Pestisit indüklü kardiyak toksisite araştırmalarında zebra balığı (Danio rerio)

Year 2019, Volume: 7 Issue: 3, 1417 - 1430, 31.07.2019

Sezgi Arman

https://doi.org/10.29130/dubited.528427

Cited By: 2

Abstract

Çevresel kirleticiler, karasal ve
sucul ekosistemlerde bozulmalara sebep olmalarının yanı sıra pek çok sağlık
sorununa da yol açmaktadır. Pestisitler, devamlı kullanımla çevreye yayılan,
hareket eden, farklı çevre fazlarında karşılaştıkları hedef dışı organizmalarda
biyolojik etki gösteren kirleticiler olarak bilinmektedir. Pestisitlerin
kardiyovasküler hastalıklarla da ilişkili oldukları düşünülmektedir. Bu
kimyasalların kalpte meydana getirebilecekleri olası etkilerin araştırılmasında
laboratuvar çalışmalarının önemi büyüktür. Zebra balığı (Danio rerio), kardiyak toksisite çalışmalarında gerek embriyonik
gerekse ergin dönemde araştırıcılara sayısız kolaylık sağlayan bir model
organizma olarak kabul edilmektedir. Pestisitlerin kalp üzerindeki toksik
etkilerinin ortaya konması ve etki mekanizmalarının araştırılmasında son
yıllarda zebra balıkları sıklıkla kullanılmaktadır. Bu derlemede, pestisit
maruziyetine bağlı ortaya çıkan kalp anomalilerinin değerlendirilmesinde neden
son yıllarda zebra balığının model sistem olarak kabul edildiğine ayrıntıları
ile değinilmiştir.

Keywords

Zebra balığı, Danio rerio, pestisit, kalp

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