Donepezil HCl Salımı İçin Düşük Konsantrasyonlarda Titanyum Dioksit Nanopartikülü İçeren Fotopolimerize Edilebilir HEMA/PEG-DA Tabanlı Hidrojellerin Hazırlanması

Abstract

2-hidroksil etil metakrilat/poli (etilen glikol) diakrilat (HEMA / PEG-DA) tabanlı hidrojeller, biyobozunur olma ve sürekli salım gibi çekici özellikleri nedeniyle ilgi çekici ilaç taşıyıcılarıdır. Bu çalışmanın kapsamı, düşük konsantrasyonlarda titanyum dioksit (TiO2) nanopartikülü içeren HEMA / PEG-DA tabanlı hidrojellerin şişme ve salınım davranışlarını araştırmaktır. Hidrojeller, fotopolimerizasyon ile başarılı bir şekilde sentezlenmiştir. Fotopolimerizasyon için 2,2-dimetoksi-2-fenil-asetofenon (Irgacure 651), 1-hidroksisikloheksil fenil keton (Irgacure 184) ve 2-hidroksi-4'-(2-Hidroksietoksi) -2 metilpropiofenon (Irgacure 2959) seçilmiştir. Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR), hidrojellerin fonksiyonel grubunu doğrulamak için kullanılmıştır. Digital mikroskop ve taramalı elektron mikroskopu hidrojellerin karakterizasyonu için kulanılmıştır. Bu çalışma, hidrojel içeriğinin, fotobaşlatıcıların türünün ve pH'ın, Donepezil Hidroklorür’ün (Alzheimer hastalığı için ilaç etken maddesi (Active Pharmaceutical Ingredient (API)) şişme ve salım davranışlarının üzerinde önemli bir etkiye sahip olduğunu ortaya koymuştur.

Keywords

• titanyum dioksit nanopartikülü,
• Donepezil HCl
• Şişme
• Salım
• HEMA/PEG-DA tabanlı hidrojeller,

Preparation of Photopolymerizable HEMA/PEG-DA Based Hydrogels Filled with Low Concentrations of Nanoparticle Titanium Dioxide for Release Of Donepezil HCl

Abstract

: 2-hydroxyl ethyl methacrylate/poly(ethylene glycol) diacrylate (HEMA/PEG-DA) based hydrogels are attractive drug carriers due to their appealing properties such as biodegradability and sustained release. The scope of this study was to investigate the swelling and release behaviors of HEMA/PEG-DA-based hydrogels filled with low concentrations of nanoparticle titanium dioxide (TiO2). Hydrogels have been synthesized successfully by photopolymerization. 2,2-Dimethoxy-2-Phenyl-Acetophenone (Irgacure 651), 1-Hydroxycyclohexyl Phenyl Ketone (Irgacure 184) and 2-Hydroxy-4'-(2-Hydroxyethoxy)-2 Methylpropiophenone (Irgacure 2959) were selected for photopolymerization. Fourier Transform Infrared Spectroscopy (FT-IR) had been used in confirming the functional group of hydrogels. A digital microscope and Scanning Electron Microscope (SEM) were used for characterizing synthesized hydrogels. This study revealed that the content of hydrogels, the kind of photo-initiators and pH have a significant effect on the swelling and releasing of Donepezil Hydrochloride (active pharmaceutical ingredient (API) for Alzheimer disease) behaviours.

Keywords

• HEMA/PEG-DA based hydrogels
• Nanaoparticle titanium dioxide
• Donepezil HCl,
• Swelling
• Releasing

References

1. [1]. Senol, S., Akyol, E., Study on the Preparation and Drug Release Property of Modified PEG-DA Based Hydrogels. Journal of The Turkish Chemical Society: Chemistry A, 2019, 6, 1- 14.
2. [2]. Taşdemir, T., Başaran, H.B. Removal of Suspended Particles from Wastewater by Conventional Flotation and Floc-flotation. El-Cezerî Journal of Science and Engineering, 2021, 8, 421-431.
3. [3]. Yuan, X., Praphakar, R., Munsamy, M., Alarfaj, A., Kumar, S., Rajan, M., Mucoadhesive Guargum Hydrogel Inter-connected Chitosan-g-polycaprolactone Micelles for Rifampicin Delivery, Carbohydrate Polymers, 2019, 206, 1-10.
4. [4]. Liang, Y., Zhao, X., Ma, P., Guo, B., Du, Y., Han, X., pH-responsive Injectable with Mucosal Adhesiveness Based on Chitosan-grafted-di hydrocaffeic Acid and Oxidized Pullulan for Localized Drug Delivery, Journal of Colloid and Interface Science, 2019, 536, 224–234.
5. [5]. Aycan, D., Alemdar, N., Development of pH-Responsive Chitosan-based Hydrogel Modified with Bone Ash for Controlled Release of Amoxicillin, Carbohydrate Polymers, 2018,184, 401-417.
6. [6]. Senol, S., Akyol, E., Controlled Release of Donepezil Hydrochloride From PEG-DA Hydrogels, Bulgarian Chemical Communications, 2018, 1, 12-17.
7. [7]. Senol S., Akyol, E., Synthesis and Characterization of Hydrogels Based on poly (2-hydroxyethyl methacrylate) for Drug Delivery Under UV Irradiation, Journal of Materials Science, 2018, 53, 14953-14963.
8. [8]. Sinani, G., Sessevmez, M., Gök, K., Özgümüş, S., Okyar, A., Alpar, O., Cevher, E., Nasal Vaccination with poly(aminoester)-poly(D,L-lactide-co-glycolide) Hybrid Nanoparticles, International Journal of Pharmaceutics, 2017, 529, 1-14.

9. [9]. Demir S, Hahraman M.V, Bora N, Kayaman Apohan N, Ogan A. Preparation, Characterization,and Drug Release Properties of Poly(2-hydroxyethyl methacrylate) Hydrogels Having β-Cyclodextrin Functionality, Journal of Applied Polymer Science, 2008, 109, 1360–1368.
10. [10].Bounabi, L., Mokhnachi, N-B., Haddadine, N., Ouazib, F., Barille, R., Development of poly(2-Hydroxyethyl Methacrylate)/Clay Composites as Drug Delivery Systems of Paracetamol, Journal of Drug Delivery Science and Technology, 2016, 33, 58-65.
11. [11]. Kamoun, E., Menzel, H., Crosslinking Behavior of Dextran Modified with Hydroxyethyl Methacrylate upon Irradiation with Visible Light-Effect of Concentration, Coinitiator Type and Solvent, Journal of Applied Polymer Science, 2010, 117, 3128–3138.
12. [12]. Sadeghi, M., Synthesis of Starch-g-poly(acrylic acid-co-2-hydroxy ethyl methacrylate) as a Potential pH-sensitive Hydrogel-based Drug Delivery System, Turk J Chem, 2011, 35, 723- 733.
13. [13]. Lv, Chao., Xia, H., Shi, Q., Wang, G., Wang, Y-S., Chen, Q-D., Zhang, Y-L., Liu, L-Q., Sun, H-B., Sensitively Humidity-Driven Actuator Based on Photopolymerizable PEG-DA Films, Advanced Materials Interfaces, 2017, 4, 1601002-10.
14. [14]. Tan, G., Liao, J., Ning, C., Zhang, L., Preparation, Characterization and Drug-Release Properties of PEG-DA-Based Copolymer Hydrogel Microspheres. Journal of Applied Polymer Science, 2011, 125, 3509–16.
15. [15]. Kocabay, G-O., Ismail, O., Synthesis And Characterization of Poly(Ɛ-Caprolactone)–Poly(Ethylene Glycol)–Poly(Ɛ-Caprolactone) Copolymers: Investigation of the Effect of Blocks On Micellization, Revue Roumaine de Chimie, 2018, 63(12), 1165-75.
16. [16].Shashwat, S.B., Naval, A., Rajesh, P., Jayant, K., Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications, Journal of Drug Delivery, 2012, 1-17. (doi:10.1155/2012/103973).
17. [17]. Onuki, Y., Hasegawa, N., Kıda, C., Obata, Y., Takayama, K., Study of the Contribution of the State of Water to the Gel Properties of a Photocrosslinked Polyacrylic Acid Hydrogel Using Magnetic Resonance Imaging, Journal Of Pharmaceutical Sciences, 2014, 103, 3532– 3541.
18. [18]. Akyol, E., Senol, S., Dogan, O., Controlled Release of Donepezil Hydrochloride from the Ternary Sodium Alginate Based Hydrogels. Bulgarian Chemical Communications, 2017, 49, 57-63.
19. [19]. Ayhan, H., Ayhan, F., Photocrosslinked poly(ethylen glycol) Hydrogels for Controlled Drug Delivery, Turk J Biochem, 2014, 39, 403-415. [20]. Kazemi, F., Mohamadnia, Z., Kaboudin, B., Karimi, Z., Photodegradation of Methylene Blue with a Titanium dioxide/polyacrylamide Photocatalyst Under Sunlight, Journal of Applied Polymer Science, 2016, 133, 43386–43395.
20. [21]. Wang, Di., Tan, Y., Xu, H., Wang, X., Yu, L., Xiao, Z., Wang, J,, Xu, S., A Tough and Fluorescent Dual Nanocomposite Hydrogel Based On SiO2@TiO2 Core-Shell Nanoparticles, Applied Surface Science, 2019, 467, 588–595.
21. [22]. Dogan, O., Bodur, B., Investigation of Hydroxyapatite Morphology at Different Experimental Conditions, Bulgarian Chemical Communications, 2017, 49, 122-127.
22. [23]. Zhang, H., Shi, R., Xie A, Li J, Chen L, Chen P, Li S, Huang F, Shen Y. Novel TiO2/PEG- DA Hybrid Hydrogel Prepared in Situ on Tumor Cells for Effective Photodynamic Therapy, Applied Material&Interfaces, 2013, 5, 12317-12322.
23. [24]. Li, Q., Chu, T-T., Chen, Y-X., Li ,Y-M., Tau Protein Associated Inhibitors in Alzheimer Disease, Chinese Journal of Chemistry, 2014, 32, 964-968.
24. [25]. Lasagna-Reeves, C.A., Kayed. R., Astrocytes Contain Amyloid-β Annular Protofibrils in Alzheimer’s Disease Brains, FEBS Letters, 2011, 585, 3052–57.
25. [26]. Asil, T., Uzuner, N., Differentiation of Vascular Dementia and Alzheimer Disease, J Ultrasound Med, 2005, 24, 1065–107.
26. [27]. Jackson, S., Ham, R., Wilkinson, D., The Safety and Tolerability of Donepezil In Patients with Alzheimer’s Disease, British Journal of Clinical Pharmacology, 2004, 58, 1-8.
27. [28]. Amir, Oleyaei S., Razavi, S.M. A., Mikkonen, K.S., Physicochemical and Rheo-mechanical Properties of Titanium Dioxide Reinforced Sage Seed Gum Nanohybrid Hydrogel, International Journal of Biological Macromolecules, 2018, 118, 661-670.
28. [29]. Senol, S., Akyol, E., Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide, Materials Science-Poland, 2020, 38, 443-449.