Mucous Membrane Pemphigoid with Floor of Mouth Involvement: Case Report

Year 2025, Volume: 11 Issue: 2, 109 - 114, 29.08.2025

Müberra Deniz , Can Aydın , Tuğrul Kırtıloğlu , Abbas Akbari

https://doi.org/10.21306/dishekimligi.1727479

Abstract

ABSTRACT:
Objective:
Mucous membrane pemphigoid (MMP) is a rare autoimmune disease characterized by subepithelial bullae on mucosal surfaces. The aim of this case report is to highlight the involvement of the floor of the mouth—a localization rarely reported in the literature—and the therapeutic approach for lesions in this region.
Materials and Methods:
A 59-year-old female patient presented to our clinic with complaints of gingival bleeding and periodic bullae. Clinical examination revealed extensive oral involvement, including the floor of the mouth. Following a thorough clinical evaluation and histopathological analysis, a diagnosis of MMP was established. The patient was treated with a systemic regimen consisting of methylprednisolone, dapsone, and mycophenolate mofetil.
Results:
During the six-month follow-up period, a marked regression of the oral lesions and clinical improvement were observed. The patient responded favorably to the treatment.
Conclusion:
This case is significant as it demonstrates that MMP can also involve the floor of the mouth. Early diagnosis and appropriate systemic therapy are crucial for achieving successful outcomes.

Keywords

Oral mucosa , floor of the mouth , bullous lesion , mucous membrane pemphigoid

Mukoz Membran Pemfigoidi’nde Ağız Tabanı Tutulumu: Olgu Sunumu

Abstract

Amaç:
Mukoz membran pemfigoidi (MMP), mukozal yüzeylerde subepitelyal büllerle seyreden nadir görülen otoimmün bir hastalıktır. Bu olgu sunumunun amacı, mukoz membran pemfigoidinin literatürde nadiren bildirilen ağız tabanı tutulumuna ve bu bölgedeki lezyonların tedavi sürecine dikkat çekmektir.
Gereç ve Yöntemler:
Diş eti kanaması ve periyodik büller şikâyetiyle kliniğimize başvuran 59 yaşındaki kadın hastada, ağız tabanı dahil olmak üzere yaygın oral tutulum mevcuttu. Yapılan detaylı klinik değerlendirme ve histopatolojik inceleme sonucunda MMP tanısı konulmuştur. Hastaya sistemik metilprednizolon, dapson ve mikofenolat mofetil içeren bir tedavi protokolü uygulanmıştır.
Bulgular:
Altı aylık takip sürecinde oral lezyonlarda belirgin gerileme ve klinik iyileşme gözlenmiştir. Tedaviye olumlu yanıt alınmıştır.
Sonuç:
Bu olgu, MMP’nin ağız tabanını da tutabileceğini göstermesi açısından önem taşımaktadır. Erken tanı ve uygun sistemik tedavi ile başarılı sonuçlar elde edilebileceği vurgulanmalıdır.

Keywords

Ağız mukozası , ağız tabanı , büllöz lezyon , mukoz membran pemfigoid

Ethical Statement

Bu olgu sunumu, Helsinki Bildirgesi ilkeleri doğrultusunda yürütülmüş olup, etik kurallara uygun olarak gerçekleştirilmiştir. Hastadan, olguya ait bilgilerin bilimsel amaçlarla kullanılmasına yönelik onam alınmıştır.

Supporting Institution

Ondokuz Mayıs Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji Anabilim Dalı

Thanks

Ondokuz Mayıs Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Anabilim Dalı’na verdikleri akademik destek ve katkılarından dolayı teşekkür ederiz.

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