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Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu

Year 2022, , 1508 - 1523, 31.07.2022
https://doi.org/10.29130/dubited.1053119

Abstract

Bu çalışmanın amacı, Pleurotus cornucopiae var. citrinopileatus mantarı ekstraksiyon koşullarının yapay zekâ metotlarıyla optimize edilmesidir. Bu amaç doğrultusunda %0, 30, 60, 90 etanol oranı kullanılarak, 1, 2 ve 4 mg/mL ekstrakt konsantrasyonunda elde edilen ekstraktların, 1,2, 3, 4,2 ve 6 pH koşullarındaki antioksidan aktiviteleri mevcut bir deneysel çalışmadan elde edilmiştir. Ekstraksiyon koşullarının modellenmesi Yapay Sinir Ağları (YSA) ile yapılmış ve Güve-Alev Optimizasyon (GAO) algoritması kullanılarak optimize edilmiştir. En iyi tahmin modelini elde etmek için farklı gizli nöron sayıları denenmiş ve en uygun gizli nöron sayısı 5 olarak bulunmuştur. Elde edilen bu modelin hata karelerinin ortalaması ve ortalama mutlak yüzde hatası tüm veri seti için sırasıyla 1,79 ve %3,24 olarak bulunmuştur. Optimizasyon süreci sonrasında maksimum antioksidan aktivite %56,76 olarak bulunmuştur ve bu sonucu elde etmek için optimum ekstraksiyon parametreleri %66,34 etanol oranı, 4 mg/mL ekstrakt konsantrasyonu ve 2,36 pH olarak belirlenmiştir. Bu çalışma, YSA ve GAO algoritmasının birlikte kullanılması ile ekstraksiyon koşullarının optimizasyonunda zaman, emek ve maliyet
verimliliği sağlandığını ortaya koymuştur.

References

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  • [2] M.E. Valverde, T. Hernández-Pérez, and O. Paredes-López, "Edible mushrooms: improving human health and promoting quality life". International Journal of Microbiology, vol. 2015, pp. 1-14, 2015.
  • [3] Y. Liu, X.X. Xie, S.A. Ibrahim, S.G. Khaskheli, H. Yang, Y.F. Wang, and W. Huang, "Characterization of Lactobacillus pentosus as a starter culture for the fermentation of edible oyster mushrooms (Pleurotus spp.)". LWT-Food Science Technology, vol. 68, pp. 21-26, 2016.
  • [4] L. Pathmashini, V. Arulnandhy, and R. Wijeratnam, "Efficacy of different spawn types on sawdust media". Tropical Agricultural Research Extension, vol. 11, pp. 55-59, 2010.
  • [5] M. Ritota and P. Manzi, "Pleurotus spp. cultivation on different agri-food by-products: Example of biotechnological application". Sustainability, vol. 11, no.18, pp. 5049, 2019.
  • [6] J. Raman, K.Y. Jang, Y.L. Oh, M. Oh, J.H. Im, H. Lakshmanan, and V. Sabaratnam, "Cultivation and nutritional value of prominent Pleurotus spp.: An overview". Mycobiology, vol. 49, no.1, pp. 1-14, 2021.
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  • [15] N. Doğan, and C. Doğan, "İstiridye Mantarının (Pleurotus ostreatus) Farklı Flaş Zamanlarına Göre Antioksidan Aktivitesinin ve Hiperglisemide Anahtar Enzim Rolü Olan α-amilaz ve α- glukozidaz İnhibisyon Potansiyelinin Belirlenmesi". Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, vol. 24, no.6, pp. 1177-1186, 2021.
  • [16] S.J. Wang, L. Bao, J.J. Han, Q.X. Wang, X.L. Yang, H.A. Wen, L.D. Guo, S.J. Li, F. Zhao, and H.W. Liu, "Pleurospiroketals A–E, Perhydrobenzannulated 5, 5-Spiroketal Sesquiterpenes from the edible mushroom Pleurotus cornucopia e". Journal of Natural Products, vol. 76, no.1, pp. 45-50, 2013.
  • [17] S.N. Um, G.E. Jin, K.W. Park, Y.B. Yu, and K.M. Park, "Physiological activity and nutritional composition of Pleurotus species". Korean Journal of Food Science Technology, vol. 42, no.1, pp. 90- 96, 2010.
  • [18] J. Dai and R.J. Mumper, "Plant phenolics: extraction, analysis and their antioxidant and anticancer properties". Molecules, vol. 15, no.10, pp. 7313-7352, 2010.
  • [19] P . Garcia-Salas, A. Morales-Soto, A. Segura-Carretero, and A. Fernández-Gutiérrez, "Phenolic-compound-extraction systems for fruit and vegetable samples". Molecules, vol. 15, no.12, pp. 8813-8826, 2010.
  • [20] S. Jiang, S. Liu, and M. Qin, "Effects of extraction conditions on crude polysaccharides and antioxidant activities of the lion's mane medicinal mushroom, Hericium erinaceus (Agaricomycetes)". International Journal of Medicinal Mushrooms, vol. 21, no.10, pp. 1007-1018, 2019.
  • [21] H.S. Yim, F.Y. Chye, S.M. Koo, P. Matanjun, S.E. How, and C.W. Ho, "Optimization of extraction time and temperature for antioxidant activity of edible wild mushroom, Pleurotus porrigens". Food Bioproducts Processing, vol. 90, no.2, pp. 235-242, 2012.
  • [22] J.A. Michiels, C. Kevers, J. Pincemail, J.O. Defraigne, and J. Dommes, "Extraction conditions can greatly influence antioxidant capacity assays in plant food matrices". Food Chemistry, vol. 130, no.4, pp. 986-993, 2012.
  • [23] G. Nguyen and T. Nguyen, "Effect of extraction conditions (temperature, pH and time) by cellulase on chemical properties of dried oyster mushroom (Pleurotus sajor-caju) extract". Food Research, vol. 5, no.3, pp. 351-358, 2021.
  • [24] N. Doğan, C. Doğan and Atila, F. "Parts from life-cycle of H. erinaceus: response surface methodology approach to optimize extraction conditions and determination of its antioxidant, antidiabetic and antimicrobial effect". Journal of Microbiology, Biotechnology and Food Sciences, vol. 10, no.6, pp. e3703-e3703, 2021.
  • [25] J.H. Maeng, H. Muhammad Shahbaz, K. Ameer, Y. Jo, and J.H. Kwon, "Optimization of microwave‐assisted extraction of bioactive compounds from Coriolus versicolor mushroom using response surface methodology". Journal of Food Process Engineering, vol. 40, no.2, pp. e12421, 2017.
  • [26] J.Y. Cho, N.B. Sadiq, J.C. Kim, B. Lee, M. Hamayun, T.S. Lee, H.S. Kim, S.H. Park, C.W. Nho, and H.-Y. Kim, "Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology". Food Chemistry, vol. 335, pp. 127645, 2021.
  • [27] B. Abbasi and H. Mahlooji, "Improving response surface methodology by using artificial neural network and simulated annealing". Expert Systems with Applications, vol. 39, no.3, pp. 3461- 3468, 2012.
  • [28] P. Poonnoy, A. Tansakul, and M. Chinnan, "Estimation of moisture ratio of a mushroom undergoing microwave-vacuum drying using artificial neural network and regression models". Chemical Product Process Modeling, vol. 2, no.3, pp. 2007.
  • [29] A. Tarafdar, N.C. Shahi, and A. Singh, "Freeze-drying behaviour prediction of button mushrooms using artificial neural network and comparison with semi-empirical models". Neural Computing Applications, vol. 31, no.11, pp. 7257-7268, 2019.
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  • [31] K.M. Rajković, J.M. Avramović, P.S. Milić, O.S. Stamenković and V.B. Veljković, "Optimization of ultrasound-assisted base-catalyzed methanolysis of sunflower oil using response surface and artifical neural network methodologies". Chemical Engineering Journal, vol. 215, pp. 82- 89, 2013.
  • [32] E. Betiku and S.O. Ajala, "Modeling and optimization of Thevetia peruviana (yellow oleander) oil biodiesel synthesis via Musa paradisiacal (plantain) peels as heterogeneous base catalyst: A case of artificial neural network vs. response surface methodology". Industrial Crops and Products, vol. 53, pp. 314-322, 2014.
  • [33] M. Rebollo-Hernanz, S. Cañas, D. Taladrid, V. Benítez, B. Bartolomé, Y. Aguilera, and M.A. Martín-Cabrejas, "Revalorization of Coffee Husk: Modeling and Optimizing the Green Sustainable Extraction of Phenolic Compounds". Foods, vol. 10, no.3, pp. 653, 2021.
  • [34] S. Mirjalili, "The ant lion optimizer". Advances in Engineering Software, vol. 83, pp. 80-98, 2015.
  • [35] D.H. Wolpert and W.G. Macready, "No free lunch theorems for optimization", IEEE Transactions on Evolutionary Computation, vol. 1, no.1, pp. 67-82, 1997.
  • [36] S. Mirjalili, S.M. Mirjalili, and A. Lewis, "Grey wolf optimizer". Advances in Engineering Software, vol. 69, pp. 46-61, 2014.
  • [37] H.J. Lee, J.R. Do, M.Y. Chung, and H.K. Kim, "Antioxidant activities of Pleurotus cornucopiae extracts by extraction conditions". Journal of the Korean Society of Food Science Nutrition, vol. 43, no.6, pp. 836-841, 2014.
  • [38] J. Gray and L. Dugan Jr, "Inhibition of n‐nitrosamine formation in model food systems". Journal of Food Science, vol. 40, no.5, pp. 981-984, 1975.
  • [39] S. Haykin, Neural Networks: A Comprehensive Foundation, New York: Macmillan, 1994.
  • [40] M. Karakoyun, and A. Özkış, "Transfer Fonksiyonları Kullanarak İkili Güve-Alev Optimizasyonu Algoritmalarının Geliştirilmesi ve Performanslarının Karşılaştırılması". Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, vol. 3, no.2, pp. 1-10, 2021.
  • [41] S. Mirjalili, "Moth-flame optimization algorithm: A novel nature-inspired heuristic paradigm". Knowledge-based systems, vol. 89, pp. 228-249, 2015.

Optimizing Pleurotus cornucopiae var. citrinopileatus Mushroom Extraction Conditions Using Moth-Flame Optimization Algorithm

Year 2022, , 1508 - 1523, 31.07.2022
https://doi.org/10.29130/dubited.1053119

Abstract

The aim of this study is to optimize the extraction conditions of Pleurotus cornucopiae using artificial intelligence methods. For this purpose, the data of antioxidant activities of mushrooms extracted at 0, 30, 60, 90 % ethanol ratio, 1, 2 and 4 mg/mL extract concentration and 1,2, 3, 4.2 and 6 pH conditions were obtained from an previous experimental study. The extraction conditions were modelled using artificial neural networks and optimized using Moth-Flame Optimization algorithm. In order to obtain the best prediction model, different numbers of hidden neurons were tried and the optimal number of hidden neurons was found to be 5. The mean of squares of error and mean absolute percent error of this model were found to be 1.79 and 3.24%, respectively, for the all data set. After the optimization process, the maximum antioxidant activity was found to be 56.76%, and the optimum extraction parameters were determined as 66.34% ethanol ratio, 4 mg/mL extract concentration and 2.36 pH to obtain this result. This study revealed that the use of artificial neural networks and Moth-Flame Optimization Algorithm integration provides time, labor and cost efficiency in the optimization of extraction conditions.

References

  • [1] S.P. Wasser and A.L. Weis, "Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives". International Journal of Medicinal Mushrooms, vol. 19, no.1, pp. 31-62, 1999.
  • [2] M.E. Valverde, T. Hernández-Pérez, and O. Paredes-López, "Edible mushrooms: improving human health and promoting quality life". International Journal of Microbiology, vol. 2015, pp. 1-14, 2015.
  • [3] Y. Liu, X.X. Xie, S.A. Ibrahim, S.G. Khaskheli, H. Yang, Y.F. Wang, and W. Huang, "Characterization of Lactobacillus pentosus as a starter culture for the fermentation of edible oyster mushrooms (Pleurotus spp.)". LWT-Food Science Technology, vol. 68, pp. 21-26, 2016.
  • [4] L. Pathmashini, V. Arulnandhy, and R. Wijeratnam, "Efficacy of different spawn types on sawdust media". Tropical Agricultural Research Extension, vol. 11, pp. 55-59, 2010.
  • [5] M. Ritota and P. Manzi, "Pleurotus spp. cultivation on different agri-food by-products: Example of biotechnological application". Sustainability, vol. 11, no.18, pp. 5049, 2019.
  • [6] J. Raman, K.Y. Jang, Y.L. Oh, M. Oh, J.H. Im, H. Lakshmanan, and V. Sabaratnam, "Cultivation and nutritional value of prominent Pleurotus spp.: An overview". Mycobiology, vol. 49, no.1, pp. 1-14, 2021.
  • [7] P. Kalač, "Chemical composition and nutritional value of European species of wild growing mushrooms: A review". Food chemistry, vol. 113, no.1, pp. 9-16, 2009.
  • [8] G. Cardwell, J.F. Bornman, A.P. James, and L.J. Black, "A review of mushrooms as a potential source of dietary vitamin D". Nutrients, vol. 10, no.10, pp. 1498, 2018.
  • [9] H.J.M.H.J. Masri, P.M.P. Maftoun, R. Abd Malek, A.Z. Boumehira, A. Pareek, S.Z. Hanapi, O.M. Ling, and H. El Enshasy, "The edible mushroom Pleurotus spp.: II. Medicinal values". International Journal of Biotechnology for Wellness Industries, vol. 6, no.1, pp. 1-11, 2017.
  • [10] G. Chilanti, K. Todescatto, L.B. Andrade, C.S. Branco, M. Salvador, M. Camassola, R.C. Fontana, and A.J. Dillon, "Polyphenolic Content and Antioxidant Activity of Mycelia and Basidiomes of Oyster Mushrooms Pleurotus spp.(Agaricomycetes) from Brazil". International Journal of Medicinal Mushrooms, vol. 23, no.6, pp. 13-23, 2021.
  • [11] D. Roy, S. Ansari, A. Chatterjee, A. Luganini, S. Ghosh, and N. Chakraborty, "In Vitro Search for Antiviral Activity against Human Cytomegalovirus from Medicinal Mushrooms Pleurotus sp. and Lentinus sp". Journal of Antivirals & Antiretrovirals vol. 12, no.3, pp. 1-12, 2020.
  • [12] M. Özdal, Ö. Gülmez, Ö.G. Özdal, and Ö.F. Algur, "Antibacterial and antioxidant activity of mycelial extracts of different Pleurotus species". Food Health, vol. 5, no.1, pp. 12-18, 2019.
  • [13] V. Mishra, S. Tomar, P. Yadav, and M. Singh, "Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review". International Journal of Biological Macromolecules, vol. 182, pp. 1628-1637, 2021.
  • [14] I. Golak-Siwulska, A. Kałużewicz, T. Spiżewski, M. Siwulski, and K. Sobieralski, "Bioactive compounds and medicinal properties of Oyster mushrooms (Pleurotus sp.)". Folia Horticulturae, vol. 30, no.2, pp. 191-201, 2018.
  • [15] N. Doğan, and C. Doğan, "İstiridye Mantarının (Pleurotus ostreatus) Farklı Flaş Zamanlarına Göre Antioksidan Aktivitesinin ve Hiperglisemide Anahtar Enzim Rolü Olan α-amilaz ve α- glukozidaz İnhibisyon Potansiyelinin Belirlenmesi". Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, vol. 24, no.6, pp. 1177-1186, 2021.
  • [16] S.J. Wang, L. Bao, J.J. Han, Q.X. Wang, X.L. Yang, H.A. Wen, L.D. Guo, S.J. Li, F. Zhao, and H.W. Liu, "Pleurospiroketals A–E, Perhydrobenzannulated 5, 5-Spiroketal Sesquiterpenes from the edible mushroom Pleurotus cornucopia e". Journal of Natural Products, vol. 76, no.1, pp. 45-50, 2013.
  • [17] S.N. Um, G.E. Jin, K.W. Park, Y.B. Yu, and K.M. Park, "Physiological activity and nutritional composition of Pleurotus species". Korean Journal of Food Science Technology, vol. 42, no.1, pp. 90- 96, 2010.
  • [18] J. Dai and R.J. Mumper, "Plant phenolics: extraction, analysis and their antioxidant and anticancer properties". Molecules, vol. 15, no.10, pp. 7313-7352, 2010.
  • [19] P . Garcia-Salas, A. Morales-Soto, A. Segura-Carretero, and A. Fernández-Gutiérrez, "Phenolic-compound-extraction systems for fruit and vegetable samples". Molecules, vol. 15, no.12, pp. 8813-8826, 2010.
  • [20] S. Jiang, S. Liu, and M. Qin, "Effects of extraction conditions on crude polysaccharides and antioxidant activities of the lion's mane medicinal mushroom, Hericium erinaceus (Agaricomycetes)". International Journal of Medicinal Mushrooms, vol. 21, no.10, pp. 1007-1018, 2019.
  • [21] H.S. Yim, F.Y. Chye, S.M. Koo, P. Matanjun, S.E. How, and C.W. Ho, "Optimization of extraction time and temperature for antioxidant activity of edible wild mushroom, Pleurotus porrigens". Food Bioproducts Processing, vol. 90, no.2, pp. 235-242, 2012.
  • [22] J.A. Michiels, C. Kevers, J. Pincemail, J.O. Defraigne, and J. Dommes, "Extraction conditions can greatly influence antioxidant capacity assays in plant food matrices". Food Chemistry, vol. 130, no.4, pp. 986-993, 2012.
  • [23] G. Nguyen and T. Nguyen, "Effect of extraction conditions (temperature, pH and time) by cellulase on chemical properties of dried oyster mushroom (Pleurotus sajor-caju) extract". Food Research, vol. 5, no.3, pp. 351-358, 2021.
  • [24] N. Doğan, C. Doğan and Atila, F. "Parts from life-cycle of H. erinaceus: response surface methodology approach to optimize extraction conditions and determination of its antioxidant, antidiabetic and antimicrobial effect". Journal of Microbiology, Biotechnology and Food Sciences, vol. 10, no.6, pp. e3703-e3703, 2021.
  • [25] J.H. Maeng, H. Muhammad Shahbaz, K. Ameer, Y. Jo, and J.H. Kwon, "Optimization of microwave‐assisted extraction of bioactive compounds from Coriolus versicolor mushroom using response surface methodology". Journal of Food Process Engineering, vol. 40, no.2, pp. e12421, 2017.
  • [26] J.Y. Cho, N.B. Sadiq, J.C. Kim, B. Lee, M. Hamayun, T.S. Lee, H.S. Kim, S.H. Park, C.W. Nho, and H.-Y. Kim, "Optimization of antioxidant, anti-diabetic, and anti-inflammatory activities and ganoderic acid content of differentially dried Ganoderma lucidum using response surface methodology". Food Chemistry, vol. 335, pp. 127645, 2021.
  • [27] B. Abbasi and H. Mahlooji, "Improving response surface methodology by using artificial neural network and simulated annealing". Expert Systems with Applications, vol. 39, no.3, pp. 3461- 3468, 2012.
  • [28] P. Poonnoy, A. Tansakul, and M. Chinnan, "Estimation of moisture ratio of a mushroom undergoing microwave-vacuum drying using artificial neural network and regression models". Chemical Product Process Modeling, vol. 2, no.3, pp. 2007.
  • [29] A. Tarafdar, N.C. Shahi, and A. Singh, "Freeze-drying behaviour prediction of button mushrooms using artificial neural network and comparison with semi-empirical models". Neural Computing Applications, vol. 31, no.11, pp. 7257-7268, 2019.
  • [30] V.M. Simić, K.M. Rajković, S.S. Stojičević, D.T. Veličković, N.Č. Nikolić, M.L. Lazić and I.T. Karabegović, "Optimization of microwave-assisted extraction of total polyphenolic compounds from chokeberries by response surface methodology and artificial neural network". Separation and Purification Technology, vol. 160, pp. 89-97, 2016
  • [31] K.M. Rajković, J.M. Avramović, P.S. Milić, O.S. Stamenković and V.B. Veljković, "Optimization of ultrasound-assisted base-catalyzed methanolysis of sunflower oil using response surface and artifical neural network methodologies". Chemical Engineering Journal, vol. 215, pp. 82- 89, 2013.
  • [32] E. Betiku and S.O. Ajala, "Modeling and optimization of Thevetia peruviana (yellow oleander) oil biodiesel synthesis via Musa paradisiacal (plantain) peels as heterogeneous base catalyst: A case of artificial neural network vs. response surface methodology". Industrial Crops and Products, vol. 53, pp. 314-322, 2014.
  • [33] M. Rebollo-Hernanz, S. Cañas, D. Taladrid, V. Benítez, B. Bartolomé, Y. Aguilera, and M.A. Martín-Cabrejas, "Revalorization of Coffee Husk: Modeling and Optimizing the Green Sustainable Extraction of Phenolic Compounds". Foods, vol. 10, no.3, pp. 653, 2021.
  • [34] S. Mirjalili, "The ant lion optimizer". Advances in Engineering Software, vol. 83, pp. 80-98, 2015.
  • [35] D.H. Wolpert and W.G. Macready, "No free lunch theorems for optimization", IEEE Transactions on Evolutionary Computation, vol. 1, no.1, pp. 67-82, 1997.
  • [36] S. Mirjalili, S.M. Mirjalili, and A. Lewis, "Grey wolf optimizer". Advances in Engineering Software, vol. 69, pp. 46-61, 2014.
  • [37] H.J. Lee, J.R. Do, M.Y. Chung, and H.K. Kim, "Antioxidant activities of Pleurotus cornucopiae extracts by extraction conditions". Journal of the Korean Society of Food Science Nutrition, vol. 43, no.6, pp. 836-841, 2014.
  • [38] J. Gray and L. Dugan Jr, "Inhibition of n‐nitrosamine formation in model food systems". Journal of Food Science, vol. 40, no.5, pp. 981-984, 1975.
  • [39] S. Haykin, Neural Networks: A Comprehensive Foundation, New York: Macmillan, 1994.
  • [40] M. Karakoyun, and A. Özkış, "Transfer Fonksiyonları Kullanarak İkili Güve-Alev Optimizasyonu Algoritmalarının Geliştirilmesi ve Performanslarının Karşılaştırılması". Necmettin Erbakan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, vol. 3, no.2, pp. 1-10, 2021.
  • [41] S. Mirjalili, "Moth-flame optimization algorithm: A novel nature-inspired heuristic paradigm". Knowledge-based systems, vol. 89, pp. 228-249, 2015.
There are 41 citations in total.

Details

Primary Language Turkish
Subjects Engineering
Journal Section Articles
Authors

Ayşenur Gürgen 0000-0002-2263-7323

Publication Date July 31, 2022
Published in Issue Year 2022

Cite

APA Gürgen, A. (2022). Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu. Duzce University Journal of Science and Technology, 10(3), 1508-1523. https://doi.org/10.29130/dubited.1053119
AMA Gürgen A. Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu. DÜBİTED. July 2022;10(3):1508-1523. doi:10.29130/dubited.1053119
Chicago Gürgen, Ayşenur. “Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus Cornucopiae Var. Citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu”. Duzce University Journal of Science and Technology 10, no. 3 (July 2022): 1508-23. https://doi.org/10.29130/dubited.1053119.
EndNote Gürgen A (July 1, 2022) Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu. Duzce University Journal of Science and Technology 10 3 1508–1523.
IEEE A. Gürgen, “Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu”, DÜBİTED, vol. 10, no. 3, pp. 1508–1523, 2022, doi: 10.29130/dubited.1053119.
ISNAD Gürgen, Ayşenur. “Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus Cornucopiae Var. Citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu”. Duzce University Journal of Science and Technology 10/3 (July 2022), 1508-1523. https://doi.org/10.29130/dubited.1053119.
JAMA Gürgen A. Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu. DÜBİTED. 2022;10:1508–1523.
MLA Gürgen, Ayşenur. “Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus Cornucopiae Var. Citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu”. Duzce University Journal of Science and Technology, vol. 10, no. 3, 2022, pp. 1508-23, doi:10.29130/dubited.1053119.
Vancouver Gürgen A. Güve-Alev Optimizasyon Algoritması Kullanarak Pleurotus cornucopiae var. citrinopileatus Mantarı Ekstraksiyon Koşullarının Optimizasyonu. DÜBİTED. 2022;10(3):1508-23.