Drug Delivery Based on Nanoparticulate Systems

Year 2024, , 1993 - 2015, 23.10.2024

Kemal Çetin , Koray Şarkaya

https://doi.org/10.29130/dubited.1469423

Abstract

The administration route of an active ingredient and the materials used to deliver it are as important as the synthesis of that active ingredient. For the treatment to be effective, the active ingredient must be present in the right amount and in the right place at the right time. Therefore, researchers have been studying a wide variety of drug delivery systems, taking into account the route of administration of the drug, its half-life, and its effective and toxic amounts. Because of its numerous benefits, nanotechnology has attracted attention in pharmaceutical research as well as many other fields. Nanoparticles have the potential to disperse hydrophobic drugs in an aqueous solution, deliver drugs to the targeted site, and thus selectively direct therapeutic agents such as antineoplastic drugs. This study provides a detailed discussion of the many inorganic, polymeric, and lipid-based nanoparticulate systems designed for drug delivery.

Keywords

Drug delivery systems, Nanomedicine, Nanoparticles, Nanotechnology

Nanopartikül Sistemlere Dayalı İlaç Taşıma

Abstract

Bir etkin maddenin veriliş yolu ve vermek için kullanılan malzemeler, o etkin maddenin sentezi kadar önemlidir. Tedavinin etkili olabilmesi için etken maddenin doğru miktarda ve doğru zamanda doğru yerde bulunması gerekir. Bu nedenle araştırmacılar, ilacın veriliş yolunu, yarı ömrünü, etkili ve toksik miktarlarını dikkate alarak çok çeşitli ilaç taşıyıcı sistemler üzerinde çalışmaktadır. Nanoteknoloji, sayısız faydaları nedeniyle pek çok alanda olduğu gibi farmasötik araştırmalarda da ilgi çekmektedir. Nanopartiküller, hidrofobik ilaçları sulu bir çözelti içinde dağıtma, ilaçları hedeflenen bölgeye iletme ve dolayısıyla antineoplastik ilaçlar gibi terapötik ajanları seçici olarak yönlendirme potansiyeline sahiptir. Bu çalışma, ilaç dağıtımı için tasarlanmış birçok inorganik, polimerik ve lipit bazlı nanopartikül sistemin ayrıntılı bir tartışmasını sunmaktadır.

Keywords

İlaç taşıyıcı sistemler, Nanotıp, Nanopartiküller, Nanoteknoloji

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