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Cardiovascular risk factors in childhood chronic kidney disease

Year 2013, Volume: 40 Issue: 1, 169 - 176, 01.03.2013
https://doi.org/10.5798/diclemedj.0921.2013.01.0250

Abstract

Cardiovascular diseases are the principal cause of mor­bidity and mortality among child and adults with chronic renal disease. Recent data demonstrate a high incidence and prevalence of traditional and uremia related cardio­vascular risk factors in children. This review summarizes the current literature on cardiovascular risk factors, mor­tality and morbidity in children with chronic kidney dis­ease.

References

  • Fine RN, Whyte DA, Bodystun II. Conservative manage- ment of chronic renal inssufficiency. In: Avner ED, Har- mon WE, Niaduet P (eds). Pediatric Nephrology. 5th edn. Philadelphia USA Lippincott Williams and Wilkins, 2004: 1296-1298.
  • Flynn JT. Cardiovascular disease in children with chronic renal failure. Growth Horm IGF Res 2006:84-90.
  • Chavers BM, Solid CA, Sinaiko A, et al. Diagnosis of cardiac disease in pediatric end-stage renal disease. Nephrol Dial Transplant 2011;26:1640-5.
  • Poyrazoglu HM, Dusunsel R, Yikilmaz A, et al. Carotid ar- tery thickness in children and young adults with end stage renal disease. Pediatr Nephrol 2007;22:109-16.
  • Chavers BM, Herzog CA. The spectrum of cardiovascular disease in children with predialysis chronic kidney disease. Adv Chronic Kidney Dis 2004;11:319-27.
  • Parekh RS, Carroll CE, Wolfe RA, Port FK. Cardiovascular mortality in children and young adults with end-stage kid- ney disease. J Pediatr 2002;141:191-7.
  • Foley RN, Parfrey PS, Harnett JD, et al. Clinical and echo- cardiographic disease in patients starting end-stage renal disease therapy. Kidney Int 1995;47:186-92.
  • Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Left ventricular mass and systolic perfor- mance in pediatric patients with chronic renal failure. Cir- culation 2003;107:864-8.
  • Mitsnefes MM, Daniels SR, Schwartz SM, Khoury P, Strife CF. Changes in left ventricular mass in children and adoles- cents during chronic dialysis. Pediatr Nephrol 2001;16:318- 23.
  • Mitsnefes MM. Cardiovascular complications of pediatric chronic kidney disease. Pediatr Nephrol 2008;23:27-39.
  • Johnstone LM, Jones CL, Grigg LE, Wilkinson JL, Walker RG, Powell HR. Left ventricular abnormalities in children, adolescents and young adults with renal disease. Kidney Int 1996;50:998-1006.
  • Mitsnefes MM, Daniels SR, Schwartz SA, Khoury P, Meyer RA, Strife CF. Severe left ventricular hypertrophy in pedi- atric dialysis: prevalance and predictors. Pediatr Nephrol 2000;14:898-902.
  • Matteucci MC, Wuhl E, Picca S, et al. Left ventricular ge- ometry in children with mild to moderate chronic renal in- sufficiency. J Am Soc Nephrol 2006;17:218-26.
  • Mitsnefes MM, Kimball TR, Kartal J, et al. Progres- sion of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study. J Pediatr 2006;149:671-5.
  • Morris KP, Skinner JR, Hunter S, Couldthard MG. Cardio- vascular abnormalities in end stage renal failure: the effect of anemia or uraemia? Arch Dis Child 1994;71:119-22.
  • Zoccali C, Bode-Böger S, Mallamaci F, et al. Plasma con- centration of asymmetrical dimethylarginine and mortality in patints with end-stage renal disease: a prospective study. Lancet 2001;358:2113-7.
  • Goren A, Glaser J, Drukker A. Diastolic function in children and adolescents on dialysis and after kidney transplanta- tion: an echocardiographic assessment. Pediatr Nephrol 1993;7:725-8.
  • Mitsnefes MM, Kimball TR, Border WL, et al. Impaired left ventricular diastolic function in children with chronic renal failure. Kidney Int 2004;65:1461-6.
  • Mitsnefes MM, Ho P-L, McEnery PT. Hypertension and progression of chronic renal insufficiency in children: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). J Am Soc Nephrol 2003 ;14:2618-22.
  • Wingen AM, Fabian-Bach C, Schaefer F, Mehls O. Ran- domised multicentre study of a low-protein diet on the progression of chronic renal failure in children: European study group of nutritional treatment of chronic renal failure in childhood. Lancet 1997;349:1117-23.
  • Semizel E, Çil E. Kronik Böbrek Yetersizliği Olan Hastalar- da Kardiyak Tutulum. Güncel Pediatri 2004;2:32-8.
  • Warady BA, Ho M. Morbidity and mortalityin children with anemia at initiation of dialysis. Pediatr Nephrol 2003;18:1055-62.
  • Değer SM, Reis KA. Hiperlipidemi ve Renal Hastalık- lar. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2006;15:181-5.
  • Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardio- vascular risk factors and atherosclerosis in children and young adults. N Engl J Med 1998;338:1650-6.
  • Querfeld U, Lang M, Friedrich JB, Kohl B, Fiehn W, Schär- er K. Lipoprotein (a) serum levels and apolipoprotein (a) phenotypes in children with chronic renal disease. Pediatr Res 1993;34:772-6.
  • Bakkaloğlu SA. Homosistein ve Kronik Böbrek Yetmez- liği. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2002;11:68-73.
  • Moustapha A, Naso A, Nahlawi M, et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998;97:138- 41.
  • Lilien M, Duran M, Hoeck KV, Poll-The BT, Schroder C. Hyperhomocysteinemia in children with renal disease. Nephrol Dial Transplant 1999;14:366-8.
  • Massry S, Smogorzewski M. Mechanisms through which paratyroid hormone mediates its deleterious effects on or- gan function in uremia. Semin Nephrol 1994;14:219-31.
  • Oh J, Wunsch R, Turzer M, et al. Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 2002;106:100-5.
  • Mitsnefes MM, Kimball TR, Kartal J, et al. Cardiac and vascular adaptation in pediatric patients with chronic kid- ney disease: role of calcium-phosphorus metabolism. J Am Soc Nephrol 2005;16:2796-803.
  • Sylvestre LC, Fonseca KP, Stinghen AE, Pereira AM, Men- eses RP, Pecoits-Filho R. The malnutrition and inflamma- tion axis in pediatric patients with chronic kidney disease. Pediatr Nephrol 2007;22:864-73.
  • Balakrishnan VS, Guo D, Rao M, et al. Cytokine gene polymorphisms in hemodialysis patients: association with comorbidity, functionality, and serum albumin. Kidney Int 2004;65:1449-1460.
  • Pecoits-Filho R, Sylvestre LC, Stenvinkel P. Chronic kid- ney disease and inflammation in pediatric patients: from bench to playground. Pediatr Nephrol 2005;20:714-20.
  • Demir M, Tonbul HZ. Son Dönem Böbrek Yetmezlikli Hastalarda Malnütrisyon-İnflamasyon-Ateroskleroz (MİA Sendromu). Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 2005;14:160-5.
  • Tomson CRV. Cardiovascular disease in chronic renal fail- ure. In: Compreherensive Clinical Nephrology. Johnson RJ, Feehally J (Eds). Mosby, 2000:1-14.
  • Shishido S, Sato H. Asanuma H, et al. Unexpectedly high prevalence of pretransplant abnormal glucose tolerance in pediatric kidney transplant recipients. Pediatr Transplant 2006;10:67-73.
  • Lai HL, Kartal J, Mitsnefes M. Hyperinsulinemia in pediat- ric patients with chronic kidney disease: the role of tumor necrosis factor-alpha. Pediatr Nephrol 2007;22:1751-6.
  • Zoccali C, Mallamaci F, Tripepi G. Novel cardiovascular risk factors in end-stage renal disease. J Am Soc Nephrol 2004;15:77-80.
  • Shinohara K, Shoji T, Emoto M, et al. Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. J Am Soc Nephrol 2002;13:1894-900.
  • Koçak G, Atalay S, Bakkaloglu S, Ekim M, Tutar HE, Ima- moglu A. QT/corrected QT (QTc) intervals and QT/QTc dispersions in children with chronic renal failure. Int J Car- diol 1999;70:63-7.

Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri

Year 2013, Volume: 40 Issue: 1, 169 - 176, 01.03.2013
https://doi.org/10.5798/diclemedj.0921.2013.01.0250

Abstract

Kronik böbrek hastalığı (KBH) olan çocuk ve erişkinlerde kardiyovasküler hastalıklar, mortalite ve morbiditenin baş­lıca sebebidir. Son zamanlarda elde edilen veriler çocuk­larda, geleneksel ve üremi ile ilişkili kardiyovasküler risk faktörlerinin prevalansının artmış olduğunu göstermekte­dir. Bu derlemede, KBH olan çocuklarda kardiyovasküler risk faktörleri, mortalite ve morbidite üzerine güncel litera­tür bilgileri gözden geçirilmiştir.

References

  • Fine RN, Whyte DA, Bodystun II. Conservative manage- ment of chronic renal inssufficiency. In: Avner ED, Har- mon WE, Niaduet P (eds). Pediatric Nephrology. 5th edn. Philadelphia USA Lippincott Williams and Wilkins, 2004: 1296-1298.
  • Flynn JT. Cardiovascular disease in children with chronic renal failure. Growth Horm IGF Res 2006:84-90.
  • Chavers BM, Solid CA, Sinaiko A, et al. Diagnosis of cardiac disease in pediatric end-stage renal disease. Nephrol Dial Transplant 2011;26:1640-5.
  • Poyrazoglu HM, Dusunsel R, Yikilmaz A, et al. Carotid ar- tery thickness in children and young adults with end stage renal disease. Pediatr Nephrol 2007;22:109-16.
  • Chavers BM, Herzog CA. The spectrum of cardiovascular disease in children with predialysis chronic kidney disease. Adv Chronic Kidney Dis 2004;11:319-27.
  • Parekh RS, Carroll CE, Wolfe RA, Port FK. Cardiovascular mortality in children and young adults with end-stage kid- ney disease. J Pediatr 2002;141:191-7.
  • Foley RN, Parfrey PS, Harnett JD, et al. Clinical and echo- cardiographic disease in patients starting end-stage renal disease therapy. Kidney Int 1995;47:186-92.
  • Mitsnefes MM, Kimball TR, Witt SA, Glascock BJ, Khoury PR, Daniels SR. Left ventricular mass and systolic perfor- mance in pediatric patients with chronic renal failure. Cir- culation 2003;107:864-8.
  • Mitsnefes MM, Daniels SR, Schwartz SM, Khoury P, Strife CF. Changes in left ventricular mass in children and adoles- cents during chronic dialysis. Pediatr Nephrol 2001;16:318- 23.
  • Mitsnefes MM. Cardiovascular complications of pediatric chronic kidney disease. Pediatr Nephrol 2008;23:27-39.
  • Johnstone LM, Jones CL, Grigg LE, Wilkinson JL, Walker RG, Powell HR. Left ventricular abnormalities in children, adolescents and young adults with renal disease. Kidney Int 1996;50:998-1006.
  • Mitsnefes MM, Daniels SR, Schwartz SA, Khoury P, Meyer RA, Strife CF. Severe left ventricular hypertrophy in pedi- atric dialysis: prevalance and predictors. Pediatr Nephrol 2000;14:898-902.
  • Matteucci MC, Wuhl E, Picca S, et al. Left ventricular ge- ometry in children with mild to moderate chronic renal in- sufficiency. J Am Soc Nephrol 2006;17:218-26.
  • Mitsnefes MM, Kimball TR, Kartal J, et al. Progres- sion of left ventricular hypertrophy in children with early chronic kidney disease: 2-year follow-up study. J Pediatr 2006;149:671-5.
  • Morris KP, Skinner JR, Hunter S, Couldthard MG. Cardio- vascular abnormalities in end stage renal failure: the effect of anemia or uraemia? Arch Dis Child 1994;71:119-22.
  • Zoccali C, Bode-Böger S, Mallamaci F, et al. Plasma con- centration of asymmetrical dimethylarginine and mortality in patints with end-stage renal disease: a prospective study. Lancet 2001;358:2113-7.
  • Goren A, Glaser J, Drukker A. Diastolic function in children and adolescents on dialysis and after kidney transplanta- tion: an echocardiographic assessment. Pediatr Nephrol 1993;7:725-8.
  • Mitsnefes MM, Kimball TR, Border WL, et al. Impaired left ventricular diastolic function in children with chronic renal failure. Kidney Int 2004;65:1461-6.
  • Mitsnefes MM, Ho P-L, McEnery PT. Hypertension and progression of chronic renal insufficiency in children: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS). J Am Soc Nephrol 2003 ;14:2618-22.
  • Wingen AM, Fabian-Bach C, Schaefer F, Mehls O. Ran- domised multicentre study of a low-protein diet on the progression of chronic renal failure in children: European study group of nutritional treatment of chronic renal failure in childhood. Lancet 1997;349:1117-23.
  • Semizel E, Çil E. Kronik Böbrek Yetersizliği Olan Hastalar- da Kardiyak Tutulum. Güncel Pediatri 2004;2:32-8.
  • Warady BA, Ho M. Morbidity and mortalityin children with anemia at initiation of dialysis. Pediatr Nephrol 2003;18:1055-62.
  • Değer SM, Reis KA. Hiperlipidemi ve Renal Hastalık- lar. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2006;15:181-5.
  • Berenson GS, Srinivasan SR, Bao W, Newman WP, Tracy RE, Wattigney WA. Association between multiple cardio- vascular risk factors and atherosclerosis in children and young adults. N Engl J Med 1998;338:1650-6.
  • Querfeld U, Lang M, Friedrich JB, Kohl B, Fiehn W, Schär- er K. Lipoprotein (a) serum levels and apolipoprotein (a) phenotypes in children with chronic renal disease. Pediatr Res 1993;34:772-6.
  • Bakkaloğlu SA. Homosistein ve Kronik Böbrek Yetmez- liği. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2002;11:68-73.
  • Moustapha A, Naso A, Nahlawi M, et al. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998;97:138- 41.
  • Lilien M, Duran M, Hoeck KV, Poll-The BT, Schroder C. Hyperhomocysteinemia in children with renal disease. Nephrol Dial Transplant 1999;14:366-8.
  • Massry S, Smogorzewski M. Mechanisms through which paratyroid hormone mediates its deleterious effects on or- gan function in uremia. Semin Nephrol 1994;14:219-31.
  • Oh J, Wunsch R, Turzer M, et al. Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 2002;106:100-5.
  • Mitsnefes MM, Kimball TR, Kartal J, et al. Cardiac and vascular adaptation in pediatric patients with chronic kid- ney disease: role of calcium-phosphorus metabolism. J Am Soc Nephrol 2005;16:2796-803.
  • Sylvestre LC, Fonseca KP, Stinghen AE, Pereira AM, Men- eses RP, Pecoits-Filho R. The malnutrition and inflamma- tion axis in pediatric patients with chronic kidney disease. Pediatr Nephrol 2007;22:864-73.
  • Balakrishnan VS, Guo D, Rao M, et al. Cytokine gene polymorphisms in hemodialysis patients: association with comorbidity, functionality, and serum albumin. Kidney Int 2004;65:1449-1460.
  • Pecoits-Filho R, Sylvestre LC, Stenvinkel P. Chronic kid- ney disease and inflammation in pediatric patients: from bench to playground. Pediatr Nephrol 2005;20:714-20.
  • Demir M, Tonbul HZ. Son Dönem Böbrek Yetmezlikli Hastalarda Malnütrisyon-İnflamasyon-Ateroskleroz (MİA Sendromu). Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 2005;14:160-5.
  • Tomson CRV. Cardiovascular disease in chronic renal fail- ure. In: Compreherensive Clinical Nephrology. Johnson RJ, Feehally J (Eds). Mosby, 2000:1-14.
  • Shishido S, Sato H. Asanuma H, et al. Unexpectedly high prevalence of pretransplant abnormal glucose tolerance in pediatric kidney transplant recipients. Pediatr Transplant 2006;10:67-73.
  • Lai HL, Kartal J, Mitsnefes M. Hyperinsulinemia in pediat- ric patients with chronic kidney disease: the role of tumor necrosis factor-alpha. Pediatr Nephrol 2007;22:1751-6.
  • Zoccali C, Mallamaci F, Tripepi G. Novel cardiovascular risk factors in end-stage renal disease. J Am Soc Nephrol 2004;15:77-80.
  • Shinohara K, Shoji T, Emoto M, et al. Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. J Am Soc Nephrol 2002;13:1894-900.
  • Koçak G, Atalay S, Bakkaloglu S, Ekim M, Tutar HE, Ima- moglu A. QT/corrected QT (QTc) intervals and QT/QTc dispersions in children with chronic renal failure. Int J Car- diol 1999;70:63-7.
There are 41 citations in total.

Details

Primary Language Turkish
Journal Section Collection
Authors

Ahmet Midhat Elmacı This is me

Publication Date March 1, 2013
Submission Date March 2, 2015
Published in Issue Year 2013 Volume: 40 Issue: 1

Cite

APA Elmacı, A. M. (2013). Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri. Dicle Medical Journal, 40(1), 169-176. https://doi.org/10.5798/diclemedj.0921.2013.01.0250
AMA Elmacı AM. Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri. diclemedj. March 2013;40(1):169-176. doi:10.5798/diclemedj.0921.2013.01.0250
Chicago Elmacı, Ahmet Midhat. “Çocukluk çağı Kronik böbrek hastalığında kardiyovasküler Risk faktörleri”. Dicle Medical Journal 40, no. 1 (March 2013): 169-76. https://doi.org/10.5798/diclemedj.0921.2013.01.0250.
EndNote Elmacı AM (March 1, 2013) Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri. Dicle Medical Journal 40 1 169–176.
IEEE A. M. Elmacı, “Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri”, diclemedj, vol. 40, no. 1, pp. 169–176, 2013, doi: 10.5798/diclemedj.0921.2013.01.0250.
ISNAD Elmacı, Ahmet Midhat. “Çocukluk çağı Kronik böbrek hastalığında kardiyovasküler Risk faktörleri”. Dicle Medical Journal 40/1 (March 2013), 169-176. https://doi.org/10.5798/diclemedj.0921.2013.01.0250.
JAMA Elmacı AM. Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri. diclemedj. 2013;40:169–176.
MLA Elmacı, Ahmet Midhat. “Çocukluk çağı Kronik böbrek hastalığında kardiyovasküler Risk faktörleri”. Dicle Medical Journal, vol. 40, no. 1, 2013, pp. 169-76, doi:10.5798/diclemedj.0921.2013.01.0250.
Vancouver Elmacı AM. Çocukluk çağı kronik böbrek hastalığında kardiyovasküler risk faktörleri. diclemedj. 2013;40(1):169-76.