Research Article
Year 2016,
Volume: 3 Issue: 2, 281 - 286, 31.05.2016
Abstract
Bu çalışmada gama radyasyonun Lamotrijin ve Flurbiprofen’de oluşturduğu hasarları belirlemek için Elektron Paramanyetik Rezonans Spektroskopisi kullanıldı. Örneklerde oluşan serbest radikallerin bazı alkil ve amin türü radikaller olabileceği şeklinde yorumlandı. Radikallerin g değerleri ve aşırı ince yapı sabitleri belirlendi. Örneklerin spektrum simülasyonları bilgisayar kullanılarak gerçekleştirildi. Örneklerde oluşan serbest radikallerin oda sıcaklığında iki aydan daha fazla kararlı olduğu ortaya çıktı
Keywords
References
- References
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- Gibella, M., Crucq, A.S.,Tilquin, B., Stocer, P., Lesgards, G., Raffi, J., 2000. Electron spin resonance studies of some irradiated pharmaceuticals. Radiat. Phys. Chem. 58, 69-76
- Petrişor, D., Damian, G., Ionila, M., Dragan, F., Simon, S., 2004. EPR study of radical kinetics in some γ-irradiated beta- blocker drugs. Stud. Univ. Babes-Bol. Phys. XLIX. 3, 23-29
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- Piccerelle, P., Reynier, J.P., Joachim, J., Tilquin, B., J.Raffi, J., 2000. J. Pharma. Belg, 131-136
- Jacobs, G.P., 1985. A review: Radiation sterilization of Pharmaceuticals. Radiat. Phys. Chem., 26, 133-142
- Crucq, A.S., 1994. Etude de mecanismesradicalaires de medicaments irradies. Chim. Nouvelle, 12, 1356-1359
- Yordanov, N.D., Gancheva, V., 2000. A new approach for extension of the identification period of irradiated cellulose containing foodstuffs by EPR spectroscopy. Appl. Rad. Isotopes, 52,195-198
- McKelvey, R.D., 1987. J. Chem. Educ., 64, 479
- Asadollahi, M., Ramezani, M., Karimialavijeh, E., Tavakolian, M., Ramezani, M., 2015. Can physiologic menstrual cycle change serum lamotrigine concentration?.Seizure, 33, 35-37
- Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C., 2015. Pharmacological and neuroethological study of the acute andchronic effects of lamotrigine in the genetic audiogenic seizurehamster (GASH:Sal). Epilepsy and Behavior
- Morton, J.R., 1964. Electron spin resonance spectra of oriented radicals. Chem. Rev., 64, 453
- Wood, D.E., Loyd, R.G., 1969. Isotropic EPR spectra from free radicals trapped in an adamantine matrix. J. Chem. Phys. 52, 3840
- Başkan, M.H., Aydın, M., Osmanoğlu, Ş., 2007. EPR of γ-irradiated single crystal of iminodiacetic acid. Radiat. Eff. Def. in Solid. 163, 65-70
- Jang, Y.J., Cho, K.H., 2016. Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method. Asian Journal of pharmaceutical sciences II, 108-109
- Zhanga, L., Zhanga, Q., Wanga, X., Zhangb, W., Lina C., Chena, F., Yanga, X., Pana, W., 2015. Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen. Int. J. Pharmaceutics, 492, 40-45
Year 2016,
Volume: 3 Issue: 2, 281 - 286, 31.05.2016
Abstract
Electron paramagnetic resonance (EPR) spectroscopy was used to determine the gamma radiation damages in Lamotrigine and Flurbiprofen.The free radicals produced in the samples were interpreted in terms of some type of alkyl and amine radical fragments. The g values and hyperfine structure constants of the radicals were determined and the spectra were computer simulated. In this study, the free radicals were appeared to be stable at room temperature for more than two months.
Keywords
References
- References
- Diehl, J.F., 2002. Food irradiation-past, present and future. Radiat. Phys. Chem. 63, 211-215
- Gibella, M., Crucq, A.S.,Tilquin, B., Stocer, P., Lesgards, G., Raffi, J., 2000. Electron spin resonance studies of some irradiated pharmaceuticals. Radiat. Phys. Chem. 58, 69-76
- Petrişor, D., Damian, G., Ionila, M., Dragan, F., Simon, S., 2004. EPR study of radical kinetics in some γ-irradiated beta- blocker drugs. Stud. Univ. Babes-Bol. Phys. XLIX. 3, 23-29
- Sivri, N.N., Özer, A.Y., Özalp, M., Atakan, N., Polat,M., 2006. Decontamination of cosmetic products and raw materials by gamma irradiation. FABAT J, Pharm. Sci., 31, 198-209
- Damian, G., 2003. EPR investigation of gamma-irradiated anti-emetic drugs. Talanta, 60, 923-927
- Basly, J.P., Basly, I., Bernard. M., 1998. Radiosterilization dosimetry of vitamins: an ESR study. Int. J. Radiat. Biol. 74, 521-528
- Piccerelle, P., Reynier, J.P., Joachim, J., Tilquin, B., J.Raffi, J., 2000. J. Pharma. Belg, 131-136
- Jacobs, G.P., 1985. A review: Radiation sterilization of Pharmaceuticals. Radiat. Phys. Chem., 26, 133-142
- Crucq, A.S., 1994. Etude de mecanismesradicalaires de medicaments irradies. Chim. Nouvelle, 12, 1356-1359
- Yordanov, N.D., Gancheva, V., 2000. A new approach for extension of the identification period of irradiated cellulose containing foodstuffs by EPR spectroscopy. Appl. Rad. Isotopes, 52,195-198
- McKelvey, R.D., 1987. J. Chem. Educ., 64, 479
- Asadollahi, M., Ramezani, M., Karimialavijeh, E., Tavakolian, M., Ramezani, M., 2015. Can physiologic menstrual cycle change serum lamotrigine concentration?.Seizure, 33, 35-37
- Barrera-Bailón, B., Oliveira, J.A.C., López, D.E., Muñoz, L.J., Garcia-Cairasco, N., Sancho, C., 2015. Pharmacological and neuroethological study of the acute andchronic effects of lamotrigine in the genetic audiogenic seizurehamster (GASH:Sal). Epilepsy and Behavior
- Morton, J.R., 1964. Electron spin resonance spectra of oriented radicals. Chem. Rev., 64, 453
- Wood, D.E., Loyd, R.G., 1969. Isotropic EPR spectra from free radicals trapped in an adamantine matrix. J. Chem. Phys. 52, 3840
- Başkan, M.H., Aydın, M., Osmanoğlu, Ş., 2007. EPR of γ-irradiated single crystal of iminodiacetic acid. Radiat. Eff. Def. in Solid. 163, 65-70
- Jang, Y.J., Cho, K.H., 2016. Preparation and characterization of solidified SMEDDS containing flurbiprofen by spray drying method. Asian Journal of pharmaceutical sciences II, 108-109
- Zhanga, L., Zhanga, Q., Wanga, X., Zhangb, W., Lina C., Chena, F., Yanga, X., Pana, W., 2015. Drug-in-cyclodextrin-in-liposomes: A novel drug delivery system for flurbiprofen. Int. J. Pharmaceutics, 492, 40-45
There are 19 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Engineering |
| Journal Section | Makaleler |
| Authors | |
| Publication Date | May 31, 2016 |
| Submission Date | March 25, 2016 |
| Published in Issue | Year 2016 Volume: 3 Issue: 2 |
Cited By
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https://doi.org/10.2139/ssrn.2964236
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