Mevsimsel Alerjik Konjonktivitli Çocuklarda Sistemik İnflamasyon Biyobelirteçlerinin İncelenmesi

Year 2020, Volume: 10 Issue: 2, 201 - 206, 31.05.2020

Hanife Tuba Akçam

https://doi.org/10.33631/duzcesbed.728203

Abstract

Amaç: Oküler alerjinin
en sık formu olan mevsimsel alerjik konjonktivit ağırlıklı olarak genç
popülasyonu etkilemesi ve son yıllarda artan insidansı nedeniyle dikkat çekmeye
devam etmektedir. Daha çok lokal inflamatuar bir konjonktiva hastalığı olduğu
düşünülen bu rahatsızlığın sistemik kökenleri belirsizdir. Bu çalışmada
mevsimsel alerjik konjonktivitli çocuklarda tam kan sayımı parametreleri ve kan
temelli sistemik inflamasyon biyobelirteçlerinin düzeylerinin incelenmesi
amaçlanmıştır.

Gereç ve
Yöntemler: Mevsimsel
alerjik konjonktivit dışında herhangi bir oküler ya da sistemik hastalığı
olmayan 26 çocuk hasta ve yaş-cinsiyet uyumlu 31 sağlıklı gönüllü çalışmaya
dahil edildi. Retrospektif olarak olguların son bir ay içindeki hemogram sonuçlarına
bakılarak nötrofil sayı/yüzdesi, lenfosit sayı/yüzdesi, hemoglobin, eritrosit
sayısı, lökosit sayısı, ortalama trombosit hacmi, eritrosit dağılım genişliği
ve trombosit sayıları belirlendi ve nötrofil/lenfosit oranı, trombosit/lenfosit
oranı, sistemik immün-inflamasyon indeksi hesaplandı. İstatistiksel
değerlendirmede ki-kare testi, bağımsız örneklemler t-testi ve Mann-Whitney U
testi kullanıldı.

Bulgular: Gruplar
arasında lökosit, eritrosit, trombosit sayı ve yüzdelerinin benzer olduğu
görüldü. Hemoglobin, eritrosit dağılım genişliği ve ortalama trombosit hacmi
açısından da anlamlı fark saptanmadı. Nötrofil/lenfosit oranı,
trombosit/lenfosit oranı ve sistemik immün-inflamasyon indeksi oranları da
benzerdi (sırasıyla P=0,848 P=0,276 ve P=0,701).

Sonuç: Mevsimsel
alerjik konjonktivitli çocuklarda kan temelli sistemik inflamasyon
biyobelirteçlerinin düzeylerinde anlamlı farklılık görülmemiştir. Bu hastalığın
sistemik inflamatuar temeline yönelik daha geniş çaplı araştırmalar gereklidir.

Keywords

Alerji, alerjik konjonktivit, inflamasyon, kan hücresi sayımı, konjonktivit

Investigation of Systemic Inflammation Biomarkers in Children with Seasonal Allergic Conjunctivitis

Abstract

Aim: Seasonal allergic conjunctivitis, the most frequent form of ocular allergy,
keeps drawing attention as it predominantly affects the young population and
its incidence rate increases recently. The systemic origins of this disorder,
which is thought to be a more local inflammatory conjunctival disease, are
uncertain. In this study, we aimed to examine the complete blood count
parameters and blood-based systemic inflammatory markers in children with
seasonal allergic conjunctivitis.

Materials and Methods: 26 children with no ocular or systemic disease
apart from seasonal allergic conjunctivitis and 31 age and sex-matched
healthy volunteers were included in the study. Retrospectively, by recording
the complete blood count for previous month, neutrophil count/percentage,
lymphocyte count/percentage, hemoglobin, red blood cell count, white blood cell
count, mean platelet volume, red cell distribution width and platelet count
were determined and neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and
systemic immune-inflammation index were calculated. Chi-square test,
independent samples t-test and Mann-Whitney U test were used
for statistical evaluation.

Results: The number and percentage of leukocytes, erythrocytes, platelets
were observed to be similar in groups. There was no significant difference
in terms of hemoglobin, erythrocyte distribution width and mean platelet volume
as well. Neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and systemic
immune-inflammation index were also similar (P=0.848 P=0.276 and P=0.701
respectively).

Conclusion: No significant difference was observed in the level of blood-based systemic
inflammatory biomarkers in children with seasonal allergic conjunctivitis.
Further research is required to explore the systemic inflammatory basis of this
disease.

Keywords

Allergy, allergic conjunctivitis, blood cell count, conjunctivitis, inflammation

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