Paraneoplastic Syndrome in Dogs

Abstract

Paraneoplastic disorders are indirect and usually remote effects that are caused by tumor cell products rather than by the primary tumor or its metastases. For this reason recognition of paraneoplastic syndrome is important for early tumor diagnosis, treatment of metabolic abnormalities and management. Paraneoplastic syndromes are a group of noncancerous disease associated with internal neoplasia. Paraneoplastic conditions result from production and release of substances (hormone, cytokines, peptides, growth factors) that are not normally produced by the cell of origin of the tumor. Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as cardiac abnormalities, neuromuscular changes, ocular changes, hematological changes as well as general clinical signs of weight loss, poliuria, polydipsia, diarrhea and anorexia. A number of diseases can be result in paraneoplastic syndrome, including: hypercalcemia, disseminated intravascular coagulation, weight loss, enteropathi, gastroduodenal ulcer, hypoglisemi, hyperrgastrinemia and hyperhistanemia, hyperviscosity, anemia, eosinophilia, leucocytosis, neurological syndrome, hypertrophic osteoartropathy and cuteneous syndrome.

Keywords

• Paraneoplastic syndrome,dog

Köpeklerde Paraneoplastik Sendrom

Öz

Paraneoplastik bozukluklar primer tümör ve metastazlarından daha çok tümör hücrelerinin uzak dokularda neden olduğu değişikliklerdir. Bu nedenle paraneoplastik sendrom tümörün erken tanısı, tedavisi ve metabolik değişikliklerin yönetimi açısından önemlidir. Paraneoplastik sendrom tümörle ilgili kansorejen olmayan hastalık gruplarına verilen isimdir. Paraneoplastik durum tümör orijinli hücreler hücreler tarafından normalde üretilmeyen bazı ürün ve maddelerle (hormon, sitokinler, peptidler, büyüme faktörleri gibi) ilişkilidir. Köpeklerde paraneoplastik sendrom genellikle dermatolojik semptomlarla karakterizedir, fakat aynı zamanda kalp anormallikleri, nörümüsküler, göz ile hematolojik değişiklikler ve de kilo kaybı, poliüri, polidipsi, ishal ve iştahsızlık ta görülen değişikliklerdendir. En yaygın paraneoplastik sendrom: hiperkalsemi, dissemine intravasküler koagülasyon, kilo kaybı, enteropati, gastroduodenal ülser, hipoglisemi, hipergastrinemi ve hiperhistanemi, hipervizkosite, anemi, eritrositozis, lökositozis, trombositopeni, nörolojik sendrom, iskelet sistemine bağlı problemler ve kutenöz sendromdur.

Anahtar Kelimeler

• Paraneoplastik sendrom,köpek

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