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Oxidative DNA Damage Products and Diseases

Year 2012, Issue: 2, 40 - 57, 01.10.2012

Nazlı Ercan , Ulvi Reha Fidancı

Abstract

The free radicals formed with many ways and antioxidant defence mechanism is in a balance within the organism. In cases when
the free radicals are not cleaned enough from the organism, it causes damage to the DNA and damage products are formed. These
damage products can lead to many metabolic diseases, to aging, to cancer and even modifications in the structure of DNA which is a
genetic material. 8-hydroxy-2’-deoxyguanosine (8-OHdG) is a damage product whose mutagenity is most known.

Keywords

DNA Diseases Oxidative Damage 8-OHdG

References

  • 1. Akira M, Ikeda T, Enomoto K et al (2000). Increased formation of oxidative DNA damage, 8-hydroxy-2’- deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett. 151: 87-95.
  • 2. Alam Z I, Jenner A, Daniel S E et al (1997). Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem. 69: 1196-1203.
  • 3. Beehler, BC, Przybyszewski, J, Box, HB, Kulesz-Martin, F (1992). Formation of 8- hydroxydeoxyguanosine within DNA of Mouse keratinocytes exposed in culture to UVB and H 2 O 2 . Carcinogenesis 13: 2003-2007.
  • 4. Bogdanov M B, Andreassen O A, Dedeoğlu A, Ferrante R J, Beal M F (2001). Increased oxidative damage to DNA in a transgenic Mouse model of Huntington’s disease. J Neurochem. 79: 1246-1249.
  • 5. Bogdanov M, Brown R H, Matson W et al (2000). Increased oxidative damage to DNA in ALS patients. Free Radical Bio Med. 7: 652-658.
  • 6. Breen A P, Murphy J A (1995). Reactions of oxyl radicals with DNA. Free Radical Bio Med. 8(6):1033-77.
  • 7. Chang C S, Chen W N, Lin H H, Wu C C, Wang C J (2004). Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor B expression and enhanced antiapoptosis- related proteins in Helicobacter pylori- infected non-cardiacgastric adenocarcinoma. World J Gastroentero. 10(15):2232-2240.
  • 8. Chuma M, Hige S, Nakanishi M et al (2008). 8-hydroxy-2’-deoxyguanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroen Hepatol. 23: 1431-1436.
  • 9. Collier A C, Dandge S D, Woodrow J E, Pritsos C A (2005). Differences in DNA damage in non smoking men and women exposed to environmental tobacco smoke (ETS). Toxicol Lett. 158: 10-19.
  • Dandona P, Thusu K, Cook S et al (1996). Oxidative damage to DNA in diabetes mellitus. Lancet. 347 (8999):444-445.
  • Dinçer Y, Erzin Y, Himmetoğlu S, Güneş K N, Bal K, Akçay T (2007). Oxidative DNA damage and antioxidant activity in patients with inflamatory Bowel Disease. Digest Dis Sci. 52: 1639-1641.
  • Dirksen ML, Blakely WF, Holwitt E, Dizdaroğlu M (1988). Effect of DNA conformation on the hydroxyl radical- induced formation of 8,5’-cyclopurine 2’-deoxyribonucleoside rezidues in DNA. Int J Radiat Biol. 54(2): 195- 204.
  • Dizdaroğlu M, Holwitt E, Hagan M, Blakely W (1986). Formation of cytosine glycol and 5,6- dihydroxycytosine in deoxyribonucleic acid on treatment with osmiumtetroxide. Biochem. 235:531- 536.
  • Dizdaroğlu M (1991). Chemical determination of free radical-induced damage to DNA. Free Radical Bio Med. 10: 225-242.
  • Dizdaroğlu M (1992). Oxidative damage to DNA in mammalian chromatin. Mutat Res. 275:331-342.
  • Dizdaroğlu, M (1992). Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol. 61(2): 175-183.
  • Dizdaroğlu M (1993). Quantative determination of oxidative base damge in DNA by stable isotope-dilution mass spectrometry. Febs Lett. 315(1):1-6.
  • Dizdaroğlu M, Laval J, Boiteux S (1993). Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine- derived lesions in DNA produced by radiation-generated free radicals. Biochem. 32(45):12105-12111.
  • Dizdaroğlu M, Bauche C, Rodriguez H, Laval J (2000). Novel substrates of Esherichia coli Nth protein and its kinetics for excision of modified bases from Dna damaged by free radicals. Biochem. 39: 5586-5592.
  • Dizdaroğlu, M (2005). Serbest Radikaller, DNA Hasarı, DNA onarımı ve Hastalıklarla ilişkisi. Kurs Kitabı.
  • 21. Dizdaroğlu M, Jaruga P, Birincioğlu M, Rodriguez H (2002). Free Radical- Induced Damaged to DNA: Mechanisms and measurement. Free Radical Bio Med. 32(11): 1102-1115.
  • 22. Dong QY, Cui Y, Chen L, Song J, Sun L (2008). Urinary 8- hydroxydeoxyguanosine levels in diabetic retinopathy patients. Eur J Ophthalmol. 18(1): 94-98.
  • 23. Ercan N, Fidancı U R (2012). Piyodermalı köpeklerde 8-hidroksi-2’- deoksiguanozin (8-OHdG) düzeyleri. Ank Üniv Vet Fak Derg. 59: 163-168.
  • 24. Evans M D, Dizdaroğlu M, Cooke M S (2004). Oxidative DNA damage and disease induction, repair and significance. Mutat Res. 567: 1-61.
  • 25. Fidancı U R, Turgay F, Zengin S, Kargın F, Çelik S, Taşdemir U (2001). Genotipin Ankara Keçilerinde antioksidatif Metabolizma Üzerine Etkisi. Turk J Vet Anim Sci. 25: 975- 981.
  • 26. Fujita S, Steenken S (1981). Pattern of OH radical addtion to uracil and methyl- and carboxyl-substitued uracils. Electron transfer of OH adducts with N,N,N’,N’-Tetramethyl- p-phenylenediamine and tetranitromethane. J Am Chem Soc. 103:2540-2545.
  • 27. Fraga C, Shigenaga M, Park J, Degan P, Ames B (1990). Oxidative damage to DNA during aging: 8-Hydroxy-2’- deoxyguanosine in rat organ DNA urine. Proc Nat Acad Sci. 87: 4533- 4537.
  • 28. Gencer M, Ceyla E, Aksoy A, Uzun K (2005). Oksidatif stres benign ve malign akciğer hastalıklarının ayırıcı tanısında belirteç olabilir mi? Akciğer arşivi 6: 89-92.
  • 29. Halliwell B (2000). Why and how should we measure oxidative DNA damage in nutritional studies? How far we come? Am J Clin Nutr. 72: 1082- 1087.
  • 30. Haliwell B (2007). Oxidative stres and cancer: have we moved forward? Biochem J. 401: 1-11.
  • 31. Hattori Y, Nishigori C, Tanaka T et al (1996). 8-hydroxy-2’-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 107(5):733-737.
  • 32. Hattori-Nakakuki, Y., Nisgiori, C., Okamato, K., Imamura, S., Hiai, H., Toyokuni, S. (1994). Formation of 8- hydroxy-2’-deoxyguanosine in epidermis of hairless mice exposed to near-UV. Biochem Biophys Res Commun. 201: 1132-1139.
  • 33. Heidarpour M, Soltani S, Mohri M, Khoshnegah J (2012). Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status. Parasitol Res.
  • 34. Heidarpour M, Mohri M, Borji H, Moghdass E (2012). Oxidative stress and trace elements in camel (Camelus dromedarius) with liver cystic echinococcosis. Vet Parasitol. 187(3- 4):459-63.
  • 35. Helbock HJ, Beckman KB, Shigenaga MK et al (1998). DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo- deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci. 95: 288-293.
  • 36. Herbert K A, Evans M D, Finnegan M et al (1996). A novel HPLC procedure fort he analysis of 8-oxoguanine in DNA. Free Radical Bio Med. 20(3): 467-473.
  • 37. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S (2000). Correlation of urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leukemia Res. 24: 461-468.
  • 38. Inoue T, Hayashi M, Takayanagi K, Morooka S (2003). Oxidative DNA damage is induced by chronic cigarette smoking but repaired by abstention. J Health Sci. 49(3):217-220.
  • 39. Ishizakai M, Yoshida K, Nishimoto N et al (2004). Urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG) in patients with chronic liver diseases. Rinsho Byori. 52(9):732-736.
  • 40. Jaruga P, Zastwany T H, Skokowski J, Dizdaroğlu M, Olinski R (1994). Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. Febs lett. 341: 59-64.
  • 41. Jaruga P, Rodriguez H, Dizdaroğlu M (2001). Measurement of 8-hydroxy-2’- deoxyadenosine in DNA by liquid chromatography/mass spectometry. Free Radical Bio Med. 31(3): 336-344.
  • 42. Kasai, H. (2002). Chemistry-based studies on oxidative DNA damage formation, repair and mutagenesis. Free Radical Bio Med. 33(4): 450-456.
  • 43. Keleş H, Fidan F, Ciğerci H, Küçükkurt İ, Karadaş E (2010). Increased DNA damage and oxidative stres in chickens with Natural Marek’ Disease. Vet Immunol Immunop. 133: 51-58.
  • 44. Koçyiğit A, Keleş H, Selek S ve ark (2005). Increased DNA damage and oxidative stres in patients with cutaneous leishmaniasis. Mutat Res. 585: 71-78.
  • 45. Koppele J M, Lucassen P J, Sakkee A N et al (1996). 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer’s disease. Neurobiol aging. 17(6):819-826.
  • 46. Köken, T, Kahraman, A, Serteser, M, Gökçe, Ç. (2004). Hemodiyaliz ve oksidatif stres. Kocatepe Tıp Dergisi. 5: 9-13.
  • 47. Lin H, Jenner A, Ong C et al (2004). A high-throughput and sensitive methodology for the quantificaition of urinary 8-hydroxy-2’-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase exraction. Biochem. 380: 541-548.
  • 48. Loft S, Nielsen A, Jeding IB, Vistisen K, Poulsen HE (1993). 8- Hydoxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Env Health. 40(2-3): 391-404.
  • 49. Long D J, Matson W R, Juhl A R et al (2012). 8OHdG as a marker for huntington disease progression. Neurobiol Dis. 46: 625-634.
  • 50. Martinis B, Bianchi M (2002). Methodology for urinary 8-hydroxy-2’- deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res. 46(2): 129-131.
  • 51. Musarrat J, Arezina-Wilson J, Wani AA (1996). Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer. 32A(7):1209-1214.
  • 52. Nagashima M, Tsuda H, Takenoshita S et al (1995). 8-hydroxydeoxyguanosine levels in DNA of human breastcancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer lett. 90(2):157-162.
  • 53. Nakai K, Yoneda K, Maeda R et al (2009). Urinary biomarker of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis. J Eur Acad Dermatol Venereol. 23(12):1405-1408.
  • 54. Nazifi S, Razavi SM, Kianiamin P, Rakhshandehroo E (2011). Evaluation of erythrocyte antioxidant mechanisms: antioxidant enzymes, lipid peroxidation, and serum trace elements associated with progressive anemia in ovine malignant theileriosis. Parasitol Res. 109(2):275-81.
  • 55. Okamoto K, Toyokuni S, Uchida K et al (1994). Formation of 8-hydroxy-2’- deoxyguanosine and 4-hydroxy-2- nonenal-modified proteins in human renal cell carcinoma. Int J Cancer. 58(6): 825-829.
  • 56. Pilger A, Ivancsits S, Germadnik D, Rudiger HW (2002). Urinary excretion of 8-hydroxy-2’-deoxyguanosine measured by high-performance liquid chromatography with electrochemical detection. J Chromatogr B. 778: 393- 401.
  • 57. Rajski S, Jackson B, Barton J (2000). DNA repair: models for damage and mismatch recognition. Mutat Res. 447: 49-72.
  • 58. Rall L C, Roubenoff R, Meydani S N, Han S N, Meydani M (2000). Urinary 8-hydroxy-2’-deoxyguanosine (8- OHdG) as a marker of oxidative stres in rheumatoid arthritis and aging: Effect of progressive resistance training. J Nutr Biochem. 11: 581-584.
  • 59. Razavi SM, Nazifi S, Bateni M, Rakhshandehroo E (2011). Alterations of erythrocyte antioxidant mechanisms: antioxidant enzymes, lipid peroxidation and serum trace elements associated with anemia in bovine tropical theileriosis. Vet Parasitol. 180(3-4): 209-14.
  • 60. Rehman A, Jenner A, Halliwell B (2000). Gas chromatography-mass spectrometry analysis of DNA: Optimization of protocols for isolation and analysis of DNA from human blood. Method Enzymol. 319: 401-417.
  • 61. Şentürker S, Karahalil B, İnal M ve ark (1997). Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia. Febs Lett. 416: 286-290.
  • 62. Tanaka H, Fujita N, Sugimoto R et al (2008). Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C. Brit J Cancer. 98: 580-586.
  • 63. Thier R, Brüning T, Kocher K et al (1999). Determination of urinary thymidine glycol using affinity chromatography, HPLC and pot- column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation. Arch Toxicol. 73(8-9): 479-484.
  • 64. Tsuboi H, Kouda K, Takeuchi H et al (1998). 8-Hydroxydeoxyguanosine in urine as an index of oxidative damage to DNA in the evaluation of atopic dermatitis. Brit J Dermatol. 138(6): 1033-1035.
  • 65. Vladimirova O, O’Connor J, Cahill A et al (1998). Oxidative damage to DNA in plaques of MS brains. Mult Scler. 4(5): 413-418.
  • 66. Wagner J R, Lier J E, Berger M, Cadet J (1994). Thymidine hydroxyperoxides: Structural assignment, conformational features and thermal decomposition in water. J Am Chem Soc. 116(6): 2235-2242.
  • 67. Wiseman H, Kaur H, Halliwell B (1995). DNA damage and cancer: measurement and mechanism. Cancer Lett. 93: 113-120.
  • 68. Witherell H L, Hiatt R A, Replogle M, Parsonnet J (1998). Helicobacter pylori infection and urinary excretion of 8- hydroxy-2’-deoxyguanosine, an oxidative DNA adduct. Cancer Epidem Biomar Prev. 7: 91-96.
  • 69. Yano T, Shoji F, Baba H et al (2009). Significance of the urinary 8-OHdG levels as an oxidative stres marker in lung cancer patients. Lung cancer. 63: 111-114.
  • 70. Yokuş B, Akdağ MZ, Daşdağ S, Çakır DU, Kızıl M (2008). Extremely low frequency magnetic fields cause oxidative DNA damage in rats. Int J Radiat Biol. Oct; 84(10): 789-795.
  • 71. Yu S, Paetau-Robinson I (2006). Dietary supplements of vitamins E and C and β-carotene reduce oxidative stres in cats with renal insufficency. Vet Res Commun. 30(3): 403-413.
  • 72. Zhang F, Stott WT, Clark AJ et al (2007). Quantitation of 8-hydroxydeoxyguanosine in DNA by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectometry. Rapid Commun Mass Sp. 21: 3949-3955.

Oksidatif DNA Hasar Ürünleri ve Hastalıklar

Year 2012, Issue: 2, 40 - 57, 01.10.2012

Nazlı Ercan , Ulvi Reha Fidancı

Abstract

Organizmada, çeşitli yollarla oluşan serbest radikallerle antioksidan savunma sistemi denge halindedir. Bununla beraber serbest
radikallerin organizmadan yeterince temizlenemediği durumlarda DNA’da hasara yol açmakta ve hasar ürünleri şekillenmektedir.
Bu hasar ürünleri çeşitli metabolik hastalıklara, yaşlanmaya, kansere ve hatta genetik materyal olan DNA yapısındaki
modifikasyonlara neden olabilmektedir. Mutajenitesi en çok bilinmekte olan hasar ürünlerinden bir tanesi de 8-hidroksi-2’-
deoksiguanozin (8-OHdG)’dir.

Keywords

DNA Hastalıklar Oksidatif Hasar 8-OHdG

References

  • 1. Akira M, Ikeda T, Enomoto K et al (2000). Increased formation of oxidative DNA damage, 8-hydroxy-2’- deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett. 151: 87-95.
  • 2. Alam Z I, Jenner A, Daniel S E et al (1997). Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra. J Neurochem. 69: 1196-1203.
  • 3. Beehler, BC, Przybyszewski, J, Box, HB, Kulesz-Martin, F (1992). Formation of 8- hydroxydeoxyguanosine within DNA of Mouse keratinocytes exposed in culture to UVB and H 2 O 2 . Carcinogenesis 13: 2003-2007.
  • 4. Bogdanov M B, Andreassen O A, Dedeoğlu A, Ferrante R J, Beal M F (2001). Increased oxidative damage to DNA in a transgenic Mouse model of Huntington’s disease. J Neurochem. 79: 1246-1249.
  • 5. Bogdanov M, Brown R H, Matson W et al (2000). Increased oxidative damage to DNA in ALS patients. Free Radical Bio Med. 7: 652-658.
  • 6. Breen A P, Murphy J A (1995). Reactions of oxyl radicals with DNA. Free Radical Bio Med. 8(6):1033-77.
  • 7. Chang C S, Chen W N, Lin H H, Wu C C, Wang C J (2004). Increased oxidative DNA damage, inducible nitric oxide synthase, nuclear factor B expression and enhanced antiapoptosis- related proteins in Helicobacter pylori- infected non-cardiacgastric adenocarcinoma. World J Gastroentero. 10(15):2232-2240.
  • 8. Chuma M, Hige S, Nakanishi M et al (2008). 8-hydroxy-2’-deoxyguanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroen Hepatol. 23: 1431-1436.
  • 9. Collier A C, Dandge S D, Woodrow J E, Pritsos C A (2005). Differences in DNA damage in non smoking men and women exposed to environmental tobacco smoke (ETS). Toxicol Lett. 158: 10-19.
  • Dandona P, Thusu K, Cook S et al (1996). Oxidative damage to DNA in diabetes mellitus. Lancet. 347 (8999):444-445.
  • Dinçer Y, Erzin Y, Himmetoğlu S, Güneş K N, Bal K, Akçay T (2007). Oxidative DNA damage and antioxidant activity in patients with inflamatory Bowel Disease. Digest Dis Sci. 52: 1639-1641.
  • Dirksen ML, Blakely WF, Holwitt E, Dizdaroğlu M (1988). Effect of DNA conformation on the hydroxyl radical- induced formation of 8,5’-cyclopurine 2’-deoxyribonucleoside rezidues in DNA. Int J Radiat Biol. 54(2): 195- 204.
  • Dizdaroğlu M, Holwitt E, Hagan M, Blakely W (1986). Formation of cytosine glycol and 5,6- dihydroxycytosine in deoxyribonucleic acid on treatment with osmiumtetroxide. Biochem. 235:531- 536.
  • Dizdaroğlu M (1991). Chemical determination of free radical-induced damage to DNA. Free Radical Bio Med. 10: 225-242.
  • Dizdaroğlu M (1992). Oxidative damage to DNA in mammalian chromatin. Mutat Res. 275:331-342.
  • Dizdaroğlu, M (1992). Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol. 61(2): 175-183.
  • Dizdaroğlu M (1993). Quantative determination of oxidative base damge in DNA by stable isotope-dilution mass spectrometry. Febs Lett. 315(1):1-6.
  • Dizdaroğlu M, Laval J, Boiteux S (1993). Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine- derived lesions in DNA produced by radiation-generated free radicals. Biochem. 32(45):12105-12111.
  • Dizdaroğlu M, Bauche C, Rodriguez H, Laval J (2000). Novel substrates of Esherichia coli Nth protein and its kinetics for excision of modified bases from Dna damaged by free radicals. Biochem. 39: 5586-5592.
  • Dizdaroğlu, M (2005). Serbest Radikaller, DNA Hasarı, DNA onarımı ve Hastalıklarla ilişkisi. Kurs Kitabı.
  • 21. Dizdaroğlu M, Jaruga P, Birincioğlu M, Rodriguez H (2002). Free Radical- Induced Damaged to DNA: Mechanisms and measurement. Free Radical Bio Med. 32(11): 1102-1115.
  • 22. Dong QY, Cui Y, Chen L, Song J, Sun L (2008). Urinary 8- hydroxydeoxyguanosine levels in diabetic retinopathy patients. Eur J Ophthalmol. 18(1): 94-98.
  • 23. Ercan N, Fidancı U R (2012). Piyodermalı köpeklerde 8-hidroksi-2’- deoksiguanozin (8-OHdG) düzeyleri. Ank Üniv Vet Fak Derg. 59: 163-168.
  • 24. Evans M D, Dizdaroğlu M, Cooke M S (2004). Oxidative DNA damage and disease induction, repair and significance. Mutat Res. 567: 1-61.
  • 25. Fidancı U R, Turgay F, Zengin S, Kargın F, Çelik S, Taşdemir U (2001). Genotipin Ankara Keçilerinde antioksidatif Metabolizma Üzerine Etkisi. Turk J Vet Anim Sci. 25: 975- 981.
  • 26. Fujita S, Steenken S (1981). Pattern of OH radical addtion to uracil and methyl- and carboxyl-substitued uracils. Electron transfer of OH adducts with N,N,N’,N’-Tetramethyl- p-phenylenediamine and tetranitromethane. J Am Chem Soc. 103:2540-2545.
  • 27. Fraga C, Shigenaga M, Park J, Degan P, Ames B (1990). Oxidative damage to DNA during aging: 8-Hydroxy-2’- deoxyguanosine in rat organ DNA urine. Proc Nat Acad Sci. 87: 4533- 4537.
  • 28. Gencer M, Ceyla E, Aksoy A, Uzun K (2005). Oksidatif stres benign ve malign akciğer hastalıklarının ayırıcı tanısında belirteç olabilir mi? Akciğer arşivi 6: 89-92.
  • 29. Halliwell B (2000). Why and how should we measure oxidative DNA damage in nutritional studies? How far we come? Am J Clin Nutr. 72: 1082- 1087.
  • 30. Haliwell B (2007). Oxidative stres and cancer: have we moved forward? Biochem J. 401: 1-11.
  • 31. Hattori Y, Nishigori C, Tanaka T et al (1996). 8-hydroxy-2’-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J Invest Dermatol. 107(5):733-737.
  • 32. Hattori-Nakakuki, Y., Nisgiori, C., Okamato, K., Imamura, S., Hiai, H., Toyokuni, S. (1994). Formation of 8- hydroxy-2’-deoxyguanosine in epidermis of hairless mice exposed to near-UV. Biochem Biophys Res Commun. 201: 1132-1139.
  • 33. Heidarpour M, Soltani S, Mohri M, Khoshnegah J (2012). Canine visceral leishmaniasis: relationships between oxidative stress, liver and kidney variables, trace elements, and clinical status. Parasitol Res.
  • 34. Heidarpour M, Mohri M, Borji H, Moghdass E (2012). Oxidative stress and trace elements in camel (Camelus dromedarius) with liver cystic echinococcosis. Vet Parasitol. 187(3- 4):459-63.
  • 35. Helbock HJ, Beckman KB, Shigenaga MK et al (1998). DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo- deoxyguanosine and 8-oxo-guanine. Proc Natl Acad Sci. 95: 288-293.
  • 36. Herbert K A, Evans M D, Finnegan M et al (1996). A novel HPLC procedure fort he analysis of 8-oxoguanine in DNA. Free Radical Bio Med. 20(3): 467-473.
  • 37. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S (2000). Correlation of urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leukemia Res. 24: 461-468.
  • 38. Inoue T, Hayashi M, Takayanagi K, Morooka S (2003). Oxidative DNA damage is induced by chronic cigarette smoking but repaired by abstention. J Health Sci. 49(3):217-220.
  • 39. Ishizakai M, Yoshida K, Nishimoto N et al (2004). Urinary 8-hydroxy-2’- deoxyguanosine (8-OHdG) in patients with chronic liver diseases. Rinsho Byori. 52(9):732-736.
  • 40. Jaruga P, Zastwany T H, Skokowski J, Dizdaroğlu M, Olinski R (1994). Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. Febs lett. 341: 59-64.
  • 41. Jaruga P, Rodriguez H, Dizdaroğlu M (2001). Measurement of 8-hydroxy-2’- deoxyadenosine in DNA by liquid chromatography/mass spectometry. Free Radical Bio Med. 31(3): 336-344.
  • 42. Kasai, H. (2002). Chemistry-based studies on oxidative DNA damage formation, repair and mutagenesis. Free Radical Bio Med. 33(4): 450-456.
  • 43. Keleş H, Fidan F, Ciğerci H, Küçükkurt İ, Karadaş E (2010). Increased DNA damage and oxidative stres in chickens with Natural Marek’ Disease. Vet Immunol Immunop. 133: 51-58.
  • 44. Koçyiğit A, Keleş H, Selek S ve ark (2005). Increased DNA damage and oxidative stres in patients with cutaneous leishmaniasis. Mutat Res. 585: 71-78.
  • 45. Koppele J M, Lucassen P J, Sakkee A N et al (1996). 8OHdG levels in brain do not indicate oxidative DNA damage in Alzheimer’s disease. Neurobiol aging. 17(6):819-826.
  • 46. Köken, T, Kahraman, A, Serteser, M, Gökçe, Ç. (2004). Hemodiyaliz ve oksidatif stres. Kocatepe Tıp Dergisi. 5: 9-13.
  • 47. Lin H, Jenner A, Ong C et al (2004). A high-throughput and sensitive methodology for the quantificaition of urinary 8-hydroxy-2’-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase exraction. Biochem. 380: 541-548.
  • 48. Loft S, Nielsen A, Jeding IB, Vistisen K, Poulsen HE (1993). 8- Hydoxydeoxyguanosine as a urinary biomarker of oxidative DNA damage. J Toxicol Env Health. 40(2-3): 391-404.
  • 49. Long D J, Matson W R, Juhl A R et al (2012). 8OHdG as a marker for huntington disease progression. Neurobiol Dis. 46: 625-634.
  • 50. Martinis B, Bianchi M (2002). Methodology for urinary 8-hydroxy-2’- deoxyguanosine analysis by HPLC with electrochemical detection. Pharmacol Res. 46(2): 129-131.
  • 51. Musarrat J, Arezina-Wilson J, Wani AA (1996). Prognostic and aetiological relevance of 8-hydroxyguanosine in human breast carcinogenesis. Eur J Cancer. 32A(7):1209-1214.
  • 52. Nagashima M, Tsuda H, Takenoshita S et al (1995). 8-hydroxydeoxyguanosine levels in DNA of human breastcancers are not significantly different from those of non-cancerous breast tissues by the HPLC-ECD method. Cancer lett. 90(2):157-162.
  • 53. Nakai K, Yoneda K, Maeda R et al (2009). Urinary biomarker of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis. J Eur Acad Dermatol Venereol. 23(12):1405-1408.
  • 54. Nazifi S, Razavi SM, Kianiamin P, Rakhshandehroo E (2011). Evaluation of erythrocyte antioxidant mechanisms: antioxidant enzymes, lipid peroxidation, and serum trace elements associated with progressive anemia in ovine malignant theileriosis. Parasitol Res. 109(2):275-81.
  • 55. Okamoto K, Toyokuni S, Uchida K et al (1994). Formation of 8-hydroxy-2’- deoxyguanosine and 4-hydroxy-2- nonenal-modified proteins in human renal cell carcinoma. Int J Cancer. 58(6): 825-829.
  • 56. Pilger A, Ivancsits S, Germadnik D, Rudiger HW (2002). Urinary excretion of 8-hydroxy-2’-deoxyguanosine measured by high-performance liquid chromatography with electrochemical detection. J Chromatogr B. 778: 393- 401.
  • 57. Rajski S, Jackson B, Barton J (2000). DNA repair: models for damage and mismatch recognition. Mutat Res. 447: 49-72.
  • 58. Rall L C, Roubenoff R, Meydani S N, Han S N, Meydani M (2000). Urinary 8-hydroxy-2’-deoxyguanosine (8- OHdG) as a marker of oxidative stres in rheumatoid arthritis and aging: Effect of progressive resistance training. J Nutr Biochem. 11: 581-584.
  • 59. Razavi SM, Nazifi S, Bateni M, Rakhshandehroo E (2011). Alterations of erythrocyte antioxidant mechanisms: antioxidant enzymes, lipid peroxidation and serum trace elements associated with anemia in bovine tropical theileriosis. Vet Parasitol. 180(3-4): 209-14.
  • 60. Rehman A, Jenner A, Halliwell B (2000). Gas chromatography-mass spectrometry analysis of DNA: Optimization of protocols for isolation and analysis of DNA from human blood. Method Enzymol. 319: 401-417.
  • 61. Şentürker S, Karahalil B, İnal M ve ark (1997). Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia. Febs Lett. 416: 286-290.
  • 62. Tanaka H, Fujita N, Sugimoto R et al (2008). Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C. Brit J Cancer. 98: 580-586.
  • 63. Thier R, Brüning T, Kocher K et al (1999). Determination of urinary thymidine glycol using affinity chromatography, HPLC and pot- column reaction detection: a biomarker of oxidative DNA damage upon kidney transplantation. Arch Toxicol. 73(8-9): 479-484.
  • 64. Tsuboi H, Kouda K, Takeuchi H et al (1998). 8-Hydroxydeoxyguanosine in urine as an index of oxidative damage to DNA in the evaluation of atopic dermatitis. Brit J Dermatol. 138(6): 1033-1035.
  • 65. Vladimirova O, O’Connor J, Cahill A et al (1998). Oxidative damage to DNA in plaques of MS brains. Mult Scler. 4(5): 413-418.
  • 66. Wagner J R, Lier J E, Berger M, Cadet J (1994). Thymidine hydroxyperoxides: Structural assignment, conformational features and thermal decomposition in water. J Am Chem Soc. 116(6): 2235-2242.
  • 67. Wiseman H, Kaur H, Halliwell B (1995). DNA damage and cancer: measurement and mechanism. Cancer Lett. 93: 113-120.
  • 68. Witherell H L, Hiatt R A, Replogle M, Parsonnet J (1998). Helicobacter pylori infection and urinary excretion of 8- hydroxy-2’-deoxyguanosine, an oxidative DNA adduct. Cancer Epidem Biomar Prev. 7: 91-96.
  • 69. Yano T, Shoji F, Baba H et al (2009). Significance of the urinary 8-OHdG levels as an oxidative stres marker in lung cancer patients. Lung cancer. 63: 111-114.
  • 70. Yokuş B, Akdağ MZ, Daşdağ S, Çakır DU, Kızıl M (2008). Extremely low frequency magnetic fields cause oxidative DNA damage in rats. Int J Radiat Biol. Oct; 84(10): 789-795.
  • 71. Yu S, Paetau-Robinson I (2006). Dietary supplements of vitamins E and C and β-carotene reduce oxidative stres in cats with renal insufficency. Vet Res Commun. 30(3): 403-413.
  • 72. Zhang F, Stott WT, Clark AJ et al (2007). Quantitation of 8-hydroxydeoxyguanosine in DNA by liquid chromatography/positive atmospheric pressure photoionization tandem mass spectometry. Rapid Commun Mass Sp. 21: 3949-3955.
There are 72 citations in total.

Details

Subjects Veterinary Surgery
Journal Section Review
Authors

Nazlı Ercan

Ulvi Reha Fidancı This is me

Publication Date October 1, 2012
Published in Issue Year 2012 Issue: 2

Cite

APA Ercan, N., & Fidancı, U. R. (2012). Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniversitesi Veteriner Fakültesi Dergisi(2), 40-57.
AMA Ercan N, Fidancı UR. Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniv Vet Fak Derg. October 2012;(2):40-57.
Chicago Ercan, Nazlı, and Ulvi Reha Fidancı. “Oksidatif DNA Hasar Ürünleri Ve Hastalıklar”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, no. 2 (October 2012): 40-57.
EndNote Ercan N, Fidancı UR (October 1, 2012) Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniversitesi Veteriner Fakültesi Dergisi 2 40–57.
IEEE N. Ercan and U. R. Fidancı, “Oksidatif DNA Hasar Ürünleri ve Hastalıklar”, Dicle Üniv Vet Fak Derg, no. 2, pp. 40–57, October 2012.
ISNAD Ercan, Nazlı - Fidancı, Ulvi Reha. “Oksidatif DNA Hasar Ürünleri Ve Hastalıklar”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 2 (October 2012), 40-57.
JAMA Ercan N, Fidancı UR. Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniv Vet Fak Derg. 2012;:40–57.
MLA Ercan, Nazlı and Ulvi Reha Fidancı. “Oksidatif DNA Hasar Ürünleri Ve Hastalıklar”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, no. 2, 2012, pp. 40-57.
Vancouver Ercan N, Fidancı UR. Oksidatif DNA Hasar Ürünleri ve Hastalıklar. Dicle Üniv Vet Fak Derg. 2012(2):40-57.