Atlarda Sefkuinomun Çoklu Doz Uygulamalarının Hematolojik ve Biyokimyasal Parametreler Üzerine Etkisi

Öz

Sefkuinomun (CFQ) çoklu doz uygulamalarının, atların hematolojik ve biyokimyasal profilleri üzerinde bir etkisi olup olmadığı bilinmemektedir. Bu çalışmanın amacı, atlarda çoklu artan CFQ dozlarının bazı hematolojik (WBC, LYM, MON, GRA, RBC, HB, HT, MCV, MCH, MCHC, RDW ve PLT) ve biyokimyasal parametreler üzerine (ALB, ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG ve BUN) etkisini belirlemektir. Araştırma 16 adet erişkin at (4.6 ± 2.1 yaş, 302 ± 38 kg) üzerinde gerçekleştirildi. Atlara damar içi olarak 7 gün boyunca her 12 saatte dört doz seviyesinde CFQ uygulandı: Grup I; 1 mg/kg, Grup II; 2 mg/kg, Grup III; 4 mg/kg, Grup IV; 6 mg/kg) uygulanan toplam 13 enjeksiyon gerçekleştirildi. Belirlenen hematolojik ve biyokimyasal parametreler ilaç uygulamasından önce (0 gün) ve ilk CFQ dozunun uygulanmasından 1, 3, 7 ve 14 gün sonra izlendi. Tedavi günlerinde gruplar arasında serum biyokimyasal parametrelerinde anlamlı bir fark bulunmadı (p> 0.05). Hematolojik parametrelerde (MONO, GRAN, RBC, HB, HCT, MCH ve PCT) doz grupları arasında referans değerler içinde anlamlı farklar bulundu (p <0.05). Bu sonuçlar, atlarda CFQ’un 6 mg/kg kadar çoklu doz uygulamalarının, değerlendirilen kan parametreleri üzerinde klinik olarak önemli bir etkisi olmadığını göstermektedir.

Anahtar Kelimeler

• At,güvenilirlik,sefkuinom

Effect of Multiple-Dose Administration of Cefquinome on Hematological and Biochemical Parameters in Horse

Abstract

The negative impact of multiple ascending doses of cefquinome (CFQ) on hematological and serum biochemical profile of horse unknown. The objective of this study was to evaluate the effect of multiple ascending doses of cefquinome (CFQ) in horses on the following hematological (WBCs, LYM, MON, GRA, RBCs, HB, HT, MCV, MCH, MCHC, RDW, and PLT) and biochemical parameters (ALB, ALP, ALT, AST, CH, CR, GGT, LDH, TB, TP, TRIG, and BUN). The study was performed on the sixteen mature horses (4.6 ± 2.1 years, 302 ± 38 kg). Four dosages of CFQ were applied as Group I; 1 mg/kg, Group II; 2 mg/kg, Group III; 4 mg/kg and Group IV; 6 mg/kg, and each animal received intravenously a total of 13 injections, administered every 12 h for 7 days. The hematological and biochemical parameters of horses were monitored on the before 0 day and 1, 3, 7, and 14 days after the administration of the first CFQ. No significant differences in serum biochemical parameters were found amongst the groups (p>0.05). Significant differences were found in certain hematological parameters (MONO, GRAN, RBC, HB, HCT, MCH, and PCT) amongst the groups (p<0.05) within the reference ranges. These results indicate that the administration of multiple doses of up to 6 mg/kg of CFQ in the horse had no clinically significant impact on the blood parameters measured.

Keywords

• Horse,safety,cefquinome

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