The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression

R.gokcen Gozubatik-celik; Mecbure Nalbantoglu; Mesrure Koseoglu

doi:10.5798/dicletip.755689

Research Article

The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression

Year 2020, Volume: 47 Issue: 2, 260 - 267, 17.06.2020

R.gokcen Gozubatik-celik Mecbure Nalbantoglu Mesrure Koseoglu

https://doi.org/10.5798/dicletip.755689

Abstract

Öz
Amaç: Bu çalışmada epilepsi hastalarında psikojenik-nonepileptik-nöbet (PNES) sıklığını araştırmayı; hastalığın süresi, demografik / klinik veriler ile depresyon anksiyete varlığı arasındaki ilişkiyi araştırmayı amaçladık.
Yöntemler: Kesin epilepsi tanılı 108 hasta prospektif olarak çalışmaya dahil edildi. Hastalardaki PNES'lere video EEG ve hasta kayıtları değerlendirilerek tanı konuldu. Demografik özellikler, hastalık süresi, nöbet sıklığı, nöbet tipleri, tedavilerin tümü kaydedildi. Tüm hastalara Beck Depresyon ve Anksiyete Skalası uygulandı. Hastalar sadece epileptik nöbet geçirenler (Grup 1), PNES de eşlik edenler olarak iki gruba ayrıldı (Grup 2).
Bulgular: Hastaların yaş ortalaması 48 ± 12.31 yıldı. Hastaların 50'sini (%51,8) kadındı. Epileptik nöbet geçiren 108 epileptik hastanın 41'inde (%37,9) PNES izlendi; 41 hastanın 25'i (%60,9) kadındı. Non-epileptik nöbet geçiren 41 hastanın 23'ünde (%56) epilepsi nöbetleri kontrol altındaydı. Depresyon ve anksiyete skorları Grup 2'de Grup 1'e göre anlamlı derecede yüksekti (p≤0.005).
Tartışma: Uzun süreli ve depresif/anksiyöz semptomları olan hastalarda, özellikle farklı tipte nöbet veya tedaviye direnç varlığında nöbetler kontrol altında bile olsa PNES sorgulanmalıdır.

Keywords

Anksiyete, depresyon, epileptik nöbetler

References

1. Yeni SN. Epilepsi Epidemiyolojisi. Turkiye Klinikleri J Neurol-Special Topics 1. 2008: 9-16.
2. Çakıl D, İnanır S, Baykan H, et al. Epilepsi ayırıcı tanısında psikojenik non-epileptik Nöbetler. Göztepe Tıp Dergisi. 2013; 28: 41-7.
3. Fisher RS, Acevedo C, Arzimanoglou A et al. ILAE official report: a practical clinical def-inition of epilepsy. Epilepsia. 2014; 55: 475-82.
4. Akdağ G, Algın DI, Erdinç OO. Epilepsi Osmangazi Journal of Medicine. 2016; 38: 35-41.
5. Lesser, R. P. Psychogenic seizures. Neurology, 1996; 46: 1499-507.
6. Bradley WG, Daroff RB, Fenichel GM, et al. Neurology in clinical practice (principles of diagnosis and manage¬ment) 4th ed. Phledelphia 2004: 1971-2.
7. Reuber M, Qurishi A, Bauer J, et al. Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy? Seizure. 2003; 12: 561–7.
8. Benbadis SR, Agrawal V, Tatum WO. How many patients with psychogenic nonepileptic seizures also have epilepsy? Neurology. 2001; 57: 915–7.
9. Martin R, Burneo JG, Prasad A, et al. Frequency of epilepsy in patients with psychogenic seizures monitored by video EEG. Neurology. 2003; 61: 1791–2.
10. Chen-Block S, Abou-Khalil BW, Arain A, et al. Video-EEG results and clinical charac-teristics in patients with psychogenic nonepileptic spells: the effect of a coexistent epilepsy. Epilepsy Behav. 2016; 62: 62–5.
11. El-Naggar H, Moloney P, Widdess-Walsh P, et al. Simultaneous occurrence of nonepileptic and epileptic seizures during a single period of in-patient video- electroencephalographic monitoring. Epilepsia Open. 2017; 2: 467–71.
12. Robbins NM,Larimer P, Bourgeois JA et al. Number of patient-reported allergies helps distinguish epilepsy from psychogenic non-epileptic spells (pseudoseizures). Epilepsy Behav. 2016; 55: 174–7.
13. Benbadis SR, Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure. 2000; 9: 280-1.
14. LaFrance WC, Alosco ML, Davis JD, et al. Impact of family functioning on quality of life in patients with psychogenic nonepileptic seizures versus epilepsy. Epilepsia. 2011; 52: 292-300.
15. MarcTesta S, Lesser RP, Krauss GL, et al. Personality Assessment Inventory among pa-tients with psychogenic sei¬zures and those with epilepsy. Epilepsia. 2011; 52: 84-8.
16. Myers L, Trobliger R, Bortnik K, et al. Psychological trauma, somatization, dissociation, and psychiatric comorbidities in patients with psychogenic nonepileptic seizures compared with those in patients with intractable partial epilepsy. Epilepsy & Behavior. 2019; 108-13.
17. Neze H, Havle N, Inem C, Yener F. Epilepsi Tanısı ile Takip Edilen Kişilerde Psikiyatrik Hastalıklar ve Bunun Yaşam Kalitesi Üzerine Etkisi New/Yeni Symposium Journal. 2009; 47: 147-54.
18. Bora S, Yeni S, Gürses N, Epilepsi. 1. Basım, Nobel Tıp Kitabevleri, İstanbul. 2008; 707-34.
19. Josephson CB, Jette N. Psychiatric comorbidities in epilepsy. Int Rev Psychiatry. 2017; 29: 409-24.
21. Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. Lancet Neurol. 2016; 15: 106- 15.
22. Bowman ES, Markand ON. Psychodynamics and psychiatric diagnoses of pseudo-seizure subjects. Am J Psychiatry. 1996; 153: 57-63.
23. Angus-Leppan H. Diagnosing epilepsy in neurology clinics: a prospective study. Seizure. 2008; 17: 431-6.
24. Syed TU, LaFrance WC Jr, Kahriman ES, et al. Can semiology predict psychogenic nonepileptic seizures? A prospective study. Ann Neurol. 2011; 69: 997-1004.
25. Moore PM, Baker GA, McDade G, et al. Epilepsy, pseudoseizures and perceived family characteristics: a controlled study. Epilepsy Res. 1994; 18: 75-83.

Year 2020, Volume: 47 Issue: 2, 260 - 267, 17.06.2020

R.gokcen Gozubatik-celik Mecbure Nalbantoglu Mesrure Koseoglu

https://doi.org/10.5798/dicletip.755689

Abstract

References

1. Yeni SN. Epilepsi Epidemiyolojisi. Turkiye Klinikleri J Neurol-Special Topics 1. 2008: 9-16.
2. Çakıl D, İnanır S, Baykan H, et al. Epilepsi ayırıcı tanısında psikojenik non-epileptik Nöbetler. Göztepe Tıp Dergisi. 2013; 28: 41-7.
3. Fisher RS, Acevedo C, Arzimanoglou A et al. ILAE official report: a practical clinical def-inition of epilepsy. Epilepsia. 2014; 55: 475-82.
4. Akdağ G, Algın DI, Erdinç OO. Epilepsi Osmangazi Journal of Medicine. 2016; 38: 35-41.
5. Lesser, R. P. Psychogenic seizures. Neurology, 1996; 46: 1499-507.
6. Bradley WG, Daroff RB, Fenichel GM, et al. Neurology in clinical practice (principles of diagnosis and manage¬ment) 4th ed. Phledelphia 2004: 1971-2.
7. Reuber M, Qurishi A, Bauer J, et al. Are there physical risk factors for psychogenic non-epileptic seizures in patients with epilepsy? Seizure. 2003; 12: 561–7.
8. Benbadis SR, Agrawal V, Tatum WO. How many patients with psychogenic nonepileptic seizures also have epilepsy? Neurology. 2001; 57: 915–7.
9. Martin R, Burneo JG, Prasad A, et al. Frequency of epilepsy in patients with psychogenic seizures monitored by video EEG. Neurology. 2003; 61: 1791–2.
10. Chen-Block S, Abou-Khalil BW, Arain A, et al. Video-EEG results and clinical charac-teristics in patients with psychogenic nonepileptic spells: the effect of a coexistent epilepsy. Epilepsy Behav. 2016; 62: 62–5.
11. El-Naggar H, Moloney P, Widdess-Walsh P, et al. Simultaneous occurrence of nonepileptic and epileptic seizures during a single period of in-patient video- electroencephalographic monitoring. Epilepsia Open. 2017; 2: 467–71.
12. Robbins NM,Larimer P, Bourgeois JA et al. Number of patient-reported allergies helps distinguish epilepsy from psychogenic non-epileptic spells (pseudoseizures). Epilepsy Behav. 2016; 55: 174–7.
13. Benbadis SR, Allen Hauser W. An estimate of the prevalence of psychogenic non-epileptic seizures. Seizure. 2000; 9: 280-1.
14. LaFrance WC, Alosco ML, Davis JD, et al. Impact of family functioning on quality of life in patients with psychogenic nonepileptic seizures versus epilepsy. Epilepsia. 2011; 52: 292-300.
15. MarcTesta S, Lesser RP, Krauss GL, et al. Personality Assessment Inventory among pa-tients with psychogenic sei¬zures and those with epilepsy. Epilepsia. 2011; 52: 84-8.
16. Myers L, Trobliger R, Bortnik K, et al. Psychological trauma, somatization, dissociation, and psychiatric comorbidities in patients with psychogenic nonepileptic seizures compared with those in patients with intractable partial epilepsy. Epilepsy & Behavior. 2019; 108-13.
17. Neze H, Havle N, Inem C, Yener F. Epilepsi Tanısı ile Takip Edilen Kişilerde Psikiyatrik Hastalıklar ve Bunun Yaşam Kalitesi Üzerine Etkisi New/Yeni Symposium Journal. 2009; 47: 147-54.
18. Bora S, Yeni S, Gürses N, Epilepsi. 1. Basım, Nobel Tıp Kitabevleri, İstanbul. 2008; 707-34.
19. Josephson CB, Jette N. Psychiatric comorbidities in epilepsy. Int Rev Psychiatry. 2017; 29: 409-24.
21. Keezer MR, Sisodiya SM, Sander JW. Comorbidities of epilepsy: current concepts and future perspectives. Lancet Neurol. 2016; 15: 106- 15.
22. Bowman ES, Markand ON. Psychodynamics and psychiatric diagnoses of pseudo-seizure subjects. Am J Psychiatry. 1996; 153: 57-63.
23. Angus-Leppan H. Diagnosing epilepsy in neurology clinics: a prospective study. Seizure. 2008; 17: 431-6.
24. Syed TU, LaFrance WC Jr, Kahriman ES, et al. Can semiology predict psychogenic nonepileptic seizures? A prospective study. Ann Neurol. 2011; 69: 997-1004.
25. Moore PM, Baker GA, McDade G, et al. Epilepsy, pseudoseizures and perceived family characteristics: a controlled study. Epilepsy Res. 1994; 18: 75-83.

There are 24 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Original Articles
Authors	R.gokcen Gozubatik-celik This is me Mecbure Nalbantoglu This is me Mesrure Koseoglu This is me
Publication Date	June 17, 2020
Submission Date	March 9, 2020
Published in Issue	Year 2020 Volume: 47 Issue: 2

Cite

APA	Gozubatik-celik, R., Nalbantoglu, M., & Koseoglu, M. (2020). The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression. Dicle Medical Journal, 47(2), 260-267. https://doi.org/10.5798/dicletip.755689
AMA	Gozubatik-celik R, Nalbantoglu M, Koseoglu M. The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression. diclemedj. June 2020;47(2):260-267. doi:10.5798/dicletip.755689
Chicago	Gozubatik-celik, R.gokcen, Mecbure Nalbantoglu, and Mesrure Koseoglu. “The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship With Anxiety and Depression”. Dicle Medical Journal 47, no. 2 (June 2020): 260-67. https://doi.org/10.5798/dicletip.755689.
EndNote	Gozubatik-celik R, Nalbantoglu M, Koseoglu M (June 1, 2020) The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression. Dicle Medical Journal 47 2 260–267.
IEEE	R. Gozubatik-celik, M. Nalbantoglu, and M. Koseoglu, “The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression”, diclemedj, vol. 47, no. 2, pp. 260–267, 2020, doi: 10.5798/dicletip.755689.
ISNAD	Gozubatik-celik, R.gokcen et al. “The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship With Anxiety and Depression”. Dicle Medical Journal 47/2 (June 2020), 260-267. https://doi.org/10.5798/dicletip.755689.
JAMA	Gozubatik-celik R, Nalbantoglu M, Koseoglu M. The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression. diclemedj. 2020;47:260–267.
MLA	Gozubatik-celik, R.gokcen et al. “The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship With Anxiety and Depression”. Dicle Medical Journal, vol. 47, no. 2, 2020, pp. 260-7, doi:10.5798/dicletip.755689.
Vancouver	Gozubatik-celik R, Nalbantoglu M, Koseoglu M. The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression. diclemedj. 2020;47(2):260-7.

Article Files

Full Text