Propolisin Yara İyleşmesine Etkileri

Abstract

Yaraların tedavisinde epitelizasyonun sağlanması, mikrobiyel gelişimin önlenmesi ve ağrının azaltılması önemli sorunlardır. Propolis epitelizan, analjezik, antibakteriyel, antifungal ve antiviral etkilere sahiptir. Yan etkileri yok denecek kadar azdır. Propolise karşı mikrobiyal direncin gelişmediği bildirilmiştir. Bu derlemede, propolisin yaraların iyileşmesine etkileri hakkında bilgi verilmiştir.

Keywords

• Propolis,yara iyileşmesi,mikrobiyal direnç

The Effects of Propolis on Wound Healing

Abstract

In the treatment of wounds, epithelialization , prevention of microbial development and reduction of pain are the major problems. Propolis increases epithelialization and has analgesic, antibacterial, antifungal and antiviral effects. it has no accurate side effects. It has been reported that no microbial resistance developed against propolis. In this review, the effects of propolis on the healing of wounds has been given.

Keywords

• Propolis,Wound healing,Microbial resistance

References

1. 1. Basim E, Basim H, Özcan M. (2006). Antibacterial activities of Turkish polen and propolis extracts against plant bacterial pathogens. Journal of Food Engineering, 77: 992-996.
2. 2. Şahinler N. (2000). Arı ürünleri ve insan sağlığı açısından önemi. MKÜ Ziraat Fakültesi Dergisi, 5(1-2): 139- 148
3. 3. Kutluca S, Genç F, and Korkmaz A. (2006). Propolis. Samsun Tarım Ġl Müdürlüğü Çiftçi Eğitimi ve Yayım ġubesi, Samsun, s. 57
4. 4. Sahinler N. (2000). Arı ürünleri ve insan sağlığı açısından önemi. MKÜ Ziraat Fakültesi Dergisi, 5(1-2): 139- 148.
5. 5. Eröksüz Y, Canpolat Ġ, Silici S. (2008). Comparison of healing effects of propolis to silver sulfadiazine on full thickness skin wounds in rabbits. F.Ü. Sağ. Bil. Derg. 22 (1): 17 - 20
6. 6. Kamburoğlu K, Özen TA. (2011). Analgesic effect of anatolian propolis in mice. Apr. 23(2):47-50.
7. 7. Moriyasu J, Arai S, Motoda R, Kurimoto M. (1994). In vitro activation of mouse macrophage by propolis extract powder. Biotherapy. 8: 364- 365.
8. 8. Cuesta A, Rodr´ıguez A, Esteban MA, Meseguer J. (2005). In vivo effects of propolis, a honeybee product, on gilthead seabream innate immuneresponses. Fish & Shelfish Immunology. 18: 71–80.

9. 9. Banskota AH, Tezuka Y, Kadota S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research. 15: 561–571. 10. Kaneno R. (2005). Role of natural killer cells in antitumor resistance. Annual Review of Biomedical Sciences. 7: 127–148.
10. 11. Orsolic N, Saranovic AB, Basic I. (2006). Direct and indirect mechanism(s) of antitumour activity of propolis and its polyphenolic compounds. Planta Medica. 72: 20–27.
11. 12. Orsolic N, Sver L, Terzic S, Basic I. (2005). Peroral application of water- soluble derivative of propolis (wsdp) and its related polyphenolic compounds and their influence on immunological and antitumor activity. Veterinary Research Communications. 29: 575–593 . 13. Fernandes JrA, Leomil L, Fernandes AAH, Sforcin JM. (2001). The antibacterial activity of propolis produced by apis mellifera l. And brazilian stingless bees. The Journal of Venomous Animals and Toxins. 7: 173–182.
12. 14. Özcan M, Ceylan DA, Ünver A, Yetişir R. (2003). Türkiye’nin çesitli bölgelerinden sağlanan polen ve propolis ekstraktlarının antifungal etkisi. Uludag Arıcılık Dergisi. 3:27-34
13. 15. Amoros M, Lurton E, Boustie J, Girre L, Sauvager F, Cormier M. (1994). Comparison of the anti-herpes simplex virus activities of propolis and 3- methyl-butyl-2-enyl caffeate. Journal of Natural Products. 57: 644–647.
14. 16. Hepşen iF, Tilgen F, Seckin T, Er H, Gündüz A, Çıralık H. (1997). Propolisin antienflamatuvar etkisinin, tavşanda oluşturulan deneysel üveit modelinde prednizolon ile karşılaştırılması. Ret-Vit. 5: 95-101
15. 17. Dobrowolski JW, Vohoraq SB, Sharma K, Shah SA, Naqvi SAH, Dandiya PC. (1991). Antibacterial, antifungal, antiamoebic, antienflammatory, and antipyretic studies on propolis bee products.J Ethnopharmacol. 35 :77-82.
16. 18. Castro SL. (2001). Propolis: biological and pharmacological activities. Therapeutic uses of this bee product. Annual Rev Biom Sci. 3:49–83.
17. 19. Bankova V, Dyulgerov A, Popov S, Evstatieva L, Kuleva L,Pureb O, Zamjansan Z. (1992). Propolis produced in Bulgaria and Mongolia: Phenolic compounds and plant origin. Apidologie. 23: 79-85.
18. 20. Garcia-Viguera C, Ferreres F, Tomas- Barberan FA. (1993). Study of Canadian propolis by GC-MS and HPLC. Z Naturforsch. 48: 731-35.
19. 21. Gabrys J, Konecki J, Krol W, Scheller S, Shani J. (1986). Free aminoacids in bee hive products (Propolis) as identified andquantified by gas-liquid chromatography. Pharmacol Res Comm. 18(6): 513-18.
20. 22. Mozherenkov VP, Miniaeva TG. (1991). The use of products from bee rasing in ophthalmology and otorhinolaringology. Med Sestra. 50(11): 47-51.
21. 23. Arvouet-Grand A, Lejeune B, Bastide P, Pourrat A, Privat AM, Legret P. (1993). Propolis extract: II. Wound Healing Ġn The Ratand Rabbit. J Pharm Belg. 48(3): 171-8.
22. 24. Greenaway W, Scaysbrook T, Whatley FR. (1988). Composition of propolis in oxfordshire, uk and its relation to poplar bud exudate. Z. Naturforsch. 43, 301-305.
23. 25. Khayyal MT, El-Ghazalz MA and El- Khatib AS. (1993). Mechanisms involved in the antiinflammatory effect of propolis extract.Drugs Exptl. Clin.Res. XIX(5): 197-203
24. 26. Pascual C, Gonzales R, Toricella RG. (1994). Scavenging action of propolis extract against oxygen radicals. J Ethnopharmakol. 41: 9-13.
25. 27. Streh E, Volpert R, Elstner EF. (1994). Biochemical activities of propolis extracts: III. Inhibition of dehydrofolate reductase. Z Naturforsch. 49 (1-2): 39-43.
26. 28. Kleintok Z, Borzecki Z, Scheller S, Matuga W. (1978). Biological properties and clinical application of propolis: x. Preliminary pharmacological evaluation of ethanolextract of propolis (EEP). Arzneim Forsch/Drug Res. 28(1) 291-92.
27. 29. Frenkcl K, Wci H, Bhimani R, Ye J, Zadunasky JA, Huang MT. (1993). Inhibition of tumor promoter-mediatcd processes in mouse skin and bovine lens by caffeic acid phencthyl ester. Cancer Res. 53: 1255-61.
28. 30. Starzyk J, Scheller S, Szaflarski J, Moskwa M, Stojko A. (1997). Biological properties and clinical application of propolis: II. Studies on the antiprotozoan activity of ethanol extract of propolis. Arzneim Forsch/Drug Res. 27(1): 1198-99.
29. 31. Ikeno K, Ikeno T, Myazava C. (1991). Effects of propolis on dental caries in rats. Caries Res. 25: 347-51.
30. 32. Grange JM, Davey RW. (1990). Antibacterial properties of propolis (Bee Glue). J Royal Soci Med. 83: 159-60.
31. 33. Aksoy Z, Dığrak M. (2006). Bingöl yöresinde toplanan bal ve propolisin antimikrobiyel etkisi üzerinde in vitro araĢtırmalar. Fırat Üniv. Fen ve Müh. Bil. Dergisi. 18 (4): 471-478.
32. 34. Dığrak M, Özçelik S, Yılmaz Ö. (1995). Elazığ yöresinden toplanan propolisin antimikrobiyel etkisi üzerinde in vitro araĢtırmalar. Tr. J. of Biology. 19: 249-257
33. 35. Kaya EG, Özbilge H, Albayrak S. (2012). Kayseri propolisinin etanolik ekstraktının antimikrobiyel aktivitesi. Selçuk Tıp Derg. 28(4): 209-212.
34. 36. Uzel A, Sorkun K, Önçag Ö, Çogulu D, Gençay Ö, Salih B. (2005). Chemical composition and antimicrobial activities of four different anatolian propolis samples. Microbiological Research. 160: 189- 195.
35. 37. Bosio K, Avanzini C, D'Avolio A, Ozino O, Savoia D. (2000). In vitro activity of propolis against streptococcus pyogenes. Letters in Applied Microbiology. 31: 174-177.
36. 38. Hegazi AG, Abd El Hady FK, Abd Allah FA. (2000). Chemical composition and antimicrobial activity of europen propolis. Z Naturforsch. 55: 70-75.
37. 39. Seidel V, Peyfoon E, Watson DG, Fearnley J. (2008). Comparative study of the antibacterial activity of propolis from different geographical and climatic zones. Phytother Res. 22: 1256-1263.
38. 40. Kovalik PV. (1979). The use of propolis in the treatment of patients with chronic fungal sinusitis. Vestnik Otorindaringologii. 6: 60-62.
39. 41. Pepeljnjak S, Maysinger D, Jalsenjak I. (1982). Effect of propolis extract on some fungi. Scientia Pharmacentica. 50: 165-167.
40. 42. Amoros M, Sauvager F, Girre L,Cormier M. (1992). In vitro antiviral activity of propolis. Apidologie. 23: 231-40.
41. 43. Khan M, Elango C, Ansari MA, Singh I, Singh AK. (2007). Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem. 102(2):365-77.
42. 44. Serkedjieva J, Manolova N, Bankova V. (1997). Anti-infulenza virus effect of some propolis constituenst and their analogues (esters of substitued cinnamic acid). J Nat Prod. 55: 294- 302.
43. 45. Ecsanu V, Prahoveanu E, Cricsan I, Ciaco A (1981). The effect of aqueous propolis extract on experimental influenza virus infection in mice. Virolgie. 32: 213-215.
44. 46. De Campos RO, Alves RV, Ferreira J, Kyle DJ, Chakravarty S, Mavunkel BJ, et al. (1999). Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 360(3):278-86.
45. 47. Paulino N, Dantas AP, Bankova V, Longhi DT, Scremin A, de Castro SL, et al. (2003). Bulgarian propolis induces analgesic and anti- inflammatory effects in mice and inhibits in vitro contraction of airway smooth muscle. J Pharmacol Sci. 93(3):307-313.
46. 48. Kamburoğlu K, Özen T. (2011). Farelerde anadolu propolisinin analjezik etkisi. Ağrı. 23(2):47-50.
47. 49. Dulcettı JrO, Andreuccı V C, Cunha IBS, Araujo CE P, Olıveıra F, Marcuccı M C. (2004). Investigation of the anti-inflammatory and analgesic activities of a sample of brazilian propolis. Acta Farm. Bonaerense. 23 (3): 285-91
48. 50. Bilaloğlu GV, Harmandar M. (1999). Flavonoidler. Aktif Yayınevi, İstanbul.
49. 51. Park BH, Saxer C, Srinivas SM, Nelson J S, Boer JFDe. (2001).In vivo burn depth determination by high- speed fiber-based polarization sensitive optical coherence tomography. Journal of Biomedical Optics, vol. 6, no. 4, pp. 474–479.
50. 52. Portugal M, Barak V, Ginsburg I, and Kohen R. (2007). Interplay among oxidants, antioxidants, and cytokines in skin disorders: present status and future considerations. Biomedicine and Pharmacotherapy, vol. 61, no. 7, pp. 412–422.
51. 53. Kliment CR, Oury TD. (2010). Oxidative Stress, extracellular matrix targets, and idiopathic pulmonary fibrosis, Free Radical Biology and Medicine, vol. 49, no. 5, pp. 707–717.
52. 54. Olczyk P, Ramos P, Komosinska- Vassev K,Stojko J, and Pilawa, B. (2013). Positive effect of propolis on free radicals in burn wounds. Hindawi publishing corporation evidence-based complementary and alternative medicine Volume. Article ID 356737, 12 pages
53. 55. Krol W, Czuba Z, Scheller S, Gabrys J, Grabiec S, Shani J. (1990). Anti- oxidant property of etanolic extract of propolis (eep) evaluated by inhibiting the chemiluminescence oxidation of luminol. Biochem Int. 21(4): 593-97.
54. 56. Scheller S, Wilczok T, Imielski S, Krol W, Gabrys J, Shani J. Free radical scavenging by ethanol extract of propolis. Int J Radiat Biol 1990; 57(3): 461-65.
55. 57. Pascual C, Gonzales R, Torricella RG. Scavenging action of propolis extract against oxygen radicals. J Ethnopharmacol 1994; 41: 9-13.
56. 58. Ivanov DF, Tikonov AI, Krivenchuk PE, Liurskaia FV. (1973). Propolis and its clinical usage. Oftolmol Zh. 28(2): 1047.
57. 59. Mozherenkov VP, Prokofeva GL. (2011). Apitherapy of eye disease. Vestn Oftalmol 1991; 107 (6): 73-5.
58. 60. Pessolato, A. G. T. , Martins, D.S., Ambrosio C. E., Mancanares, C. A. F., Carvalho, A.F. propolis and amnion reepithelialise second-degree burns in rats. Burns. 37: 1192–1201
59. 61. Olczyk P, Komosinska-Vassev K, Szczotka K, Stojko J, Klimek K, Kozma E. M. (2013). Propolis ınduces chondroitin/dermatan sulphate and hyaluronic acid accumulation in the skin of burned wound. Hindawi publishing corporation evidence-based complementary and alternative medicine. Article ID 290675, 8 pages.
60. 62. Han MC, Durmus AS, Karabulut E, Yaman I. (2005). Effects of turkish propolis and silver sulfadiazine on burn wound healing in rats. Revue Méd. Vét. 156(12): 624-627.
61. 63. Durgun T, DurmuĢ AS. (2004). Köpeklerde anal kese yangılarının sağaltımında propolis ekstraktının kullanımı. Doğu Anadolu Araştırmaları Dergisi. 3(1): 159-161.