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Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice

Year 2017, Volume: 5 Issue: 1, 273 - 280, 31.01.2017

Emine Yalçın Ali Acar Kültiğin Çavuşoğlu

Abstract

The aim of this study is to investigate the genotoxic effects of ammonium sulphate and the protective role of βcarotene against genotoxicity in Swiss albino mice. Albino mice divided into one control group and five treatment groups. The body weight gain, MN frequency in erythrocyte and buccal mucosa epithelial cell, frequency of chromosomal abnormalities were investigated as genotoxicity parameters. It is determined that ammonium sulphate treatment was caused a statistically decrease in body weight gain and increase in frequency of MN and chromosomal abnormalities according to control group. It was determined that β-carotene treatment was improved the genotoxicity induced from ammonium sulphate, and caused an increase in body weight gain and a decrease in frequencies of MN and of chromosomal abnormalities. As a result, β-carotene treatment can be used in reduction of toxicity caused by chemicals as a toxicity restricting agent in near future.

Keywords

Ammonium sulphate Genotoxicity β-carotene

References

  • K.H. Zapp Ullmann's Encyclopedia of Industrial Chemistry Wiley-VCH (2012).
  • D.R. Lide, CRC Handbook of Chemistry and Physics, 87th ed., CRC Press, (2006).
  • S. Klein Gross Ingredients In Processed Foods The Huffington Post (2012).
  • WHO, Environmental Health Criteria 54, Geneva, (1986).
  • EPA, EnvironmentalProtectionAgency. Drinking Water Advisory: Consumer Acceptability Advice and Health Effects Analysis on Sulfate (Draft), USA, (2002).
  • BASF AG, Workplace measurements according GefSoffV. Project.No: DE/LU/L515/0267/04, (2004).
  • A. Sato, K. Gonmori, N. Yoshioka Forensic Science International 101(2) (1999) 141.
  • W. Stahl, W. Schwarz, H. Sies The Journal of Nutrition 123(5) (1993) 847.
  • H. Sies, W. Stahl The American Journal of Clinical Nutrition 62(6) (1995) 1315
  • M.A. Te-Hsiu, X. Zhou, G.F. Loarco, G.G. Arreola, S.U. Lecona Rev. Int. Contam. Ambient. 11(2) (1995) 98.
  • Y. Özkul, H. Donmez, A. Erenmemisoglu, H. Demirtas, N. Imamoglu Mutagenesis 12(4) (1997) 285.
  • M. Fenench, W.P. Chang, M. Kirsch-Volders, N. Holland, S. Bonassi, E. Zeiger Mutation Research 534 (2003) 65. [D. Beyersmann, S. Hechtenberg Toxicology and Applied Pharmacology 144(2) (1997) 247.
  • J.R. Savage Journal of Medical Genetics 13(2) (1976) 103.
  • M.D. Minana, G. Marcaida, S. Grisolia, V. Felipo Journal of Neuropathology & Experimental Neurology 54(5) (1995) 644.
  • B.N. Gupta, R.N. Khanna, K.K. Datta Toxicology 13 (1979) 45.
  • M. Hayashi, M. Kishi, T. Sofuni, J.R.M. Ishidate Food. Chem. Toxicol. 26(6) (1988) 487.
  • S. Tuschy, G. Obe Mutattion Research 207(2) (1988) 83.
  • C.R. Bosoi, C.F. Rose Metabolic Brain Disease 24(1) (2009) 95.
  • D. Häussinger, F. Schliess (2008) DOI: 10.1136/gut.2007.122176.
  • W. Stahl, N. Ale-Agha, M.C. Polidori Biological Chemistry 383(3-4) (2002) 553.
  • Y. Sharoni, M. Danilenko, J. Levy, W. Stahl, N.I. Krinsky, S.T. Mayne, H. Sies (Eds.), Carotenoids in Health and Disease, Marcel Dekker, (2004) 165.
  • S.T. Omaye, N.I. Krinsky, V.E. Kagan, S.T. Mayne, D.C. Liebler, W.R. Bidlack Toxicological Sciences 40(2) (1997) 163.
  • G.S. Omenn, E.G. Goodman, M.D. Thornquist, J. Balmes, M.R. Cullen, A. Glass, J.P. Keogh, F.L. Meyskens, B. Valanis, J.H. Williams, S. Barnhart, S. Hammar (1996) DOI: 10.1056/NEJM199605023341802.
  • P. Palozza, N.I. Krinsky Archives of Biochemistry and Biophysics 297(1) (1992) 184.

Albino Farelerde Amonyum Sülfat Tarafından Teşvik Edilen Toksisiteye Karşı Karoten’in Koruyucu Rolünün Araştırılması

Year 2017, Volume: 5 Issue: 1, 273 - 280, 31.01.2017

Emine Yalçın Ali Acar Kültiğin Çavuşoğlu

Abstract

Bu çalışmada amonyum sülfatın albino farelerde genotoksik etkileri ve bu etkilere karşı β-karotenin koruyucu etkisi araştırılmıştır. Albino fareler bir kontrol, beş uygulama olmak üzere toplam altı gruba ayrılmışlardır. Canlı ağırlığı kazanımı, epitel ve yanak mukoza epitelyum hücrelerinde mikronükleus (MN) sıkılığı, kromozomal anormallik sıklığı genotoksisite parametreleri olarak araştırılmıştır. Amonyum sülfat uygulamasının kontrol grubuna göre canlı ağırlığına istatistiksel açıdan önemli bir azalmaya, MN ve kromozomal anormallik sıklığında ise artışa neden olduğu belirlenmiştir. β-karoten uygulamasının amonyum sülfat tarafından oluşturulan genotoksisiteyi iyileştirerek, canlı ağırlığında tekrar bir artışa, MN ve kromozomal anormallik sıklıklarında ise azalmaya neden olduğu belirlenmiştir. Sonuç olarak β-karoten uygulaması yakın gelecekte kimyasallar tarafından sebep olunan toksisitenin azaltılmasında “toksisite sınırlayıcı” bir ajan olarak kullanılabilir.  

Keywords

Amonyum sülfat Genotoksisite β-karoten

References

  • K.H. Zapp Ullmann's Encyclopedia of Industrial Chemistry Wiley-VCH (2012).
  • D.R. Lide, CRC Handbook of Chemistry and Physics, 87th ed., CRC Press, (2006).
  • S. Klein Gross Ingredients In Processed Foods The Huffington Post (2012).
  • WHO, Environmental Health Criteria 54, Geneva, (1986).
  • EPA, EnvironmentalProtectionAgency. Drinking Water Advisory: Consumer Acceptability Advice and Health Effects Analysis on Sulfate (Draft), USA, (2002).
  • BASF AG, Workplace measurements according GefSoffV. Project.No: DE/LU/L515/0267/04, (2004).
  • A. Sato, K. Gonmori, N. Yoshioka Forensic Science International 101(2) (1999) 141.
  • W. Stahl, W. Schwarz, H. Sies The Journal of Nutrition 123(5) (1993) 847.
  • H. Sies, W. Stahl The American Journal of Clinical Nutrition 62(6) (1995) 1315
  • M.A. Te-Hsiu, X. Zhou, G.F. Loarco, G.G. Arreola, S.U. Lecona Rev. Int. Contam. Ambient. 11(2) (1995) 98.
  • Y. Özkul, H. Donmez, A. Erenmemisoglu, H. Demirtas, N. Imamoglu Mutagenesis 12(4) (1997) 285.
  • M. Fenench, W.P. Chang, M. Kirsch-Volders, N. Holland, S. Bonassi, E. Zeiger Mutation Research 534 (2003) 65. [D. Beyersmann, S. Hechtenberg Toxicology and Applied Pharmacology 144(2) (1997) 247.
  • J.R. Savage Journal of Medical Genetics 13(2) (1976) 103.
  • M.D. Minana, G. Marcaida, S. Grisolia, V. Felipo Journal of Neuropathology & Experimental Neurology 54(5) (1995) 644.
  • B.N. Gupta, R.N. Khanna, K.K. Datta Toxicology 13 (1979) 45.
  • M. Hayashi, M. Kishi, T. Sofuni, J.R.M. Ishidate Food. Chem. Toxicol. 26(6) (1988) 487.
  • S. Tuschy, G. Obe Mutattion Research 207(2) (1988) 83.
  • C.R. Bosoi, C.F. Rose Metabolic Brain Disease 24(1) (2009) 95.
  • D. Häussinger, F. Schliess (2008) DOI: 10.1136/gut.2007.122176.
  • W. Stahl, N. Ale-Agha, M.C. Polidori Biological Chemistry 383(3-4) (2002) 553.
  • Y. Sharoni, M. Danilenko, J. Levy, W. Stahl, N.I. Krinsky, S.T. Mayne, H. Sies (Eds.), Carotenoids in Health and Disease, Marcel Dekker, (2004) 165.
  • S.T. Omaye, N.I. Krinsky, V.E. Kagan, S.T. Mayne, D.C. Liebler, W.R. Bidlack Toxicological Sciences 40(2) (1997) 163.
  • G.S. Omenn, E.G. Goodman, M.D. Thornquist, J. Balmes, M.R. Cullen, A. Glass, J.P. Keogh, F.L. Meyskens, B. Valanis, J.H. Williams, S. Barnhart, S. Hammar (1996) DOI: 10.1056/NEJM199605023341802.
  • P. Palozza, N.I. Krinsky Archives of Biochemistry and Biophysics 297(1) (1992) 184.
There are 24 citations in total.

Details

Journal Section Articles
Authors

Emine Yalçın This is me

Ali Acar This is me

Kültiğin Çavuşoğlu This is me

Publication Date January 31, 2017
Published in Issue Year 2017 Volume: 5 Issue: 1

Cite

APA Yalçın, E., Acar, A., & Çavuşoğlu, K. (2017). Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice. Duzce University Journal of Science and Technology, 5(1), 273-280.
AMA Yalçın E, Acar A, Çavuşoğlu K. Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice. DUBİTED. January 2017;5(1):273-280.
Chicago Yalçın, Emine, Ali Acar, and Kültiğin Çavuşoğlu. “Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice”. Duzce University Journal of Science and Technology 5, no. 1 (January 2017): 273-80.
EndNote Yalçın E, Acar A, Çavuşoğlu K (January 1, 2017) Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice. Duzce University Journal of Science and Technology 5 1 273–280.
IEEE E. Yalçın, A. Acar, and K. Çavuşoğlu, “Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice”, DUBİTED, vol. 5, no. 1, pp. 273–280, 2017.
ISNAD Yalçın, Emine et al. “Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice”. Duzce University Journal of Science and Technology 5/1 (January 2017), 273-280.
JAMA Yalçın E, Acar A, Çavuşoğlu K. Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice. DUBİTED. 2017;5:273–280.
MLA Yalçın, Emine et al. “Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice”. Duzce University Journal of Science and Technology, vol. 5, no. 1, 2017, pp. 273-80.
Vancouver Yalçın E, Acar A, Çavuşoğlu K. Investigation of the Protective Role of Carotene Against Toxicity Encouraged by Ammonium Sulfate in Albino Mice. DUBİTED. 2017;5(1):273-80.
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