Mevsimsel Alerjik Konjonktivitli Çocuklarda Sistemik İnflamasyon Biyobelirteçlerinin İncelenmesi

Abstract

Amaç: Oküler alerjinin en sık formu olan mevsimsel alerjik konjonktivit ağırlıklı olarak genç popülasyonu etkilemesi ve son yıllarda artan insidansı nedeniyle dikkat çekmeye devam etmektedir. Daha çok lokal inflamatuar bir konjonktiva hastalığı olduğu düşünülen bu rahatsızlığın sistemik kökenleri belirsizdir. Bu çalışmada mevsimsel alerjik konjonktivitli çocuklarda tam kan sayımı parametreleri ve kan temelli sistemik inflamasyon biyobelirteçlerinin düzeylerinin incelenmesi amaçlanmıştır.

Gereç ve Yöntemler: Mevsimsel alerjik konjonktivit dışında herhangi bir oküler ya da sistemik hastalığı olmayan 26 çocuk hasta ve yaş-cinsiyet uyumlu 31 sağlıklı gönüllü çalışmaya dahil edildi. Retrospektif olarak olguların son bir ay içindeki hemogram sonuçlarına bakılarak nötrofil sayı/yüzdesi, lenfosit sayı/yüzdesi, hemoglobin, eritrosit sayısı, lökosit sayısı, ortalama trombosit hacmi, eritrosit dağılım genişliği ve trombosit sayıları belirlendi ve nötrofil/lenfosit oranı, trombosit/lenfosit oranı, sistemik immün-inflamasyon indeksi hesaplandı. İstatistiksel değerlendirmede ki-kare testi, bağımsız örneklemler t-testi ve Mann-Whitney U testi kullanıldı.

Bulgular: Gruplar arasında lökosit, eritrosit, trombosit sayı ve yüzdelerinin benzer olduğu görüldü. Hemoglobin, eritrosit dağılım genişliği ve ortalama trombosit hacmi açısından da anlamlı fark saptanmadı. Nötrofil/lenfosit oranı, trombosit/lenfosit oranı ve sistemik immün-inflamasyon indeksi oranları da benzerdi (sırasıyla P=0,848 P=0,276 ve P=0,701).

Sonuç: Mevsimsel alerjik konjonktivitli çocuklarda kan temelli sistemik inflamasyon biyobelirteçlerinin düzeylerinde anlamlı farklılık görülmemiştir. Bu hastalığın sistemik inflamatuar temeline yönelik daha geniş çaplı araştırmalar gereklidir.

Keywords

• Alerji,alerjik konjonktivit,inflamasyon,kan hücresi sayımı,konjonktivit

Investigation of Systemic Inflammation Biomarkers in Children with Seasonal Allergic Conjunctivitis

Abstract

Aim: Seasonal allergic conjunctivitis, the most frequent form of ocular allergy, keeps drawing attention as it predominantly affects the young population and its incidence rate increases recently. The systemic origins of this disorder, which is thought to be a more local inflammatory conjunctival disease, are uncertain. In this study, we aimed to examine the complete blood count parameters and blood-based systemic inflammatory markers in children with seasonal allergic conjunctivitis.

Materials and Methods: 26 children with no ocular or systemic disease apart from seasonal allergic conjunctivitis and 31 age and sex-matched healthy volunteers were included in the study. Retrospectively, by recording the complete blood count for previous month, neutrophil count/percentage, lymphocyte count/percentage, hemoglobin, red blood cell count, white blood cell count, mean platelet volume, red cell distribution width and platelet count were determined and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index were calculated. Chi-square test, independent samples t-test and Mann-Whitney U test were used for statistical evaluation.

Results: The number and percentage of leukocytes, erythrocytes, platelets were observed to be similar in groups. There was no significant difference in terms of hemoglobin, erythrocyte distribution width and mean platelet volume as well. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and systemic immune-inflammation index were also similar (P=0.848 P=0.276 and P=0.701 respectively).

Conclusion: No significant difference was observed in the level of blood-based systemic inflammatory biomarkers in children with seasonal allergic conjunctivitis. Further research is required to explore the systemic inflammatory basis of this disease.

Keywords

• Allergy,allergic conjunctivitis,blood cell count,conjunctivitis,inflammation

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