Abstract
Levothyroxine intoxication has a large and severe scale of symptoms in patients which expose to high dose. Levothyroxine is a common drug which is used in thyroid replacement therapy. Patients with intoxication clinical table varies depending on drug dose, concomitant diseases, other drugs taken together. Most of the patients exposed low dose drug remains asymptomatic. There haven’t been any established trade protocols. In this case, we report a 18 year old swallow 6 mg levothyroxin and required intensive care treatment levothyroxine intoxication patient. Patient had severe thyrotoxicosis symptoms. Patient had gastrointestinal lavage, activated charcoal, propylthiouracil, propranolol, prednisolone therapy and recurrent plasmapheresis. Patient discharged with healing
Keywords
References
- Beier C, Liebezeit B, Völkl TM, et al. Attempted suicide with
- L-thyroxine in an adolescent girl. Klin Padiatr 2006; 218:
- -37.
- Ellenhorn MJ, Schonwald S, Ordod G, Wasserberger J. Section II. Drugs. Part D. Systems Toxicology. In: Ellenhorn
- F. Kılınç, ve ark. Levotiroksin intoksikasyonuMJ, Schonwald S, Ordod G, Wasserberger J (Eds): Ellenhorn’s Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Pennsylvania: Williams& Wilkins 1997;242-244.
- Luis D.A, Duenas A, Martin J, et al. Light symptoms following a high-dose intentional L thyroxine ingestion treated with cholestyramine. Horm Res 2002;57:61-63.
- Lehrner LM, Weir MR. Acute ingestions of thyroid hormones. Pediatrics 1984;73:313-317.
- Shilo L, Kovatz S, Hadari R, et al. Massive thyroid hormone
- overdose: kinetics, clinical manifestations and management. Isr Med Assoc J 2002;4:298-299.
- Litovitz TL, White JD. Levothyroxine ingestions in children:
- an analysis of 78 cases. Am J Emerg Med 1985;3:297-300.
- Tenenbein M, Dean HJ. Benign course after massive levothyroxine ingestion. Pediatr Emerg Care 1986;2:15-17.
- Tunget CL, Clark RF, Turchen SG, et al. Raising the decontamination level for thyroid hormone ingestions.Am J
- Emerg Med 1995;13:9-13.
- Chyka PA, Seger D, Krenzelok EP, et al. Position paper: single-dose activated charcoal. Clin Toxicol (Phila)
- ;43:61-87.
- Vale JA, Kulig K. Position paper: gastric lavage. J Toxicol
- Clin Toxicol 2004;42:933-943.
- Lehrner LM, Weir MR. Acute ingestions of thyroid hormones. Pediatrics 1984;73:313-317.
- Shilo L, Kovatz S, Hadari R, et al. Massive thyroid hormone overdose: kinetics, clinical manifestations and management. Isr Med Assoc J 2002;4:298-299.
- Berkner PD, Starkman H, Person N. Acute L-thyroxine
- overdose; therapy with sodium ipodate: evaluation of clinical and physiologic parameters. J Emerg Med 1991;9:129-131.
- Kreisner E, Lutzky M, Gross JL. Charcoal hemoperfusion
- in the treatment of levothyroxine intoxication. Thyroid
- ;20:209-212.
- Binimelis J, Bassas L, Marruecos L, et al. Massive thyroxine intoxication: evaluation of plasma extraction. Intensive
- Care Med 1987;13:33-38.
Abstract
Levothyroxine intoxication has a large and severe scale of symptoms in patients which expose to high dose. Levothyroxine is a common drug which is used in thyroid replacement therapy. Patients with intoxication clinical table varies depending on drug dose, concomitant diseases, other drugs taken together. Most of the patients exposed low dose drug remains asymptomatic. There haven’t been any established trade protocols. In this case, we report a 18 year old swallow 6 mg levothyroxin and required intensive care treatment levothyroxine intoxication patient. Patient had severe thyrotoxicosis symptoms. Patient had gastrointestinal lavage, activated charcoal, propylthiouracil, propranolol, prednisolone therapy and recurrent plasmapheresis. Patient discharged with healing.
Key words: Levothyroxine, intoxication, thyrotoxicosis
Keywords
References
- Beier C, Liebezeit B, Völkl TM, et al. Attempted suicide with
- L-thyroxine in an adolescent girl. Klin Padiatr 2006; 218:
- -37.
- Ellenhorn MJ, Schonwald S, Ordod G, Wasserberger J. Section II. Drugs. Part D. Systems Toxicology. In: Ellenhorn
- F. Kılınç, ve ark. Levotiroksin intoksikasyonuMJ, Schonwald S, Ordod G, Wasserberger J (Eds): Ellenhorn’s Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Pennsylvania: Williams& Wilkins 1997;242-244.
- Luis D.A, Duenas A, Martin J, et al. Light symptoms following a high-dose intentional L thyroxine ingestion treated with cholestyramine. Horm Res 2002;57:61-63.
- Lehrner LM, Weir MR. Acute ingestions of thyroid hormones. Pediatrics 1984;73:313-317.
- Shilo L, Kovatz S, Hadari R, et al. Massive thyroid hormone
- overdose: kinetics, clinical manifestations and management. Isr Med Assoc J 2002;4:298-299.
- Litovitz TL, White JD. Levothyroxine ingestions in children:
- an analysis of 78 cases. Am J Emerg Med 1985;3:297-300.
- Tenenbein M, Dean HJ. Benign course after massive levothyroxine ingestion. Pediatr Emerg Care 1986;2:15-17.
- Tunget CL, Clark RF, Turchen SG, et al. Raising the decontamination level for thyroid hormone ingestions.Am J
- Emerg Med 1995;13:9-13.
- Chyka PA, Seger D, Krenzelok EP, et al. Position paper: single-dose activated charcoal. Clin Toxicol (Phila)
- ;43:61-87.
- Vale JA, Kulig K. Position paper: gastric lavage. J Toxicol
- Clin Toxicol 2004;42:933-943.
- Lehrner LM, Weir MR. Acute ingestions of thyroid hormones. Pediatrics 1984;73:313-317.
- Shilo L, Kovatz S, Hadari R, et al. Massive thyroid hormone overdose: kinetics, clinical manifestations and management. Isr Med Assoc J 2002;4:298-299.
- Berkner PD, Starkman H, Person N. Acute L-thyroxine
- overdose; therapy with sodium ipodate: evaluation of clinical and physiologic parameters. J Emerg Med 1991;9:129-131.
- Kreisner E, Lutzky M, Gross JL. Charcoal hemoperfusion
- in the treatment of levothyroxine intoxication. Thyroid
- ;20:209-212.
- Binimelis J, Bassas L, Marruecos L, et al. Massive thyroxine intoxication: evaluation of plasma extraction. Intensive
- Care Med 1987;13:33-38.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | July 9, 2015 |
| Submission Date | July 9, 2015 |
| Published in Issue | Year 2015 Volume: 42 Issue: 2 |