To Evaluate the Role of Systemic Inflammation on Conjunctival Pteryigum Etiopathogenesis

Abstract

Aim: To assess the complete blood count parameters and blood-based systemic inflammatory markers in patients with conjunctival pterygium.

Materials and Methods: Thirty patients with conjunctival pterygium and 31 age and sex-matched control subjects included in the study. All patients underwent detailed ophthalmologic examination. Pterygium was also graded in pterygium group. Serum samples were obtained from all subjects, and neutrophil\lymphocyte ratio, platelet\lymphocyte ratio and systemic immune-inflammation index were calculated. It is examined whether or not there exits an association between groups in terms of neutrophil count\percentage, lymphocyte count\percentage, hemoglobin, red blood cell count, white blood cell count, mean platelet volume, red cell distribution width, platelet count, neutrophil\lymphocyte ratio, platelet\lymphocyte ratio and systemic immune-inflammation index. The statistical assessment was performed with the assistance of Pearson’s Chi-square test, Independent samples t-test, Mann-Whitney U test, Pearson and Spearman correlation analysis. P<0.05 was considered statistically significant.

Results: The groups were similar in terms of cell counts. Although neutrophil\lymphocyte ratio and platelet\lymphocyte ratio are slightly higher in pterygium group, this difference is not statistically significant (respectively P=0.141, P=0.480). Systemic immune-inflammation index was similar between groups (P=0.897). Moreover, no statistically significant correlation found among complete blood count parameters, neutrophil\lymphocyte ratio, platelet\lymphocyte ratio, systemic immune-inflammation index and grade of pterygium in the pterygium group.

Conclusion: According to our study results, no evidence supporting potential systemic inflammatory origin of pterygium was found. Further randomized studies with larger sample size are needed to discover if there is a relationship between these two entities.

Keywords

• Blood cell count,conjunctiva,inflammation,lymphocytes,neutrophils,pterygium

Konjonktival Pterjium Etyopatogenezinde Sistemik İnflamasyonun Rolünün Değerlendirilmesi

Abstract

Amaç: Konjonktival pterjiumlu hastalarda hemogram parametreleri ve kan temelli sistemik inflamasyon belirteçlerinin düzeylerinin incelenmesidir.

Gereç ve Yöntemler: Çalışmaya konjonktival pterjiumu olan 30 hasta ve yaş-cinsiyet uyumlu 31 sağlıklı gönüllü dahil edildi. Tüm olgulara detaylı oftalmolojik muayene yapıldı. Ayrıca pterjium grubundaki olgularda pterjium derecelendirilmesi yapıldı. Tüm olgulardan serum örnekleri toplandı ve nötrofil/lenfosit oranı, platelet/lenfosit oranı ve sistemik immün-inflamasyon indeksi hesaplandı. Gruplar arasında nötrofil sayı-yüzdesi, lenfosit sayı-yüzdesi, hemoglobin, eritrosit sayısı, lökosit sayısı, ortalama trombosit hacmi, eritrosit dağılım genişliği, trombosit sayısı, nötrofil/lenfosit oranı, platelet/lenfosit oranı, sistemik immün-inflamasyon indeksi arasında ilişki olup olmadığı incelendi. İstatistiksel analizde Ki-kare testi, Bağımsız örneklemler t-testi, Mann-Whitney U testi, Pearson ve Spearman korelasyon analizleri kullanıldı. P<0.05 düzeyi istatistiksel olarak anlamlı kabul edildi.

Bulgular: Gruplar hücre sayıları açısından benzerdi. Nötrofil/lenfosit oranı ve platelet/lenfosit oranı pterjium grubunda hafifçe yüksek olmakla birlikte bu fark istatistiksel açıdan anlamlı değildi (sırasıyla P=0.141, P=0.480). Sistemik immün-inflamasyon indeksi gruplar arasında benzerdi (P=0.897). Ayrıca, pterjium grubunda korelasyon analizinde de hemogram parametreleri, nötrofil/lenfosit oranı, platelet/lenfosit oranı, sistemik immün-inflamasyon indeksi ve pterjium derecesi arasında istatistiksel olarak anlamlı ilişki olmadığı görüldü.

Sonuç: Çalışmamızın sonuçlarına göre pterjiumun sistemik inflamatuar etiyolojisini destekleyebilecek kanıt bulunamamıştır. Bu iki antite arasında ilişki olup olmadığını kesin olarak ortaya koyabilmek için geniş hasta popülasyonlarında yapılacak ileri randomize çalışmalara ihtiyaç vardır.

Keywords

• İnflamasyon,kan hücresi sayımı,konjonktiva,lenfositler,nötrofiller,piterjium

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