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Monosodyum İodoasetat ile İndüklenen Diz Osteoartriti Modellerinde Bitki Bazlı Tedavilerin Araştırılması

Year 2026, Volume: 7 Issue: 1 , 56 - 85 , 27.03.2026

Seda Koçak , Ekin Celik Kübra Öztürk

https://doi.org/10.46871/eams.1681881
https://izlik.org/JA42DW47XS

Abstract

Diz osteoartriti, diz ekleminde histolojik ve biyokimyasal değişikliklere yol açan bir eklem bozukluğudur. Diz osteoartriti tedavisinde farmakolojik ve farmakolojik olmayan yöntemler uygulanmaktadır. Farmakolojik olmayan yöntemler arasında bitkisel uygulamalar da yer almaktadır. Monosodyum iodoasetat (MIA) uygulaması, diz osteoartriti çalışmalarında sıklıkla kullanılan bir yöntemdir. Bu modellere yönelik çalışmalar, diz bölgesindeki ağrı ve iltihabı azaltmayı, apoptozu önlemeyi ve osteoartritin ilerlemesini yavaşlatmayı amaçlamaktadır. Bu model uygulanırken, bitki ve bitki bazlı uygulamalar da analiz edilmektedir. Derlememizde, monosodyum iodoasetat ile indüklenen diz osteoartriti modellerinde uygulanan bitki ve bitki bazlı tedaviler; kullanılan bitkiler, uygulama şekli, türler, kullanılan MIA miktarı, çözücü, MIA uygulamasından sonra kesim günü ve etkilediği yollar (pathways) açısından ele alınmıştır. Bu çalışmaların derlenmesiyle, preklinik tartışmalara katkı sağlanması amaçlanmaktadır.

Keywords

osteoartirit bitki tedaviler monosodyum iyodoasetat

References

  • 1. Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020;29.
  • 2. Uthman OA. Global, regional, national incidence, prevalence and years lived with disability for 310 acute and chronic diseases and injuries 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1545-602.
  • 3. Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis and rheumatism. 2012;64(6):1697.
  • 4. Aşkın A, Özkan A, Tosun A, Demirdal ÜS, İsnaç F. Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain. The Kaohsiung Journal of Medical Sciences. 2017;33(3):152-8.
  • 5. Vitaloni M, Botto-van Bemden A, Sciortino R, Carné X, Quintero M, Santos-Moreno P, et al. A patients’ view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study. BMC musculoskeletal disorders. 2020;21(1):727.
  • 6. Lee D, Ju M-K, Kim H. Commiphora extract mixture ameliorates monosodium iodoacetateinduced osteoarthritis. Nutrients. 2020;12(5):1477.
  • 7. Lim HJ, Park SI, Bak SG, Cheong SH, Lee S, Baek YB, et al. Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis. Food Sci Nutr. 2020;8(12):6550-6.
  • 8. Madzuki IN, Lau SF, Abdullah R, Mohd Ishak NI, Mohamed S. Vernonia amygdalina inhibited osteoarthritis development by antiinflammatory and anticollagenase pathways in cartilage explant and osteoarthritis-induced rat model. Phytotherapy Research. 2019;33(7):1784-93.
  • 9. Sa L, Wei X, Huang Q, Cai Y, Lu D, Mei R, et al. Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model. Journal of Ethnopharmacology. 2020;259:112883.
  • 10. Fusco R, Siracusa R, Peritore AF, Gugliandolo E, Genovese T, D’Amico R, et al. The role of cashew (Anacardium occidentale L.) nuts on an experimental model of painful degenerative joint disease. Antioxidants. 2020;9(6):511.
  • 11. Bethapudi B, Murugan S, Illuri R, Mundkinajeddu D, Velusami CC. Bioactive turmerosaccharides from Curcuma longa Extract (NR-INF-02): Potential ameliorating effect on osteoarthritis pain. Pharmacognosy magazine. 2017;13(Suppl 3):S623.
  • 12. Zhang H, Ding L, Shi X, Mei W, Huang Z, Zhang L, et al. Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis. Bioengineered. 2021;12(2):12954-64.
  • 13. Choi DJ, Choi S-I, Choi B-R, Lee Y-S, Lee DY, Kim GS. Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats. BMC Complementary and Alternative Medicine. 2019;19(1):325.
  • 14. Chun JM, Lee AY, Moon BC, Choi G, Kim J-S. Effects of Dipsacus asperoides and Phlomis umbrosa Extracts in a Rat Model of Osteoarthritis. Plants. 2021;10(10):2030.
  • 15. Jo HG, Lee GY, Baek CY, Song HS, Lee D. Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Plants (Basel). 2020;10(1).
  • 16. Jhun JY, Na HS, Shin JW, Jung KA, Seo HB, Ryu JY, et al. Notoginseng radix and rehmanniae radix preparata extract combination (YH23537) reduces pain and cartilage degeneration in rats with monosodium iodoacetate-induced osteoarthritis. Journal of Medicinal Food. 2018;21(8):745-54.
  • 17. Bahtiar A, Nurazizah M, Roselina T, Tambunan AP, Arsianti A. Ethanolic extracts of babandotan leaves (Ageratum conyzoides L.) prevents inflammation and proteoglycan degradation by inhibiting TNF-α and MMP-9 on osteoarthritis rats induced by monosodium iodoacetate. Asian Pacific journal of tropical medicine. 2017;10(3):270-7.
  • 18. Lee YM, Son E, Kim SH, Kim OS, Kim DS. Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract. Pharm Biol. 2019;57(1):74-81.
  • 19. Hong JM, Shin JK, Kim JY, Jang MJ, Park SK, Lee JH, et al. BST106 Protects against Cartilage Damage by Inhibition of Apoptosis and Enhancement of Autophagy in Osteoarthritic Rats. Biol Pharm Bull. 2018;41(8):1257-68.
  • 20. Tong L, Yu H, Huang X, Shen J, Xiao G, Chen L, et al. Current understanding of osteoarthritis pathogenesis and relevant new approaches. Bone research. 2022;10(1):60.
  • 21. Brumat P, Kunšič O, Novak S, Slokar U, Pšenica J, Topolovec M, et al. The surgical treatment of osteoarthritis. Life. 2022;12(7):982.
  • 22. Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. Journal of orthopaedic surgery and research. 2016;11(1):19.
  • 23. Kim HL, Lee HJ, Lee D-R, Choi B-K, Yang SH. Herbal composition LI73014F2 alleviates articular cartilage damage and inflammatory response in monosodium iodoacetate-induced osteoarthritis in rats. Molecules. 2020;25(22):5467.
  • 24. Ju L, Hu P, Chen P, Xue X, Li Z, He F, et al. Huoxuezhitong capsule ameliorates MIAinduced osteoarthritis of rats through suppressing PI3K/Akt/NF-κB pathway. Biomedicine & Pharmacotherapy. 2020;129:110471.
  • 25. Shin M-R, Kim H-Y, Choi H-Y, Park KS, Choi HJ, Roh S-S. Boswellia serrata Extract, 5-Loxin®, Prevents Joint Pain and Cartilage Degeneration in a Rat Model of Osteoarthritis Through Inhibition of Inflammatory Responses and Restoration of Matrix Homeostasis. Evidence-based Complementary and Alternative Medicine. 2022;2022(1):3067526.
  • 26. Orhan C, Tuzcu M, Durmus AS, Sahin N, Ozercan IH, Deeh PBD, et al. Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model. Biomedicine & Pharmacotherapy. 2022;151:113052.
  • 27. Aborehab NM, El Bishbishy MH, Refaiy A, Waly NE. A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis. BMC complementary and alternative medicine. 2017;17(1):495.
  • 28. Abdel-Rahman RF, Abd-Elsalam RM, Amer MS, El-Desoky AM, Mohamed SO. Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis. Food & function. 2020;11(9):7960-72.
  • 29. Balkrishna A, Sinha S, Karumuri S, Srivastava J, Haldar S, Varshney A. Peedanil Gold, Herbo-Mineral Formulation, Moderates Cytokine Levels and Attenuates Pathophysiology in Monosodium Iodoacetate Induced Osteoarthritis in SD Rat Model. Front Pharmacol. 2022;13:883475.
  • 30. Lee YM, Son E, Kim SH, Kim DS. Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model. Phytomedicine. 2019;65:153095.
  • 31. Choudhary D, Adhikary S, Ahmad N, Kothari P, Verma A, Trivedi PK, et al. Prevention of articular cartilage degeneration in a rat model of monosodium iodoacetate induced osteoarthritis by oral treatment with Withaferin A. Biomed Pharmacother. 2018;99:151-61.
  • 32. Yimam M, Lee YC, Kim TW, Moore B, Jiao P, Hong M, et al. Analgesic and anti-Inflammatory effect of UP3005, a botanical composition Containing two standardized extracts of Uncaria gambir and Morus alba. Pharmacognosy Res. 2015;7(Suppl 1):S39-46.
  • 33. Kim WK, Chung HJ, Pyee Y, Choi TJ, Park HJ, Hong JY, et al. Effects of intra-articular SHINBARO treatment on monosodium iodoacetate-induced osteoarthritis in rats. Chin Med. 2016;11:17.
  • 34. Kim JK, Park SW, Kang JW, Kim YJ, Lee SY, Shin J, et al. Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Evid Based Complement Alternat Med. 2012;2012:730907.
  • 35. Zhang Y, Zeng Y. Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-κB signal pathway. Drug Dev Res. 2019;80(3):353-9.
  • 36. Murugan S, Bethapudi B, Purusothaman D, Chandrasekaran PR, Velusami CC. Antiarthritic effect of polar extract of Curcuma longa on monosodium iodoacetate induced osteoarthritis in rats. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents). 2017;16(3):193-202.
  • 37. Wang C, Al-Ani MK, Sha Y, Chi Q, Dong N, Yang L, et al. Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis. Int J Biol Sci. 2019;15(1):229-38.
  • 38. Maresca M, Micheli L, Di Cesare Mannelli L, Tenci B, Innocenti M, Khatib M, et al. Acute effect of Capparis spinosa root extracts on rat articular pain. J Ethnopharmacol. 2016;193:456-65.
  • 39. Chin KY, Wong SK, Japar Sidik FZ, Abdul Hamid J, Abas NH, Mohd Ramli ES, et al. The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate. Int J Environ Res Public Health. 2019;16(16).
  • 40. Sa L, Wei X, Huang Q, Cai Y, Lu D, Mei R, et al. Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model. J Ethnopharmacol. 2020;259:112883.
  • 41. Wan Osman WN, Che Ahmad Tantowi NA, Lau SF, Mohamed S. Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti-inflammatory, anti-oxidative, and antiprotease pathways. J Food Biochem. 2019;43(3):e12755.
  • 42. Wan Osman WN, Lau SF, Mohamed S. Scopoletin-standardized Morinda elliptica leaf extract suppressed inflammation and cartilage degradation to alleviate osteoarthritis: A preclinical study. Phytother Res. 2017;31(12):1954-61.
  • 43. Mohammadifar M, Aarabi MH, Aghighi F, Kazemi M, Vakili Z, Memarzadeh MR, et al. Anti-osteoarthritis potential of peppermint and rosemary essential oils in a nanoemulsion form: behavioral, biochemical, and histopathological evidence. BMC Complement Med Ther. 2021;21(1):57.
  • 44. Hong J-M, Shin J-K, Kim J-Y, Jang M-J, Park S-K, Lee J-H, et al. BST106 protects against cartilage damage by inhibition of apoptosis and enhancement of autophagy in osteoarthritic rats. Biological and Pharmaceutical Bulletin. 2018;41(8):1257-68.
  • 45. Zhang X, Chen R, Liao Z, Zhu Y, Chen Y, Liu J, et al. The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium Iodoacetate Induced Osteoarthritis. Comb Chem High Throughput Screen. 2022;25(11):1914-51.
  • 46. Lee YM, Son E, Kim S-H, Kim D-S. Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model. Phytomedicine. 2019;65:153095.
  • 47. Park YJ, Cho YR, Oh JS, Ahn EK. Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. Mol Med Rep. 2017;16(4):5303-11.
  • 48. Choudhary D, Kothari P, Tripathi AK, Singh S, Adhikary S, Ahmad N, et al. Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats. BMC Complement Altern Med. 2018;18(1):69.
  • 49. Zhang L, Li T, Wang R, Xu J, Zhou L, Yan L, et al. Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis. Front Pharmacol. 2020;11:1053.
  • 50. Woo YJ, Joo YB, Jung YO, Ju JH, Cho ML, Oh HJ, et al. Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis. Exp Mol Med. 2011;43(10):561-70.
  • 51. Jeong JW, Kim J, Choi EO, Kwon DH, Kong GM, Choi IW, et al. Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats. Excli j. 2017;16:265-77.
  • 52. Kim SH, Choi HJ, Yang WK, Lee JE, Cho JH, Park IJ, et al. Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats. Evid Based Complement Alternat Med. 2017;2017:1791403.
  • 53. Kumari RR, More AS, Gupta G, Lingaraju MC, Balaganur V, Kumar P, et al. Effect of alcoholic extract of Entada pursaetha DC on monosodium iodoacetate-induced osteoarthritis pain in rats. Indian J Med Res. 2015;141(4):454-62.
  • 54. Lee YM, Son E, Kim S-H, Kim D-S. Antiinflammatory and analgesic effects of Schisandra chinensis leaf extracts and monosodium iodoacetate-induced osteoarthritis in rats and acetic acid-induced writhing in mice. Nutrients. 2022;14(7):1356.
  • 55. Lim HJ, Park SI, Bak SG, Cheong SH, Lee S, Baek YB, et al. Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis. Food Science & Nutrition. 2020;8(12):6550-6.
  • 56. Heydari Nasrabadi M, Parsivand M, Mohammadi N, Asghari Moghaddam N. Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis. J Ayurveda Integr Med. 2022;13(2):100529.
  • 57. Jeong YJ, Kim I, Cho JH, Park DW, Kwon JE, Jung MW, et al. Anti-osteoarthritic effects of the Litsea japonica fruit in a rat model of osteoarthritis induced by monosodium iodoacetate. PLoS One. 2015;10(8):e0134856.
  • 58. Yamada EF, Olin LC, Pontel CL, da Rosa HS, Folmer V, da Silva MD. Sida tuberculata reduces oxidative stress and pain caused by the knee osteoarthritis. Journal of Ethnopharmacology. 2020;248:112277.
  • 59. Ma P, Yue L, Yang H, Fan Y, Bai J, Li S, et al. Chondroprotective and anti-inflammatory effects of amurensin H by regulating TLR4/Syk/NF-κB signals. J Cell Mol Med. 2020;24(2):1958-68.
  • 60. Wu W, Xu X, Dai Y, Xia L. Therapeutic effect of the saponin fraction from Clematis chinensis Osbeck roots on osteoarthritis induced by monosodium iodoacetate through protecting articular cartilage. Phytother Res. 2010;24(4):538-46.
  • 61. Ju L, Hu P, Chen P, Xue X, Li Z, He F, et al. Huoxuezhitong capsule ameliorates MIAinduced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway. Biomed Pharmacother. 2020;129:110471.
  • 62. Feng D, Zhu X. Preventive Effect of Saussurea lappa Extract on Osteoarthritis in Mice Model through Inhibition of NF-κB Pathway. Dokl Biochem Biophys. 2021;496(1):56-61.
  • 63. Min GY, Park JM, Joo IH, Kim DH. Inhibition effect of Caragana sinica root extracts on Osteoarthritis through MAPKs, NF-κB signaling pathway. Int J Med Sci. 2021;18(4):861-72.
  • 64. Tantowi NACA, Hussin P, Lau SF, Mohamed S. Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. Menopause. 2017;24(9):1071-80.
  • 65. Tantowi NACA, Mohamed S, Lau SF, Hussin P. Comparison of diclofenac with apigeninglycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. DARU Journal of Pharmaceutical Sciences. 2020;28(2):443-53.
  • 66. Kwon JY, Lee SH, Jhun J, Choi J, Jung K, Cho KH, et al. The combination of probiotic complex, rosavin, and zinc improves pain and cartilage destruction in an osteoarthritis rat model. Journal of medicinal food. 2018;21(4):364-71.
  • 67. Kwon HO, Lee M, Kim O-K, Ha Y, Jun W, Lee J. Effect of Hijikia fusiforme extracts on degenerative osteoarthritis in vitro and in vivo models. Nutrition research and practice. 2016;10(3):265-73.
  • 68. Wang C, Guo L, Tian F, An N, Luo L, Hao R, et al. Naringenin regulates production of matrix metalloproteinases in the knee-joint and primary cultured articular chondrocytes and alleviates pain in rat osteoarthritis model. Brazilian Journal of Medical and Biological Research. 2017;50(4):e5714.
  • 69. Kim C, Kim JH, Lee S, Lee C, Jang GY, Choi J, et al. Chrysanthemum zawadskii ethanol extract inhibits the replication of alpha-coronavirus and beta-coronavirus. PLoS One. 2025;20(6):e0326225.
  • 70. Kang M, Jung I, Hur J, Kim SH, Lee JH, Kang J-Y, et al. The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. Journal of ethnopharmacology. 2010;131(2):485-96.
  • 71. Wang Q, Zhuang D, Feng W, Ma B, Qin L, Jin L. Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage in vivo. Saudi Pharm J. 2020;28(12):1499-506.
  • 72. Kothari P, Tripathi AK, Girme A, Rai D, Singh R, Sinha S, et al. Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins. Journal of ethnopharmacology. 2022;282:114315.
  • 73. Chun JM, Kim HS, Lee AY, Kim S-H, Kim HK. Anti-inflammatory and antiosteoarthritis effects of Saposhnikovia divaricata ethanol extract: in vitro and in vivo studies. Evidence-Based Complementary and Alternative Medicine. 2016;2016(1):1984238.
  • 74. Park YM, Shin DY, Lee HY, Hwang HM, Kim JG, Kim BS, et al. Pinus densiflora Root Extract Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Cartilage Degradation in Interleukin-1β and Monosodium Iodoacetate-Induced Osteoarthritis Models. Nutrients. 2024;16(22):3882.
  • 75. Jeong J-H, Moon S-J, Jhun J-Y, Yang E-J, Cho M-L, Min J-K. Eupatilin exerts antinociceptive and chondroprotective properties in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. PloS one. 2015;10(6):e0130882.
  • 76. Chun JM, Lee AY, Kim JS, Choi G, Kim S-H. Protective effects of Peucedanum japonicum extract against osteoarthritis in an animal model using a combined systems approach for compound-target prediction. Nutrients. 2018;10(6):754.
  • 77. Lu YC, Jayakumar T, Duann YF, Chou YC, Hsieh CY, Yu SY, et al. Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. J Agric Food Chem. 2011;59(9):4969-78.
  • 78. Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, et al. Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis. Journal of Ethnopharmacology. 2024;325:117887.
  • 79. Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res. 2016;11:19.
  • 80. Jo H-G, Lee G-Y, Baek CY, Song HS, Lee D. Analgesic and anti-inflammatory effects of aucklandia lappa root extracts on acetic acidinduced writhing in mice and monosodium iodoacetate-induced osteoarthritis in rats. Plants. 2020;10(1):42.
  • 81. Bao Z, Chen M, Li C, Shan Q, Wang Y, Yang W. Monosodium iodoacetate-induced subchondral bone microstructure and inflammatory changes in an animal model of osteoarthritis. Open Life Sci. 2022;17(1):781-93.
  • 82. Wang XD, Kou XX, He DQ, Zeng MM, Meng Z, Bi RY, et al. Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate. PLoS One. 2012;7(9):e45036.
  • 83. de Sousa Valente J. The Pharmacology of Pain Associated With the Monoiodoacetate Model of Osteoarthritis. Front Pharmacol. 2019;10:974.

Investigation of Plant-Based Treatments, Mechanisms of Action, and Related Molecular Pathways in Models of Monosodium Iodoacetate Induced Knee Osteoarthritis: A Narrative Review

Year 2026, Volume: 7 Issue: 1 , 56 - 85 , 27.03.2026

Seda Koçak , Ekin Celik Kübra Öztürk

https://doi.org/10.46871/eams.1681881
https://izlik.org/JA42DW47XS

Abstract

Osteoarthritis of the knee is a disorder of the joint that results in changes to the histology and biochemistry of knee joint. Pharmacological and non-pharmacological treatment methods are applied for knee osteoarthritis. Non-pharmacological methods include herbal applications. Application of monosodium iodoacetate (mia) is a frequently used method in studies of knee osteoarthritis. Studies of these models aimed to reduce pain and inflammation in the knee area, prevent apoptosis and slow the development of osteoarthritis. While applying this model, plant and plant-based applications are also analyzed. In our review, plant and plant-based treatments applied in monosodium iodoacetate-induced knee osteoarthritis models are discussed according to plants, administration way of plants, species, mia amount used, solvent, slaughtered days after mia induction and pathways. It is aimed to contribute to the preclinical discussions by compiling the studies.

Keywords

Osteoarthritis Plant Treatments Monosodium iodoacetate

Ethical Statement

N7A

Supporting Institution

N/A

References

  • 1. Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020;29.
  • 2. Uthman OA. Global, regional, national incidence, prevalence and years lived with disability for 310 acute and chronic diseases and injuries 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1545-602.
  • 3. Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis and rheumatism. 2012;64(6):1697.
  • 4. Aşkın A, Özkan A, Tosun A, Demirdal ÜS, İsnaç F. Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain. The Kaohsiung Journal of Medical Sciences. 2017;33(3):152-8.
  • 5. Vitaloni M, Botto-van Bemden A, Sciortino R, Carné X, Quintero M, Santos-Moreno P, et al. A patients’ view of OA: the Global Osteoarthritis Patient Perception Survey (GOAPPS), a pilot study. BMC musculoskeletal disorders. 2020;21(1):727.
  • 6. Lee D, Ju M-K, Kim H. Commiphora extract mixture ameliorates monosodium iodoacetateinduced osteoarthritis. Nutrients. 2020;12(5):1477.
  • 7. Lim HJ, Park SI, Bak SG, Cheong SH, Lee S, Baek YB, et al. Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis. Food Sci Nutr. 2020;8(12):6550-6.
  • 8. Madzuki IN, Lau SF, Abdullah R, Mohd Ishak NI, Mohamed S. Vernonia amygdalina inhibited osteoarthritis development by antiinflammatory and anticollagenase pathways in cartilage explant and osteoarthritis-induced rat model. Phytotherapy Research. 2019;33(7):1784-93.
  • 9. Sa L, Wei X, Huang Q, Cai Y, Lu D, Mei R, et al. Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model. Journal of Ethnopharmacology. 2020;259:112883.
  • 10. Fusco R, Siracusa R, Peritore AF, Gugliandolo E, Genovese T, D’Amico R, et al. The role of cashew (Anacardium occidentale L.) nuts on an experimental model of painful degenerative joint disease. Antioxidants. 2020;9(6):511.
  • 11. Bethapudi B, Murugan S, Illuri R, Mundkinajeddu D, Velusami CC. Bioactive turmerosaccharides from Curcuma longa Extract (NR-INF-02): Potential ameliorating effect on osteoarthritis pain. Pharmacognosy magazine. 2017;13(Suppl 3):S623.
  • 12. Zhang H, Ding L, Shi X, Mei W, Huang Z, Zhang L, et al. Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis. Bioengineered. 2021;12(2):12954-64.
  • 13. Choi DJ, Choi S-I, Choi B-R, Lee Y-S, Lee DY, Kim GS. Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats. BMC Complementary and Alternative Medicine. 2019;19(1):325.
  • 14. Chun JM, Lee AY, Moon BC, Choi G, Kim J-S. Effects of Dipsacus asperoides and Phlomis umbrosa Extracts in a Rat Model of Osteoarthritis. Plants. 2021;10(10):2030.
  • 15. Jo HG, Lee GY, Baek CY, Song HS, Lee D. Analgesic and Anti-Inflammatory Effects of Aucklandia lappa Root Extracts on Acetic Acid-Induced Writhing in Mice and Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Plants (Basel). 2020;10(1).
  • 16. Jhun JY, Na HS, Shin JW, Jung KA, Seo HB, Ryu JY, et al. Notoginseng radix and rehmanniae radix preparata extract combination (YH23537) reduces pain and cartilage degeneration in rats with monosodium iodoacetate-induced osteoarthritis. Journal of Medicinal Food. 2018;21(8):745-54.
  • 17. Bahtiar A, Nurazizah M, Roselina T, Tambunan AP, Arsianti A. Ethanolic extracts of babandotan leaves (Ageratum conyzoides L.) prevents inflammation and proteoglycan degradation by inhibiting TNF-α and MMP-9 on osteoarthritis rats induced by monosodium iodoacetate. Asian Pacific journal of tropical medicine. 2017;10(3):270-7.
  • 18. Lee YM, Son E, Kim SH, Kim OS, Kim DS. Anti-inflammatory and anti-osteoarthritis effect of Mollugo pentaphylla extract. Pharm Biol. 2019;57(1):74-81.
  • 19. Hong JM, Shin JK, Kim JY, Jang MJ, Park SK, Lee JH, et al. BST106 Protects against Cartilage Damage by Inhibition of Apoptosis and Enhancement of Autophagy in Osteoarthritic Rats. Biol Pharm Bull. 2018;41(8):1257-68.
  • 20. Tong L, Yu H, Huang X, Shen J, Xiao G, Chen L, et al. Current understanding of osteoarthritis pathogenesis and relevant new approaches. Bone research. 2022;10(1):60.
  • 21. Brumat P, Kunšič O, Novak S, Slokar U, Pšenica J, Topolovec M, et al. The surgical treatment of osteoarthritis. Life. 2022;12(7):982.
  • 22. Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. Journal of orthopaedic surgery and research. 2016;11(1):19.
  • 23. Kim HL, Lee HJ, Lee D-R, Choi B-K, Yang SH. Herbal composition LI73014F2 alleviates articular cartilage damage and inflammatory response in monosodium iodoacetate-induced osteoarthritis in rats. Molecules. 2020;25(22):5467.
  • 24. Ju L, Hu P, Chen P, Xue X, Li Z, He F, et al. Huoxuezhitong capsule ameliorates MIAinduced osteoarthritis of rats through suppressing PI3K/Akt/NF-κB pathway. Biomedicine & Pharmacotherapy. 2020;129:110471.
  • 25. Shin M-R, Kim H-Y, Choi H-Y, Park KS, Choi HJ, Roh S-S. Boswellia serrata Extract, 5-Loxin®, Prevents Joint Pain and Cartilage Degeneration in a Rat Model of Osteoarthritis Through Inhibition of Inflammatory Responses and Restoration of Matrix Homeostasis. Evidence-based Complementary and Alternative Medicine. 2022;2022(1):3067526.
  • 26. Orhan C, Tuzcu M, Durmus AS, Sahin N, Ozercan IH, Deeh PBD, et al. Protective effect of a novel polyherbal formulation on experimentally induced osteoarthritis in a rat model. Biomedicine & Pharmacotherapy. 2022;151:113052.
  • 27. Aborehab NM, El Bishbishy MH, Refaiy A, Waly NE. A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis. BMC complementary and alternative medicine. 2017;17(1):495.
  • 28. Abdel-Rahman RF, Abd-Elsalam RM, Amer MS, El-Desoky AM, Mohamed SO. Manjarix attenuated pain and joint swelling in a rat model of monosodium iodoacetate-induced osteoarthritis. Food & function. 2020;11(9):7960-72.
  • 29. Balkrishna A, Sinha S, Karumuri S, Srivastava J, Haldar S, Varshney A. Peedanil Gold, Herbo-Mineral Formulation, Moderates Cytokine Levels and Attenuates Pathophysiology in Monosodium Iodoacetate Induced Osteoarthritis in SD Rat Model. Front Pharmacol. 2022;13:883475.
  • 30. Lee YM, Son E, Kim SH, Kim DS. Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model. Phytomedicine. 2019;65:153095.
  • 31. Choudhary D, Adhikary S, Ahmad N, Kothari P, Verma A, Trivedi PK, et al. Prevention of articular cartilage degeneration in a rat model of monosodium iodoacetate induced osteoarthritis by oral treatment with Withaferin A. Biomed Pharmacother. 2018;99:151-61.
  • 32. Yimam M, Lee YC, Kim TW, Moore B, Jiao P, Hong M, et al. Analgesic and anti-Inflammatory effect of UP3005, a botanical composition Containing two standardized extracts of Uncaria gambir and Morus alba. Pharmacognosy Res. 2015;7(Suppl 1):S39-46.
  • 33. Kim WK, Chung HJ, Pyee Y, Choi TJ, Park HJ, Hong JY, et al. Effects of intra-articular SHINBARO treatment on monosodium iodoacetate-induced osteoarthritis in rats. Chin Med. 2016;11:17.
  • 34. Kim JK, Park SW, Kang JW, Kim YJ, Lee SY, Shin J, et al. Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Evid Based Complement Alternat Med. 2012;2012:730907.
  • 35. Zhang Y, Zeng Y. Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF-κB signal pathway. Drug Dev Res. 2019;80(3):353-9.
  • 36. Murugan S, Bethapudi B, Purusothaman D, Chandrasekaran PR, Velusami CC. Antiarthritic effect of polar extract of Curcuma longa on monosodium iodoacetate induced osteoarthritis in rats. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Inflammatory and Anti-Allergy Agents). 2017;16(3):193-202.
  • 37. Wang C, Al-Ani MK, Sha Y, Chi Q, Dong N, Yang L, et al. Psoralen Protects Chondrocytes, Exhibits Anti-Inflammatory Effects on Synoviocytes, and Attenuates Monosodium Iodoacetate-Induced Osteoarthritis. Int J Biol Sci. 2019;15(1):229-38.
  • 38. Maresca M, Micheli L, Di Cesare Mannelli L, Tenci B, Innocenti M, Khatib M, et al. Acute effect of Capparis spinosa root extracts on rat articular pain. J Ethnopharmacol. 2016;193:456-65.
  • 39. Chin KY, Wong SK, Japar Sidik FZ, Abdul Hamid J, Abas NH, Mohd Ramli ES, et al. The Effects of Annatto Tocotrienol Supplementation on Cartilage and Subchondral Bone in an Animal Model of Osteoarthritis Induced by Monosodium Iodoacetate. Int J Environ Res Public Health. 2019;16(16).
  • 40. Sa L, Wei X, Huang Q, Cai Y, Lu D, Mei R, et al. Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model. J Ethnopharmacol. 2020;259:112883.
  • 41. Wan Osman WN, Che Ahmad Tantowi NA, Lau SF, Mohamed S. Epicatechin and scopoletin rich Morinda citrifolia (Noni) leaf extract supplementation, mitigated Osteoarthritis via anti-inflammatory, anti-oxidative, and antiprotease pathways. J Food Biochem. 2019;43(3):e12755.
  • 42. Wan Osman WN, Lau SF, Mohamed S. Scopoletin-standardized Morinda elliptica leaf extract suppressed inflammation and cartilage degradation to alleviate osteoarthritis: A preclinical study. Phytother Res. 2017;31(12):1954-61.
  • 43. Mohammadifar M, Aarabi MH, Aghighi F, Kazemi M, Vakili Z, Memarzadeh MR, et al. Anti-osteoarthritis potential of peppermint and rosemary essential oils in a nanoemulsion form: behavioral, biochemical, and histopathological evidence. BMC Complement Med Ther. 2021;21(1):57.
  • 44. Hong J-M, Shin J-K, Kim J-Y, Jang M-J, Park S-K, Lee J-H, et al. BST106 protects against cartilage damage by inhibition of apoptosis and enhancement of autophagy in osteoarthritic rats. Biological and Pharmaceutical Bulletin. 2018;41(8):1257-68.
  • 45. Zhang X, Chen R, Liao Z, Zhu Y, Chen Y, Liu J, et al. The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium Iodoacetate Induced Osteoarthritis. Comb Chem High Throughput Screen. 2022;25(11):1914-51.
  • 46. Lee YM, Son E, Kim S-H, Kim D-S. Effect of Alpinia oxyphylla extract in vitro and in a monosodium iodoacetate-induced osteoarthritis rat model. Phytomedicine. 2019;65:153095.
  • 47. Park YJ, Cho YR, Oh JS, Ahn EK. Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. Mol Med Rep. 2017;16(4):5303-11.
  • 48. Choudhary D, Kothari P, Tripathi AK, Singh S, Adhikary S, Ahmad N, et al. Spinacia oleracea extract attenuates disease progression and sub-chondral bone changes in monosodium iodoacetate-induced osteoarthritis in rats. BMC Complement Altern Med. 2018;18(1):69.
  • 49. Zhang L, Li T, Wang R, Xu J, Zhou L, Yan L, et al. Evaluation of Long-Time Decoction-Detoxicated Hei-Shun-Pian (Processed Aconitum carmichaeli Debeaux Lateral Root With Peel) for Its Acute Toxicity and Therapeutic Effect on Mono-Iodoacetate Induced Osteoarthritis. Front Pharmacol. 2020;11:1053.
  • 50. Woo YJ, Joo YB, Jung YO, Ju JH, Cho ML, Oh HJ, et al. Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis. Exp Mol Med. 2011;43(10):561-70.
  • 51. Jeong JW, Kim J, Choi EO, Kwon DH, Kong GM, Choi IW, et al. Schisandrae Fructus ethanol extract ameliorates inflammatory responses and articular cartilage damage in monosodium iodoacetate-induced osteoarthritis in rats. Excli j. 2017;16:265-77.
  • 52. Kim SH, Choi HJ, Yang WK, Lee JE, Cho JH, Park IJ, et al. Suppressive Effect of the n-Hexane Extract of Litsea japonica Fruit Flesh on Monosodium-Iodoacetate-Induced Osteoarthritis in Rats. Evid Based Complement Alternat Med. 2017;2017:1791403.
  • 53. Kumari RR, More AS, Gupta G, Lingaraju MC, Balaganur V, Kumar P, et al. Effect of alcoholic extract of Entada pursaetha DC on monosodium iodoacetate-induced osteoarthritis pain in rats. Indian J Med Res. 2015;141(4):454-62.
  • 54. Lee YM, Son E, Kim S-H, Kim D-S. Antiinflammatory and analgesic effects of Schisandra chinensis leaf extracts and monosodium iodoacetate-induced osteoarthritis in rats and acetic acid-induced writhing in mice. Nutrients. 2022;14(7):1356.
  • 55. Lim HJ, Park SI, Bak SG, Cheong SH, Lee S, Baek YB, et al. Beneficial effects of Vigna angularis extract in osteoporosis and osteoarthritis. Food Science & Nutrition. 2020;8(12):6550-6.
  • 56. Heydari Nasrabadi M, Parsivand M, Mohammadi N, Asghari Moghaddam N. Comparison of Elaeagnus angustifolia L. extract and quercetin on mouse model of knee osteoarthritis. J Ayurveda Integr Med. 2022;13(2):100529.
  • 57. Jeong YJ, Kim I, Cho JH, Park DW, Kwon JE, Jung MW, et al. Anti-osteoarthritic effects of the Litsea japonica fruit in a rat model of osteoarthritis induced by monosodium iodoacetate. PLoS One. 2015;10(8):e0134856.
  • 58. Yamada EF, Olin LC, Pontel CL, da Rosa HS, Folmer V, da Silva MD. Sida tuberculata reduces oxidative stress and pain caused by the knee osteoarthritis. Journal of Ethnopharmacology. 2020;248:112277.
  • 59. Ma P, Yue L, Yang H, Fan Y, Bai J, Li S, et al. Chondroprotective and anti-inflammatory effects of amurensin H by regulating TLR4/Syk/NF-κB signals. J Cell Mol Med. 2020;24(2):1958-68.
  • 60. Wu W, Xu X, Dai Y, Xia L. Therapeutic effect of the saponin fraction from Clematis chinensis Osbeck roots on osteoarthritis induced by monosodium iodoacetate through protecting articular cartilage. Phytother Res. 2010;24(4):538-46.
  • 61. Ju L, Hu P, Chen P, Xue X, Li Z, He F, et al. Huoxuezhitong capsule ameliorates MIAinduced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway. Biomed Pharmacother. 2020;129:110471.
  • 62. Feng D, Zhu X. Preventive Effect of Saussurea lappa Extract on Osteoarthritis in Mice Model through Inhibition of NF-κB Pathway. Dokl Biochem Biophys. 2021;496(1):56-61.
  • 63. Min GY, Park JM, Joo IH, Kim DH. Inhibition effect of Caragana sinica root extracts on Osteoarthritis through MAPKs, NF-κB signaling pathway. Int J Med Sci. 2021;18(4):861-72.
  • 64. Tantowi NACA, Hussin P, Lau SF, Mohamed S. Mistletoe fig (Ficus deltoidea Jack) leaf extract prevented postmenopausal osteoarthritis by attenuating inflammation and cartilage degradation in rat model. Menopause. 2017;24(9):1071-80.
  • 65. Tantowi NACA, Mohamed S, Lau SF, Hussin P. Comparison of diclofenac with apigeninglycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. DARU Journal of Pharmaceutical Sciences. 2020;28(2):443-53.
  • 66. Kwon JY, Lee SH, Jhun J, Choi J, Jung K, Cho KH, et al. The combination of probiotic complex, rosavin, and zinc improves pain and cartilage destruction in an osteoarthritis rat model. Journal of medicinal food. 2018;21(4):364-71.
  • 67. Kwon HO, Lee M, Kim O-K, Ha Y, Jun W, Lee J. Effect of Hijikia fusiforme extracts on degenerative osteoarthritis in vitro and in vivo models. Nutrition research and practice. 2016;10(3):265-73.
  • 68. Wang C, Guo L, Tian F, An N, Luo L, Hao R, et al. Naringenin regulates production of matrix metalloproteinases in the knee-joint and primary cultured articular chondrocytes and alleviates pain in rat osteoarthritis model. Brazilian Journal of Medical and Biological Research. 2017;50(4):e5714.
  • 69. Kim C, Kim JH, Lee S, Lee C, Jang GY, Choi J, et al. Chrysanthemum zawadskii ethanol extract inhibits the replication of alpha-coronavirus and beta-coronavirus. PLoS One. 2025;20(6):e0326225.
  • 70. Kang M, Jung I, Hur J, Kim SH, Lee JH, Kang J-Y, et al. The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. Journal of ethnopharmacology. 2010;131(2):485-96.
  • 71. Wang Q, Zhuang D, Feng W, Ma B, Qin L, Jin L. Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage in vivo. Saudi Pharm J. 2020;28(12):1499-506.
  • 72. Kothari P, Tripathi AK, Girme A, Rai D, Singh R, Sinha S, et al. Caviunin glycoside (CAFG) from Dalbergia sissoo attenuates osteoarthritis by modulating chondrogenic and matrix regulating proteins. Journal of ethnopharmacology. 2022;282:114315.
  • 73. Chun JM, Kim HS, Lee AY, Kim S-H, Kim HK. Anti-inflammatory and antiosteoarthritis effects of Saposhnikovia divaricata ethanol extract: in vitro and in vivo studies. Evidence-Based Complementary and Alternative Medicine. 2016;2016(1):1984238.
  • 74. Park YM, Shin DY, Lee HY, Hwang HM, Kim JG, Kim BS, et al. Pinus densiflora Root Extract Attenuates Osteoarthritis Progression by Inhibiting Inflammation and Cartilage Degradation in Interleukin-1β and Monosodium Iodoacetate-Induced Osteoarthritis Models. Nutrients. 2024;16(22):3882.
  • 75. Jeong J-H, Moon S-J, Jhun J-Y, Yang E-J, Cho M-L, Min J-K. Eupatilin exerts antinociceptive and chondroprotective properties in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes. PloS one. 2015;10(6):e0130882.
  • 76. Chun JM, Lee AY, Kim JS, Choi G, Kim S-H. Protective effects of Peucedanum japonicum extract against osteoarthritis in an animal model using a combined systems approach for compound-target prediction. Nutrients. 2018;10(6):754.
  • 77. Lu YC, Jayakumar T, Duann YF, Chou YC, Hsieh CY, Yu SY, et al. Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells. J Agric Food Chem. 2011;59(9):4969-78.
  • 78. Jia L, Gong Y, Jiang X, Fan X, Ji Z, Ma T, et al. Ginkgolide C inhibits ROS-mediated activation of NLRP3 inflammasome in chondrocytes to ameliorate osteoarthritis. Journal of Ethnopharmacology. 2024;325:117887.
  • 79. Kuyinu EL, Narayanan G, Nair LS, Laurencin CT. Animal models of osteoarthritis: classification, update, and measurement of outcomes. J Orthop Surg Res. 2016;11:19.
  • 80. Jo H-G, Lee G-Y, Baek CY, Song HS, Lee D. Analgesic and anti-inflammatory effects of aucklandia lappa root extracts on acetic acidinduced writhing in mice and monosodium iodoacetate-induced osteoarthritis in rats. Plants. 2020;10(1):42.
  • 81. Bao Z, Chen M, Li C, Shan Q, Wang Y, Yang W. Monosodium iodoacetate-induced subchondral bone microstructure and inflammatory changes in an animal model of osteoarthritis. Open Life Sci. 2022;17(1):781-93.
  • 82. Wang XD, Kou XX, He DQ, Zeng MM, Meng Z, Bi RY, et al. Progression of cartilage degradation, bone resorption and pain in rat temporomandibular joint osteoarthritis induced by injection of iodoacetate. PLoS One. 2012;7(9):e45036.
  • 83. de Sousa Valente J. The Pharmacology of Pain Associated With the Monoiodoacetate Model of Osteoarthritis. Front Pharmacol. 2019;10:974.
There are 83 citations in total.

Details

Primary Language English
Subjects Orthopaedics
Journal Section Review
Authors

Seda Koçak 0000-0003-1183-4847

Ekin Celik This is me 0000-0003-4772-3807

Kübra Öztürk This is me 0000-0002-4488-0164

Submission Date April 27, 2025
Acceptance Date February 2, 2026
Early Pub Date March 27, 2026
Publication Date March 27, 2026
DOI https://doi.org/10.46871/eams.1681881
IZ https://izlik.org/JA42DW47XS
Published in Issue Year 2026 Volume: 7 Issue: 1

Cite

Vancouver 1.Seda Koçak, Ekin Celik, Kübra Öztürk. Investigation of Plant-Based Treatments, Mechanisms of Action, and Related Molecular Pathways in Models of Monosodium Iodoacetate Induced Knee Osteoarthritis: A Narrative Review. Exp Appl Med Sci. 2026 Mar. 1;7(1):56-85. doi:10.46871/eams.1681881

Aim & Scope

Deneysel ve Uygulamalı Tıp Bilimleri, tıp bilimlerinin her alanından özgün ve yaşam kalitesini artıracak çarpıcı araştırma sonuçlarının yer aldığı güncel ve kolay erişilebilir bir akademik yayın olmayı hedeflemektedir.

Experimental and Applied Medical Science, Gaziantep İslam Bilim ve Teknoloji Üniversitesi Tıp Fakültesi bünyesinde yılda dört kez İngilizce olarak yayımlanan, açık erişimli, uluslararası çift-kör hakemli akademik bir tıp dergisidir. Dergi, hastalıkların patogenezi ile ilgili deneysel hayvan çalışmaları, farmakolojik, klinik, epidemiyolojik ve deontolojik çalışmalar, ayrıca halk sağlığını geliştirme, sağlık hizmetleri veya sağlık sigortası alanlarındaki çalışmaları içeren, yurt içinden veya yurt dışından sunulmuş araştırma makalesi, derleme, editöre mektup, kısa bildirim, özet bildirim vb. şeklinde yayınlanmak üzere yazıları kabul etmektedir.

Değerlendirme veya yayın sırasında yazarlardan herhangi bir ücret talep edilmez. Dergi 3 ayda bir (Mart, Temmuz, Eylül ve Aralık) olmak üzere yılda 4 sayı yayınlanmaktadır. Derginin yazım dili İngilizcedir. Makalenin sadece özet kısmı Türkçe olarak da gönderilmelidir.

Deneysel ve Uygulamalı Tıp Bilimleri dergisi; özgün araştırma makaleleri, derlemeler, olgu sunumları ve editöre mektuplar kabul etmektedir. Bir makalenin gönderilmesi, daha önce yayımlanmadığını ve başka bir yerde yayımlanmak üzere değerlendirilmediğini ima eder. Gönderilen makalelerin yayımlanıp yayımlanmayacağına dair karar, makalenin önemine ve özgünlüğüne ilişkin Editör Kurulu'nun görüşüne dayanır.
Dergiye gönderilen makalelerin tüm yazarları (sorumlu yazar ve diğer yazarlar), bireysel bir ORCID (Open Researcher and Contributor ID) numarası almalı (http://orcid.org) ve bu numarayı makalenin başlık sayfasında belirtmelidir. Sorumlu yazar, tüm yazarları DergiPark sistemine eklemelidir.
Makaleler
Makaleler, elektronik olarak "Microsoft Word" formatında, "Times New Roman" yazı tipi, 12 punto ve çift aralıklı olarak yazılmalıdır. Makaleler İngilizce yazılmalı; özetler ise hem Türkçe hem de İngilizce hazırlanmalıdır. Sayfanın her iki yanında 2.5 cm boşluk bırakılmalı ve metin iki yana yaslı olmalıdır. Kelimeler satır sonlarında kesilmemelidir. Sayfalar ardışık olarak numaralandırılmalıdır.
Makale, "Başlık sayfası", "Türkçe Özet", "İngilizce Özet", "Metin", "Kaynaklar", "Tablolar" ve "Şekiller" gibi bölümleri içermeli ve her bölüm ayrı bir sayfadan başlamalıdır.
Özgün araştırma makaleleri için gerekli etik kurul izinleri alınmalı ve etik kurul numarası ile tarihi makalede belirtilmelidir. Çalışmanın intihal raporu yüklenmeli ve intihal oranı %30'u geçmemelidir.
Makalenizi sisteme yüklerken dosya adını sorumlu yazarın adı ve soyadı olarak belirleyiniz.
Başlık Sayfası
Başlık sayfasında Türkçe ve İngilizce başlıklar ayrı ayrı verilmelidir. Başlıkta kısaltmalar kullanılmamalıdır.
• Tüm yazarlar için ORCID numaraları, özet ve metnin kelime sayıları (özet, tablolar ve kaynaklar hariç) belirtilmelidir.
• Yazarların tam isimleri, soyadları, akademik unvanları, görev yaptıkları kurum, çalışmanın yapıldığı klinik/bölüm/enstitü/hastane/üniversitenin tam adı ve adresi ile e-posta adresleri belirtilmelidir.
• Sorumlu yazarın iletişim bilgileri (güncel adres, e-posta adresi ve GSM telefon numarası) eklenmelidir.
• Çalışma daha önce bir bilimsel toplantıda sunulmuşsa ya da özeti yayımlanmışsa bu durum belirtilmelidir.
• Tüm yazarların olası çıkar çatışmaları ve finansal destek bilgileri, konu ile doğrudan ilişkili olup olmadığına bakılmaksızın, bireysel olarak açıklanmalıdır.
Özet
Türkçe ve İngilizce özetler ayrı hazırlanmalı ve her biri 250 kelimeyi geçmemelidir. Türkçe özet şu başlıkları içermelidir: Amaç, Yöntem, Bulgular, Sonuç, Anahtar Kelimeler. İngilizce özet ise şu başlıklardan oluşmalıdır: Purpose, Methods, Results, Conclusion, Keywords.
Metin
Metin; "Giriş", "Yöntem", "Bulgular", "Tartışma" ve "Sonuç" bölümlerinden oluşmalıdır. Metin sonunda "Çıkar Çatışması" ve "Teşekkür" bölümleri eklenmelidir.
• Fazla kısaltma kullanılmamalıdır.
• Tablolar, grafikler ve şekiller metin sonunda ayrı birer sayfada yer almalıdır.
Kaynaklar, Vancouver formatında düzenlenmeli ve metinde geçtiği sıraya göre numaralandırılmalıdır.

Makaleler yalnızca orijinal olmaları, başka bir dergide eşzamanlı olarak değerlendirilmemeleri veya daha önce yayımlanmamış olmaları koşuluyla yayımlanmak üzere değerlendirilir. Telif hakkı ile korunan herhangi bir materyalden alınan doğrudan alıntılar, tablolar veya görseller için telif hakkı sahiplerinden yazılı izin alınmalıdır. Tüm makaleler editörler ve hakemler tarafından incelenir. Yayınlanmaya uygunluk, sunulan materyalin önemine ve özgünlüğüne dayanır. Yayınlanması uygun görülen makaleler, sunulan veriler değiştirilmeden, açık ve anlaşılır bir şekilde sunulması için editöryal revizyona tabi tutulabilir.
Experimental and Applied Medical Science, aşağıdaki web adresinde yer alan “Helsinki Bildirgesi” ilkelerine sıkı sıkıya bağlıdır:
Helsinki Bildirgesi
Editör Kurulu, insanlarla yapılan tüm çalışmaların bu ilkelere uygun olması gerektiğini beyan eder.
İnsan katılımcılarla yapılan çalışmaların verilerini içeren makalelerde, Yöntem ve Materyal bölümünde çalışmanın kurum etik inceleme kurulu tarafından onaylandığını ve her katılımcıdan “bilgilendirilmiş onam” alındığını belirten açıklamalar yer almalıdır. Ayrıca, laboratuvar hayvanlarıyla yapılan deneyleri bildiren makalelerde, hayvanların “Laboratuvar Hayvanlarının Bakımı ve Kullanımı Kılavuzu” ile uyumlu bir şekilde insan bakımına tabi tutulduğunu ve kurum etik kurul onayının alındığını doğrulayan açıklamalar Yöntem ve Materyal bölümünde yer almalıdır.
Laboratuvar Hayvanları Kılavuzu
Eğer çalışmayı destekleyen ticari bir ilişki veya mali destek sağlayan bir kurum varsa, yazarlar bu ürün, ilaç veya şirket ile ticari bir ilişkileri olmadığını veya varsa ne tür bir ilişkiye (danışmanlık ya da başka bir anlaşma) sahip olduklarını beyan etmelidir.
Dergi için işlem ve yayın ücretsizdir. Değerlendirme ve yayın sürecinin hiçbir aşamasında yazarlardan ücret talep edilmez. Tüm makaleler, yalnızca çevrimiçi başvuru sistemi aracılığıyla gönderilmelidir:
https://dergipark.org.tr/tr/pub/eams
Derginin yönergeleri, teknik bilgileri ve gerekli formlar da derginin web sayfasında mevcuttur.
Derginin tüm masrafları Gaziantep İslam Bilim ve Teknoloji Üniversitesi Tıp Fakültesi tarafından karşılanmaktadır. Potansiyel reklam verenler derginin Editör Ofisi ile iletişime geçmelidir. Reklam görselleri yalnızca Baş Editör'ün onayı ile yayımlanır.
Makalelerde ifade edilen görüş ve öneriler, Gaziantep İslam Bilim ve Teknoloji Üniversitesi Tıp Fakültesi, editörler, editör kurulu ve/veya yayıncıların görüşlerini yansıtmaz; bu içeriklerin sorumluluğu tamamen yazar(lar)a aittir.
Araştırma çalışmalarını içeren tüm makaleler, biyostatistik açısından değerlendirilmelidir ve uygun çalışma tasarımı, analiz ve sonuçlarla birlikte sunulmalıdır. Makalelerde p değerleri net bir şekilde belirtilmelidir. Araştırma makaleleri dışındaki (derleme, olgu sunumu, editöre mektup vb.) yazılar da özgün, güncel ve kaynaklarıyla birlikte açık, anlaşılır ve tatmin edici olmalıdır.
Derginin yayın dili İngilizce’dir. Ancak makalenin özet kısmı hem Türkçe hem de İngilizce olarak yüklenmelidir. Makaleler dergiye gönderilmeden önce bir dil uzmanı tarafından değerlendirilmelidir.
Telif Hakkı ve Yayımlama Hakları:
5846 sayılı ve 13.12.1951 tarihli Fikir ve Sanat Eserleri Kanunu’na göre (aşağıdaki bağlantıda yer alan) yayımlanması kabul edilen makalelerin tüm yayım hakları dergiyi yayımlayan kuruma aittir. Ancak makalelerde ifade edilen düşünceler ve öneriler tamamen yazarların sorumluluğundadır.
Fikir ve Sanat Eserleri Kanunu

Experimental and Applied Medical Science dergisinde makale değerlendirme ve yayın süreci tamamen ücretsizdir.

Other Indexes

Europub
Türk Medline
ROAD
Asos İndeks

Editör

Default avatar
Ayşegül Burçin YILDIRIM
Cell Development, Proliferation and Death, Histology and Embryology, Reproduction

Editör Yardımcıları

Seçil Eroğlu
Seçil EROĞLU
Molecular Genetics
Mehmet Göl
Mehmet GÖL

2008 yılında Hacettepe Üniversitesi Tıp (İng). Fakültesi'nden mezun oldu. 2018 yılında Gaziantep Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı'nda Tıbbi Fizyoloji alanında doktoramı tamamladı. 2019 yılından bu yana Gaziantep İslam Bilim ve Teknoloji Üniversitesi Tıp Fakültesi Fizyoloji Anabilim Dalı'nda öğretim üyesi olarak görev yapmaktadır. Başlıca çalışma alanları, Alzheimer Hastalığı, egzersiz ve elektrokardiyografidir.
Medical Physiology, Family Medicine
Bengisu Tüfekçi
Bengisu TÜFEKÇİ
Physiotherapy

Yayın Kurulu

Default avatar
Hadiye DEMİRBAKAN
Medical Microbiology, Health Sciences
Default avatar
Derya KARABULUT
Histology and Embryology
Default avatar
Tulin GUVEN GOKMEN
Medical Microbiology, Veterinary Microbiology
Default avatar
Leyla TUTAR
Biological Sciences, Genomics and Transcriptomics, Cancer Biology, Epigenetics, Molecular Genetics
Bircan Ulaş Kadıoğlu
Bircan ULAŞ KADIOĞLU
Nutrition and Dietetics, Public Health Nutrition, Nutritional Epidemiology, Public Health
Default avatar
Hikmet DİNÇ
Pharmaceutical Toxicology, Basic Pharmacology, Medical Pharmacology, Toxicology, Health Sciences
Ömer Erdoğan
Ömer ERDOĞAN
Medical Biochemistry and Metabolomics

Alan Editörleri

Default avatar
Mahshid HODJAT
Health Sciences
Çağla Yiğitbaş
Çağla YİĞİTBAŞ
Public Health, Preventative Health Care, Health Promotion, Social Determinants of Health, Community Child Health, Health Literacy
Default avatar
Hasan ULUSAL
Medical Biochemistry and Metabolomics
Tülay Öncü Öner
Tülay ÖNCÜ ÖNER
Molecular Genetics, Medical Genetics (Excl. Cancer Genetics), Bioengineering, Animal Cell Culture and Tissue Engineering
Default avatar
Sultan CİNGÖZ
Developmental Genetics, Neurogenetics, Cytogenetic, Molecular Genetics
Default avatar
Rabia TAŞDEMİR
Anatomy
Default avatar
Zekiye İpek KATIRCI KIRMACI
Physiotherapy, Rehabilitation
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Özlem AKAY
Statistics, Biostatistics, Statistical Analysis, Applied Statistics
Default avatar
Ayşegül Burçin YILDIRIM
Cell Development, Proliferation and Death, Histology and Embryology, Reproduction
Default avatar
Sinem YILMAZ
Cell Development, Proliferation and Death, Proteomics and Intermolecular Interactions, Animal Cell and Molecular Biology, Bioengineering (Other)
Default avatar
Gönül ELPEZE
Physiotherapy, Rehabilitation
Default avatar
Daniele SAVERİNO

Daniele Saverino is an Associate Professor of Human Anatomy at the University of Genoa. He holds the following university degrees: Degree in Medicine, Degree in Biological Sciences, Specialization in Allergology and Clinical Immunology, and Master's in Microbiological Sciences.

He is currently a member of the Board of the Department of Experimental Medicine, a member of the Scientific Council University Service Center, University Service Center of Simulation and Advanced Training – SIMAV of the University of Genoa (Italy); he is also a medical director at the IRCCS San Martino Polyclinic in Genoa.

He is the holder of the Human Anatomy courses for the degree courses in Medicine and Surgery, Physiotherapy, Motor Sciences at the University of Genoa and the Neuroanatomy Course, Degree in Medicine at the Vita e Salute University of Milan (Italy) He was a Research fellow, Brown University, The Miriam Hospital, Providence, Rhode Island, USA.

His research interests and activity are mostly closely connected to diagnostic activity: study and experimentation of new analytical technologies, diagnostic experimentation of new autoantibody markers in various areas of pathology, development, experimentation and validation of specific diagnostic algorithms, participation, for the diagnostic part of competence, in clinical trials and studies.

He is also involved in pathophysiological studies concerning alterations of immunoregulatory and effector mechanisms in systemic and organ-specific autoimmune diseases, with particular reference to the role and regulation of "immune checkpoint" molecules.
Autoimmunity
Emel Şahin
Emel ŞAHİN
Cancer Biology, Immunogenetics, Transplantation Immunology, Tumour Immunology, Cancer Genetics, Cancer Cell Biology, Medical Biochemistry and Metabolomics
Ferhat Aslan
Ferhat ASLAN
Obstetrics and Gynaecology
Default avatar
Safiah OLABİ
Cancer Biology, Molecular Genetics, Mechanobiology
Kaifee Arman
Kaifee ARMAN
Cancer Biology, Molecular Genetics, Cancer Genetics, Cancer Cell Biology
Default avatar
Roghaiyeh SAFARİ

Dr. Roghaiyeh Safari, 15 yılı aşkın deneyimiyle moleküler tıp alanında uzmanlaşmış bir bilim insanıdır. Imperial College London, Sahlgrenska Kanser Merkezi (İsveç), Liège Üniversitesi (Belçika) ve İzmir Biyotıp ve Genom Merkezi (IBG) gibi prestijli kurumlarda yürüttüğü araştırmalarla moleküler biyoloji ve genetik alanında geniş bir uzmanlık edinmiştir.

RS & RS Scientific’in Kurucu Ortağı ve Bilimsel Direktörü (CSO) olarak, iş birliğine dayalı bir araştırma ortamı oluşturmakta ve bilimsel keşifleri kanser tedavisine yönelik pratik çözümlere dönüştürme konusunda endüstri deneyimini kullanmaktadır.

Moleküler araştırmalar konusundaki uzmanlığının yanı sıra, liderlik koçluğu yapmaktadır ve klinik geçmişi sayesinde hasta odaklı bir yaklaşım benimsemektedir.
Cancer Biology, Molecular Genetics
Default avatar
Marie CUTİONGCO
Cellular Interactions, Mechanobiology
İbrahim Edhem Yılmaz
İbrahim Edhem YILMAZ

Avrupa Board sertifikalı göz hastalıkları uzmanı ve Gaziantep İslam Bilim ve Teknoloji Üniversitesi’nde öğretim üyesidir. Oküloplastik cerrahi ve ön segment alanında uzmanlaşmış olup 2.000’den fazla katarakt, 600’den fazla oküloplastik ve 200’den fazla şaşılık ameliyatı deneyimine sahiptir. Ulusal ve uluslararası dergilerde çok sayıda yayını, kitap bölümleri ve kongre sunumları bulunan Yılmaz, akademik hareketlilik programları ve bilimsel işbirlikleriyle mesleki gelişimini sürdürmekte ve göz hastalıkları eğitimine katkı sağlamaktadır.  
War Surgery, Ophthalmology and Optometry, Ophthalmology

Teknik Editör

Default avatar
Demet YILMAZKAYA GÖĞÜŞ
Biological Sciences, Mycology

Mizanpaj Editörleri

Default avatar
Şerife KÜÇÜKHÜYÜK
Histology and Embryology
Nazlı Hilal Eke
Nazlı Hilal EKE
Medical Physiology, Medical Physiology (Other), Health Sciences
Ebru Sena Poyraz
Ebru Sena POYRAZ
Anatomy

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