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Facial Contouring and Rejuvenation with the Use of Fat Injection

Year 2021, Volume: 11 Issue: 1, 61 - 66, 21.01.2021
https://doi.org/10.33631/duzcesbed.787229

Abstract

Aim: Reversing the effects of facial aging is achieved through a combination of the best techniques. Minimizing the appearance of fine wrinkles is an important part of treatment, which can include skin resurfacing, intradermal filling injections, or a combination of the two. The search for the ideal filling material continues, but intradermal fat injections can be a cheap and safe alternative to classic intradermal fillers. This study aims to evaluate the feasibility, validity, and reliability of micrograft, nanofat graft, sharp needle intradermal fat grafting (SNIF) technique.
Material and Methods: In this retrospective study, the records of 13 consecutive patients treated over 3 years were reviewed to evaluate the results of the technique including panfacial rejuvenation, contouring, augmentation with fat injection, and its complications.
Results: The results were evaluated by clinical examination and patient photographs. Aesthetically good healing was achieved using microfat graft, nanofat graft, sharp needle emulsified fat with intradermal injection techniques, the results lasted more than 1 year, which exceeded the expected time for absorbable dermal fillers (typically 3 to 6 months). No major complications were encountered; the most common minor complications were bruising and swelling.
Conclusion: Microfat and nanofat grafts, SNIF, are a safe and effective alternative to conventional absorbable dermal fillers for patients who can accept minor discomfort from donor site fat harvesting. Fat harvesting and injection techniques should be done precisely to achieve proper results and prevent complications

References

  • References 1. Coleman SR. Structural fat grafting. Aesthet Surg J 1998; 18(5): 386, 8. 1998/09/01. doi: 10.1016/S1090-820X(98)70098-6.
  • 2. Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 2006; 118(3 Suppl): 108S-20S. 2006/08/29. doi: 10.1097/01.prs.0000234610.81672.e7.
  • 3. Coleman SR. Facial augmentation with structural fat grafting. Clin Plast Surg 2006; 33(4): 567-77. 2006/11/07. doi: 10.1016/j.cps.2006.09.002.
  • 4. Li X, Kubiak CA, Yang X, Kemp SWP, Cederna PS, Ma J. Forehead Fat Grafting: Asian Facial Contouring and Augmentation. Plast Reconstr Surg 2019; 144(5): 1057-65. 2019/11/07. doi: 10.1097/PRS.0000000000006122.
  • 5. Lindenblatt N, van Hulle A, Verpaele AM, Tonnard PL. The Role of Microfat Grafting in Facial Contouring. Aesthet Surg J 2015; 35(7): 763-71. 2015/06/04. doi: 10.1093/asj/sjv083.
  • 6. Serra-Mestre JM, Serra-Renom JM, Martinez L, Almadori A, D'Andrea F. Platelet-rich plasma mixed-fat grafting: a reasonable prosurvival strategy for fat grafts? Aesthetic Plast Surg 2014; 38(5): 1041-9. 2014/07/17. doi: 10.1007/s00266-014-0374-7.
  • 7. Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2013; 132(4): 1017-26. 2013/06/21. doi: 10.1097/PRS.0b013e31829fe1b0.
  • 8. Zeltzer AA, Tonnard PL, Verpaele AM. Sharp-needle intradermal fat grafting (SNIF). Aesthet Surg J 2012; 32(5): 554-61. 2012/06/30. doi: 10.1177/1090820X12445082.
  • 9. Friji MT. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2014; 134(2): 333e-4e. 2014/07/30. doi: 10.1097/PRS.0000000000000333.
  • 10. Memar O, Nezamabadi A, Milani BY, Milani FY, Djalilian A. Nanofat grafting: basic research and clinical application. Plast Reconstr Surg 2014; 133(5): 728e. 2014/04/30. doi: 10.1097/PRS.0000000000000135.
  • 11. Tonnard P, Verpaele A, Carvas M. Fat Grafting for Facial Rejuvenation with Nanofat Grafts. Clin Plast Surg 2020; 47(1): 53-62. 2019/11/20. doi: 10.1016/j.cps.2019.08.006.
  • 12. Illouz YG. Body contouring by lipolysis: a 5-year experience with over 3000 cases. Plast Reconstr Surg 1983; 72(5): 591-7. 1983/11/01. doi: 10.1097/00006534-198311000-00001.
  • 13. Coleman SR. Long-term survival of fat transplants: controlled demonstrations. Aesthetic Plast Surg 1995; 19(5): 421-5. 1995/09/01. doi: 10.1007/BF00453875.
  • 14. Fawzy El-Sayed KM, Dorfer C, Fandrich F, Gieseler F, Moustafa MH, Ungefroren H. Adult mesenchymal stem cells explored in the dental field. Adv Biochem Eng Biotechnol 2013; 130: 89-103. 2012/09/01. doi: 10.1007/10_2012_151.
  • 15. Oh JS, Park IS, Kim KN, Yoon DH, Kim SH, Ha Y. Transplantation of an adipose stem cell cluster in a spinal cord injury. Neuroreport 2012; 23(5): 277-82. 2012/02/18. doi: 10.1097/WNR.0b013e3283505ae2.
  • 16. Okura H, Saga A, Soeda M, Miyagawa S, Sawa Y, Daimon T, et al. Intracoronary artery transplantation of cardiomyoblast-like cells from human adipose tissue-derived multi-lineage progenitor cells improve left ventricular dysfunction and survival in a swine model of chronic myocardial infarction. Biochem Biophys Res Commun 2012; 425(4): 859-65. 2012/08/18. doi: 10.1016/j.bbrc.2012.08.004.
  • 17. Puissant B, Barreau C, Bourin P, Clavel C, Corre J, Bousquet C, et al. Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005; 129(1): 118-29. 2005/04/02. doi: 10.1111/j.1365-2141.2005.05409.x.
  • 18. Toplu G, Ozcelik D, Serin M, Erdem H, Topacoglu AT. Adipose Tissue-Derived Stromal Vascular Fraction Increases Osteogenesis in an Experimental Design Zygomatic Bone Defect Model. J Craniofac Surg 2017; 28(8): 2179-82. 2017/09/25. doi: 10.1097/SCS.0000000000003980.
  • 19. Turkseven A, Ozcelik D, Calis M, Celik HH, Yilmaz F, Onbas O, et al. Does Periosteal Graft Combined With Platelet-Rich Plasma Enhance the Healing of Bone Defect? J Craniofac Surg 2018; 29(4): 1072-80. 2018/02/14. doi: 10.1097/SCS.0000000000004229.
  • 20. Yoo KH, Jang IK, Lee MW, Kim HE, Yang MS, Eom Y, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cell Immunol 2009; 259(2): 150-6. 2009/07/18. doi: 10.1016/j.cellimm.2009.06.010.
  • 21. Zhou B, Yuan J, Zhou Y, Ghawji M, Jr., Deng YP, Lee AJ, et al. Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. Clin Immunol 2011; 141(3): 328-37. 2011/09/29. doi: 10.1016/j.clim.2011.08.014.
  • 22. Obagi S, Willis C. Autologous Fat Augmentation of the Face. Atlas Oral Maxillofac Surg Clin North Am 2018; 26(1): 41-50. 2018/01/25. doi: 10.1016/j.cxom.2017.10.004.
  • 23. Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg 2007; 119(7): 2219-27; discussion 28-31. 2007/05/24. doi: 10.1097/01.prs.0000265403.66886.54.
  • 24. Carraway JH. Commentary on: Sharp-needle intradermal fat grafting (SNIF). Aesthet Surg J 2012; 32(5): 562-3. 2012/06/30. doi: 10.1177/1090820X12445084.
  • 25. De Boulle K. Management of complications after implantation of fillers. J Cosmet Dermatol 2004; 3(1): 2-15. 2006/12/14. doi: 10.1111/j.1473-2130.2004.00058.x.
  • 26. Zhanqiang L. Fat Grafting for Pan-Facial Contouring in Asians: A Goal-Oriented Approach Based on the Facial Fat Compartments. Clin Plast Surg 2020; 47(1): 111-7. 2019/11/20. doi: 10.1016/j.cps.2019.08.014.
  • 27. Marten TJ, Elyassnia D. Fat grafting in facial rejuvenation. Clin Plast Surg 2015; 42(2): 219-52. 2015/04/02. doi: 10.1016/j.cps.2014.12.003.

Yağ Enjeksiyonunun Yüze Kontür Verme ve Yüz Gençleştirmede Kullanımı

Year 2021, Volume: 11 Issue: 1, 61 - 66, 21.01.2021
https://doi.org/10.33631/duzcesbed.787229

Abstract

Amaç: Yüz yaşlanmasının etkilerini tersine çevirmek en iyi tekniklerin bir kombinasyonu ile elde edilir. İnce kırışıklıkların görünümünü en aza indirmek, yüzey yenileme, intradermal dolgu enjeksiyonları veya ikisinin bir kombinasyonunu içerebilen tedavinin önemli bir parçasıdır. İdeal dolgu malzemesi arayışı devam etmektedir, ancak intradermal yağ enjeksiyonları klasik intradermal dolgulara ucuz ve güvenli bir alternatif olabilir. Bu çalışmanın amacı mikrogreft, nanogreft, keskin iğne intradermal yağ greftleme (SNIF) tekniğinin fizibilitesini, geçerliliğini ve güvenilirliğini değerlendirmektir.
Gereç ve Yöntemler: Çalışmamızda, 3 yıllık bir süre içinde tedavi edilen 13 ardışık hastanın kayıtları panfasiyal gençleştirme, kontür verme, augmente etme amaçlı yağ alma ve verme tekniğini ve komplikasyonlar dahil sonuçlarını değerlendirmek için gözden geçirildi.
Bulgular: Sonuçlar klinik muayene ve hasta fotoğrafları ile değerlendirildi. Mikroyağ grefti, nanoyağ grefti, keskin iğne ile emülsifiye edilmiş yağ ile intradermal enjeksiyon teknikleri kullanılarak estetik açıdan iyi iyileşme sağlandı, sonuçlar 1 yıldan fazla sürdü, bu da emilebilir dermal dolgu maddeleri (tipik olarak 3 ila 6 ay) için beklenen süreyi aştı. Hiçbir önemli komplikasyon oluşmadı; en sık görülen küçük komplikasyonlar morarma ve şişlikti.
Sonuç: Mikroyağ ve nanoyağ grefti, SNIF, donör bölgesinden yağ alımındaki küçük rahatsızlığı kabul edebilen hastalar için, klasik emilebilir dermal dolgu maddelerine güvenli ve etkili bir alternatiftir. Yağ alma ve enjeksiyon teknikleri uygun sonuçlar elde etmek ve komplikasyonları önlemek için hassas bir şekilde yapılmalıdır.

References

  • References 1. Coleman SR. Structural fat grafting. Aesthet Surg J 1998; 18(5): 386, 8. 1998/09/01. doi: 10.1016/S1090-820X(98)70098-6.
  • 2. Coleman SR. Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 2006; 118(3 Suppl): 108S-20S. 2006/08/29. doi: 10.1097/01.prs.0000234610.81672.e7.
  • 3. Coleman SR. Facial augmentation with structural fat grafting. Clin Plast Surg 2006; 33(4): 567-77. 2006/11/07. doi: 10.1016/j.cps.2006.09.002.
  • 4. Li X, Kubiak CA, Yang X, Kemp SWP, Cederna PS, Ma J. Forehead Fat Grafting: Asian Facial Contouring and Augmentation. Plast Reconstr Surg 2019; 144(5): 1057-65. 2019/11/07. doi: 10.1097/PRS.0000000000006122.
  • 5. Lindenblatt N, van Hulle A, Verpaele AM, Tonnard PL. The Role of Microfat Grafting in Facial Contouring. Aesthet Surg J 2015; 35(7): 763-71. 2015/06/04. doi: 10.1093/asj/sjv083.
  • 6. Serra-Mestre JM, Serra-Renom JM, Martinez L, Almadori A, D'Andrea F. Platelet-rich plasma mixed-fat grafting: a reasonable prosurvival strategy for fat grafts? Aesthetic Plast Surg 2014; 38(5): 1041-9. 2014/07/17. doi: 10.1007/s00266-014-0374-7.
  • 7. Tonnard P, Verpaele A, Peeters G, Hamdi M, Cornelissen M, Declercq H. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2013; 132(4): 1017-26. 2013/06/21. doi: 10.1097/PRS.0b013e31829fe1b0.
  • 8. Zeltzer AA, Tonnard PL, Verpaele AM. Sharp-needle intradermal fat grafting (SNIF). Aesthet Surg J 2012; 32(5): 554-61. 2012/06/30. doi: 10.1177/1090820X12445082.
  • 9. Friji MT. Nanofat grafting: basic research and clinical applications. Plast Reconstr Surg 2014; 134(2): 333e-4e. 2014/07/30. doi: 10.1097/PRS.0000000000000333.
  • 10. Memar O, Nezamabadi A, Milani BY, Milani FY, Djalilian A. Nanofat grafting: basic research and clinical application. Plast Reconstr Surg 2014; 133(5): 728e. 2014/04/30. doi: 10.1097/PRS.0000000000000135.
  • 11. Tonnard P, Verpaele A, Carvas M. Fat Grafting for Facial Rejuvenation with Nanofat Grafts. Clin Plast Surg 2020; 47(1): 53-62. 2019/11/20. doi: 10.1016/j.cps.2019.08.006.
  • 12. Illouz YG. Body contouring by lipolysis: a 5-year experience with over 3000 cases. Plast Reconstr Surg 1983; 72(5): 591-7. 1983/11/01. doi: 10.1097/00006534-198311000-00001.
  • 13. Coleman SR. Long-term survival of fat transplants: controlled demonstrations. Aesthetic Plast Surg 1995; 19(5): 421-5. 1995/09/01. doi: 10.1007/BF00453875.
  • 14. Fawzy El-Sayed KM, Dorfer C, Fandrich F, Gieseler F, Moustafa MH, Ungefroren H. Adult mesenchymal stem cells explored in the dental field. Adv Biochem Eng Biotechnol 2013; 130: 89-103. 2012/09/01. doi: 10.1007/10_2012_151.
  • 15. Oh JS, Park IS, Kim KN, Yoon DH, Kim SH, Ha Y. Transplantation of an adipose stem cell cluster in a spinal cord injury. Neuroreport 2012; 23(5): 277-82. 2012/02/18. doi: 10.1097/WNR.0b013e3283505ae2.
  • 16. Okura H, Saga A, Soeda M, Miyagawa S, Sawa Y, Daimon T, et al. Intracoronary artery transplantation of cardiomyoblast-like cells from human adipose tissue-derived multi-lineage progenitor cells improve left ventricular dysfunction and survival in a swine model of chronic myocardial infarction. Biochem Biophys Res Commun 2012; 425(4): 859-65. 2012/08/18. doi: 10.1016/j.bbrc.2012.08.004.
  • 17. Puissant B, Barreau C, Bourin P, Clavel C, Corre J, Bousquet C, et al. Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells. Br J Haematol 2005; 129(1): 118-29. 2005/04/02. doi: 10.1111/j.1365-2141.2005.05409.x.
  • 18. Toplu G, Ozcelik D, Serin M, Erdem H, Topacoglu AT. Adipose Tissue-Derived Stromal Vascular Fraction Increases Osteogenesis in an Experimental Design Zygomatic Bone Defect Model. J Craniofac Surg 2017; 28(8): 2179-82. 2017/09/25. doi: 10.1097/SCS.0000000000003980.
  • 19. Turkseven A, Ozcelik D, Calis M, Celik HH, Yilmaz F, Onbas O, et al. Does Periosteal Graft Combined With Platelet-Rich Plasma Enhance the Healing of Bone Defect? J Craniofac Surg 2018; 29(4): 1072-80. 2018/02/14. doi: 10.1097/SCS.0000000000004229.
  • 20. Yoo KH, Jang IK, Lee MW, Kim HE, Yang MS, Eom Y, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cell Immunol 2009; 259(2): 150-6. 2009/07/18. doi: 10.1016/j.cellimm.2009.06.010.
  • 21. Zhou B, Yuan J, Zhou Y, Ghawji M, Jr., Deng YP, Lee AJ, et al. Administering human adipose-derived mesenchymal stem cells to prevent and treat experimental arthritis. Clin Immunol 2011; 141(3): 328-37. 2011/09/29. doi: 10.1016/j.clim.2011.08.014.
  • 22. Obagi S, Willis C. Autologous Fat Augmentation of the Face. Atlas Oral Maxillofac Surg Clin North Am 2018; 26(1): 41-50. 2018/01/25. doi: 10.1016/j.cxom.2017.10.004.
  • 23. Rohrich RJ, Pessa JE. The fat compartments of the face: anatomy and clinical implications for cosmetic surgery. Plast Reconstr Surg 2007; 119(7): 2219-27; discussion 28-31. 2007/05/24. doi: 10.1097/01.prs.0000265403.66886.54.
  • 24. Carraway JH. Commentary on: Sharp-needle intradermal fat grafting (SNIF). Aesthet Surg J 2012; 32(5): 562-3. 2012/06/30. doi: 10.1177/1090820X12445084.
  • 25. De Boulle K. Management of complications after implantation of fillers. J Cosmet Dermatol 2004; 3(1): 2-15. 2006/12/14. doi: 10.1111/j.1473-2130.2004.00058.x.
  • 26. Zhanqiang L. Fat Grafting for Pan-Facial Contouring in Asians: A Goal-Oriented Approach Based on the Facial Fat Compartments. Clin Plast Surg 2020; 47(1): 111-7. 2019/11/20. doi: 10.1016/j.cps.2019.08.014.
  • 27. Marten TJ, Elyassnia D. Fat grafting in facial rejuvenation. Clin Plast Surg 2015; 42(2): 219-52. 2015/04/02. doi: 10.1016/j.cps.2014.12.003.
There are 27 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Articles
Authors

Gaye Toplu 0000-0002-6899-3788

Dinçer Altınel This is me 0000-0002-8287-7943

Publication Date January 21, 2021
Submission Date August 28, 2020
Published in Issue Year 2021 Volume: 11 Issue: 1

Cite

APA Toplu, G., & Altınel, D. (2021). Facial Contouring and Rejuvenation with the Use of Fat Injection. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 11(1), 61-66. https://doi.org/10.33631/duzcesbed.787229
AMA Toplu G, Altınel D. Facial Contouring and Rejuvenation with the Use of Fat Injection. J DU Health Sci Inst. January 2021;11(1):61-66. doi:10.33631/duzcesbed.787229
Chicago Toplu, Gaye, and Dinçer Altınel. “Facial Contouring and Rejuvenation With the Use of Fat Injection”. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 11, no. 1 (January 2021): 61-66. https://doi.org/10.33631/duzcesbed.787229.
EndNote Toplu G, Altınel D (January 1, 2021) Facial Contouring and Rejuvenation with the Use of Fat Injection. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 11 1 61–66.
IEEE G. Toplu and D. Altınel, “Facial Contouring and Rejuvenation with the Use of Fat Injection”, J DU Health Sci Inst, vol. 11, no. 1, pp. 61–66, 2021, doi: 10.33631/duzcesbed.787229.
ISNAD Toplu, Gaye - Altınel, Dinçer. “Facial Contouring and Rejuvenation With the Use of Fat Injection”. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 11/1 (January 2021), 61-66. https://doi.org/10.33631/duzcesbed.787229.
JAMA Toplu G, Altınel D. Facial Contouring and Rejuvenation with the Use of Fat Injection. J DU Health Sci Inst. 2021;11:61–66.
MLA Toplu, Gaye and Dinçer Altınel. “Facial Contouring and Rejuvenation With the Use of Fat Injection”. Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, vol. 11, no. 1, 2021, pp. 61-66, doi:10.33631/duzcesbed.787229.
Vancouver Toplu G, Altınel D. Facial Contouring and Rejuvenation with the Use of Fat Injection. J DU Health Sci Inst. 2021;11(1):61-6.