Karbonhidrat ve Yağ Metabolizmasında D-alluloz (D-psikoz)

Abstract

Değişen yaşam koşulları nedeniyle obezite ve obezite ile ilişkili endokrin hastalıkların görülme sıklığı artmıştır. Bu hastalıkların önlenmesinde yaşam tarzı değişikliklerine ek tedavi seçenekleri aranmaya başlamıştır. D-alluloz fruktozun 3. karbon epimeridir ve doğada nadiren bulunmaktadır. D- alluloz, güçlü antioksidan etkileri, bağırsak sindirim enzimlerine karşı inhibe edici aktivitesi, hepatik çekirdekten sitoplazmaya glukokinazın translokasyonu ve intestinal mukoza yoluyla glukozla rekabetçi transport gibi çeşitli mekanizmalar yoluyla aktivite göstermektedir. Ayrıca, yağların metabolizması ile ilgili olarak antihiperlipidemik, antihipertrigliseridemik etkileri de bulunmaktadır. D-alluloz ile ilgili ratlar üzerinde yapılan toksisite çalışmalarında herhangi bir yan etkisi gösterilmemiş ve güvenli olarak kabul edilmiştir. Oral yol ile alınan monosakkaritlerin emilimini azaltması, yağ asidi oksidasyonunu arttırırken, glukoz oksidasyonunu baskılaması gibi etkilerinden dolayı obezite ve ilişkili hastalıkların tedavisinde yaşam tarzı değişikliği ile beraber alternatif bir tedavi yöntemi olarak düşünülebilir.

Keywords

• Obezite,diyabet,karbonhidrat metabolizması,lipid metabolizması

D-allulose (D-psicose) in Carbohydrate and Lipid Metabolism

Abstract

Due to changing living conditions, the incidence of obesity and endocrine diseases related to obesity has increased. In addition to lifestyle changes, alternative treatment options are being sought in the prevention of these diseases. D-allulose is the 3rd carbon epimer of fructose and is rarely found in nature. D-allulose shows activity through various mechanisms such as strong antioxidant effects, inhibitory activity against intestinal digestive enzymes, translocation of glucokinase from hepatic nucleus to cytoplasm and competitive transport by glucose through intestinal mucosa. In addition, there are antihyperlipidemic, antihypertriglyceridemic effects related to lipid metabolism. Toxicity studies on D-allulose-related rats did not show any side effects and were considered safe. Reducing absorption of oral monosaccharides can be thought of as an alternative treatment modality with obesity and lifestyle changes due to its effects such as suppressing glucose oxidation while increasing fatty acid oxidation.

Keywords

• Obesity,diabetes mellitus,carbohydrate metabolism,lipid metabolism

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