Synthesis, Characterization and Photophysical Properties of 2-Quinolone-Based Compounds

Year 2024, , 642 - 653, 29.04.2024

Tahir Savran

https://doi.org/10.29130/dubited.1377215

Abstract

2-Quinolone (1,2-dihydroquinoline) and 1-aza coumarin derivatives are quinoline class pharmacophore structures known for their versatile bioactive and stable photophysical properties. In the present study, N-amino (2) and N-acetamido (3) derivatives of 2-quinolone-based 1-aza Coumarin-3-carboxylic acid were synthesized. Structure characterizations of the synthesized compounds were performed using 1H NMR, IR, 13C NMR spectral techniques. The synthesized compounds are thought to be precursor structures for the development of new bioactive agents because of their structural similarity. The photophysical sensitivities of compounds (2 and 3), which have the 1-Aza coumarin skeleton, in different solvents were examined by ultraviolet−visible (UV−Vis) absorption spectroscopy and fluorescence spectroscopy methods. In addition, the compounds synthesized in this study could serve as fluorophores, fluorescently active and bioactive new Schiff base sensors in different fluorescence studies.

Keywords

1,2-Dihydroquinoline, 2-Quinolone-3-carboxylic acid, 1-Aza coumarin, Photophysical properties

Ethical Statement

This work is an original work; Scientific ethical principles and rules were followed at all stages of the study, including preparation, data collection, analysis and presentation of information. I have cited and included references for all data and information not obtained within the scope of the study; No changes were made to the data used. If at any time a situation contrary to this statement regarding the study is detected, all moral and legal consequences will be accepted.

Supporting Institution

Karamanoglu Mehmetbey University

Project Number

15–YL–20

Thanks

This work is supported by Karamanoglu Mehmetbey University Scientific Project (Project no: 15–YL–20)

2-Kinolon Temelli Bileşiklerin Sentezi, Karakterizasyonu ve Fotofiziksel Özellikleri

Abstract

2-Kinolon (1,2-dihidrokinolin) ve 1-aza kumarin türevleri çok yönlü biyoaktif ve kararlı fotofiziksel özellikleriyle bilinen kinolin sınıfı farmakofor yapılardır. Sunulan çalışmada 2-kinolon temelli 1-aza kumarin-3-karboksilik asit’in N-amino (2) ve N-asetamido (3) türevlerinin sentezi yapılmıştır. Sentezlenen bileşiklerin yapı karakterizasyonu 1H NMR, IR, 13C NMR spektral teknikleriyle gerçekleştirilmiştir. Sentezlenen bileşiklerin yapı benzerliğinden dolayı yeni biyoaktif ajanların geliştirilmesinde öncü yapılar olabileceği düşünülmektedir. 1-Aza kumarin iskeletine sahip bu bileşiklerin (2 ve 3) farklı çözücülerdeki fotofiziksel duyarlılıkları mor ötesi-görünür bölge (UV-GB) absorpsiyon spektroskopisi ve floresans spektroskopisi yöntemleriyle incelenmiştir. Ayrıca çalışmada sentezlenen bileşikler, farklı floresans çalışmalarda florofor, floresan aktif ve biyoaktif yeni Schiff bazı algılayıcı gibi görevler alabilir.

Keywords

1.2-Dihidrokinolin, 2-Kinolon-3-karboksilik asit, 1-Aza kumarin, Fotofiziksel özellikler

Ethical Statement

Bu çalışma, özgün bir çalışma olup; çalışmanın hazırlık, veri toplama, analiz ve bilgilerin sunumu olmak üzere tüm aşamalarından bilimsel etik ilke ve kurallarına uygun davranılmıştır. Çalışma kapsamında elde edilmeyen tüm veri ve bilgiler için kaynak gösterilmiş ve bu kaynaklarda yer verdiğimi; kullanılan verilerde herhangi bir değişiklik yapılmamıştır. Herhangi bir zamanda, çalışmayla ilgili yapılan bu beyana aykırı bir durumun saptanması durumunda, ortaya çıkacak tüm ahlaki ve hukuki sonuçlar kabul edilecektir.

Supporting Institution

Karamanoğlu Mehmetbey Üniversitesi

Project Number

15–YL–20

Thanks

Bu çalışma Karamanoğlu Mehmetbey Üniversitesi Bilimsel Projesi (Proje no: 15–YL–20) tarafından desteklenmektedir.

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