Radyasyonun Lamotrijin ve Flurbiprofen Üzerine Etkisinin EPR Çalışması

Abstract

Bu çalışmada gama radyasyonun Lamotrijin ve Flurbiprofen’de oluşturduğu hasarları belirlemek için Elektron Paramanyetik Rezonans Spektroskopisi kullanıldı. Örneklerde oluşan serbest radikallerin bazı alkil ve amin türü radikaller olabileceği şeklinde yorumlandı. Radikallerin g değerleri ve aşırı ince yapı sabitleri belirlendi. Örneklerin spektrum simülasyonları bilgisayar kullanılarak gerçekleştirildi. Örneklerde oluşan serbest radikallerin oda sıcaklığında iki aydan daha fazla kararlı olduğu ortaya çıktı

Keywords

• EPR
• ilaç
• serbest radikal
• gama radyasyonu

Radiation Effects on Lamotrigine and Flourbiprofen: an EPR study

Abstract

Electron paramagnetic resonance (EPR) spectroscopy was used to determine the gamma radiation damages in Lamotrigine and Flurbiprofen.The free radicals produced in the samples were interpreted in terms of some type of alkyl and amine radical fragments. The g values and hyperfine structure constants of the radicals were determined and the spectra were computer simulated. In this study, the free radicals were appeared to be stable at room temperature for more than two months.

Keywords

• EPR
• drugs
• free radicals
• gamma irradiation

References

1. References
2. Diehl, J.F., 2002. Food irradiation-past, present and future. Radiat. Phys. Chem. 63, 211-215
3. Gibella, M., Crucq, A.S.,Tilquin, B., Stocer, P., Lesgards, G., Raffi, J., 2000. Electron spin resonance studies of some irradiated pharmaceuticals. Radiat. Phys. Chem. 58, 69-76
4. Petrişor, D., Damian, G., Ionila, M., Dragan, F., Simon, S., 2004. EPR study of radical kinetics in some γ-irradiated beta- blocker drugs. Stud. Univ. Babes-Bol. Phys. XLIX. 3, 23-29
5. Sivri, N.N., Özer, A.Y., Özalp, M., Atakan, N., Polat,M., 2006. Decontamination of cosmetic products and raw materials by gamma irradiation. FABAT J, Pharm. Sci., 31, 198-209
6. Damian, G., 2003. EPR investigation of gamma-irradiated anti-emetic drugs. Talanta, 60, 923-927
7. Basly, J.P., Basly, I., Bernard. M., 1998. Radiosterilization dosimetry of vitamins: an ESR study. Int. J. Radiat. Biol. 74, 521-528
8. Piccerelle, P., Reynier, J.P., Joachim, J., Tilquin, B., J.Raffi, J., 2000. J. Pharma. Belg, 131-136

9. Jacobs, G.P., 1985. A review: Radiation sterilization of Pharmaceuticals. Radiat. Phys. Chem., 26, 133-142
10. Crucq, A.S., 1994. Etude de mecanismesradicalaires de medicaments irradies. Chim. Nouvelle, 12, 1356-1359
11. Yordanov, N.D., Gancheva, V., 2000. A new approach for extension of the identification period of irradiated cellulose containing foodstuffs by EPR spectroscopy. Appl. Rad. Isotopes, 52,195-198
12. McKelvey, R.D., 1987. J. Chem. Educ., 64, 479
13. Asadollahi, M., Ramezani, M., Karimialavijeh, E., Tavakolian, M., Ramezani, M., 2015. Can physiologic menstrual cycle change serum lamotrigine concentration?.Seizure, 33, 35-37
14. Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C., 2015. Pharmacological and neuroethological study of the acute andchronic effects of lamotrigine in the genetic audiogenic seizurehamster (GASH:Sal). Epilepsy and Behavior
15. Morton, J.R., 1964. Electron spin resonance spectra of oriented radicals. Chem. Rev., 64, 453
16. Wood, D.E., Loyd, R.G., 1969. Isotropic EPR spectra from free radicals trapped in an adamantine matrix. J. Chem. Phys. 52, 3840
17. Başkan, M.H., Aydın, M., Osmanoğlu, Ş., 2007. EPR of γ-irradiated single crystal of iminodiacetic acid. Radiat. Eff. Def. in Solid. 163, 65-70
18. Jang, Y.J., Cho, K.H., 2016. Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method. Asian Journal of pharmaceutical sciences II, 108-109
19. Zhanga, L., Zhanga, Q., Wanga, X., Zhangb, W., Lina C., Chena, F., Yanga, X., Pana, W., 2015. Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen. Int. J. Pharmaceutics, 492, 40-45