Seksual Siklus Süresince İnek Tuba Uterinasında ErbB1/HER1 ile ErbB2/HER2 Reseptörlerinin Dağılımı

Year 2020, , 87 - 91, 31.12.2020

Bayram Bayram

https://doi.org/10.47027/duvetfd.779723

Abstract

Tuba uterina, memeli üremesinde çok önemli bir rol oynar ve oosit olgunlaşması, sperm kapasitasyonu, döllenme ve gamet ve embriyoların taşınması için en uygun ortamı sağlar. ErB ailesi reseptörlerinin tuba uterinanın fonksiyonlarında etkili olduğu düşünülmektedir. Birçok araştırmacı ErbB1/HER1 ve ErbB2/HER2 reseptörlerinin seksual ya da menstrual siklus süresince tuba uterinanın luminal epitel, bağdoku ve düz kas hücrelerinden değişen yoğunluklarda ekspresse olduğunu göstermişlerdir. Sunulan çalışmada, erbB1/HER1 ve erbB2/HER2 reseptörlerinin ekspresyonu immunohistokimyasal olarak incelendi. Bu çalışmada 23 farklı holştayn ineğin ovaryum, uterus ve tuba uterinadan doku örnekleri alındı. Sonuç olarak, seksual siklus süresince erbB1/HER1 ve erbB2/HER2 reseptörlerinin inek tuba uterinasında hücre tiplerine göre değişen yoğunluklarda lokalize olması, bu reseptörlerin inek tuba uterinasında önemli fizyolojik etkilere sahip olabileceğini akla getirdi.

Keywords

tuba uterina, ErbB1/HER1, ErbB2/HER2

References

• Abe H, Hoshi H. (1997). Bovine oviductal epithelial cells: their cell culture and applications in studies for reproductive biology. Cytotechnology. 23: 171–183.
• Ellington JE. (1991). The bovine oviduct and its role in reproduction: a review of the literature. Cornell Veterinarian. 81: 313–328.
• Hunter RH. (2003). Reflections upon sperm–endosalpingeal and sperm to zona pellucida interactions in vivo and in vitro. Reprod Dom Anim. 38: 147–154.
• Ejskjær K, Sørensen BS, Poulsen SS, Mogensen O, Forman A, Nexø E. (2005). Expression of the epidermal growth factor system in human endometrium during the menstrual cycle. Mol Hum Reprod. 11: 543–51.
• Sağsöz H, Ketani MA. (2010). The role of estrogen receptors, erbB receptors, vascular endothelial growth factor and its receptors, and vascular endothelial growth inhibitor in the development of the rat mammary gland. Growth Factors. 28:379-93.
• Chobotova K, Muchmore M-E, Carver J, Yoo H-J, Manek S, Gullick WJ, Barlow DH, Mardon HJ. (2002). The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-α. J Clin Endocr Metab. 87: 5769–77.
• Chobotova K, Karpovich N, Carver J, Manek S, Gullick WJ, Barlow DH, Mardon HJ. (2002). Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. J Clin Endocr Metab. 90: 913-9.
• David B.Smotrich, Robert J.Stillman, Eric A.Widra,Paul R.Gindoff, Paul Kaplan, Michael Graubert and Kurt E Johnson. (1996). Immunocytochemical localization of growth factors and their receptors in human pre-embryos and Fallopian tubes. Human Reproduction vol.11 no.l pp.184-190.
• Wijayagunawardane MPB, Hambruch N, Haeger JD, Pfarrer C. (2015). Effect of epidermal growth factor (EGF) on the phosphorylation of mitogen-activated protein kinase (MAPK) in the bovine oviduct in vitro: Alteration by heat stress . Journal of Reproduction and Development, Vol. 61, No 5.
• 1Swanchara KW, Henricks DM, Birrenkott GP, Bodine AB, Richardson ME. (1995). Expression of Epidermal Growth Factor (EGF) and the EGF Receptor in the Porcine Oviduct. Biology Of Reproduction 53, 911-922.
• Wollenhaupt K, Tomek W, Brüssow KP, Tiemann U, Viergutz T, Schneider F, Nürnberg G. (2002). Effects of ovarian steroids and epidermal growth factor (EGF) on expression and bioactivation of specific regulators of transcription and translation in oviductal tissue in pigs. Reproduction. 123, 87–96
• Kennedy TG, Brown KD, Vaughan TJ. (1994). Expression of the Genes for the Epidermal Growth Factor Receptor and Its Ligands in Porcine Oviduct and Endometrium. Biology Of Reproduction 50, 751-756.
• Wollenhaupt K, Welter H, Einspanier R, Manabe N, Brüssow KP. (2004) Expression of epidermal growth factor receptor (EGF-R), vascular endothelial growth factor receptor (VEGF-R) and fibroblast growth factor receptor (FGF-R) systems in porcine oviduct and endometrium during the time of implantation. J Reprod Dev. 50(3):269-78.
• Leblanc SJ. (2008). Postpartum uterine disease and dairy herd reproductive performance: A review. The Veterinary Journal. 176, 102–114.
• Sheldon IM, Lewis GS, LeBlanc SJ, Gilbert RO. (2006). Defining postpartum uterine disease in cattle. Theriogenology. 65, 1516–1530.
• De Vries A. (2006). Economic value of pregnancy in dairy cattle. Journal of Dairy Science. 89, 3876-3885.
• Topaloğlu U, Akbalık ME, Güney Saruhan B, Ketani M, Kılıç M, Sağsöz H. (2016). Sıçan Uterusunda Anöstrus Süresince Epidermal Büyüme Faktörü Reseptörlerinin Dağılımı. Dicle Üniv Vet Fak Derg. 1(5):28-34.
• Schultz GA, Heyner S. (1993). Growth factors in preimplantation mammalian embryos. Oxford Rev. Reprod. BioL. 15, 43-81.
• Nelson EL. (2014). HER2/neu: an increasingly important therapeutic target. Part 2: Distribution of HER2/neu overexpression and gene amplification by organ, tumor site and histology. Clin. Invest. (Lond.) 4(8), 705–728.
• Carpenter G. (2003). ErbB-4: mechanism of action and biology. Exp Cell Res. 284:66–77.
• Citri A, Skaria KB, Yarden Y. (2003). The deaf and the dumb: the biology of ErbB-2 and ErbB-3. Exp Cell Res. 284:54–65.
• Harris RC, Chung E, Coffey RJ. (2003). EGF receptor ligands. Exp Cell Res. 284:2–13.
• Nelson KG, Takahashı T, Bossert NL, Walmert DK, Mclachlan JA. (1991). Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. Proc Natl Acad Sci USA. 88:21-5.
• Olayioye MA, Neve RM, Lane HA, Hynes NE. (2000). The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 19:3159–67.
• Bigsby RM, Li AX, Bomalaski J, Stehman FB, Look KY, Sutton GP. (1992). Immunohistochemical study of HER-2/neu, epidermal growth factor receptor, and steroid receptor expression in normal and malignant endometrium. Obstet Gynecol. 79:95–100.
• Bukowska D, Kempisty B, Jackowska M, Woźna M, Antosik P, Piotrowska H, Jaśkowski JM. (2011). Differential expression of epidermal growth factor and transforming growth factor beta isoforms in dog endometrium during different periods of the estrus cycle. Pol J Vet Sci. 14:259-64.
• Falls DL. (2003). Neuregulins: functions, forms, and signaling strategies. Exp Cell Res. 284:14–30.