrique C, Herrero A, Suarez C. Expression of E-cadherin in squamous cell carcinomas of the supraglottic larynx with correlations to clinicopathological features. Eur J Cancer 2002;38:1059- 64.
- Tataroğlu C, Polat A, Kargı A, Şengiz S, Çamdeviren H, Küpelioğlu A. Kolorektal karsinomlarda invazyon derinli- ğinin neovaskülarizasyon, peritümöral NK hücresi, makro- faj ve eozinofil lökositlerle ilişkisinin araştırılması. Türk Patoloji Dergisi 2005;21:49-53.
Supraglottik larinks karsinomlarında tümör ilişkili doku eozinofilisinin prognostik parametreler ile ilişkisi
Abstract
Amaç: Tümör ilişkili doku eozinofilisi (TİDE) birçok in­san kanserinde izlenebilir, klinik gidiş ile ilişkisi değişik sonuçlar gösterebilir. Bu çalışmada TİDE ile supraglottik karsinomların prognostik parametrelerinin ilişkisi analiz edilmiştir. Gereç ve yöntem: Merkezimizde supraglottik skuamöz hücreli larinks kanseri tanısı alan ve cerrahi uygulanan 62 olgu incelendi. Olgular her büyük büyütme alanındaki (400x) ortalama eozinofil sayısına göre şu şekilde 3 ka­tegoriye ayrılmıştır: 0 (negatif), 1-5 (derece 1+) ve 5\'den çok (derece 2+). Bulgular: Olgular 24 TİDE-negatif (%38,7) ve 38 Tİ­DE-pozitif (%61,3) olarak saptandı. Tümör evresi, tümör diferansiasyon derecesi, lenf nodu metastaz varlığı, len­fovasküler invazyon varlığı, perinöral invazyon ve hasta yaşı ile eozinofilik reaksiyonun derecesi arasında anlamlı ilişki saptanmadı. Beklendiği gibi lenfovasküler invazyon ile lenf nodu metastazı görülmesi arasında istatiksel ola­rak anlamlı bir ilişki saptandı (p= 0,001). Sonuç: Bu çalışmanın sonuçları supraglottik larinks sku­amöz hücreli karsinomlarında, tümör ilişkili doku eozino­filisi ile yaş, tümör diferansiasyon derecesi, tümör evresi, vasküler invazyon, perinöral invazyon, lenf nodu metas­tazı gibi prognostik faktörler arasında bir ilişki olmadığını göstermiştir. Bu bulgular stromal eozinofil infiltrasyonu­nun supraglottik larinks karsinomlarının biyolojik agresi­vitesini belirlemede kullanılamayacağını telkin etmektedir.
References
- Kirchner J A, Crater D. Pathology of the Larynx In: Mills SE, Carter D, Greeson JK, Stoler MH, Oberman HA, eds. Sten- berg’s Diagnostic Surgical Pathology. 4th edn. Philadelphia: Lippincott Williams and Wilkins; 2004; 1007-31.
- Myers EN, Alvi A. Management of carcinoma of the su- praglottic larynx: evolution, current concepts, and future trends. Laryngoscope 1996;106:559-67.
- Lotfi R, Lee JJ, Lotze MT. Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs) role in the inflammatory response within tumors. J Immu- nother 2007;30:16-28.
- Carusa R A, Ieni A, Fedele F, et al. Degranulation patterns of eosinophils in advanced gastric carcinoma: an electron microscopic study. Ultrastruct Pathol 2005;29:29-36.
- Dorta RG, Landman G, Kowalski LP, Lauris JR, Latorre MR, Oliveira DT. Tumour-associated tissue eosinophilia as a prognostic factor in oral squamous cell carcinomas. His- topathology 2002;41:152-7.
- Spiegel GW, Ashraf M, Brooks JJ. Eosinophils as a marker for invasion in cervical squamous neoplastic lesions. Int J Gynecol Pathol 21:117-24.
- Amini RM, Aaltonen K, Nevanlinna H, et al. Mast cells and eosinophils in invasive breast carcinoma. BMC Cancer 2007;7:165.
- Tutar E, Karataş E, Kibar Y, Bağlam T, Durucu C. Larinks karsinomlarında stromal eozinofilik reaksiyonun prognos- tik parametreler ile ilişkisi. KBB-Forum 2006;5:142-4.
- Ercan I, Çakır B, Başak T, Özdemir T, Sayın İ, Turgut S. Prognostic significance of stromal eosinophilic infiltra- tion in cancer of the larynx. Otolaryngol. Head Neck Surg 2005;132:869-73.
- Cann CI, Fried MP, Rothman KJ. Epidemiology of squa- mous cell cancer of the head and neck. Otolaryngol Clin North Am 1985;18: 367-88.
- Ali S, Kaur J, Patel KD. Intercellular cell adhesion mol- ecule-1, vascular cell adhesion molecule-1, and regulated on activation normal T cell expressed and secreted are ex- pressed by human breast carcinoma cells and support eosin- ophil adhesion and activation. Am J Pathol 2000;157:313- 21.
- Fujii M, Yamashita T, Ishiguro R, Tashiro M, Kameyama K. Significance of epidermal growth factor receptor and tumor associated tissue eosinophilia in the prognosis of patients with nasopharyngeal carcinoma. Auris Nasus Larynx 2002; 29:175-81.
- Katori H, Nozawa A, Tsukuda M. Histopathological param- eters of recurrence and malignant transformation in sinona- sal inverted papilloma. Acta Otolaryngol 2006;126:214-8.
- Tadbir AA, Ashraf MJ, Sardari Y. Prognotic significance of stromal eosinophilic infiltration in oral squamous cell car- cinoma. J Craniofac Surg 2009;20:287-9.
- Sessions DG, Lenox J, Spector GJ. Supraglottic laryn- geal cancer: analysis of treatment results. Laryngoscope 2005;115:1402-10.
- Rodrigo JP, Dominguez F, Alvarez C, Manrique C, Herrero A, Suarez C. Expression of E-cadherin in squamous cell carcinomas of the supraglottic larynx with correlations to clinicopathological features. Eur J Cancer 2002;38:1059- 64.
- Tataroğlu C, Polat A, Kargı A, Şengiz S, Çamdeviren H, Küpelioğlu A. Kolorektal karsinomlarda invazyon derinli- ğinin neovaskülarizasyon, peritümöral NK hücresi, makro- faj ve eozinofil lökositlerle ilişkisinin araştırılması. Türk Patoloji Dergisi 2005;21:49-53.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Research Articles |
| Authors | |
| Publication Date | March 1, 2013 |
| Submission Date | March 2, 2015 |
| Published in Issue | Year 2013 Volume: 40 Issue: 1 |