Bazı o-Hidroxsi Enaminon Türevlerinin ve Siklohekzadienin Tetrachloro-1,4-benzoquinone (TCB) Ortamında Tandem Oxidative-Reaksiyonu ile Sentezi

Year 2023, Volume: 11 Issue: 4, 2168 - 2175, 24.10.2023

Nesimi Uludağ

https://doi.org/10.29130/dubited.1184209

Abstract

Bu çalışmada 7 adet orjinal o-hidroksi aril enaminon ile siklohekzadienin türevleri TCB ortamında tandem reaksiyonu ile sentezlenip, yapıları 1H NMR, 13C NMR ve HR-MS spektroskopisi aydınlatılmıştır. Ayrıca, bu reaksiyon oxidatif birleşme ve molekül içi halkalaşma tepkimesini içermektedir. Kromonlar, doğal olarak oluşan bileşiklerden meydana gelen bir gruptur. Doğada, özellikle bitkilerin bileşenleri içerisinde bulunur. Halkalı kromonların yaygın olarak doğal biyolojik aktif özelliklere sahip olmasından dolayı, literatüre giren her kromon türevlerinin sentezi literatüre önemli katkı yapacağı düşünülmektedir. Bu çalışmada sentezlenen söz konusu bileşiklerin yüzdesel verimleri oldukça yüksek değerlere sahip olup, oda sıcaklığında ılımlı şartlarda gerçekleştirilmiştir.

Keywords

TCB, Oksidasyon, Tandem halkalaşması

Supporting Institution

Tekirdağ Namık Kemal Üniversitesi tarafından desteklenmiştir

Project Number

(Proje no: NKUBAP.00.10.AR.12.15).

Thanks

Tekirdağ Namık Kemal Üniversitesi

Synthesis of some o-Hidroksi Enaminone Derivatives and Cyclohexadiene by Tandem Oxidative-Reaction in Tetrachloro-1,4-benzoquinone (TCB) Medium

Abstract

In this study, 7 original o-hydroxy aryl enaminone and cyclohexadiene derivatives were synthesized by tandem reaction in TCB medium and their structures were elucidated by 1H NMR, 13C NMR and HR-MS spectroscopy. Also, this reaction includes oxidative coupling and intramolecular cyclization reaction. Chromones are a group of naturally occurring compounds. It is ubiquitous in nature, especially in plants. Since cyclic chromones have common natural biologically active properties, it is thought that the synthesis of each chromone derivative that enters the literature will make an important contribution to the literature. The percent yields of the synthesized compounds were quite high and occurred under mild conditions at room temperature.

Keywords

TCB, Oxidation, Tandem annulation

Project Number

(Proje no: NKUBAP.00.10.AR.12.15).

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