Kadmiyum ile Oluşturulan Deneysel Karaciğer Hasarına Karşı Bal ve Polenin Lipid Peroksidayon ve Bazı Antioksidanlar Üzerine Etkisi

Year 2018, Volume: 11 Issue: 2, 88 - 92, 31.12.2018

Halil Şimşek , Osman Şimşek

Abstract

Bu çalışmada kadmiyum (Cd) verilen ratlarda
karaciğer dokusunda; glutatyon peroksidaz (GSH-Px), katalaz (KAT), glutatyon
(GSH) ve malondialdehit (MDA) düzeylerine bal ve polen verilmesi ile oluşacak
değişikliklerin belirlenmesi amaçlanmıştır. Çalışma ratlar üzerinde yapıldı ve
5 grup oluşturulmuştur. 1. Grup Kontrol, 2. Grup Cd, 3. Grup Cd+bal, 4. Grup
Cd+polen, 5. Grup Cd+bal+polen şeklinde düzenlenmiştir. Uygulama 6 hafta
sürmüştür. Uygulama sonrası doku GSH-Px, KAT, GSH ve MDA düzeyleri ölçülmüştür.
Yapılan istatistiksel değerlendirmede kontrol grubunda, Cd grubuna kıyasla,
doku GSH-Px, KAT ve MDA düzeyleri önemli bulunurken, GSH düzeyinin ise önemsiz
olduğu bulunmuştur. GSH-Px ve KAT aktivitesi; Cd grubu ile Cd+bal, Cd+polen ve
Cd+bal+polen gruplarında önemli bulunmuş. MDA düzeyi; Cd grubu ile Cd+bal,
Cd+polen ve Cd+bal+polen gruplarında önemli bulunurken, GSH düzeyinin ise tüm
gruplarda önemsiz olduğu gözlenmiştir

Keywords

Antioksidan, Kadmiyum, Bal, Lipit Peroksidasyon, Polen, Rat

he Effect of Honey and Pollen on Lipid Peroxidation and Some Antioxidants Against Experimental Liver Damage With Cadmium

Abstract

The aim of this study was to determine the
changes in cadmium (Cd) expose rats in liver tissue by giving honey and pollen
to glutathione peroxidase (GSH-Px), catalase (CAT), glutathione (GSH) and
malondialdehyde (MDA).  The study was
performed on rats and five groups were formed. The groups were designed as
following; Group 1: Control, Group 2: Cd administered, Group 3: Cd+honey, Group
4: Cd+pollen, Group 5: Cd+honey+pollen. The application was lasted for six
weeks. At the and of the study, tissue samples were collected and the levels of
GSH-Px, CAT, GSH and MDA were measured. After statistical analyses, while the
differences of amount of tissue GSH-Px, CAT and MDA levels between control and
Cd groups were statistically important, the GSH levels were not. Activities of
GSH-Px and CAT were important in Cd+honey, Cd+pollen and Cd+honey+pollen groups
along with Cd, group. While the level of MDA were important in Cd and Cd+honey,
Cd and Cd+pollen, Cd and Cd+honey+pollen, level of GSH in was found unimportant
in all groups.

Keywords

Antioxidant, Cadmium, Honey, Lipid Peroxidation, Pollen, Rat

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