Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri

Elif Mutlu; Hasan H.s. Abuıyada

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Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri

Abstract

Organotipik beyin kesit kültürleri günümüzde nörobiyoloji araştırmalarında rutin bir protokol haline gelmiştir. Beyin kesit kültürü tekniklerindeki ilerleme sayesinde birçok beyin hastalığı patofizyolojisinin in vivo duruma çok yakın bir şekilde doku bağlamında incelenmesi fırsatı doğmuştur. In vivo çalışmalarda anesteziklerin ve kas gevşetici maddelerin uzun süreli kullanımına alternatif olması yanında hücre kültürlerinin ve homojenatlarının aksine yapısal bütünlüğünü sürdürebilmesi gibi avantajlar sunarken bu kültür ortamı bazı dezavantajları da beraberinde getirmektedir. Bu derleme çalışması boyunca beyin kesit kültürü teknolojisi avantajları ve dezavantajları ile birlikte ele alınarak nörobiyoloji çalışmalarındaki yeri incelenmiştir. Hücresel bütünlüğün korunduğu bu sistemlerin nörodejenerasyon, nörogenez, nörotoksisite gibi birçok alanda in vitro hücre kültürü ve in vivo deney hayvanı çalışmalarına kıyasla çok daha verimli ve kullanışlıdır.

Keywords

Beyin, Kesit kültürü, Organotipik beyin kesiti, Nörobiyoloji

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Details

Primary Language

Turkish

Subjects

Structural Biology

Journal Section

Review

Authors

Elif Mutlu ^*
0000-0002-2580-4043
Türkiye

Hasan H.s. Abuıyada
0000-0002-5525-779X
Türkiye

Publication Date

June 10, 2021

Submission Date

March 24, 2021

Acceptance Date

April 22, 2021

Published in Issue

Year 2021 Volume: 10 Number: 1

IZ

https://izlik.org/JA65ZN84JW

APA

Mutlu, E., & Abuıyada, H. H. (2021). Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri. Dicle Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 10(1), 95-107. https://izlik.org/JA65ZN84JW

AMA

1.Mutlu E, Abuıyada HH. Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri. DUFED. 2021;10(1):95-107. https://izlik.org/JA65ZN84JW

Chicago

Mutlu, Elif, and Hasan H.s. Abuıyada. 2021. “Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri”. Dicle Üniversitesi Fen Bilimleri Enstitüsü Dergisi 10 (1): 95-107. https://izlik.org/JA65ZN84JW.

EndNote

Mutlu E, Abuıyada HH (June 1, 2021) Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri. Dicle Üniversitesi Fen Bilimleri Enstitüsü Dergisi 10 1 95–107.

IEEE

[1]E. Mutlu and H. H. Abuıyada, “Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri”, DUFED, vol. 10, no. 1, pp. 95–107, June 2021, [Online]. Available: https://izlik.org/JA65ZN84JW

ISNAD

Mutlu, Elif - Abuıyada, Hasan H.s. “Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri”. Dicle Üniversitesi Fen Bilimleri Enstitüsü Dergisi 10/1 (June 1, 2021): 95-107. https://izlik.org/JA65ZN84JW.

JAMA

1.Mutlu E, Abuıyada HH. Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri. DUFED. 2021;10:95–107.

MLA

Mutlu, Elif, and Hasan H.s. Abuıyada. “Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri”. Dicle Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 10, no. 1, June 2021, pp. 95-107, https://izlik.org/JA65ZN84JW.

Vancouver

1.Elif Mutlu, Hasan H.s. Abuıyada. Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri. DUFED [Internet]. 2021 Jun. 1;10(1):95-107. Available from: https://izlik.org/JA65ZN84JW

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https://doi.org/10.55007/dufed.xxxxxxx

Organotipik Beyin Kesitleri Kullanımının Nörobiyolojik Çalışmalardaki Yeri

Abstract

Keywords

Use of Organotypic Brain Slices in Neurobiological Studies

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