THE THEORETICAL EVALUATION FOR THE USE OF VANADIUM (III) OXYHYDROXIDE FOR THE ELECTROCHEMICAL DETERMINATION OF BENZODIAZEPINES

Abstract

The theoretical evaluation for the use of vanadium (III) oxyhydroxide as an electrode modifier for benzodiazepines’ electrochemical determination in acid solutions has been made. The correspondent mathematical model has been developed and analyzed by means of the linear stability theory and bifurcation analysis. It was shown that VO(OH) may be an efficient electrode modifier for the benzodiazepines electrochemical determination in lightly and moderately acid solution. Its use in concentrated acidic solution may be compromised by modifier destruction. The oscillatory behavior in this system may be caused not only by the DEL influences of the electrochemical stage, but also by surface instabilities, caused by VO(OH) dissolution.

Keywords

• benzodiazepines,electrochemical sensor,chemically modified electrodes,vanadium(III)oxyhydroxide

The Theoretical Evaluation For The Use of Vanadium (Iii) Oxyhydroxide For The Electrochemical Determination of Benzodiazepines

Abstract

The theoretical evaluation for the use of vanadium (III) oxyhydroxide as an electrode modifier for benzodiazepines’ electrochemical determination in acid solutions has been made. The correspondent mathematical model has been developed and analyzed by means of the linear stability theory and bifurcation analysis. It was shown that VO(OH) may be an efficient electrode modifier for the benzodiazepines electrochemical determination in lightly and moderately acid solution. Its use in concentrated acidic solution may be compromised by modifier destruction. The oscillatory behavior in this system may be caused not only by the DEL influences of the electrochemical stage, but also by surface instabilities, caused by VO(OH) dissolution.

Keywords

• benzodiazepines,electrochemical sensor,chemically modified electrodes,vanadium(III)oxyhydroxide

References

1. [1]. M. Gladis Mondino. Compostos Heterocíclicos. Estudo e Aplicações Sintéticas. 1ª Edição. São Paulo, Editora Atheneu, Série “Ciência e Tecnologia”, 2014, 224 pág.
2. [2]. T. Mehdi, Brit. J. Med. Pract., 5(2012), 501
3. [3]. J.D. Jones, S. Mogali, S. Corner, Drug. Alcohol. Depend., 2012, 125, 8
4. [4]. J.R. Bostwick, M.I. Casher, S. Yasugi, Curr. Psych., 2012, 11; Referência: http://www.currentpsychiatry.com/home/article/benzodiazepines-a-versatile-clinical-tool/f5f4e5bdf44396acbe205ca9dd87ccea.html accessed at the 3rd of December 2017
5. [5]. Sedative-hypnotic drugs. In: Basic and clinical pharmacology, 8th edition. Katzung BG. USA: The McGraw Hill Companies, Inc, 2001:364–381
6. [6]. J. Guina, S.R. Rossetter, B.J. de Rhodes et. al., J. Psychiatr. Pract., 21(2015), 281
7. [7]. B. Moosmann, L.M. Huppertz, M. Hutter et. al., J. Mass. Spectrom., 48(2013), 1150
8. [8]. L. J. Núñez-Vergara, S. Bollo, C. Olea-Azar et. al., J. Electroanal. Chem., 1997, 436, 227

9. [9]. M.E. Lozano-Chávez, J.M. Palacios-Santander, L. M. Cubillana-Aguilera et al., Sens. Act. B. Chem., 2006, 115, 575
10. [10]. M. N. Uddin, V.F. Samanidou, I.N. Papadoyannis, Pharm. Anal. Acta, 2014, 5, 303
11. [11] Y. Zhang, X. Jing, Mat. Lett., 205(2017), 1
12. [12]. Stadnik O. Synthesis, Electrochemical and Photoelectrochemical Properties of the Oxide-hydroxide Compounds of Cobalt, Diss. Kand. Chim. N. – Kyiv. – 2011
13. [13]. O. Stadnik, N. Ivanova, Y. Boldyrev, 218th Int. Electrochem. Soc. Meeting. Abstract # 2240, http://ma.ecsdl.org/content/MA201002 /38/2240.full.pdf Accessed at 8th of August 2015 [14]. V. Tkach, S.C. de Oliveira, R. Ojani et al., Rev. Colomb. Cien. Quím. Farm., 45(2016), 362
14. [15]. V.V. Tkach, Ya. G. Ivanushko, Iryna L. Kukovs´ka et al.,Revista Química Hoy, 6(2016), 14
15. [16]. V. Tkach, S.C. de Oliveira, G. Maia et. al., Mor. J. Chem., 4(2016), 112
16. [17]. V. Tkach, S.C. de Oliveira, F.J. Anaissi et. al., Anal. Bioanal. Electrochem., 8(2016), 1