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Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association

Year 2020, Volume: 47 Issue: 2, 482 - 486, 17.06.2020

Monika Gupta Nilay Nishith

https://doi.org/10.5798/dicletip.755782
Cited By: 1

Abstract

Granulomatous inflammation is commonly seen in Hodgkin lymphoma. However; the recent literature fails to correlate the subtypes of HL with granuloma. An occasional report describes association of mixed cellularity classical Hodgkin lymphoma with granulomatous reaction. None of other variants of HL are known to manifest with granulomatous reaction. We report a 34-year-old female patient who presented with swelling in right under arm for four months with no history of fever or weight loss. Fine needle aspiration cytology of axillary swelling revealed reactive lymphadenitis. To confirm the diagnosis lymph nodes excision was performed. Histomorphological examination revealed effacement of lymph node architecture by small to intermediate sized lymphoid cells with interspersed mononuclear Reed Sternberg cells like cells along with confluent and discrete non caseating granulomas. Additionally, immunohistochemical staining was performed, which rendered a diagnosis of nodular lymphocyte predominant Hodgkin lymphoma with granulomatous inflammation. This association is uncommon thereby making it pertinent for us to report this rare pathological entity also emphasis on careful microscopic evaluation of lymph node particularly with granulomatous reaction.

Keywords

Hodgkin lymphoma Granuloma Sarcoidosis

References

  • 1. Pai K, Sharma S, Padmapriya J. Florid granulomatous response masking diagnosis of Hodgkin’s disease in FNA cytology: a diagnostic challenge. Int J Health Sci Res. 2015; 5:468-470.
  • 2. Shanbhag S, Ambinder RF. Hodgkin Lymphoma: A Review and update on Recent Progress. CA Cancer J Clin.2018;68:116-32.doi: 10.3322/caac.21438 PMID: 29194581
  • 3. Lee AI, Lacasce AS. Nodular lymphocyte predominant Hodgkin Lymphoma.The Oncologist.2009;14:739-51. PMID:19605845 DOI:10.1634/theoncologist 2009-0099.
  • 4. Shah KK, Pritt BS, Alexander MP.Histopathological review of granulomatous inflammation. Journal of Clinical Tuberculosis and other Mycobacterial Diseases.2017;7:1-12. http://dx.doi.org/10.1016/j.jctube.2017.02.001

Year 2020, Volume: 47 Issue: 2, 482 - 486, 17.06.2020

Monika Gupta Nilay Nishith

https://doi.org/10.5798/dicletip.755782
Cited By: 1

Abstract

References

  • 1. Pai K, Sharma S, Padmapriya J. Florid granulomatous response masking diagnosis of Hodgkin’s disease in FNA cytology: a diagnostic challenge. Int J Health Sci Res. 2015; 5:468-470.
  • 2. Shanbhag S, Ambinder RF. Hodgkin Lymphoma: A Review and update on Recent Progress. CA Cancer J Clin.2018;68:116-32.doi: 10.3322/caac.21438 PMID: 29194581
  • 3. Lee AI, Lacasce AS. Nodular lymphocyte predominant Hodgkin Lymphoma.The Oncologist.2009;14:739-51. PMID:19605845 DOI:10.1634/theoncologist 2009-0099.
  • 4. Shah KK, Pritt BS, Alexander MP.Histopathological review of granulomatous inflammation. Journal of Clinical Tuberculosis and other Mycobacterial Diseases.2017;7:1-12. http://dx.doi.org/10.1016/j.jctube.2017.02.001
There are 4 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Case Reports
Authors

Monika Gupta This is me

Nilay Nishith This is me

Publication Date June 17, 2020
Submission Date February 14, 2020
Published in Issue Year 2020 Volume: 47 Issue: 2

Cite

APA Gupta, M., & Nishith, N. (2020). Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association. Dicle Tıp Dergisi, 47(2), 482-486. https://doi.org/10.5798/dicletip.755782
AMA Gupta M, Nishith N. Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association. diclemedj. June 2020;47(2):482-486. doi:10.5798/dicletip.755782
Chicago Gupta, Monika, and Nilay Nishith. “Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association”. Dicle Tıp Dergisi 47, no. 2 (June 2020): 482-86. https://doi.org/10.5798/dicletip.755782.
EndNote Gupta M, Nishith N (June 1, 2020) Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association. Dicle Tıp Dergisi 47 2 482–486.
IEEE M. Gupta and N. Nishith, “Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association”, diclemedj, vol. 47, no. 2, pp. 482–486, 2020, doi: 10.5798/dicletip.755782.
ISNAD Gupta, Monika - Nishith, Nilay. “Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association”. Dicle Tıp Dergisi 47/2 (June 2020), 482-486. https://doi.org/10.5798/dicletip.755782.
JAMA Gupta M, Nishith N. Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association. diclemedj. 2020;47:482–486.
MLA Gupta, Monika and Nilay Nishith. “Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association”. Dicle Tıp Dergisi, vol. 47, no. 2, 2020, pp. 482-6, doi:10.5798/dicletip.755782.
Vancouver Gupta M, Nishith N. Nodular Lymphocyte Predominant Hodgkin Lymphoma With Sarcoid-Like Granulomas: A Rare Association. diclemedj. 2020;47(2):482-6.

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