Monosodyum İodoasetat ile İndüklenen Diz Osteoartriti Modellerinde Bitki Bazlı Tedavilerin Araştırılması

Öz

Diz osteoartriti, diz ekleminde histolojik ve biyokimyasal değişikliklere yol açan bir eklem bozukluğudur. Diz osteoartriti tedavisinde farmakolojik ve farmakolojik olmayan yöntemler uygulanmaktadır. Farmakolojik olmayan yöntemler arasında bitkisel uygulamalar da yer almaktadır. Monosodyum iodoasetat (MIA) uygulaması, diz osteoartriti çalışmalarında sıklıkla kullanılan bir yöntemdir. Bu modellere yönelik çalışmalar, diz bölgesindeki ağrı ve iltihabı azaltmayı, apoptozu önlemeyi ve osteoartritin ilerlemesini yavaşlatmayı amaçlamaktadır. Bu model uygulanırken, bitki ve bitki bazlı uygulamalar da analiz edilmektedir. Derlememizde, monosodyum iodoasetat ile indüklenen diz osteoartriti modellerinde uygulanan bitki ve bitki bazlı tedaviler; kullanılan bitkiler, uygulama şekli, türler, kullanılan MIA miktarı, çözücü, MIA uygulamasından sonra kesim günü ve etkilediği yollar (pathways) açısından ele alınmıştır. Bu çalışmaların derlenmesiyle, preklinik tartışmalara katkı sağlanması amaçlanmaktadır.

Anahtar Kelimeler

• osteoartirit
• bitki
• tedaviler
• monosodyum iyodoasetat

Investigation of Plant-Based Treatments, Mechanisms of Action, and Related Molecular Pathways in Models of Monosodium Iodoacetate Induced Knee Osteoarthritis: A Narrative Review

Öz

Osteoarthritis of the knee is a disorder of the joint that results in changes to the histology and biochemistry of knee joint. Pharmacological and non-pharmacological treatment methods are applied for knee osteoarthritis. Non-pharmacological methods include herbal applications. Application of monosodium iodoacetate (mia) is a frequently used method in studies of knee osteoarthritis. Studies of these models aimed to reduce pain and inflammation in the knee area, prevent apoptosis and slow the development of osteoarthritis. While applying this model, plant and plant-based applications are also analyzed. In our review, plant and plant-based treatments applied in monosodium iodoacetate-induced knee osteoarthritis models are discussed according to plants, administration way of plants, species, mia amount used, solvent, slaughtered days after mia induction and pathways. It is aimed to contribute to the preclinical discussions by compiling the studies.

Anahtar Kelimeler

• Osteoarthritis
• Plant
• Treatments
• Monosodium iodoacetate

Kaynakça

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