Gebe Kadınlarda Toxoplasma, Rubella ve Sitomegalovirüs Serum Antikorlarının Sıklığı

Abstract

Amaç: Gebelik esnasında geçirilen enfeksiyonlar anne ve fetüs açısından morbidite ve mortalite nedenlerinden biridir. TORCH konjenital enfeksiyonlara neden olan mikroorganizmalardır. TORCH enfeksiyonunun önlenmesi ve tedavisi, anne ve çocuk sağlığı için çok önemlidir. Bu çalışmada gebe kadınlar arasında bu enfeksiyonların seroprevalansını belirlemeyi amaçladık. Gereç ve Yöntemler: Toplam 1371 gebe kadının laboratuvar verileri retrospektif olarak değerlendirildi. Toxoplasma, Rubella ve Cytomegalovirus IgM ve IgG antikorları, Carbonylmetalloimmunoassay metodu ile test edildi. Bulgular: Laboratuvar verileri incelenen gebe kadınların yaşları 17 ile 47 arasında değişmekte olup, yaş ortalaması 30,1 ± 5,2 idi. Toxoplasma IgG antikoru %36,3 pozitif bulunurken, %1 oranında ise Toxoplasma IgM antikoru pozitifti bulundu. Rubella IgG seropozitifliği %94,3 iken Rubella IgM % 0,7 oranında saptandı. CMV IgG ve IgM pozitiflikleri sırasıyla %94,1 ve %0,9 olarak tespit edildi. Sonuç: Antenatal risk gruplarının saptanması konjenital sendromların önlenmesinde önemli bir adımdır. Bu yüzden öncelikle o bölgeye ait seropozitiflik oranlarının bilinmesi çok önemlidir. Yaygın popülasyon taraması, TORCH ajanları nedeniyle konjenital enfeksiyonların önlenmesine katkıda bulunabilir. Prevalans yüksek olmadığı için Toxoplasma gondii taraması önerilebilir. Yüksek seroprevalans nedeniyle CMV taraması anlamlı değildir. Anti-rubella IgG seropozitifliğinin yüksek olması bu bölgedeki gebelerin bağışıklık düzeyinin yüksek olduğunu göstermektedir.

Keywords

• Seroprevalans
• Gebelik
• Toksoplazmozis
• Rubella
• Sitomegalovirüs

Prevalence of Serum Antibodies to Toxoplasma, Rubella, Cytomegalovirus among Pregnant Women

Abstract

Aim: Infections during pregnancy are one of the causes of morbidity and mortality for mother and fetus. TORCH are the microorganisms that cause congenital infections. Prevention and treatment of TORCH infection is very important for maternal and child health. In this study, we aimed to determine the seroprevalence of these infections among pregnant women. Material and Methods: Laboratory data of 1371 pregnant women were evaluated retrospectively. Toxoplasma, Rubella and Cytomegalovirus IgM and IgG antibodies were tested by the carbonylmetalloimmunoassay method. Results: The ages of pregnant women whose laboratory data were examined, varied between 17 and 47, and the mean age was 30.1 ± 5.2. Positive Toxoplasma IgG antibody was found 36.3%, while 1.0% were positive for the Toxoplasma IgM antibody. Rubella IgG seropositivity was found 94.3%, and Rubella IgM was found 0.7%. CMV IgG and IgM positivities were detected in 94.1% and 0.9% respectively. Conclusion: Detection of antenatal risk groups is an important step in the prevention of congenital syndromes. Therefore, it is very important to know the seropositivity rates of that region. The common population screening may contribute to the prevention of congenital infections due to TORCH agents. Toxoplasma gondii screening can be recommended because the prevalence is not high. CMV screening is not significant due to high seroprevalence. High anti-rubella IgG seropositivity shows that pregnant women in this region have high immunity levels.

Keywords

• Seroprevelence
• Pregnancy
• Toxoplasmosis
• Rubella
• Cytomegalovirus

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