Ketiapin Kullanımı ile İlişkili Olabilecek Lökopeni: Bir Olgu Sunumu

Abstract

Ketiapin şizofreni, bipolar bozukluk gibi psikiyatrik bozuklukların tedavisinde kullanılan bir antipsikotiktir. Sedasyon, kilo alımı, kabızlık, halsizlik gibi yan etkileri bulunmaktadır. Lökopeni, ketiapin kullanımı ile ilişkili olabilecek diğer bir nadir yan etkidir. Bu olgu sunumunda, ketiapin kullanımı sırasında gelişen beyaz küre düşüklüğünü ele aldık.

Keywords

• lökopeni,ketiapin,yan etki,major depresif bozukluk

Leukopenia Associated with the Use of Quetiapine: A Case Report

Abstract

Quetiapine is an antipsychotic used in the treatment of schizophrenia and bipolar disorder. There are side effects such as sedation, weight gain, constipation and drowsiness. Leukopenia is another rare side effect associated with the use of quetiapine. In this case report, we discussed the low white blood cell count during quetiapine use.

Keywords

• leukopenia,quetiapine,side effect,major depressive disorder

References

1. 1. Aydın E, Şenormancı Ö, Altınbaş K, Kurt E. Leucopenia due to quetiapine abuse and combination with olanzapine: A case report. Düşünen Adam The Journal of Psychiatry and Neurological Sciences 2010; 23: 219-22.
2. 2. El-Saifi N, Jones C, Moyle W. Quetiapine adverse events in older adults in Australia. Australas J Ageing 2016; 35: 281-4.
3. 3. Ozen ME, Orum MH, Kalenderoglu A, Egilmez OB. Quetiapine-induced priapism. Medicine Science 2018; 7: 426-7.
4. 4. Landau J, Lu K, Choo C, Greenberg P. Neutropenia with quetiapine. Aust Prescr 2008; 31: 10-1.
5. 5. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC: Author.
6. 6. Kose S, Akin E, Cetin M. Adverse drug reactions and causality: The Turkish version of Naranjo Adverse Drug Reactions Probability Scale. Psychiatry and Clinical Psychopharmacology 2017; 27: 205-6.
7. 7. Croarkin P, Rayner T. Acute neutropenia in a patient treated with quetiapine. Psychosomatics 2001; 42: 368.
8. 8. Cowan C, Oakley C. Leukopenia and neutropenia induced by quetiapine. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 292-4.

9. 9. Tang HC, Chung KH. Quetiapine-induced neutropenia in a bipolar patient with hepatocellular carcinoma. Int J Psychiatry Med 2014; 47: 255-61.
10. 10. Information from ADRAC database, the Australian Adverse Drug Reactions Advisory Committee (ADRAC), Therapeutic Goods Administration. 2007 Nov.
11. 11. Kara MZ, Orum MH. Atomoxetine use may cause leukopenia. Psychiatry and Behavioral Sciences 2018;8(3):145-6.
12. 12. Shewmaker J. Quetiapine-induced leukopenia and neutropenia in an intensive care unit patient with delirium. J Pharm Technol 2013; 29: 9-12.
13. 13. World Health Organization. WHO Collaborating Centre for International Drug Monitoring. Causality assessment of suspected adverse reactions. http://www.who-umc.org/DynPage.aspx?id=22682 [cited 2008 Jan 11].
14. 14. Ozen ME, Orum MH, Kalenderoglu A. Difficult patient in psychiatry practice: A case-control study. Adıyaman Üni Sağlık Bilimleri Derg 2018; 4: 1064-73.