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Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder

Year 2019, Volume: 46 Issue: 3, 429 - 434, 16.09.2019
https://doi.org/10.5798/dicletip.620366

Abstract

Objective: We aimed to test ocular and systemic safety of mirabegron medication in the treatment of overactive bladder in elderly patients. 
Method: A total of 74 patients (40 male, 34 female) with symptoms of overactive bladder admitted to the urology clinic were included in the study. Patients over 60 years old were included. Patients were followed-up for 3 months. Symptom scores (according to OAB-V8 form), intraocular pressure (IOP) readings of right and left eyes, systolic and diastolic blood pressures of the patients were recorded before and after the treatment. At the end of 3 months, all values were re-evaluated and compared with pre-treatment data. 
Results: Mean age was 69.48±7.8 years. The symptom score was found to be 18.67 ± 9.87 before the treatment and 9.83 ± 2.71 after 3 months of the treatment (p=0.0001). Right eye mean IOP value was 16.06 ± 2.62 mmHg before treatment and 15.85 ± 2.31 mmHg after treatment (p=0.341). Left eye mean IOP value was 15.96±2.35 mm mmHg before treatment and 15.94±2.21 mm after treatment (p=0.855). Systolic blood pressure measurements were 128.91±11.76 mmHg before treatment and 128.43±11.95 mmHg after the treatment (p=0.110). Diastolic blood pressure measurements were 81.94±9.83 mmHg before the treatment and 81.31±10.14 mmHg after the treatment (p=0.071). 
Conclusion: Treatment of overactive bladder with mirabegron 50mg/day is well tolerated and safe in elderly patients. 

References

  • 1. Chapel CR, Amarenco G, Lopez Aramburu MA, et all. A proof-of-concept study: mirabegron, a new therapy for overactive bladder. Neurourol Urodyn 2013; 32: 1116-22.
  • 2. Thiagamoorthy G, Kotes S, Zacche M, et all. The efficacy and tolerability of mirabegron, a β3 adrenoceptor agonist, in patients with symptoms of overactive bladder. TherAdv Urol 2016; 8: 38-46.
  • 3. Tripathi RC, Tripathi BJ, Haggerty C. Drug-induced glaucomas: mechanism and management. Drug Saf 2003; 26: 749–67.
  • 4. Tarcan T, Mangır N, Özgür MÖ, et all. OAB-V8 Aşırı aktif mesane sorgulama formu validasyon çalışması. Üroloji Bülteni 2012; 21: 113-16.
  • 5. Geyer O, Bar-Ilan, A., Nachman, R, et all. Beta3-adrenergic relaxation of bovine iris sphincter. FEBS Lett 1998; 429: 356–8.
  • 6. Diebold Y, Rios J.D, Hodges R.R, et all. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci 2001; 42: 2270–82.
  • 7. Mori A, Miwa T, Sakamoto K, et all. Pharmacological evidence for the presence of functional ocular safety of mırabegron ın healthy volunteers 679 beta (3)-adrenoceptors in rat retinal blood vessels. Naunyn Schmiedebergs Arch Pharmacol 2010; 382: 119–126. Steinle J.J, Zamora D.O, Rosenbaum J.T, Granger H.J. Beta 3-adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation. Exp. Eye Res 2005; 80: 83–91.
  • 9. Lee C-L, Kuo H-C. Efficacy and safety of mirabegron, a β3-adrenoceptor agonist, in patients with detrusor hyperactivity and impaired contractility. Lower Urinary Tract Symptoms 2019; 11: 93-97. https://doi.org/10.1111/luts.12224.
  • 10. Gray SL, Anderson ML, Dublin S, et all. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015; 175: 401–7.
  • 11. Chapple C, DuBeau C, Ebinger U, et all. Darifenacin treatment of patients >or= 65 years with overactive bladder: results of a randomized, controlled, 12-week trial. Curr Med Res Opin 2007 ; 23:2347–58.
  • 12. Wagg A, Arumi D, Herschorn S, et all. A pooled analysis of the efficacy of fesoterodine for the treatment of overactive bladder, and the relationship between safety, co-morbidity and polypharmacy in patients aged 65 years or older. Age Ageing 2017; 46: 620–6.
  • 13. Chapple CR, Kaplan SA, Mitcheson D, et all. Randomized doubleblind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β (3)-adrenoceptor agonist, in overactive bladder. Eur Urol 2013; 63: 296–305.
  • 14. Abrams P, Andersson KE. Muscarinic receptor antagonists for overactive bladder. BJU Int 2007; 100: 987–1006.
  • 15. Sung VC, Corridan PG. Acute-angle closure glaucoma as a sideeffect of oxybutynin. Br J Urol 1998; 81: 634–5.
  • 16. Tripathi RC, Tripathi BJ, Haggerty C. Drug-induced glaucomas: mechanism and management. Drug Saf 2003; 26: 749–67.
  • 17. Turkoglu AR, Yener NP, Coban S, Guzelsoy M, Demirbas M, Demirci H. Changes in intraocular pressure and tear secretion in patients given 5 mg solifenacin for the treatment of overactive bladder. Int Urogynecol J 2017; 28: 777-81. doi: 10.1007/s00192-016-3199-x. Epub 2016 Nov 14.
  • 18. Garely AD, Kaufman JM, Sand PK, et all. Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: the VESIcare Open-Label Trial (VOLT). ClinTher 2006; 28: 1935–46.
  • 19. Nambiar AK, Bosch R, Cruz F, et all. EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence. Eur Urol 2018; 73: 596-609. Doi: 10.1016/j.eururo.2017.12.031. Epub 2018 Feb
Year 2019, Volume: 46 Issue: 3, 429 - 434, 16.09.2019
https://doi.org/10.5798/dicletip.620366

Abstract

References

  • 1. Chapel CR, Amarenco G, Lopez Aramburu MA, et all. A proof-of-concept study: mirabegron, a new therapy for overactive bladder. Neurourol Urodyn 2013; 32: 1116-22.
  • 2. Thiagamoorthy G, Kotes S, Zacche M, et all. The efficacy and tolerability of mirabegron, a β3 adrenoceptor agonist, in patients with symptoms of overactive bladder. TherAdv Urol 2016; 8: 38-46.
  • 3. Tripathi RC, Tripathi BJ, Haggerty C. Drug-induced glaucomas: mechanism and management. Drug Saf 2003; 26: 749–67.
  • 4. Tarcan T, Mangır N, Özgür MÖ, et all. OAB-V8 Aşırı aktif mesane sorgulama formu validasyon çalışması. Üroloji Bülteni 2012; 21: 113-16.
  • 5. Geyer O, Bar-Ilan, A., Nachman, R, et all. Beta3-adrenergic relaxation of bovine iris sphincter. FEBS Lett 1998; 429: 356–8.
  • 6. Diebold Y, Rios J.D, Hodges R.R, et all. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Invest. Ophthalmol. Vis. Sci 2001; 42: 2270–82.
  • 7. Mori A, Miwa T, Sakamoto K, et all. Pharmacological evidence for the presence of functional ocular safety of mırabegron ın healthy volunteers 679 beta (3)-adrenoceptors in rat retinal blood vessels. Naunyn Schmiedebergs Arch Pharmacol 2010; 382: 119–126. Steinle J.J, Zamora D.O, Rosenbaum J.T, Granger H.J. Beta 3-adrenergic receptors mediate choroidal endothelial cell invasion, proliferation, and cell elongation. Exp. Eye Res 2005; 80: 83–91.
  • 9. Lee C-L, Kuo H-C. Efficacy and safety of mirabegron, a β3-adrenoceptor agonist, in patients with detrusor hyperactivity and impaired contractility. Lower Urinary Tract Symptoms 2019; 11: 93-97. https://doi.org/10.1111/luts.12224.
  • 10. Gray SL, Anderson ML, Dublin S, et all. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med 2015; 175: 401–7.
  • 11. Chapple C, DuBeau C, Ebinger U, et all. Darifenacin treatment of patients >or= 65 years with overactive bladder: results of a randomized, controlled, 12-week trial. Curr Med Res Opin 2007 ; 23:2347–58.
  • 12. Wagg A, Arumi D, Herschorn S, et all. A pooled analysis of the efficacy of fesoterodine for the treatment of overactive bladder, and the relationship between safety, co-morbidity and polypharmacy in patients aged 65 years or older. Age Ageing 2017; 46: 620–6.
  • 13. Chapple CR, Kaplan SA, Mitcheson D, et all. Randomized doubleblind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a β (3)-adrenoceptor agonist, in overactive bladder. Eur Urol 2013; 63: 296–305.
  • 14. Abrams P, Andersson KE. Muscarinic receptor antagonists for overactive bladder. BJU Int 2007; 100: 987–1006.
  • 15. Sung VC, Corridan PG. Acute-angle closure glaucoma as a sideeffect of oxybutynin. Br J Urol 1998; 81: 634–5.
  • 16. Tripathi RC, Tripathi BJ, Haggerty C. Drug-induced glaucomas: mechanism and management. Drug Saf 2003; 26: 749–67.
  • 17. Turkoglu AR, Yener NP, Coban S, Guzelsoy M, Demirbas M, Demirci H. Changes in intraocular pressure and tear secretion in patients given 5 mg solifenacin for the treatment of overactive bladder. Int Urogynecol J 2017; 28: 777-81. doi: 10.1007/s00192-016-3199-x. Epub 2016 Nov 14.
  • 18. Garely AD, Kaufman JM, Sand PK, et all. Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: the VESIcare Open-Label Trial (VOLT). ClinTher 2006; 28: 1935–46.
  • 19. Nambiar AK, Bosch R, Cruz F, et all. EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence. Eur Urol 2018; 73: 596-609. Doi: 10.1016/j.eururo.2017.12.031. Epub 2018 Feb
There are 18 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Mehmet Solakhan 0000-0001-9123-9196

Burak Bilgin This is me 0000-0001-6332-2371

Publication Date September 16, 2019
Submission Date February 4, 2019
Published in Issue Year 2019 Volume: 46 Issue: 3

Cite

APA Solakhan, M., & Bilgin, B. (2019). Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Tıp Dergisi, 46(3), 429-434. https://doi.org/10.5798/dicletip.620366
AMA Solakhan M, Bilgin B. Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. diclemedj. September 2019;46(3):429-434. doi:10.5798/dicletip.620366
Chicago Solakhan, Mehmet, and Burak Bilgin. “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People With Overactive Bladder”. Dicle Tıp Dergisi 46, no. 3 (September 2019): 429-34. https://doi.org/10.5798/dicletip.620366.
EndNote Solakhan M, Bilgin B (September 1, 2019) Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. Dicle Tıp Dergisi 46 3 429–434.
IEEE M. Solakhan and B. Bilgin, “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder”, diclemedj, vol. 46, no. 3, pp. 429–434, 2019, doi: 10.5798/dicletip.620366.
ISNAD Solakhan, Mehmet - Bilgin, Burak. “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People With Overactive Bladder”. Dicle Tıp Dergisi 46/3 (September 2019), 429-434. https://doi.org/10.5798/dicletip.620366.
JAMA Solakhan M, Bilgin B. Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. diclemedj. 2019;46:429–434.
MLA Solakhan, Mehmet and Burak Bilgin. “Ocular and Systemic Safety of Mirabegron Treatment in Elderly People With Overactive Bladder”. Dicle Tıp Dergisi, vol. 46, no. 3, 2019, pp. 429-34, doi:10.5798/dicletip.620366.
Vancouver Solakhan M, Bilgin B. Ocular and Systemic Safety of Mirabegron Treatment in Elderly People with Overactive Bladder. diclemedj. 2019;46(3):429-34.