To Evaluate the Role of Systemic Inflammation on Conjunctival Pteryigum Etiopathogenesis

Year 2019, Volume: 9 Issue: 3, 145 - 149, 30.09.2019

Hanife Tuba Akçam

https://doi.org/10.33631/duzcesbed.590992

Abstract

Aim: To assess the
complete blood count parameters and blood-based systemic inflammatory markers
in patients with conjunctival pterygium.

Materials and Methods: Thirty patients with conjunctival pterygium and 31 age and sex-matched
control subjects included in the study. All patients underwent detailed
ophthalmologic examination. Pterygium was also graded in pterygium group. Serum
samples were obtained from all subjects, and neutrophil\lymphocyte ratio,
platelet\lymphocyte ratio and systemic immune-inflammation index were
calculated. It is examined whether or not there exits an association between
groups in terms of neutrophil count\percentage, lymphocyte count\percentage,
hemoglobin, red blood cell count, white blood cell count, mean platelet volume,
red cell distribution width, platelet count, neutrophil\lymphocyte ratio,
platelet\lymphocyte ratio and systemic immune-inflammation index. The
statistical assessment was performed with the assistance of Pearson’s
Chi-square test, Independent samples t-test, Mann-Whitney U test, Pearson and
Spearman correlation analysis. P<0.05 was considered statistically
significant.

Results: The
groups were similar in terms of cell counts. Although neutrophil\lymphocyte
ratio and platelet\lymphocyte ratio are slightly higher in pterygium group, this difference is not
statistically significant (respectively P=0.141, P=0.480). Systemic
immune-inflammation index was similar between groups (P=0.897). Moreover, no
statistically significant correlation found among complete blood count
parameters, neutrophil\lymphocyte ratio, platelet\lymphocyte ratio, systemic
immune-inflammation index and grade of pterygium in the pterygium group.

Conclusion: According to our study results, no evidence supporting potential
systemic inflammatory origin of pterygium was found. Further randomized studies
with larger sample size are needed to discover if there is a relationship
between these two entities.

Keywords

Blood cell count, conjunctiva, inflammation, lymphocytes, neutrophils, pterygium

Konjonktival Pterjium Etyopatogenezinde Sistemik İnflamasyonun Rolünün Değerlendirilmesi

Abstract

Amaç: Konjonktival
pterjiumlu hastalarda hemogram parametreleri ve kan temelli sistemik
inflamasyon belirteçlerinin düzeylerinin incelenmesidir.

Gereç ve
Yöntemler:
Çalışmaya konjonktival pterjiumu olan 30 hasta ve yaş-cinsiyet uyumlu 31
sağlıklı gönüllü dahil edildi. Tüm olgulara detaylı oftalmolojik muayene
yapıldı. Ayrıca pterjium grubundaki olgularda pterjium derecelendirilmesi
yapıldı. Tüm olgulardan serum örnekleri toplandı ve nötrofil/lenfosit oranı,
platelet/lenfosit oranı ve sistemik immün-inflamasyon indeksi hesaplandı.
Gruplar arasında nötrofil sayı-yüzdesi, lenfosit sayı-yüzdesi, hemoglobin,
eritrosit sayısı, lökosit sayısı, ortalama trombosit hacmi, eritrosit dağılım
genişliği, trombosit sayısı, nötrofil/lenfosit oranı, platelet/lenfosit oranı,
sistemik immün-inflamasyon indeksi arasında ilişki olup olmadığı incelendi.
İstatistiksel analizde Ki-kare testi, Bağımsız örneklemler t-testi,
Mann-Whitney U testi, Pearson ve Spearman korelasyon analizleri kullanıldı.
P<0.05 düzeyi istatistiksel olarak anlamlı kabul edildi.

Bulgular: Gruplar hücre
sayıları açısından benzerdi. Nötrofil/lenfosit oranı ve platelet/lenfosit oranı
pterjium grubunda hafifçe yüksek olmakla birlikte bu fark istatistiksel açıdan
anlamlı değildi (sırasıyla P=0.141, P=0.480). Sistemik immün-inflamasyon
indeksi gruplar arasında benzerdi (P=0.897). Ayrıca, pterjium grubunda
korelasyon analizinde de hemogram parametreleri, nötrofil/lenfosit oranı,
platelet/lenfosit oranı, sistemik immün-inflamasyon indeksi ve pterjium
derecesi arasında istatistiksel olarak anlamlı ilişki olmadığı görüldü.

Sonuç: Çalışmamızın
sonuçlarına göre pterjiumun sistemik inflamatuar etiyolojisini
destekleyebilecek kanıt bulunamamıştır. Bu iki antite arasında ilişki olup
olmadığını kesin olarak ortaya koyabilmek için geniş hasta popülasyonlarında
yapılacak ileri randomize çalışmalara ihtiyaç vardır.

Keywords

İnflamasyon, kan hücresi sayımı, konjonktiva, lenfositler, nötrofiller, piterjium

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