The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury

Mustafa Can Güler; Ayhan Tanyeli

Research Article

Year 2020, Volume: 6 Issue: 1, 46 - 51, 24.06.2020

Mustafa Can Güler Ayhan Tanyeli

Abstract

References

1. Oelsner G, Cohen SB, Soriano D, Admon D, Mashiach S, Carp H. 2003. Minimal surgery for the twisted ischaemic adnexa can preserve ovarian function. Hum Reprod 18:2599-602
2. Vaghasiya J, Sheth N, Bhalodia Y, Manek R. 2011. Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regulatory peptides 166:48-54
3. Sehirli AO, Sener G, Satiroglu H, Ayanoglu-Dulger G. 2003. Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat. Journal of nephrology 16:75-80
4. Kurose I, Granger DN. 1994. Evidence implicating xanthine oxidase and neutrophils in reperfusion-induced microvascular dysfunction. Annals of the New York Academy of Sciences 723:158-79
5. Sozer S, Diniz G, Lermioglu F. 2011. Effects of celecoxib in young rats: histopathological changes in tissues and alterations of oxidative stress/antioxidant defense system. Archives of pharmacal research 34:253-9
6. Del Rio D, Stewart AJ, Pellegrini N. 2005. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutrition, metabolism, and cardiovascular diseases : NMCD 15:316-28
7. Bozkurt S, Arikan DC, Kurutas EB, Sayar H, Okumus M, et al. 2012. Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation. J Pediatr Surg 47:1735-41
8. Yasar M, Erdi I, Kaya B. 2018. The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats. Bratisl Lek Listy 119:167-74
9. McCord JM. 1985. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159-63
10. Eltzschig HK, Collard CD. 2004. Vascular ischaemia and reperfusion injury. British medical bulletin 70:71-86
11. Dinarello CA. 2000. Proinflammatory cytokines. Chest 118:503-8
12. Eraslan E, Tanyeli A, Polat E, Polat E. 2019. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol 234:4572-81
13. Eraslan E, Tanyeli A, Polat E, Yetim Z. 2019. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. J Cell Biochem 120:17159-66
14. Ozturk D, Erdogan DG, Tanyeli A, Çomaklı S, Baylan H, Polat E. 2019. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 44:539
15. Tanyeli A, author N, Guler M, Eraslan E, Eki F, et al. 2020. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 9:246
16. Dogan C, Halici Z, Topcu A, Cadirci E, Karakus E, et al. 2016. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. Andrologia 48:441-52
17. Altavilla D, Squadrito F, Campo GM, Squadrito G, Arlotta M, et al. 1999. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. European journal of pharmacology 369:49-55
18. Saija A, Tomaino A, Pellegrino ML, Giuffrida N, Trombetta D, Castelli F. 2001. In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G. Life sciences 68:1351-66
19. Garvin PJ, Niehoff ML, Robinson SM, Mistry B, Esterl R, et al. 1997. Renoprotective effects of the 21-aminosteroid U74389G in ischemia-reperfusion injury and cold storage preservation. Transplantation 63:194-201
20. de Oca J, Cuadrado S, Vallet J, Benasco C, Martín E, et al. 1998. Protective effects of lazaroid U74389G on intestinal graft after heterotopic small bowel transplantation in rats. The Journal of surgical research 75:18-23
21. Fukuma K, Marubayashi S, Okada K, Yamada K, Kimura A, Dohi K. 1999. Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice. Surgery 125:421-30
22. Ekinci Akdemir FN, Yildirim S, Kandemir FM, Tanyeli A, Kucukler S, Bahaeddin Dortbudak M. 2019. Protective effects of gallic acid on doxorubicin-induced cardiotoxicity; an experimantal study. Archives of physiology and biochemistry:1-8
23. Sun Y, Oberley LW, Li Y. 1988. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 34:497-500
24. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 95:351-8
25. Bradley PP, Priebat DA, Christensen RD, Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
26. Houry D, Abbott JT. 2001. Ovarian torsion: a fifteen-year review. Ann Emerg Med 38:156-9
27. Jennings RB, Murry CE, Steenbergen C, Jr., Reimer KA. 1990. Development of cell injury in sustained acute ischemia. Circulation 82:Ii2-12
28. Hibbard LT. 1985. Adnexal torsion. Am J Obstet Gynecol 152:456-61
29. Mashiach S, Bider D, Moran O, Goldenberg M, Ben-Rafael Z. 1990. Adnexal torsion of hyperstimulated ovaries in pregnancies after gonadotropin therapy. Fertil Steril 53:76-80
30. Ergun Y, Koc A, Dolapcioglu K, Akaydin Y, Dogruer G, et al. 2010. The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary. Eur J Obstet Gynecol Reprod Biol 152:186-90
31. Sak ME, Soydinc HE, Sak S, Evsen MS, Alabalik U, et al. 2013. The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. Int J Surg 11:967-70
32. Gutteridge JM. 1993. Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Commun 19:141-58
33. Girotti AW. 1998. Lipid hydroperoxide generation, turnover, and effector action in biological systems. J Lipid Res 39:1529-42
34. A Tanyeli DG. 2019. Investigation into the Biochemical Effects of Barbaloin on Renal Tissue in Cecal Ligation and Puncture-Induced Polymicrobial Sepsis Model in Rats. Southern Clinics of Istanbul Eurasia 30:285-9
35. Ayhan Tanyeli DG. 2019. Alliin mitigates Cecal Ligation Puncture (CLP)-induced lung injury through antioxidant and antiinflammatory effects. Turhish Journal of Sciences 4:46-59
36. Ekinci Akdemir FN TA. 2019. The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture. 4:22-9
37. Ayhan Tanyeli EE, Mustafa Can Guler, Saime Ozbek Sebin, Demet Celebi, Fatma Betul Ozgeris, Erdem Toktay. 2019. Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats. Medicine Science International Medical Journal 8:644-50
38. Zhang Y, Zhu J, Guo L, Zou Y, Wang F, et al. 2017. Cholecystokinin protects mouse liver against ischemia and reperfusion injury. International immunopharmacology 48:180-6
39. Raup-Konsavage WM, Gao T, Cooper TK, Morris SM, Jr., Reeves WB, Awad AS. 2017. Arginase-2 mediates renal ischemia-reperfusion injury. American journal of physiology. Renal physiology 313:F522-f34
40. Hasturk A, Atalay B, Calisaneller T, Ozdemir O, Oruckaptan H, Altinors N. 2009. Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia/reperfusion injury and correlation with tissue damage. Turkish neurosurgery 19:353-9
41. Granger DN, Kvietys PR. 2015. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol 6:524-51
42. Halliwell B, Aeschbach R, Löliger J, Aruoma OI. 1995. The characterization of antioxidants. Food Chem Toxicol 33:601-17
43. Yigiter M, Halici Z, Odabasoglu F, Keles ON, Atalay F, et al. 2011. Growth hormone reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. European journal of obstetrics, gynecology, and reproductive biology 157:94-100
44. Bakan V, Ciralik H, Tolun FI, Atli Y, Mil A, Ozturk S. 2009. Protective effect of erythropoietin on torsion/detorsion injury in rat model. Journal of pediatric surgery 44:1988-94
45. Rabus M, Demirbag R, Sezen Y, Konukoglu O, Yildiz A, et al. 2008. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 36:536-40
46. Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103-11
47. Yazici S, Demirtas S, Guclu O, Karahan O, Yavuz C, et al. 2014. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 29:450-5
48. Andreadou I, Poussios D, Papalois A, Gavalakis N, Aroni K, et al. 2003. Effect of U-74389G (21-lazaroid) on intestinal recovery after acute mesenteric ischemia and reperfusion in rats. In vivo (Athens, Greece) 17:463-8
49. Tanyeli A, Ekinci Akdemir F, Eraslan E, Guler M, Sebin S, Gülçin I. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal 9:166-73
50. Topdagi O, Tanyeli A, Akdemir FNE, Eraslan E, Guler MC, Comakli S. 2020. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences 242:117217
51. Derya Guzel AT. 2018. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal 8:410-5
52. Derya GÜZEL AT. 2018. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal 8:260-5
53. Ö TOPDAĞI AT, FNE AKDEMİR, DG ERDOĞAN, MC GÜLER. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 4
54. Ayhan Tanyeli FNEA, Ersen Eraslan, Mustafa Can Güler, Saime Özbek Sebin, İlhami Gülçin. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal 9:166-73

The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury

Year 2020, Volume: 6 Issue: 1, 46 - 51, 24.06.2020

Mustafa Can Güler Ayhan Tanyeli

Abstract

Purpose: It was planned to search the possible beneficial effects of Lazaroid U-74389G (Laz) on ovarian tissue injury caused by bilateral ovarian torsion detorsion (T/D) in the experimental rat model. Material and Methods: Wistar type female rats were allocated to 3 groups as randomly. Groups of this research were designed as sham, T/D, and T/D+Laz groups. In sham group, the abdomen was incised and sutured but no intervention was performed. In T/D group, following the incision, T/D model was carried out and the incision was sutured. In treatment group, Laz was administered intraperitoneally at 20 mg/kg dose and later T/D model was established as defined in T/D group. After the detorsion period, rats were sacrificed and ovarian tissues were excised. Results and Conclusion: Oxidant parameters elevated and antioxidant activity declined significantly in T/D group compared to sham group in ovarian tissues. Laz treatment reversed the oxidant and antioxidant parameters. Thereby, Laz protected against ovarian tissue injury in T/D-induced experimental rats.

Keywords

Lazaroid U-74389G, Ovarian Torsion Detorsion, Ovary

References

1. Oelsner G, Cohen SB, Soriano D, Admon D, Mashiach S, Carp H. 2003. Minimal surgery for the twisted ischaemic adnexa can preserve ovarian function. Hum Reprod 18:2599-602
2. Vaghasiya J, Sheth N, Bhalodia Y, Manek R. 2011. Sitagliptin protects renal ischemia reperfusion induced renal damage in diabetes. Regulatory peptides 166:48-54
3. Sehirli AO, Sener G, Satiroglu H, Ayanoglu-Dulger G. 2003. Protective effect of N-acetylcysteine on renal ischemia/reperfusion injury in the rat. Journal of nephrology 16:75-80
4. Kurose I, Granger DN. 1994. Evidence implicating xanthine oxidase and neutrophils in reperfusion-induced microvascular dysfunction. Annals of the New York Academy of Sciences 723:158-79
5. Sozer S, Diniz G, Lermioglu F. 2011. Effects of celecoxib in young rats: histopathological changes in tissues and alterations of oxidative stress/antioxidant defense system. Archives of pharmacal research 34:253-9
6. Del Rio D, Stewart AJ, Pellegrini N. 2005. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutrition, metabolism, and cardiovascular diseases : NMCD 15:316-28
7. Bozkurt S, Arikan DC, Kurutas EB, Sayar H, Okumus M, et al. 2012. Selenium has a protective effect on ischemia/reperfusion injury in a rat ovary model: biochemical and histopathologic evaluation. J Pediatr Surg 47:1735-41
8. Yasar M, Erdi I, Kaya B. 2018. The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats. Bratisl Lek Listy 119:167-74
9. McCord JM. 1985. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 312:159-63
10. Eltzschig HK, Collard CD. 2004. Vascular ischaemia and reperfusion injury. British medical bulletin 70:71-86
11. Dinarello CA. 2000. Proinflammatory cytokines. Chest 118:503-8
12. Eraslan E, Tanyeli A, Polat E, Polat E. 2019. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol 234:4572-81
13. Eraslan E, Tanyeli A, Polat E, Yetim Z. 2019. Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study. J Cell Biochem 120:17159-66
14. Ozturk D, Erdogan DG, Tanyeli A, Çomaklı S, Baylan H, Polat E. 2019. The protective effects of urapidil on lung tissue after intestinal ischemia-reperfusion injury. 44:539
15. Tanyeli A, author N, Guler M, Eraslan E, Eki F, et al. 2020. Barbaloin attenuates ischemia reperfusion-induced oxidative renal injury via antioxidant and anti-inflammatory effects. 9:246
16. Dogan C, Halici Z, Topcu A, Cadirci E, Karakus E, et al. 2016. Effects of amlodipine on ischaemia/reperfusion injury in the rat testis. Andrologia 48:441-52
17. Altavilla D, Squadrito F, Campo GM, Squadrito G, Arlotta M, et al. 1999. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. European journal of pharmacology 369:49-55
18. Saija A, Tomaino A, Pellegrino ML, Giuffrida N, Trombetta D, Castelli F. 2001. In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G. Life sciences 68:1351-66
19. Garvin PJ, Niehoff ML, Robinson SM, Mistry B, Esterl R, et al. 1997. Renoprotective effects of the 21-aminosteroid U74389G in ischemia-reperfusion injury and cold storage preservation. Transplantation 63:194-201
20. de Oca J, Cuadrado S, Vallet J, Benasco C, Martín E, et al. 1998. Protective effects of lazaroid U74389G on intestinal graft after heterotopic small bowel transplantation in rats. The Journal of surgical research 75:18-23
21. Fukuma K, Marubayashi S, Okada K, Yamada K, Kimura A, Dohi K. 1999. Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice. Surgery 125:421-30
22. Ekinci Akdemir FN, Yildirim S, Kandemir FM, Tanyeli A, Kucukler S, Bahaeddin Dortbudak M. 2019. Protective effects of gallic acid on doxorubicin-induced cardiotoxicity; an experimantal study. Archives of physiology and biochemistry:1-8
23. Sun Y, Oberley LW, Li Y. 1988. A Simple Method for Clinical Assay of Superoxide-Dismutase. Clin Chem 34:497-500
24. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for Lipid Peroxides in Animal-Tissues by Thiobarbituric Acid Reaction. Anal Biochem 95:351-8
25. Bradley PP, Priebat DA, Christensen RD, Rothstein G. 1982. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78:206-9
26. Houry D, Abbott JT. 2001. Ovarian torsion: a fifteen-year review. Ann Emerg Med 38:156-9
27. Jennings RB, Murry CE, Steenbergen C, Jr., Reimer KA. 1990. Development of cell injury in sustained acute ischemia. Circulation 82:Ii2-12
28. Hibbard LT. 1985. Adnexal torsion. Am J Obstet Gynecol 152:456-61
29. Mashiach S, Bider D, Moran O, Goldenberg M, Ben-Rafael Z. 1990. Adnexal torsion of hyperstimulated ovaries in pregnancies after gonadotropin therapy. Fertil Steril 53:76-80
30. Ergun Y, Koc A, Dolapcioglu K, Akaydin Y, Dogruer G, et al. 2010. The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary. Eur J Obstet Gynecol Reprod Biol 152:186-90
31. Sak ME, Soydinc HE, Sak S, Evsen MS, Alabalik U, et al. 2013. The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. Int J Surg 11:967-70
32. Gutteridge JM. 1993. Free radicals in disease processes: a compilation of cause and consequence. Free Radic Res Commun 19:141-58
33. Girotti AW. 1998. Lipid hydroperoxide generation, turnover, and effector action in biological systems. J Lipid Res 39:1529-42
34. A Tanyeli DG. 2019. Investigation into the Biochemical Effects of Barbaloin on Renal Tissue in Cecal Ligation and Puncture-Induced Polymicrobial Sepsis Model in Rats. Southern Clinics of Istanbul Eurasia 30:285-9
35. Ayhan Tanyeli DG. 2019. Alliin mitigates Cecal Ligation Puncture (CLP)-induced lung injury through antioxidant and antiinflammatory effects. Turhish Journal of Sciences 4:46-59
36. Ekinci Akdemir FN TA. 2019. The Antioxidant Effect of Fraxin against Acute Organ Damage in Polymicrobial Sepsis Model induced by Cecal Ligation and Puncture. 4:22-9
37. Ayhan Tanyeli EE, Mustafa Can Guler, Saime Ozbek Sebin, Demet Celebi, Fatma Betul Ozgeris, Erdem Toktay. 2019. Investigation of biochemical and histopathological effects of tarantula cubensis D6 on lung tissue in cecal ligation and puncture-induced polymicrobial sepsis model in rats. Medicine Science International Medical Journal 8:644-50
38. Zhang Y, Zhu J, Guo L, Zou Y, Wang F, et al. 2017. Cholecystokinin protects mouse liver against ischemia and reperfusion injury. International immunopharmacology 48:180-6
39. Raup-Konsavage WM, Gao T, Cooper TK, Morris SM, Jr., Reeves WB, Awad AS. 2017. Arginase-2 mediates renal ischemia-reperfusion injury. American journal of physiology. Renal physiology 313:F522-f34
40. Hasturk A, Atalay B, Calisaneller T, Ozdemir O, Oruckaptan H, Altinors N. 2009. Analysis of serum pro-inflammatory cytokine levels after rat spinal cord ischemia/reperfusion injury and correlation with tissue damage. Turkish neurosurgery 19:353-9
41. Granger DN, Kvietys PR. 2015. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol 6:524-51
42. Halliwell B, Aeschbach R, Löliger J, Aruoma OI. 1995. The characterization of antioxidants. Food Chem Toxicol 33:601-17
43. Yigiter M, Halici Z, Odabasoglu F, Keles ON, Atalay F, et al. 2011. Growth hormone reduces tissue damage in rat ovaries subjected to torsion and detorsion: biochemical and histopathologic evaluation. European journal of obstetrics, gynecology, and reproductive biology 157:94-100
44. Bakan V, Ciralik H, Tolun FI, Atli Y, Mil A, Ozturk S. 2009. Protective effect of erythropoietin on torsion/detorsion injury in rat model. Journal of pediatric surgery 44:1988-94
45. Rabus M, Demirbag R, Sezen Y, Konukoglu O, Yildiz A, et al. 2008. Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 36:536-40
46. Erel O. 2005. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 38:1103-11
47. Yazici S, Demirtas S, Guclu O, Karahan O, Yavuz C, et al. 2014. Using oxidant and antioxidant levels to predict the duration of both acute peripheral and mesenteric ischemia. Perfusion 29:450-5
48. Andreadou I, Poussios D, Papalois A, Gavalakis N, Aroni K, et al. 2003. Effect of U-74389G (21-lazaroid) on intestinal recovery after acute mesenteric ischemia and reperfusion in rats. In vivo (Athens, Greece) 17:463-8
49. Tanyeli A, Ekinci Akdemir F, Eraslan E, Guler M, Sebin S, Gülçin I. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Kocaeli Medical Journal 9:166-73
50. Topdagi O, Tanyeli A, Akdemir FNE, Eraslan E, Guler MC, Comakli S. 2020. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life sciences 242:117217
51. Derya Guzel AT. 2018. Investigation of Chlorogenic Acid (Cga) as An Antioxidant in Renal Ischemia-Reperfusion Injury: An Experimental Study. Sakarya Medical Journal 8:410-5
52. Derya GÜZEL AT. 2018. Investigation of Oxidative Damage of Lung Tissue in Experimental Renal Ischemia Reperfusion Model and The Protective Effects of Chlorogenic Acid (CGA). Sakarya Medical Journal 8:260-5
53. Ö TOPDAĞI AT, FNE AKDEMİR, DG ERDOĞAN, MC GÜLER. Higenamine decreases testicular damage injured by ischemia reperfusion: A biochemical study Turkish Journal of Science 4
54. Ayhan Tanyeli FNEA, Ersen Eraslan, Mustafa Can Güler, Saime Özbek Sebin, İlhami Gülçin. 2020. Role of p-Coumaric acid in Alleviating of the Intestinal Ischemia/Reperfusion Injury. Sakarya Medical Journal 9:166-73

There are 54 citations in total.

Details

Primary Language	English
Journal Section	makaleler
Authors	Mustafa Can Güler Ayhan Tanyeli 0000-0002-0095-0917
Publication Date	June 24, 2020
Published in Issue	Year 2020 Volume: 6 Issue: 1

Cite

APA	Güler, M. C., & Tanyeli, A. (2020). The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury. Eastern Anatolian Journal of Science, 6(1), 46-51.
AMA	Güler MC, Tanyeli A. The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury. Eastern Anatolian Journal of Science. June 2020;6(1):46-51.
Chicago	Güler, Mustafa Can, and Ayhan Tanyeli. “The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury”. Eastern Anatolian Journal of Science 6, no. 1 (June 2020): 46-51.
EndNote	Güler MC, Tanyeli A (June 1, 2020) The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury. Eastern Anatolian Journal of Science 6 1 46–51.
IEEE	M. C. Güler and A. Tanyeli, “The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury”, Eastern Anatolian Journal of Science, vol. 6, no. 1, pp. 46–51, 2020.
ISNAD	Güler, Mustafa Can - Tanyeli, Ayhan. “The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury”. Eastern Anatolian Journal of Science 6/1 (June 2020), 46-51.
JAMA	Güler MC, Tanyeli A. The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury. Eastern Anatolian Journal of Science. 2020;6:46–51.
MLA	Güler, Mustafa Can and Ayhan Tanyeli. “The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury”. Eastern Anatolian Journal of Science, vol. 6, no. 1, 2020, pp. 46-51.
Vancouver	Güler MC, Tanyeli A. The Possible Beneficial Effects of Lazaroid U-74389G on Ovarian Injury. Eastern Anatolian Journal of Science. 2020;6(1):46-51.

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