Parkinson Hastalığı ve İlişkili Olduğu Genler

Year 2018, Volume: 6 Issue: 1, 231 - 239, 31.01.2018

Yener Kurman

https://doi.org/10.29130/dubited.359368

Abstract

Parkinson
Hastalığı, Alzheimer hastalığından sonra ikinci en sık görülen nörodejeneratif
bir hastalıktır. Parkinson
hastalığının temel patolojik bulguları; orta beyindeki substantia nigra pars
compacta ve striatumdaki dopaminerjik nöronların ilerleyici kaybı ve Lewy
cisimcikleri olarak adlandırılan inklüzyonların nöronlarda birikimidir. Birçok araştırmacı, Parkinson
hastalığının nadiren ailesel olduğunu, özellikle sporadik faktörlerin (çevresel
ve genetik) bu hastalığın başlamasına ve ilerlemesine neden olduğunu
göstermiştir. Bugüne
kadar Parkinson hastalığına bağlı 26 gen lokusu tanımlanmıştır. Bu çalışmanın
amacı, Parkinson hastalığı ile ilişkili genler üzerine literatüre katkı
sağlamaktır.

Keywords

SNCA, Parkinson hastalığı, α-Sinüklein, Lewy cisimcikleri

Parkinson Disease and Associated Genes

Abstract

Parkinson disease is the second most common neurodegenerative disease after Alzheimer's disease. Essential pathological findings of Parkinson's disease; progressive loss of dopaminergic neurons in the substantia nigra pars compacta and striatum in the midbrain and accumulation of inclusions in the neurons called Lewy bodies. Many researchers have shown that Parkinson's disease is rarely caused by familial, especially sporadic factors (environmental and genetics) contribute to the initiation and progression of this disease. 26 gene loci related to Parkinson's disease have been identified until now. Aims of this study, contributing to the literature on genes associated with Parkinson's disease.

Keywords

Parkinson disease, SNCA, α-Synuclein, Lewy bodies

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