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The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice

Year 2021, Volume: 48 Issue: 3, 514 - 522, 01.09.2021
https://doi.org/10.5798/dicletip.988063

Abstract

Objective: Ethyl pyruvate (EP) is a molecule with antioxidant, anti-inflammatory, and anti-apoptotic features. The present study investigates EP's effects on behavioral and biochemical alterations induced by immobilization (IM) stress.
Methods: In this outcome, 45 male BALB/c mice were separated into five groups [CONT (control), IM, IM+EP, EP, IM+F (fluoxetine)]. IM applied groups had 6 hours of immobilization stress procedure a day for a week. EP (50 mg/day) and fluoxetine (5 mg/day) were applied to the mice intraperitoneally. After the stress induction protocol, passive avoidance, open field (OF), and forced swimming tests (FST) were executed. After behavioral tests, brain tissues were obtained for biochemical investigations.
Results: Immobilization application increased immobility times in the FST and decreased the total distance moved and the center time in the OF test. Immobile times were reduced with fluoxetine and EP applied groups compared with the IM group due to decreased learned helplessness. The IM group had decreased brain-derived neurotrophic factor (BDNF), superoxide dismutase, and glutathione peroxidase levels, which were increased with EP applications.
Conclusion: These results show that EP generates antidepressant-like effects with decreasing oxidation and increasing BDNF levels.

References

  • 1. Terzi F, Türkoğlu HD, Bölen F, et al. Residents’ perception of cultural activities as quality of life in Istanbul. Soc Indic Res. 2015; 122: 211-34.
  • 2. Deveci SE, Çalmaz A, Açık Y. The relationship between anxiety level and health, social and demographical factors in the students of a newly established university in Eastern Anatolia. Dicle Med J. 2012; 39: 189-96.
Year 2021, Volume: 48 Issue: 3, 514 - 522, 01.09.2021
https://doi.org/10.5798/dicletip.988063

Abstract

References

  • 1. Terzi F, Türkoğlu HD, Bölen F, et al. Residents’ perception of cultural activities as quality of life in Istanbul. Soc Indic Res. 2015; 122: 211-34.
  • 2. Deveci SE, Çalmaz A, Açık Y. The relationship between anxiety level and health, social and demographical factors in the students of a newly established university in Eastern Anatolia. Dicle Med J. 2012; 39: 189-96.
There are 2 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Mihrab Abul This is me

Hasan Akkoc This is me

Emre Uyar This is me

Suleyman Donmezdil This is me

Publication Date September 1, 2021
Submission Date January 18, 2021
Published in Issue Year 2021 Volume: 48 Issue: 3

Cite

APA Abul, M., Akkoc, H., Uyar, E., Donmezdil, S. (2021). The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice. Dicle Medical Journal, 48(3), 514-522. https://doi.org/10.5798/dicletip.988063
AMA Abul M, Akkoc H, Uyar E, Donmezdil S. The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice. diclemedj. September 2021;48(3):514-522. doi:10.5798/dicletip.988063
Chicago Abul, Mihrab, Hasan Akkoc, Emre Uyar, and Suleyman Donmezdil. “The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice”. Dicle Medical Journal 48, no. 3 (September 2021): 514-22. https://doi.org/10.5798/dicletip.988063.
EndNote Abul M, Akkoc H, Uyar E, Donmezdil S (September 1, 2021) The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice. Dicle Medical Journal 48 3 514–522.
IEEE M. Abul, H. Akkoc, E. Uyar, and S. Donmezdil, “The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice”, diclemedj, vol. 48, no. 3, pp. 514–522, 2021, doi: 10.5798/dicletip.988063.
ISNAD Abul, Mihrab et al. “The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice”. Dicle Medical Journal 48/3 (September 2021), 514-522. https://doi.org/10.5798/dicletip.988063.
JAMA Abul M, Akkoc H, Uyar E, Donmezdil S. The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice. diclemedj. 2021;48:514–522.
MLA Abul, Mihrab et al. “The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice”. Dicle Medical Journal, vol. 48, no. 3, 2021, pp. 514-22, doi:10.5798/dicletip.988063.
Vancouver Abul M, Akkoc H, Uyar E, Donmezdil S. The Effects of Ethyl Pyruvate on Behavioral and Biochemical Parameters in Immobilization Stress-Induced Mice. diclemedj. 2021;48(3):514-22.