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Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI

Year 2021, Volume: 48 Issue: 4, 688 - 695, 01.12.2021
https://doi.org/10.5798/dicletip.1001964

Abstract

Objective: Fibrinogen plasma level rises in the event of inflammatory cases. It is known that there is a powerful intercourse between fibrinogen level and plasma viscosity. Albumin plasma level dropes during the inflammatory cases. The aim of this work determine significance of fibrinogen albumin ratio (FAR) as a indicator emphases the burden of atherosclerosis.
Method: The study included 83 patients diagnosed with non-ST-segment elevation myocardial infarction (NSTEMI) between January and September 2015. The definition of NSTEMI was made according to “Definition of Third Universal Myocardial Infarction” guidelines published on 2013 by European Society of Cardiology. Burden of atherosclerosis was evaluated by Syntax score (SS) and Gensini Score. Patients were seperated two groups as medium-high SS (n=23) and low SS (n=60). FAR levels were compared.
Results: FAR was 80.71 ± 30.3 in low SS group and 120 ± 49.72 in the mid-high SS group respectively (p <0.001). In correlation evaluation, FAR and SS showed a poor positive correlation (r = 0.496, p <0.001). In multivariate logistic regression assesment of elements impacting the SS, prominent variable was found to be FAR [p = 0.01, 95% CI (1005-1042)]. In ROC evaluation FAR values of 85 and over demonstrated 83% sensitivity and 68% specificity in determining the burden of coronary artery disease (CAD).
Conclusions: In moderate-high SS group FAR value is considerably higher than those with a low SS group. FAR value may be usefull indicator in clinical practice to determine the burden of coronary artery disease.
Keywords: Fibrinogen, albumin, syntax score

References

  • 1. Ross R. Atherosclerosis an inflammatory disease.N Engl J Med. 1999; 340: 115-26.
  • 2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005; 352: 685-95.
  • 3. Kristensen SD. The platelet-vessel wall interaction in experimental atherosclerosis and ischaemic heart disease with special reference to thrombopoiesis. Dan Med Bull. 1992; 39: 110-27.

Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI

Year 2021, Volume: 48 Issue: 4, 688 - 695, 01.12.2021
https://doi.org/10.5798/dicletip.1001964

Abstract

Objective: Fibrinogen plasma level rises in the event of inflammatory cases. It is known that there is a powerful intercourse between fibrinogen level and plasma viscosity. Albumin plasma level dropes during the inflammatory cases. The aim of this work determine significance of fibrinogen albumin ratio (FAR) as a indicator emphases the burden of atherosclerosis.
Method: The study included 83 patients diagnosed with non-ST-segment elevation myocardial infarction (NSTEMI) between January and September 2015. The definition of NSTEMI was made according to “Definition of Third Universal Myocardial Infarction” guidelines published on 2013 by European Society of Cardiology. Burden of atherosclerosis was evaluated by Syntax score (SS) and Gensini Score. Patients were seperated two groups as medium-high SS (n=23) and low SS (n=60). FAR levels were compared.
Results: FAR was 80.71 ± 30.3 in low SS group and 120 ± 49.72 in the mid-high SS group respectively (p <0.001). In correlation evaluation, FAR and SS showed a poor positive correlation (r = 0.496, p <0.001). In multivariate logistic regression assesment of elements impacting the SS, prominent variable was found to be FAR [p = 0.01, 95% CI (1005-1042)]. In ROC evaluation FAR values of 85 and over demonstrated 83% sensitivity and 68% specificity in determining the burden of coronary artery disease (CAD).
Conclusions: In moderate-high SS group FAR value is considerably higher than those with a low SS group. FAR value may be usefull indicator in clinical practice to determine the burden of coronary artery disease.

References

  • 1. Ross R. Atherosclerosis an inflammatory disease.N Engl J Med. 1999; 340: 115-26.
  • 2. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005; 352: 685-95.
  • 3. Kristensen SD. The platelet-vessel wall interaction in experimental atherosclerosis and ischaemic heart disease with special reference to thrombopoiesis. Dan Med Bull. 1992; 39: 110-27.
There are 3 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Articles
Authors

Muhammed Demir This is me

Mehmet Özbek This is me

Adem Aktan This is me

Faruk Ertaş This is me

Publication Date December 1, 2021
Submission Date June 22, 2021
Published in Issue Year 2021 Volume: 48 Issue: 4

Cite

APA Demir, M., Özbek, M., Aktan, A., Ertaş, F. (2021). Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI. Dicle Tıp Dergisi, 48(4), 688-695. https://doi.org/10.5798/dicletip.1001964
AMA Demir M, Özbek M, Aktan A, Ertaş F. Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI. diclemedj. December 2021;48(4):688-695. doi:10.5798/dicletip.1001964
Chicago Demir, Muhammed, Mehmet Özbek, Adem Aktan, and Faruk Ertaş. “Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients With NSTEMI”. Dicle Tıp Dergisi 48, no. 4 (December 2021): 688-95. https://doi.org/10.5798/dicletip.1001964.
EndNote Demir M, Özbek M, Aktan A, Ertaş F (December 1, 2021) Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI. Dicle Tıp Dergisi 48 4 688–695.
IEEE M. Demir, M. Özbek, A. Aktan, and F. Ertaş, “Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI”, diclemedj, vol. 48, no. 4, pp. 688–695, 2021, doi: 10.5798/dicletip.1001964.
ISNAD Demir, Muhammed et al. “Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients With NSTEMI”. Dicle Tıp Dergisi 48/4 (December 2021), 688-695. https://doi.org/10.5798/dicletip.1001964.
JAMA Demir M, Özbek M, Aktan A, Ertaş F. Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI. diclemedj. 2021;48:688–695.
MLA Demir, Muhammed et al. “Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients With NSTEMI”. Dicle Tıp Dergisi, vol. 48, no. 4, 2021, pp. 688-95, doi:10.5798/dicletip.1001964.
Vancouver Demir M, Özbek M, Aktan A, Ertaş F. Fibrinogen to Albumin Ratio Predicts Burden of Coronary Artery Disease in Patients with NSTEMI. diclemedj. 2021;48(4):688-95.