Research Article
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Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi

Year 2019, Volume: 46 Issue: 3, 499 - 504, 16.09.2019

Murat Akkuş

https://doi.org/10.5798/dicletip.620523

Abstract

Amaç: Göğüs deformitelerinin metal alaşımlı barlar vasıtasıyla rekonstrüksiyon yönteminin kullanılması, metal barlara bağlı eser elementlerin vücuda yayılmasına da sebep olabilmektedir. Bu çalışma, pektus bar kullanılan sınırlı sayıda olguda serum ve idrarlarında bar alaşımı olan Demir(Fe), Nikel(Ni) ve Krom(Cr) seviyeleri analiz edilmiş ve literatürle karşılaştırılarak bir ön çalışma olarak sunulması amaçlanmıştır.
Yöntemler: Daha önce bar takılmış11 Erkek (E) ve 3 Kadın (K) toplam 14 olgunun ortalama bar kalış süresi 39,70 (7-60) ay sonunda alınan serum ve idrarlarında Fe, Ni ve Cr seviyeleri çözündürülerek indüktif plazma kütle spektrofotometresi (ICP-MS) cihazı ile değerlendirildi. Sonuçlar literatür ile karşılaştırıldı.
Bulgular: Serum Fe ve Ni seviyeleri normal değerler arasında saptanırken serum Cr seviyesi normal değerlerden yüksek saptanmıştır. İdrar da ise Fe ve Cr atılımı normalin çok üstünde bulunurken Ni idrarda normal seviyede saptanmıştır.
Sonuç: İdrar Fe atılımı arttırılarak serum Fe seviyesinin normal tutulması sağlanabilmiş, ancak idrar Cr atılımı artmasına rağmen serum Cr seviyesi yüksek saptanmıştır. Bu da yüksek Cr serum seviyesinin vücutta birikici etki oluşturabileceği şeklinde yorumlanmıştır.

Keywords

Metal salınımı; İyon salınımı; Eser element analizi; Çelik bar; Metal toksisitesi.

References

  • 1. Kajzer A, Kajzer W, Dzielicki J. et all. The study of physicochemical properties of stabilizing plates removed from the body after treatment of pectus excavatum. Acta of Bioengineering and Biomechanics. 2015; 17: 35-42.
  • 2. Alonso Rubio JCG, Alonso MC, Clemente MA, et all. Determination of metallic traces in kidneys, livers, lungs and spleens of rats with metallic implants after a long implantation time. Journal of Materials Science:Material in Medicine; Jan 2008, Vol.19 Issue 1, 369-75.
  • 3. Avino P, Capannesi G, Manigrasso M, et all. Element assessment in whole blood, serum and urine of three Italian healty sub-populatıons by INAA. Microchemical Journal, 2011, Nov 1; 99: 548-55.
  • 4. Pazzaglia UE, Minoia C, Gualtieri I, et all. Metal ions in body fluids after arthroplasty. Acta Orthop. Scand. 1986 Oct; 57: 415-8.
  • 5. Chassot E, Ouadedesse H, Barbotteau Y, et all. Tentavive for trace elements evalation by pixe method versus depth in soft tıssues near metallic implants. Journal of Trace and Microprobe Techniques, 2002, Vol.20: 571-80.
  • 6. Graham JA, Gardner DE, Waters MD, et all. Effect of trace metals on phagocytosis by alveolar macrophages. Infection and immunity. 1975 Jun 1; 11: 1278-83.
  • 7. Lopez GD. Biodeterioration and corrosion of metallic implants and prostheses. Medicina. 1993; 53: 260-74.
  • 8. Krischak GD, Gebhard F, Mohr W, et all. Difference in metallic wear distribution released from commercially pure titanium compared with stainless steel plates. Arch Orthop Trauma Surg. 2004, Mar 1; 124: 104-13.
  • 9. Zhou Z, Liu X, Liu Q, et all. Evaluation of the potential cytotoxicity of metals associated with implanted biomaterials. Preparative Biochemistry & Biotechnology, 2008,Dec 23; 39: 81-91.
  • 10. Fraga G. Cesar. Relevance, essentiality and toxicity of trace elements in human health. Moleculer Aspect of Medicine. 2005, Aug 1; 26; 235-44.
  • 11. Michel R, Hofmann J, Löer F, et all. Trace element burdening of human tissues due to the corrosion of hip – joint prostheses made of cobalt-chromium alloys. Archives of Orthopaedic and Trauma Surgery. 1984, June 1; 103: 85-95.
  • 12. Rushing GD, Goretsky MJ, Gustin T, et all. When it is not an infection: metal allergy after the Nuss procedure for repair of pectus excavatum. Journal of pediatric surgery. 2007, Jan 1; 42: 93-7.
  • 13. Shah B, Cohee A, Deyerle A, et all. High rates of metal allergy amongst Nuss procedure patients dictate broader pre-operative testing. Journal of pediatric surgery. 2014 Mar 1; 49: 451-4.
  • 14. Fortmann C, Göen T, Krüger M, et all. Trace metal release after minimally-invasive repair of pectus excavatum. PloS one. 2017 Oct 12; 12: e0186323.
  • 15. Cundy TP, Kirby CP. Serum metal levels after minimally invasive repair of pectus excavatum. Journal of pediatric surgery. 2012 Aug 1; 47: 1506-11.
  • 16. Kim YJ, Kassab F, Berven SH, et all. Serum levels of nickel and chromium after instrumented posterior spinal arthrodesis. Spine. 2005 Apr 15; 30: 923-6.
  • 17. Nwashindi A, Dim EM. Adverse effects of nickel in transosseous wires and surgical implants: literature review. Nigerian journal of medicine: journal of the National Association of Resident Doctors of Nigeria. 2014; 23: 335-43.
  • 18. Falagiani P et al. Systemic nickel allergy syndrome (SNAS): A review. Rev Port Immunoalergologia 2008; 16: 135-47.

Year 2019, Volume: 46 Issue: 3, 499 - 504, 16.09.2019

Murat Akkuş

https://doi.org/10.5798/dicletip.620523

Abstract

References

  • 1. Kajzer A, Kajzer W, Dzielicki J. et all. The study of physicochemical properties of stabilizing plates removed from the body after treatment of pectus excavatum. Acta of Bioengineering and Biomechanics. 2015; 17: 35-42.
  • 2. Alonso Rubio JCG, Alonso MC, Clemente MA, et all. Determination of metallic traces in kidneys, livers, lungs and spleens of rats with metallic implants after a long implantation time. Journal of Materials Science:Material in Medicine; Jan 2008, Vol.19 Issue 1, 369-75.
  • 3. Avino P, Capannesi G, Manigrasso M, et all. Element assessment in whole blood, serum and urine of three Italian healty sub-populatıons by INAA. Microchemical Journal, 2011, Nov 1; 99: 548-55.
  • 4. Pazzaglia UE, Minoia C, Gualtieri I, et all. Metal ions in body fluids after arthroplasty. Acta Orthop. Scand. 1986 Oct; 57: 415-8.
  • 5. Chassot E, Ouadedesse H, Barbotteau Y, et all. Tentavive for trace elements evalation by pixe method versus depth in soft tıssues near metallic implants. Journal of Trace and Microprobe Techniques, 2002, Vol.20: 571-80.
  • 6. Graham JA, Gardner DE, Waters MD, et all. Effect of trace metals on phagocytosis by alveolar macrophages. Infection and immunity. 1975 Jun 1; 11: 1278-83.
  • 7. Lopez GD. Biodeterioration and corrosion of metallic implants and prostheses. Medicina. 1993; 53: 260-74.
  • 8. Krischak GD, Gebhard F, Mohr W, et all. Difference in metallic wear distribution released from commercially pure titanium compared with stainless steel plates. Arch Orthop Trauma Surg. 2004, Mar 1; 124: 104-13.
  • 9. Zhou Z, Liu X, Liu Q, et all. Evaluation of the potential cytotoxicity of metals associated with implanted biomaterials. Preparative Biochemistry & Biotechnology, 2008,Dec 23; 39: 81-91.
  • 10. Fraga G. Cesar. Relevance, essentiality and toxicity of trace elements in human health. Moleculer Aspect of Medicine. 2005, Aug 1; 26; 235-44.
  • 11. Michel R, Hofmann J, Löer F, et all. Trace element burdening of human tissues due to the corrosion of hip – joint prostheses made of cobalt-chromium alloys. Archives of Orthopaedic and Trauma Surgery. 1984, June 1; 103: 85-95.
  • 12. Rushing GD, Goretsky MJ, Gustin T, et all. When it is not an infection: metal allergy after the Nuss procedure for repair of pectus excavatum. Journal of pediatric surgery. 2007, Jan 1; 42: 93-7.
  • 13. Shah B, Cohee A, Deyerle A, et all. High rates of metal allergy amongst Nuss procedure patients dictate broader pre-operative testing. Journal of pediatric surgery. 2014 Mar 1; 49: 451-4.
  • 14. Fortmann C, Göen T, Krüger M, et all. Trace metal release after minimally-invasive repair of pectus excavatum. PloS one. 2017 Oct 12; 12: e0186323.
  • 15. Cundy TP, Kirby CP. Serum metal levels after minimally invasive repair of pectus excavatum. Journal of pediatric surgery. 2012 Aug 1; 47: 1506-11.
  • 16. Kim YJ, Kassab F, Berven SH, et all. Serum levels of nickel and chromium after instrumented posterior spinal arthrodesis. Spine. 2005 Apr 15; 30: 923-6.
  • 17. Nwashindi A, Dim EM. Adverse effects of nickel in transosseous wires and surgical implants: literature review. Nigerian journal of medicine: journal of the National Association of Resident Doctors of Nigeria. 2014; 23: 335-43.
  • 18. Falagiani P et al. Systemic nickel allergy syndrome (SNAS): A review. Rev Port Immunoalergologia 2008; 16: 135-47.
There are 18 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Research Article
Authors

Murat Akkuş This is me 0000-0002-3762-6328

Publication Date September 16, 2019
Submission Date May 10, 2019
Published in Issue Year 2019 Volume: 46 Issue: 3

Cite

APA Akkuş, M. (2019). Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi. Dicle Tıp Dergisi, 46(3), 499-504. https://doi.org/10.5798/dicletip.620523
AMA Akkuş M. Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi. diclemedj. September 2019;46(3):499-504. doi:10.5798/dicletip.620523
Chicago Akkuş, Murat. “Pektus Bar’lı Olguların Serum Ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi”. Dicle Tıp Dergisi 46, no. 3 (September 2019): 499-504. https://doi.org/10.5798/dicletip.620523.
EndNote Akkuş M (September 1, 2019) Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi. Dicle Tıp Dergisi 46 3 499–504.
IEEE M. Akkuş, “Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi”, diclemedj, vol. 46, no. 3, pp. 499–504, 2019, doi: 10.5798/dicletip.620523.
ISNAD Akkuş, Murat. “Pektus Bar’lı Olguların Serum Ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi”. Dicle Tıp Dergisi 46/3 (September 2019), 499-504. https://doi.org/10.5798/dicletip.620523.
JAMA Akkuş M. Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi. diclemedj. 2019;46:499–504.
MLA Akkuş, Murat. “Pektus Bar’lı Olguların Serum Ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi”. Dicle Tıp Dergisi, vol. 46, no. 3, 2019, pp. 499-04, doi:10.5798/dicletip.620523.
Vancouver Akkuş M. Pektus Bar’lı Olguların Serum ve İdrar Örneklerinde Eser Elementlerin Değerlendirilmesi. diclemedj. 2019;46(3):499-504.