(3-(4-chlorophenyl)-4,5-dihydroisoxazole-4,5-diyl)dimethanol Compound: Antibacterial Activity, Antifungal Activity and Calculated Structural Parameters

Year 2022, , 815 - 822, 30.04.2022

Meryem Pir , Fatma Budak

https://doi.org/10.29130/dubited.944684

Cited By: 1

Abstract

We intended to quantify the antibacterial and antifungal activity results of 4,5-dihydroisoxazole dimethanol compound (1a) against several bacteria and fungi and also calculate some structural parameters (theoretical descriptors) of compound (1a) with this work. Microdilution broth procedures were studied using microdilution wells for the minimal inhibitory concentrations (MICs) test. Compound (1a) exhibited fair activities against all the bacteria and fungi. Compound (1a) has been a good result (MIC = 50 µg/ml) against particularly P. aeruginosa. The structure of compound (1a) was drawn, and geometrical optimization was done using the Ab initio (RHF/3-21G) level.

Keywords

Antimicrobial activity, Dihydroisoxazole dimethanol compound, MIC

Supporting Institution

Kocaeli University BAP

Project Number

Project No:2019/009HD

Thanks

This study is based on the Project No:2019/009HD supported by Kocaeli University, BAP.

(3-(4-klorofenil)-4,5-dihidroizoksazol-4,5-diil)dimetanol Bileşiği: Antibakteriyel Aktivite, Antifungal Aktivite ve Hesaplanmış Yapısal Parametreler

Abstract

Bu çalışma ile, 4,5-dihidroizoksazol dimetanol bileşiğinin (1a) çeşitli bakteri ve mantara karşı antibakteriyel ve antifungal aktivite sonuçlarını ölçmeyi ve ayrıca (1a) bileşiğinin bazı yapısal parametrelerini (teorik tanımlayıcıları) hesaplamayı amaçladık. Mikrodilüsyon kuyucukları kullanılarak minimal inhibisyon konsantrasyonları (MİK) testi için mikrodilüsyon broth prosedürleri çalışılmıştır. Bileşik (1a), tüm bakteri ve mantara karşı etkili aktiviteler sergilemiştir. Bileşik (1a), özellikle P. aeruginosa'ya karşı iyi bir sonuç (MİK = 50 µg/ml) vermiştir. Bileşik (1a) 'nın yapısı çizilmiştir ve geometrik optimizasyonu Ab initio (RHF/3-21G) seviyesi kullanılarak yapılmıştır.

Keywords

Antimikrobiyal aktivite, Dihidroizoksazol dimetanol bileşiği, MİK

Project Number

Project No:2019/009HD

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