Year 2019, Volume 7 , Issue 3, Pages 1976 - 1984 2019-07-31

The Relationship between HMGB1, Cancer and Its Treatment
HMGB1’in Kanser ve Tedavisiyle İlişkisi

Eylem TAŞKIN GÜVEN [1] , Celal GÜVEN [2] , Salih Tunç KAYA [3] , Yusuf SEVGİLER [4]

High mobility group box-1 (HMGB1), one of nonhiston protein, plays role as danger signals, and alarming shortly named as DAMP. HMGB1 released from damaged and cancer cells triggers mitogen activated kinases (MAPK) to act intracellular effect by binding the receptor for advanced glycation end products (RAGE) and toll like receptor (TLR). HMGB1 is essential to develop resistant against anticancer drugs. In addition, there is evidence that HMGB1 participate in developing to heart failure-induced by Adriamycin, one of anticancer drug against for solid cancer. Therefore, HMGB1 could be a good candidate for drug-resistant against to cancer and/or anticancer drug toxicity. The aim of the present review is to explain the relationship between HMBG1, cancer and Adriamycin used for cancer’s treatment.

Yüksek mobilite grup kutusu 1 (HMGB1) histon olmayan DNA proteini olup, kısaca DAMP olarak ifade edilen (Damage-associated molecular pattern) tehlike sinyali veya alarmı olarak görev yapar. Hasarlanmış veya kanserli hücrelerden salınan HMGB1, gelişmiş glikasyon son ürünleri için reseptör (RAGE) ve Toll benzeri reseptörlerine (TLRs) bağlanarak mitojenle aktive olan kinaz (MAPK)’ları aktive ederek hücre içi etkilerini oluşturur. HMGB1 kanser ilaçlarına karşı gelişen dirençte önemli rol oynar. Aynı zamanda, yumuşak doku kanserlerine karşı kullanılan ilaçlardan biri olan adriyamisinin (ADR) neden olduğu kalp yetmezliğinin gelişiminde de önemli rol oynağına dair kanıtlar mevcuttur. Dolayısıyla HMGB1 kanser tedavisinde ilaçlara karşı gelişen direncin ve/veya ilacın toksik etkisine karşı iyi bir terapötik ajan adayıdır. Bu derlemenin amacı, HMGB1 ile kanser ve tedavisinde kullanılan bir ilaç olan ADR arasındaki ilişkiyi açıklamaktır.

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Primary Language tr
Subjects Engineering
Journal Section Articles

Orcid: 0000-0001-8172-4980
Author: Eylem TAŞKIN GÜVEN (Primary Author)
Country: Turkey

Orcid: 0000-0003-0499-7787
Author: Celal GÜVEN
Country: Turkey

Orcid: 0000-0002-4133-407X
Author: Salih Tunç KAYA
Country: Turkey

Orcid: 0000-0002-4373-2389
Author: Yusuf SEVGİLER
Country: Turkey


Publication Date : July 31, 2019

Bibtex @review { dubited579185, journal = {Düzce Üniversitesi Bilim ve Teknoloji Dergisi}, issn = {}, eissn = {2148-2446}, address = {}, publisher = {Duzce University}, year = {2019}, volume = {7}, pages = {1976 - 1984}, doi = {10.29130/dubited.579185}, title = {HMGB1’in Kanser ve Tedavisiyle İlişkisi}, key = {cite}, author = {Taşkın Güven, Eylem and Güven, Celal and Kaya, Salih Tunç and Sevgi̇ler, Yusuf} }
APA Taşkın Güven, E , Güven, C , Kaya, S , Sevgi̇ler, Y . (2019). HMGB1’in Kanser ve Tedavisiyle İlişkisi . Düzce Üniversitesi Bilim ve Teknoloji Dergisi , 7 (3) , 1976-1984 . DOI: 10.29130/dubited.579185
MLA Taşkın Güven, E , Güven, C , Kaya, S , Sevgi̇ler, Y . "HMGB1’in Kanser ve Tedavisiyle İlişkisi" . Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019 ): 1976-1984 <>
Chicago Taşkın Güven, E , Güven, C , Kaya, S , Sevgi̇ler, Y . "HMGB1’in Kanser ve Tedavisiyle İlişkisi". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 (2019 ): 1976-1984
RIS TY - JOUR T1 - HMGB1’in Kanser ve Tedavisiyle İlişkisi AU - Eylem Taşkın Güven , Celal Güven , Salih Tunç Kaya , Yusuf Sevgi̇ler Y1 - 2019 PY - 2019 N1 - doi: 10.29130/dubited.579185 DO - 10.29130/dubited.579185 T2 - Düzce Üniversitesi Bilim ve Teknoloji Dergisi JF - Journal JO - JOR SP - 1976 EP - 1984 VL - 7 IS - 3 SN - -2148-2446 M3 - doi: 10.29130/dubited.579185 UR - Y2 - 2019 ER -
EndNote %0 Düzce Üniversitesi Bilim ve Teknoloji Dergisi HMGB1’in Kanser ve Tedavisiyle İlişkisi %A Eylem Taşkın Güven , Celal Güven , Salih Tunç Kaya , Yusuf Sevgi̇ler %T HMGB1’in Kanser ve Tedavisiyle İlişkisi %D 2019 %J Düzce Üniversitesi Bilim ve Teknoloji Dergisi %P -2148-2446 %V 7 %N 3 %R doi: 10.29130/dubited.579185 %U 10.29130/dubited.579185
ISNAD Taşkın Güven, Eylem , Güven, Celal , Kaya, Salih Tunç , Sevgi̇ler, Yusuf . "HMGB1’in Kanser ve Tedavisiyle İlişkisi". Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 / 3 (July 2019): 1976-1984 .
AMA Taşkın Güven E , Güven C , Kaya S , Sevgi̇ler Y . HMGB1’in Kanser ve Tedavisiyle İlişkisi. DÜBİTED. 2019; 7(3): 1976-1984.
Vancouver Taşkın Güven E , Güven C , Kaya S , Sevgi̇ler Y . HMGB1’in Kanser ve Tedavisiyle İlişkisi. Düzce Üniversitesi Bilim ve Teknoloji Dergisi. 2019; 7(3): 1976-1984.