A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design

Sezen Sivrikaya

doi:10.29130/dubited.721252

EN TR

A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design

Abstract

This study presents microextraction and determination of four parabens by vortex-assisted microextraction based on deep eutectic solvents (DESs) in cosmetic baby oils. The most suitable DES, ChCl-ethylene glycol mole ratios of DES were determined as 1:2 for use in this study. The effect of DES types has been explored at traditional one factor experiment at a time. The effect of DES volume, dilution solvent volume and vortex time on extraction recovery were examined and optimized by the Box-Behnken design. After optimum conditions were determined, vortex-assisted microextraction based on DES, 0.1-100 µg mL-1 concentration in the range of the calibration curve was plotted for all parabens. The recovery values of parabens in cosmetic baby oil samples were in the range of 82.02-101.95% and the RSDs were varied from 1.64% to 2.91%. This developed method is very suitable and effective method for the extraction of parabens from cosmetic products of similar structure.

Keywords

Deep eutectic solvents, paraben, liquid phase microextraction, Box-Behnken design

Project Number

2018.07.06.803

Kozmetik Bebek Yağlarında Dört Parabenin Tayini için Derin Ötektik Çözücülere Dayanan Vorteks Destekli Mikro Ekstraksiyon ve Box-Behnken Tasarımı ile Optimizasyon

Abstract

Bu çalışma kozmetik bebek yağlarında derin ötektik çözücülere (DES'ler) dayalı vorteks destekli mikroekstraksiyon ile dört parabenin mikro ekstraksiyonu ve tayinini sunmaktadır. En uygun DES, ChCl-etilen glikol mol oranları bu çalışmada kullanılmak üzere 1:2 olarak belirlenmiştir. DES türlerinin etkisi, geleneksel tek faktörlü deneyde araştırılmıştır. DES hacmi, seyreltme çözücü hacmi ve vorteks süresinin ekstraksiyon geri kazanımı üzerindeki etkisi Box-Behnken tasarımı ile incelenmiş ve optimize edilmiştir. Optimum koşullar belirlendikten sonra, DES'e dayalı vorteks destekli mikro ekstraksiyon, kalibrasyon eğrisi 0.1-100 µg mL-1 konsantrasyon tüm parabenler için çizildi. Kozmetik bebek yağı numunelerindeki parabenlerin geri kazanım değerleri % 82.02-101.95 aralığındadır ve RSD'ler %1.64 ile %2.91 arasında değişmektedir. Bu geliştirilen yöntem, benzer yapıdaki kozmetik ürünlerden parabenlerin ekstraksiyonu için çok uygun ve etkili bir yöntemdir.

Keywords

Derin ötektik çözücüler, paraben, sıvı faz mikroekstraksiyon, Box-Behnken tasarımı

Supporting Institution

Düzce Üniversitesi

Project Number

2018.07.06.803

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Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Sezen Sivrikaya ^*
0000-0003-4483-2880
Türkiye

Publication Date

July 31, 2020

Submission Date

April 16, 2020

Acceptance Date

June 3, 2020

Published in Issue

Year 2020 Volume: 8 Number: 3

DOI

https://doi.org/10.29130/dubited.721252

IZ

https://izlik.org/JA58TM39KZ

APA

Sivrikaya, S. (2020). A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design. Duzce University Journal of Science and Technology, 8(3), 1936-1947. https://doi.org/10.29130/dubited.721252

AMA

1.Sivrikaya S. A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design. DUBİTED. 2020;8(3):1936-1947. doi:10.29130/dubited.721252

Chicago

Sivrikaya, Sezen. 2020. “A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design”. Duzce University Journal of Science and Technology 8 (3): 1936-47. https://doi.org/10.29130/dubited.721252.

EndNote

Sivrikaya S (July 1, 2020) A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design. Duzce University Journal of Science and Technology 8 3 1936–1947.

IEEE

[1]S. Sivrikaya, “A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design”, DUBİTED, vol. 8, no. 3, pp. 1936–1947, July 2020, doi: 10.29130/dubited.721252.

ISNAD

Sivrikaya, Sezen. “A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design”. Duzce University Journal of Science and Technology 8/3 (July 1, 2020): 1936-1947. https://doi.org/10.29130/dubited.721252.

JAMA

1.Sivrikaya S. A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design. DUBİTED. 2020;8:1936–1947.

MLA

Sivrikaya, Sezen. “A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design”. Duzce University Journal of Science and Technology, vol. 8, no. 3, July 2020, pp. 1936-47, doi:10.29130/dubited.721252.

Vancouver

1.Sezen Sivrikaya. A Vortex-Assisted Microextraction Based On Deep Eutectic Solvents for Determination of Four Parabens from Cosmetic Baby Oils and Optimization by Box-Behnken Design. DUBİTED. 2020 Jul. 1;8(3):1936-47. doi:10.29130/dubited.721252