Koroner arter baypass cerrahisinde statinin antikardiyolipin antikor seviyelerine etkisi

Abstract

Amaç: Bu araştırmanın amacı, koroner baypas cerrahisi hastalarında statinin lipit düşürme mekanizması ile diğer yararlı biyolojik etkileri arasındaki bağlantıyı preoperatif statin ile preoperatif, perioperatif ve postoperatif kardiyolipin IgG ve IgM antikor düzeyleri arasındaki ilişkiyi ortaya koyarak incelemektir. Açık kalp cerrahisinde durum sadece kalbin atmasını sağlamak değil, miyokardiyal hasarı önlemek veya en aza indirmektir. Bu nedenle kan elementlerinin ve miyokardın korunması için yeni bir yöntemin ortaya çıkarılması gerekmektedir. Gereç ve Yöntemler: Elektif koroner arter baypas greft cerrahisi planlanan ve araştırma kriterlerimize uyan koroner iskemik hastalığı olan 30 hasta, 40 mg/gün atorvastatin ile standart lipid düşürücü tedavi görenler olmak üzere iki gruba ayrıldı. ameliyattan en az 7 gün önce (grup A) ve ikinci grup ameliyat öncesi düzenli lipid düşürücü tedavi almayanlar (B). Demografik, hemodinamik, laboratuvar ve cerrahi teknik dahil olmak üzere tüm parametreler belgelendi ve kaydedildi. Bulgular: Kaydedilen parametreler ve değerler bilgisayar programında şu testler kullanılarak analiz edildi: Kolmogorov-Smirnov testi, student t testi, paired t testi ve Ki-kare testi. Tüm sonuçlar, basit ve daha iyi değerlendirme için 6 tabloda planlanmıştır. Sonuç: Bulgular, açık kalp cerrahisinde perioperatif ve postoperatif erken dönemde (ilk 24 saat) statinin yararlı etkilerini desteklemektedir.

Keywords

• Açık kalp cerrahisi
• statin
• antikardiyolipin antikoru

Effect of statin on anticardiolipin antibody levels in coronary artery bypass surgery

Abstract

Objectives: The aim of this research is to study the link between lipid lowering mechanism and other beneficial biological effects of statin in patients of coronary bypass surgery by revealing the relation of preoperative statin on pre- , peri- and postoperative cardiolipin IgG and IgM antibody levels. The case in open cardiac surgery was not keeping the heart beating only but preventing or minimizing the myocardial injury. For this reason, a new method for preservation of blood elements and myocardium must be uncovered. Material and Methods: Thirty patients with coronary ischemic disease whose scheduled to undergo elective coronary artery bypass graft surgery and fitting the criteria for our research were divided in to two groups, those on standard lipid lowering therapy using atorvastatin ( 40 mg/day ) for at least 7 days prior to surgery (group A) and second group those without regular lipid lowering therapy preoperatively (B). All the parameters were documented and recorded, including demographic, hemodynamic, laboratory and surgical technique with outcome. Results: The recorded parameters and values were analyzed using the following tests in computer program: Kolmogorov- Smirnov test, student t test, paired t test and Chi- square test. All results were scheduled in 6 tables for simple and better evaluation. Conclusion: The findings support the beneficial effects of statin in the perioperative and early postoperative (first 24 hours) in open cardiac surgery.

Keywords

• Open cardiac surgery
• statin
• anticardiolipin antibody

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