Bioactive Glasses

Abstract

Bioactive glasses were discovered in 1969 and provided for the first time an alternative to nearly inert implant materials. They formed a rapid, strong, and stable bond with host tissues. This article examines the frontiers of research crossed to achieve clinical use of bioactive glasses and glass–ceramics. In the 1980s, it was discovered that bioactive glasses could be used in particulate form to stimulate osteogenesis, which thereby led to the concept of regeneration of tissues. Later, it was found that the dissolution ions from the glasses behaved like growth factors, providing signals to the cells. Hereby, the frontiers of knowledge crossed during four eras of development of bioactive glasses led from concept of bioactivity to widespread clinical and commercial use, with emphasis on the first composition, 45S5 Bioglases® were mentioned. The four eras are (a) discovery, (b) clinical application, (c) tissue regeneration, and (d) innovation. Questions still to be answered for the fourth era are included to stimulate innovation in the field and exploration of new frontiers that can be the basis for a general theory of bioactive stimulation of regeneration of tissues and application to numerous clinical needs. 

Keywords

• Bioactive glass,History,Development,Types,Production,Properties,Application

Biyoaktif Camlar

Abstract

Biyoaktif camlar 1969 yılında keşfedilmiş ve ilk kez neredeyse tamamen inert malzemelere bir alternatif olmuştur. Dokularla hızlı, sağlam ve kararlı bağ oluştururlar. Bu makalede konuyla ilgili yapılan çalışmalardan ve biyoaktif camlarla cam seramiklerin klinik uygulamalarından bahsedilecektir. 1980’lerde biyoaktif camların özellikle dokuların yeniden şekil alması anlamında kullanılabilecekleri bulunmuştur. Daha sonra, camdan çözünen iyonların hücrelere sinyal vererek büyütücü etken gibi davrandıkları belirlenmiştir. Mevcut çalışmada, biyoaktif camların gelişiminde (a) keşif, (b) klinik uygulama, (c) doku oluşturma (d) yenilik olmak üzere dört evrenin ortaya çıkışına ve bu grup malzemelerin biyoaktiflikleri sayesinde yaygın klinik ve ticari kullanımlarına yol açan ilk bileşimden (45S5 Bioglases®) bahsedilerek devam edilecektir.

Keywords

• Biyoaktifcam,Tarihçe,Gelişim,Tür,Üretim,Özellikler,Uygulama

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