Bioactive Glasses

Year 2017, , 436 - 471, 30.09.2017

Bekir Karasu , Ali Ozan Yanar Alper Koçak , Özden Kısacık

https://doi.org/10.31202/ecjse.323652

Cited By: 3

Abstract

Bioactive
glasses were discovered in 1969 and provided for the first time an alternative
to nearly inert implant materials. They formed a rapid, strong, and stable bond
with host tissues. This article examines the frontiers of research crossed to
achieve clinical use of bioactive glasses and glass–ceramics. In the 1980s, it
was discovered that bioactive glasses could be used in particulate form to
stimulate osteogenesis, which thereby led to the concept of regeneration of
tissues. Later, it was found that the dissolution ions from the glasses behaved
like growth factors, providing signals to the cells. Hereby, the frontiers of
knowledge crossed during four eras of development of bioactive glasses led from
concept of bioactivity to widespread clinical and commercial use, with emphasis
on the first composition, 45S5 Bioglases® were mentioned. The four eras are (a)
discovery, (b) clinical application, (c) tissue regeneration, and (d)
innovation. Questions still to be answered for the fourth era are included to
stimulate innovation in the field and exploration of new frontiers that can be
the basis for a general theory of bioactive stimulation of regeneration of
tissues and application to numerous clinical needs. 

Keywords

Bioactive glass, History, Development, Types, Production, Properties, Application

Biyoaktif Camlar

Abstract

Biyoaktif
camlar 1969 yılında keşfedilmiş ve ilk kez neredeyse tamamen inert malzemelere
bir alternatif olmuştur. Dokularla hızlı, sağlam ve kararlı bağ oluştururlar. Bu
makalede konuyla ilgili yapılan çalışmalardan ve biyoaktif camlarla cam
seramiklerin klinik uygulamalarından bahsedilecektir. 1980’lerde biyoaktif
camların özellikle dokuların yeniden şekil alması anlamında
kullanılabilecekleri bulunmuştur. Daha sonra, camdan çözünen iyonların
hücrelere sinyal vererek büyütücü etken gibi davrandıkları belirlenmiştir.
Mevcut çalışmada, biyoaktif camların gelişiminde (a) keşif, (b) klinik
uygulama, (c) doku oluşturma (d) yenilik olmak üzere dört evrenin ortaya
çıkışına ve bu grup malzemelerin biyoaktiflikleri sayesinde yaygın klinik ve
ticari kullanımlarına yol açan ilk bileşimden (45S5 Bioglases®) bahsedilerek
devam edilecektir.

Keywords

Biyoaktifcam, Tarihçe, Gelişim, Tür, Üretim, Özellikler, Uygulama

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