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Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi

Year 2019, Volume: 46 Issue: 4, 771 - 780, 15.12.2019
https://doi.org/10.5798/dicletip.661358

Abstract

Objective: Numerous studies investigating Vitamin D receptor (VDR) polymorphisms in different populations have been present in current literature. For this reason, we designed a study to investigate the role of three known common VDR genetic polymorphisms (Apa-I/rs7975232, Bsm-I/ rs1544410 and Taq-I/rs731236) in Turkish individuals affected by Obstructive sleep apnea syndrome (OSAS).
Methods: The study was carried out on a total of 175 consecutive subjects, including 80 OSAS patients and 95 healthy participants. Single Nucleotide Polymorphism (SNP) Detection was performed with the iPLEX® Assay and the MassARRAY® System for detection of Apa-I (rs7975232), Bsm-I (rs1544410), and Taq-I (rs731236) polymorphisms.
Results: Fifty-seven C alleles (71.3%) and 59 T alleles (73.8%) were detected in the group of 80 OSAS patients in terms of rs1544410 polymorphism. When the patient and control groups were evaluated statistically at allelic level, it was observed that the T allele increased the risk of disease and this increase was statistically significant (Odds Ratio (OR) = 1.549 [Confidence Interval (CI): 1.012-2.371], (p=0.043). However, there were no significant differences between other VDR polymorphisms (rs7975232 and rs731236) and OSAS clinical data (p=0.6 and p=0.9, respectively).
Discussion: As a conclusion, no statistically significant relationship was found between all three VDR polymorphisms and OSAS patients' clinical features. Further studies should be performed by creating a large sampling group. Finally, population studies should be given importance considering the variability of polymorphism according to ethnic origin.

References

  • 1. Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177: 1006-14. 2. Ragia G, Archontogeorgis K, Simmaco M, et al. Genetics of Obstructive Sleep Apnea: Vitamin D Receptor Gene Variation Affects Both Vitamin D Serum Concentration and Disease Susceptibility. OMICS. 2019; 23: 45-53. 3. Archontogeorgis K, Nena E, Papanas N, et al. Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med. 2014; 2014: 930535. Öncel G.Z., Huseyinoglu N., Ozlece H.K. 780 4. Archontogeorgis K, Nena E, Papanas N, et al. The role of vitamin D in obstructive sleep apnoea syndrome. Breathe (Sheff). 2018; 14: 206-15. 5. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008; 5: 136-43. 6. Redline S, Tishler PV. The genetics of sleep apnea. Sleep Med Rev. 2000; 4: 583-602. 7. Palmer LJ, Buxbaum SG, Larkin E, et al. A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet. 2003; 72: 340-50. 8. Strohl KP, Redline S. Recognition of obstructive sleep apnea. Am J Respir Crit Care Med. 1996; 154 (2 Pt 1): 279-89. 9. Neighbors CLP, Noller MW, Song SA, et al. Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med. 2018; 43: 100-8. 10. Fernandes de Abreu DA, Eyles D, Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009; 34 Suppl 1: S265-77. 11. Haussler MR, Whitfield GK, Kaneko I, et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int. 2013; 92: 77-98. 12. Uitterlinden AG, Fang Y, Van Meurs JB, et all. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004; 338: 143-56. 13. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991; 14: 540-5. 14. Ruehland WR, Rochford PD, O'Donoghue FJ, et al. The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index. Sleep. 2009; 32: 150-7. 15. Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics. 1997; 53: 1253-61. 16. Alizadeh S, Djafarian K, Alizadeh H, et al. Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis. J Nutrigenet Nutrigenomics. 2017; 10: 9-18. 17. Yu F, Cui LL, Li X, et al. The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes mellitus: an updated meta-analysis. Asia Pac J Clin Nutr. 2016; 25: 614-24. 18. Wang L, Ma J, Manson JE, et al. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr. 2013; 52: 1771-9.
Year 2019, Volume: 46 Issue: 4, 771 - 780, 15.12.2019
https://doi.org/10.5798/dicletip.661358

Abstract

References

  • 1. Peppard PE, Young T, Barnet JH, et al. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177: 1006-14. 2. Ragia G, Archontogeorgis K, Simmaco M, et al. Genetics of Obstructive Sleep Apnea: Vitamin D Receptor Gene Variation Affects Both Vitamin D Serum Concentration and Disease Susceptibility. OMICS. 2019; 23: 45-53. 3. Archontogeorgis K, Nena E, Papanas N, et al. Biomarkers to improve diagnosis and monitoring of obstructive sleep apnea syndrome: current status and future perspectives. Pulm Med. 2014; 2014: 930535. Öncel G.Z., Huseyinoglu N., Ozlece H.K. 780 4. Archontogeorgis K, Nena E, Papanas N, et al. The role of vitamin D in obstructive sleep apnoea syndrome. Breathe (Sheff). 2018; 14: 206-15. 5. Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008; 5: 136-43. 6. Redline S, Tishler PV. The genetics of sleep apnea. Sleep Med Rev. 2000; 4: 583-602. 7. Palmer LJ, Buxbaum SG, Larkin E, et al. A whole-genome scan for obstructive sleep apnea and obesity. Am J Hum Genet. 2003; 72: 340-50. 8. Strohl KP, Redline S. Recognition of obstructive sleep apnea. Am J Respir Crit Care Med. 1996; 154 (2 Pt 1): 279-89. 9. Neighbors CLP, Noller MW, Song SA, et al. Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis. Sleep Med. 2018; 43: 100-8. 10. Fernandes de Abreu DA, Eyles D, Feron F. Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases. Psychoneuroendocrinology. 2009; 34 Suppl 1: S265-77. 11. Haussler MR, Whitfield GK, Kaneko I, et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int. 2013; 92: 77-98. 12. Uitterlinden AG, Fang Y, Van Meurs JB, et all. Genetics and biology of vitamin D receptor polymorphisms. Gene. 2004; 338: 143-56. 13. Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991; 14: 540-5. 14. Ruehland WR, Rochford PD, O'Donoghue FJ, et al. The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index. Sleep. 2009; 32: 150-7. 15. Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics. 1997; 53: 1253-61. 16. Alizadeh S, Djafarian K, Alizadeh H, et al. Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis. J Nutrigenet Nutrigenomics. 2017; 10: 9-18. 17. Yu F, Cui LL, Li X, et al. The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes mellitus: an updated meta-analysis. Asia Pac J Clin Nutr. 2016; 25: 614-24. 18. Wang L, Ma J, Manson JE, et al. A prospective study of plasma vitamin D metabolites, vitamin D receptor gene polymorphisms, and risk of hypertension in men. Eur J Nutr. 2013; 52: 1771-9.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Gönül Zişan Öncel This is me 0000-0001-6916-5688

Nergiz Huseyinoglu This is me 0000-0002-4245-8381

Hatice Kose Ozlece This is me 0000-0001-7806-7019

Publication Date December 15, 2019
Submission Date August 5, 2019
Published in Issue Year 2019 Volume: 46 Issue: 4

Cite

APA Öncel, G. Z., Huseyinoglu, N., & Kose Ozlece, H. (2019). Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. Dicle Tıp Dergisi, 46(4), 771-780. https://doi.org/10.5798/dicletip.661358
AMA Öncel GZ, Huseyinoglu N, Kose Ozlece H. Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. diclemedj. December 2019;46(4):771-780. doi:10.5798/dicletip.661358
Chicago Öncel, Gönül Zişan, Nergiz Huseyinoglu, and Hatice Kose Ozlece. “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”. Dicle Tıp Dergisi 46, no. 4 (December 2019): 771-80. https://doi.org/10.5798/dicletip.661358.
EndNote Öncel GZ, Huseyinoglu N, Kose Ozlece H (December 1, 2019) Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. Dicle Tıp Dergisi 46 4 771–780.
IEEE G. Z. Öncel, N. Huseyinoglu, and H. Kose Ozlece, “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”, diclemedj, vol. 46, no. 4, pp. 771–780, 2019, doi: 10.5798/dicletip.661358.
ISNAD Öncel, Gönül Zişan et al. “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”. Dicle Tıp Dergisi 46/4 (December 2019), 771-780. https://doi.org/10.5798/dicletip.661358.
JAMA Öncel GZ, Huseyinoglu N, Kose Ozlece H. Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. diclemedj. 2019;46:771–780.
MLA Öncel, Gönül Zişan et al. “Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi”. Dicle Tıp Dergisi, vol. 46, no. 4, 2019, pp. 771-80, doi:10.5798/dicletip.661358.
Vancouver Öncel GZ, Huseyinoglu N, Kose Ozlece H. Obstrüktif Uyku Apne Sendromuna Sahip Türk Hastalarda Vitamin D Reseptör Polimorfizmlerinin İncelenmesi. diclemedj. 2019;46(4):771-80.