Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine

Year 2019, , 194 - 200, 31.01.2019

Sinem Aydın

https://doi.org/10.29130/dubited.432506

Abstract

This paper presents anti-urease and antibacterial activities of chloropheniramine maleat, paracetamol and
clarithromycine. Antibacterial activity of the compounds was investigated against Salmonella enterica,
Enterobacter aerogenes, Bacillus subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae and
Enterococcus faecalis. Moreover, anti-urease activity of the compounds was searched. All tested compounds
demonstrated antibacterial action with varying degree except for chloropheniramine maleat. Chloropheniramine
maleat, paracetamol and chlarithromycine exhibited higher activity than thiourea. The data obtained from the
study, chloropheniramine maleate, paracetamol and clarithromycin are thought to be useful as new urease
inhibitors and the present study should be supported by further studies. Furthermore, it is thought that paracetamol
has antibacterial properties and therefore can be used as an alternative to antibiotics

Keywords

Antibiotic, Clarithromycine, Chloropheniramine maleat, Anti-urease, Antibacterial, Paracetamol

Klorofeniramin Maleat, Parasetamol ve Klaritromisin’in Antibakteriyal ve Anti-Ureaz Aktiviteleri

Abstract

Bu çalışmada klorofeniramin maleat, parasetamol ve klaritromisin’in antibakteriyal ve anti-üreaz aktiviteleri ile
ilgilenmektedir. Maddelerin antibakteriyal aktiviteleri Salmonella enterica, Enterobacter aerogenes, Bacillus
subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae, Bacillus megaterium ve Enterococcus
faecalis’e karşı araştırıldı. Bu maddelerin anti-üreaz aktiviteleri de incelendi. Klorofeniramin maleat dışında, test
edilen tüm bileşikler değişik oranlarda antibakteriyal etki gösterdi. Klorofeniramin maleat, parasetamol ve
klaritromisin tiyoüreden daha yüksek aktivite gösterdi. Çalışmadan elde edilen veriler, klorofeniramin maleat,
parasetamol ve klaritromisin yeni üreaz inhibitörü olarak kullanılabileceğini düşünülmüş olup mevcut çalışma
daha ileri çalışmalar ile de desteklenmelidir. Ayrıca, parasetamolün antibakteriyel özelliklere sahip olduğu ve bu
nedenle antibiyotiklere alternatif olarak kullanılabileceği düşünülmektedir.

Keywords

Antibiyotik, Klaritromisin, Klorofeniramin maleat, Anti-üreaz, Antibakteriyal, Parasetamol

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