CHEMOMETRIC ANALYSIS OF MOXIFLOXACIN AND METRONIDAZOLE IN BINARY DRUG COMBINATIONS WITH SPECTROPHOTOMETRIC METHOD

Year 2017, Volume: 3 Issue: 2, 30 - 37, 30.11.2017

Güzide Pekcan Ertokuş , ÜMİT MURAT Çelik

Abstract

 In this study,
sensitive and accurate spectrophotometric-chemometric methods were developed
for metronidazole and moxifloxacin without any
separation step in pharmaceutical tablets. The examined Alzheimer's drugs are donepezil
and rivastigmine. The used chemometric methods are partial least squares
regression (PLS) and principal component regression (PCR). PLS and PCR were
successfully applied for chemometric analysis of metronidazole and moxifloxacin in synthetic mixtures and pharmaceutical tablets. A
concentration set including binary mixtures of metronidazole and moxifloxacin formed to 24 different combinations were randomly
prepared in 0.1 M HCl. The accuracy and precision of the developed method were
validated by analyzing synthetic mixtures containing the examined drugs. As a
result of the determination, high recoveries and low standard deviations were
found. Absorbance and concentration values were used in Minitab and other
chemometric programs to calculate estimated concentrations with PCR and PLS.  The second step, in drug tablets (Avelox and
Flagy), was calculated amounts for metronidazole
and moxifloxacin.

Keywords

Metronidazole and moxifloxacin, PLS

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